Quarterly 13F snapshot: US-listed longs only, no performance figures — 13F data cannot support them.
Reported portfolio value by quarter (42 quarters reported)
$551M in Q1 2016 → $4.75B now. Hover for any quarter.
As reported for the quarter ended June 30, 2026. Activity is the change in share count since the prior quarter's filing.
| Holding | % of portfolio | Activity | Shares | Value |
|---|---|---|---|---|
| Amgen Inc | 6.5% | Added 188% | 851,550 | $308M |
| Vertex Pharmaceuticals Inc | 6.0% | Trimmed 15% | 578,634 | $287M |
| Argenx Se | 5.9% | Trimmed 3.8% | 301,000 | $279M |
| Gilead Sciences Inc | 5.7% | Added 85% | 2,158,772 | $273M |
| Revolution Medicines Inc | 4.1% | Trimmed 32% | 1,048,014 | $196M |
| Oruka Therapeutics Inc | 3.3% | Added 227% | 1,657,190 | $158M |
| Insmed Inc | 3.1% | Added 13787% | 1,393,418 | $149M |
| SR Scholar Rock Hldg Corp | 2.8% | Trimmed 32% | 2,449,547 | $135M |
| Nuvalent Inc | 2.7% | Unchanged | 1,053,268 | $130M |
| Viridian Therapeutics Inc | 2.6% | Added 0.1% | 6,731,909 | $124M |
| Relay Therapeutics Inc | 2.4% | Trimmed 21% | 6,185,970 | $116M |
| Vaxcyte Inc | 2.4% | Added 66% | 1,971,935 | $115M |
| UT United Therapeutics Corp Del | 2.1% | Added 8976% | 188,515 | $102M |
| Intuitive Surgical Inc | 2.1% | Trimmed 11% | 254,809 | $101M |
| Regeneron Pharmaceuticals | 2.1% | Trimmed 44% | 157,291 | $98.1M |
| CP Crinetics Pharmaceuticals In | 2.1% | Trimmed 20% | 2,620,000 | $98M |
| Bridgebio Pharma Inc | 1.9% | Added 4587% | 1,189,506 | $88.6M |
| IH Immunocore Hldgs PLC | 1.9% | Trimmed 0.3% | 2,788,245 | $88.5M |
| Abbott Laboratories | 1.8% | Trimmed 18% | 947,115 | $85.9M |
| Stryker Corporation | 1.8% | Added 24% | 268,461 | $84.5M |
| Medtronic PLC | 1.6% | Added 3.9% | 994,233 | $77.8M |
| Ionis Pharmaceuticals Inc | 1.6% | Trimmed 47% | 972,258 | $77.1M |
| Enliven Therapeutics Inc | 1.6% | Trimmed 36% | 1,490,000 | $75.6M |
| Vera Therapeutics Inc | 1.5% | Added 0.0% | 1,710,808 | $73.4M |
| Jade Biosciences Inc | 1.4% | Trimmed 13% | 3,057,996 | $67.9M |
| Edwards Lifesciences Corp | 1.4% | Trimmed 12% | 739,234 | $66.9M |
| UP Ultragenyx Pharmaceutical In | 1.4% | Trimmed 17% | 1,982,775 | $66.2M |
| Unitedhealth Group Inc | 1.3% | Added 0.6% | 149,127 | $62M |
| Dexcom Inc | 1.2% | Added 4.3% | 822,489 | $55.4M |
| CT Celldex Therapeutics Inc New | 0.9% | Unchanged | 1,200,000 | $44.7M |
| AP Avalyn Pharmaceuticals Inc | 0.9% | New | 1,350,000 | $44.4M |
| Damora Therapeutics Inc | 0.9% | Trimmed 30% | 1,618,846 | $42.1M |
| Disc Medicine Inc | 0.9% | Added 22% | 560,000 | $41M |
| Thermo Fisher Scientific Inc | 0.8% | Added 24% | 79,816 | $40M |
| Boston Scientific Corp | 0.8% | Trimmed 39% | 887,650 | $37.9M |
| EL Eli Lilly & Co | 0.8% | Trimmed 12% | 29,882 | $35.8M |
| Cg Oncology Inc | 0.7% | New | 493,596 | $35.1M |
| IL Idexx Labs Inc | 0.7% | Trimmed 31% | 61,780 | $32.5M |
| Resmed Inc | 0.6% | Trimmed 7.0% | 148,195 | $28.9M |
| Krystal Biotech Inc | 0.6% | Trimmed 84% | 77,530 | $28.8M |
| Monte Rosa Therapeutics Inc | 0.6% | Trimmed 4.8% | 1,190,000 | $28.8M |
| DD Danaher Corp Del | 0.6% | Trimmed 29% | 143,844 | $27.4M |
| Johnson & Johnson | 0.6% | Trimmed 13% | 103,280 | $26.2M |
| Seaport Therapeutics Inc | 0.5% | New | 1,100,000 | $23.9M |
| PT Palvella Therapeutics Inc Ne | 0.5% | New | 155,000 | $23.7M |
| Align Technology Inc | 0.5% | Unchanged | 139,680 | $23.6M |
| Annexon Inc | 0.5% | Trimmed 21% | 4,100,016 | $23.4M |
| Humana Inc | 0.5% | Trimmed 9.5% | 58,398 | $23.2M |
| EH Elevance Health Inc Formerly | 0.5% | Added 7.5% | 56,449 | $21.8M |
| Tango Therapeutics Inc | 0.5% | Trimmed 71% | 694,182 | $21.7M |
| Steris PLC | 0.4% | Trimmed 0.0% | 99,877 | $21M |
| Spyre Therapeutics Inc | 0.4% | New | 229,931 | $20.4M |
| HT Hemab Therapeutics Hldgs Inc | 0.4% | New | 550,000 | $20.2M |
| Insulet Corp | 0.4% | Trimmed 22% | 127,498 | $19.4M |
| The Cigna Group | 0.4% | Trimmed 32% | 66,500 | $18.3M |
| Glaukos Corp | 0.4% | Trimmed 12% | 128,667 | $18M |
| Cvs Health Corp | 0.4% | Added 90% | 169,366 | $17.5M |
| BD Becton Dickinson & Co | 0.3% | Trimmed 10.0% | 109,729 | $16.6M |
| GH Ge Healthcare Technologies I | 0.3% | Trimmed 39% | 252,744 | $16.2M |
| Livanova PLC | 0.3% | Added 5.1% | 195,621 | $16.1M |
Showing top 60 of 148 positions.
What changed each quarter, from the filings' own share counts. Largest moves first; most recent 8 quarters.
quarter ended June 30, 2026 · filed August 14, 2026
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Amgen Inc | Added | +556,192 | +$201M | 6.5% |
| Krystal Biotech Inc | Trimmed | −404,255 | −$150M | 0.6% |
| Insmed Inc | Added | +1,383,384 | +$147M | 3.1% |
| Gilead Sciences Inc | Added | +988,893 | +$125M | 5.7% |
| Oruka Therapeutics Inc | Added | +1,150,182 | +$109M | 3.3% |
| UT United Therapeutics Corp Del | Added | +186,438 | +$101M | 2.1% |
| Revolution Medicines Inc | Trimmed | −496,442 | −$93M | 4.1% |
| Bridgebio Pharma Inc | Added | +1,164,129 | +$86.7M | 1.9% |
| Regeneron Pharmaceuticals | Trimmed | −121,383 | −$75.7M | 2.1% |
| Alnylam Pharmaceuticals Inc | Trimmed | −233,451 | −$70.3M | — |
Showing the 10 largest of 148 changes.
quarter ended March 31, 2026 · filed May 15, 2026
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Revolution Medicines Inc | Trimmed | −3,461,263 | −$337M | 3.6% |
| Ionis Pharmaceuticals Inc | Trimmed | −2,983,534 | −$224M | 3.2% |
| Neurocrine Biosciences Inc | Trimmed | −1,698,658 | −$224M | — |
| Regeneron Pharmaceuticals | Added | +264,746 | +$205M | 5.1% |
| Avidity Biosciences Inc | Exited | −2,630,969 | −$190M | — |
| Gilead Sciences Inc | Added | +1,117,127 | +$156M | 3.9% |
| Amicus Therapeutics Inc | Exited | −10,735,195 | −$153M | — |
| CP Crinetics Pharmaceuticals In | Added | +3,275,960 | +$119M | 2.8% |
| Argenx Se | Trimmed | −148,854 | −$109M | 5.4% |
| Amgen Inc | Added | +276,869 | +$97.4M | 2.5% |
Showing the 10 largest of 180 changes.
quarter ended December 31, 2025 · filed February 17, 2026
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Amicus Therapeutics Inc | New | +10,735,195 | +$153M | 2.9% |
| Agios Pharmaceuticals Inc | Exited | −3,714,736 | −$149M | — |
| Incyte Corp | Trimmed | −1,435,913 | −$142M | — |
| Viridian Therapeutics Inc | New | +4,358,527 | +$136M | 2.6% |
| Ionis Pharmaceuticals Inc | Trimmed | −1,442,252 | −$114M | 7.2% |
| Akero Therapeutics Inc | Exited | −2,389,314 | −$113M | — |
| Nuvalent Inc | New | +1,037,468 | +$104M | 2.0% |
| Krystal Biotech Inc | Added | +409,011 | +$101M | 1.9% |
| Vera Therapeutics Inc | New | +1,698,152 | +$86M | 1.6% |
| Vertex Pharmaceuticals Inc | Added | +175,315 | +$79.5M | 5.9% |
Showing the 10 largest of 176 changes.
quarter ended September 30, 2025 · filed November 14, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Ionis Pharmaceuticals Inc | Trimmed | −1,608,747 | −$105M | 8.5% |
| Alnylam Pharmaceuticals Inc | Trimmed | −229,843 | −$105M | 4.2% |
| Avidity Biosciences Inc | New | +2,152,862 | +$93.8M | 1.9% |
| Revolution Medicines Inc | Added | +994,538 | +$46.4M | 5.4% |
| Blueprint Medicines Corp | Exited | −284,900 | −$36.5M | — |
| Moderna Inc | Trimmed | −1,229,327 | −$31.8M | — |
| Stryker Corporation | Trimmed | −83,993 | −$31M | 3.5% |
| Vertex Pharmaceuticals Inc | Added | +64,195 | +$25.1M | 4.1% |
| Akero Therapeutics Inc | Added | +404,042 | +$19.2M | 2.4% |
| Argenx Se | Trimmed | −24,711 | −$18.2M | 8.4% |
Showing the 10 largest of 143 changes.
quarter ended June 30, 2025 · filed August 14, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Akero Therapeutics Inc | Added | +734,606 | +$39.2M | 2.3% |
| IH Immunocore Hldgs PLC | Added | +1,220,036 | +$38.3M | 1.7% |
| Blueprint Medicines Corp | New | +284,900 | +$36.5M | 0.8% |
| Incyte Corp | Trimmed | −521,447 | −$35.5M | 2.4% |
| Alnylam Pharmaceuticals Inc | Trimmed | −91,780 | −$29.9M | 4.9% |
| Intuitive Surgical Inc | Trimmed | −47,018 | −$25.6M | 4.5% |
| Thermo Fisher Scientific Inc | Added | +49,312 | +$20M | 1.0% |
| Boston Scientific Corp | Trimmed | −185,826 | −$20M | 4.2% |
| Cencora Inc | Trimmed | −63,390 | −$19M | 0.1% |
| Dexcom Inc | Trimmed | −203,280 | −$17.7M | 1.7% |
Showing the 10 largest of 120 changes.
quarter ended March 31, 2025 · filed May 14, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| IT Intra-cellular Therapies Inc | Exited | −2,440,240 | −$204M | — |
| Akero Therapeutics Inc | New | +1,250,666 | +$50.6M | 1.1% |
| Arvinas Inc | Exited | −2,389,600 | −$45.8M | — |
| Vertex Pharmaceuticals Inc | Trimmed | −74,363 | −$36.1M | 4.5% |
| Verona Pharma PLC | Trimmed | −507,694 | −$32.2M | 0.1% |
| Tandem Diabetes Care Inc | Exited | −782,456 | −$28.2M | — |
| Sage Therapeutics Inc | Exited | −4,460,693 | −$24.2M | — |
| Intuitive Surgical Inc | Trimmed | −38,631 | −$19.1M | 4.7% |
| Abbvie Inc | Added | +89,981 | +$18.9M | 0.6% |
| Boston Scientific Corp | Trimmed | −184,275 | −$18.6M | 4.4% |
Showing the 10 largest of 140 changes.
quarter ended December 31, 2024 · filed February 14, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Option Care Health Inc | Exited | −1,654,878 | −$51.8M | — |
| Essa Pharma Inc | Exited | −7,879,583 | −$47.8M | — |
| Exact Sciences Corp | Trimmed | −755,409 | −$42.4M | 0.8% |
| Exelixis Inc | Exited | −1,600,000 | −$41.5M | — |
| Tandem Diabetes Care Inc | Trimmed | −1,068,435 | −$38.5M | 0.5% |
| Caredx Inc | Trimmed | −1,771,044 | −$37.9M | 0.6% |
| Vertex Pharmaceuticals Inc | Trimmed | −83,972 | −$33.8M | 3.8% |
| Unitedhealth Group Inc | Trimmed | −65,837 | −$33.3M | 1.6% |
| Verona Pharma PLC | Trimmed | −651,104 | −$30.2M | 0.5% |
| Crispr Therapeutics Ag | Exited | −610,000 | −$28.7M | — |
Showing the 10 largest of 146 changes.
quarter ended September 30, 2024 · filed November 14, 2024
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| BR Bio Rad Labs Inc | Trimmed | −109,107 | −$36.5M | 0.3% |
| Insmed Inc | Trimmed | −496,266 | −$36.2M | 0.6% |
| Argenx Se | Trimmed | −59,045 | −$32M | 5.6% |
| CR Charles Riv Labs Intl Inc | Trimmed | −159,587 | −$31.4M | 0.2% |
| Alnylam Pharmaceuticals Inc | Trimmed | −110,739 | −$30.5M | 3.6% |
| Evolent Health Inc | Added | +1,000,215 | +$28.3M | 1.2% |
| CD Centene Corp Del | Trimmed | −334,750 | −$25.2M | 0.1% |
| Caredx Inc | Trimmed | −767,119 | −$24M | 1.6% |
| SR Silk Rd Med Inc | Exited | −855,293 | −$23.1M | — |
| Hutchmed China Ltd | Trimmed | −1,125,142 | −$22M | — |
Showing the 10 largest of 155 changes.
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