| Filed On | Filing |
|---|---|
| 02 Aug 2022 | SCHEDULE 13G |
| 22 Apr 2022 | SC 13G |
| 25 Oct 2021 | SC 13G |
| 22 Apr 2021 | ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 22 Apr 2021 | SC 13G |
| 12 Apr 2021 | SCHEDULE 13G |
| 16 Feb 2021 | SC 13G |
| 12 Feb 2021 | SCHEDULE 13G |
| 20 Jul 2020 | SC 13G |
| 14 Jul 2020 | SCHEDULE 13G |
| 14 Feb 2020 | SC 13G |
| 12 Feb 2020 | SC 13G |
| 09 Feb 2018 | NONE |
| 28 Jan 2016 | SC 13G |
| 08 Jan 2016 | SC 13G |
| 10 Jul 2015 | SEC SCHEDULE 13G |
| 17 Feb 2015 | SC 13G |
| 13 Feb 2015 | SC 13G |
| 12 Feb 2015 | SC 13G |
| 10 Feb 2015 | 13G INITIAL ANNUAL FILING - OTIC |
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