BIOTECHNOLOGY VALUE FUND L P 4 SEC Filings

Granted 25,370 Stock Option

Disposed of 7,593,303 shares (Tender Offer)

Sold 1,630,658 shares ($174M)

Granted 6,068 Stock Option (Right to Buy)

Granted 29,500 Stock Option (Right to buy)

Granted 22,195 Option to Buy

Received 5,003,000 shares by conversion ($20.2M)

Sold 3,750,000 shares ($63M)

Disposed of 10,166,943 shares (Tender Offer)

Disposed of 11,481,685 shares (Tender Offer)

Received 2,920,000 shares by exercise ($292) · Sold 156 shares ($293)

Granted 16,000 Stock Option (Right to Buy) · Bought 317,167 shares ($14M)

Acquired 1,270,004 shares (Other Transaction) · Acquired 587,557 Pre-Funded Warrants to Purchase Common Stock (Other Transaction)

Granted 24,150 Stock Option (Right to buy)

Granted 6,682 Option to Buy

Sold 392,723 shares ($10.6M)

Returned 16,312,872 shares to the issuer

Sold 650,717 shares ($17M)

Returned 420,000 shares to the issuer · Granted 420,000 Pre-Funded Warrant

Acquired 438,929 shares (Other Transaction)