| Filed On | Filing |
|---|---|
| 13 Feb 2019 | AMENDMENT NO.1 TO SCHEDULE 13G |
| 14 Feb 2018 | SC 13 |
| 09 Feb 2017 | ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 04 May 2016 | SC 13G/A |
| 06 Apr 2016 | SC 13G/A |
| 11 Feb 2016 | SC 13G/A |
| 25 Aug 2015 | SC 13G/A |
| 15 Jun 2015 | SC 13G/A |
| 09 Feb 2015 | SC 13G/A |
| 14 Feb 2014 | SC 13G/A |
| 06 Feb 2014 | SC 13G/A |
| 14 Feb 2013 | SC 13G/A |
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