Quarterly 13F snapshot: US-listed longs only, no performance figures — 13F data cannot support them.
Reported portfolio value by quarter (15 quarters reported)
$2.98B in Q4 2022 → $2.7B now. Hover for any quarter.
As reported for the quarter ended June 30, 2026. Activity is the change in share count since the prior quarter's filing.
| Holding | % of portfolio | Activity | Shares | Value |
|---|---|---|---|---|
| Caris Life Sciences Inc | 5.4% | Added 3.1% | 8,256,032 | $147M |
| Hinge Health Inc | 4.1% | Trimmed 8.6% | 1,330,127 | $110M |
| Glaukos Corp | 3.1% | Trimmed 22% | 591,927 | $82.7M |
| Edgewise Therapeutics Inc | 3.0% | Trimmed 15% | 1,996,965 | $81.1M |
| Spyre Therapeutics Inc | 2.9% | Trimmed 5.7% | 879,467 | $78.1M |
| Irhythm Holdings Inc | 2.9% | Added 7.2% | 654,262 | $77.8M |
| Neogenomics Inc | 2.7% | Trimmed 12% | 4,918,202 | $71.8M |
| Kodiak Sciences Inc | 2.6% | Trimmed 1.7% | 1,787,318 | $69.6M |
| Xenon Pharmaceuticals Inc | 2.5% | Trimmed 15% | 1,131,452 | $68.3M |
| AH Alphatec Hldgs Inc | 2.4% | Added 12% | 69,121,000 | $66.2M |
| Monte Rosa Therapeutics Inc | 2.2% | Trimmed 24% | 2,451,562 | $59.3M |
| Dianthus Therapeutics Inc | 2.1% | Trimmed 34% | 594,562 | $58M |
| Neurocrine Biosciences Inc | 2.1% | Trimmed 48% | 336,171 | $56.7M |
| AH Alphatec Hldgs Inc | 2.1% | Added 201% | 6,531,439 | $56.5M |
| Generate Biomedicines Inc | 2.0% | Trimmed 8.6% | 3,283,844 | $55.4M |
| ML Maravai Lifesciences Hldgs I | 2.0% | Trimmed 15% | 8,702,921 | $54.3M |
| Krystal Biotech Inc | 1.8% | Trimmed 29% | 128,975 | $47.9M |
| Humana Inc | 1.7% | New | 114,500 | $45.5M |
| Thermo Fisher Scientific Inc | 1.7% | Trimmed 3.8% | 89,395 | $44.8M |
| Kymera Therapeutics Inc | 1.6% | Added 12% | 378,163 | $43.4M |
| Rhythm Pharmaceuticals Inc | 1.6% | Added 23% | 381,128 | $42.3M |
| Damora Therapeutics Inc | 1.6% | Added 81% | 1,620,377 | $42.1M |
| Acadia Pharmaceuticals Inc | 1.5% | Trimmed 33% | 1,646,399 | $41.7M |
| BH Brightspring Health Svcs Inc | 1.5% | Trimmed 41% | 596,753 | $41.6M |
| Transmedics Group Inc | 1.5% | Added 85% | 609,715 | $40.5M |
| Mbx Biosciences Inc | 1.5% | Trimmed 52% | 710,880 | $39.2M |
| Climb Bio Inc | 1.3% | Added 83% | 2,797,375 | $36.5M |
| Caredx Inc | 1.3% | Trimmed 44% | 1,220,602 | $34.8M |
| Maze Therapeutics Inc | 1.3% | New | 1,140,040 | $34M |
| Bright Minds Biosciences Inc | 1.3% | Trimmed 10% | 483,822 | $34M |
| AH Acadia Healthcare Company In | 1.2% | Added 77% | 1,141,477 | $33.7M |
| Nektar Therapeutics | 1.2% | Added 113% | 473,617 | $33.1M |
| Corvus Pharmaceuticals Inc | 1.2% | Added 21% | 2,126,298 | $31.8M |
| Nurix Therapeutics Inc | 1.2% | Trimmed 27% | 1,286,769 | $31.2M |
| IM Inspire Med Sys Inc | 1.1% | Unchanged | 677,570 | $30.2M |
| Avalo Therapeutics Inc | 1.1% | New | 1,629,182 | $30.1M |
| Alamar Biosciences Inc | 1.1% | New | 1,083,983 | $29.4M |
| DD Danaher Corp Del | 1.1% | Added 8.1% | 150,627 | $28.7M |
| Intuitive Surgical Inc | 1.0% | Trimmed 9.3% | 70,137 | $27.9M |
| Oruka Therapeutics Inc | 1.0% | New | 278,164 | $26.5M |
| AP Avalyn Pharmaceuticals Inc | 1.0% | New | 801,395 | $26.4M |
| AH Aveanna Healthcare Hldgs Inc | 1.0% | Added 39% | 3,065,106 | $26.3M |
| Bioage Labs Inc | 0.9% | Trimmed 14% | 1,033,129 | $25.3M |
| Boston Scientific Corp | 0.9% | Added 70% | 587,567 | $25.1M |
| Vera Therapeutics Inc | 0.9% | Added 7.8% | 564,724 | $24.2M |
| Repligen Corp | 0.9% | Added 273% | 177,100 | $24.2M |
| Zura Bio Ltd | 0.9% | Trimmed 0.2% | 3,980,295 | $23.5M |
| Guardant Health Inc | 0.8% | Trimmed 70% | 147,850 | $22.2M |
| Evolus Inc | 0.8% | Added 1.6% | 3,155,209 | $21.9M |
| Natera Inc | 0.8% | Trimmed 38% | 79,500 | $21.6M |
| Orthopediatrics Corp | 0.8% | Unchanged | 1,100,370 | $21.1M |
| EH Elevance Health Inc Formerly | 0.8% | Trimmed 13% | 53,960 | $20.9M |
| Tectonic Therapeutic Inc | 0.8% | Trimmed 30% | 596,900 | $20.5M |
| Dyne Therapeutics Inc | 0.8% | Trimmed 45% | 921,598 | $20.5M |
| Neogenomics Inc | 0.6% | Trimmed 82% | 18,011,000 | $16.9M |
| IH Immunocore Hldgs PLC | 0.6% | New | 521,327 | $16.6M |
| Repligen Corp | 0.6% | Trimmed 84% | 16,000,000 | $16.4M |
| Argenx Se | 0.6% | Trimmed 79% | 17,707 | $16.4M |
| CT Celldex Therapeutics Inc New | 0.6% | Trimmed 68% | 436,646 | $16.2M |
| Ovid Therapeutics Inc | 0.6% | New | 5,919,464 | $15.9M |
Showing top 60 of 86 positions.
What changed each quarter, from the filings' own share counts. Largest moves first; most recent 8 quarters.
quarter ended June 30, 2026 · filed August 14, 2026
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Guardant Health Inc | Exited | −60,954,000 | −$103M | — |
| Repligen Corp | Trimmed | −85,000,000 | −$87.4M | 0.6% |
| Centessa Pharmaceuticals PLC | Exited | −1,986,768 | −$78.9M | — |
| Neogenomics Inc | Trimmed | −82,370,000 | −$77.2M | 0.6% |
| Nuvalent Inc | Exited | −700,429 | −$71.8M | — |
| Cg Oncology Inc | Exited | −984,783 | −$66.7M | — |
| Argenx Se | Trimmed | −67,232 | −$62.4M | 0.6% |
| Neurocrine Biosciences Inc | Trimmed | −315,950 | −$53.2M | 2.1% |
| Guardant Health Inc | Trimmed | −351,862 | −$52.8M | 0.8% |
| Humana Inc | New | +114,500 | +$45.5M | 1.7% |
Showing the 10 largest of 107 changes.
quarter ended March 31, 2026 · filed May 15, 2026
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Edgewise Therapeutics Inc | Trimmed | −2,863,248 | −$90.2M | 2.5% |
| Guardant Health Inc | Trimmed | −43,900,000 | −$73.9M | 3.4% |
| IT Irhythm Technologies Inc | Exited | −52,000,000 | −$72.8M | — |
| AH Alphatec Hldgs Inc | New | +61,621,000 | +$63.4M | 2.1% |
| Cg Oncology Inc | Trimmed | −885,788 | −$60M | 2.2% |
| Align Technology Inc | Exited | −381,004 | −$59.5M | — |
| Ironwood Pharmaceuticals Inc | Exited | −53,405,000 | −$50.5M | — |
| Irhythm Holdings Inc | Added | +392,847 | +$46.4M | 2.4% |
| Guardant Health Inc | New | +499,712 | +$46.2M | 1.5% |
| Generate Biomedicines Inc | New | +3,592,999 | +$44.9M | 1.5% |
Showing the 10 largest of 98 changes.
quarter ended December 31, 2025 · filed February 17, 2026
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Guardant Health Inc | Trimmed | −114,600,000 | −$210M | 6.2% |
| Novocure Ltd | Exited | −211,364,000 | −$210M | — |
| Xenon Pharmaceuticals Inc | Trimmed | −1,779,953 | −$79.8M | 2.6% |
| Krystal Biotech Inc | Trimmed | −318,300 | −$78.5M | 1.6% |
| Apogee Therapeutics Inc | Trimmed | −863,678 | −$65.2M | 1.4% |
| Cg Oncology Inc | Trimmed | −1,412,746 | −$58.7M | 2.5% |
| Kodiak Sciences Inc | New | +2,072,788 | +$58M | 1.9% |
| Centessa Pharmaceuticals PLC | New | +2,188,320 | +$54.7M | 1.8% |
| BH Brightspring Health Svcs Inc | New | +1,195,786 | +$44.8M | 1.4% |
| Danaher Corporation | Trimmed | −191,112 | −$43.7M | 0.9% |
Showing the 10 largest of 88 changes.
quarter ended September 30, 2025 · filed November 14, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Argenx Se | Trimmed | −118,400 | −$87.3M | 1.7% |
| Soleno Therapeutics Inc | New | +1,281,989 | +$86.7M | 2.6% |
| Novocure Ltd | Added | +70,530,000 | +$70.1M | 6.2% |
| Acadia Pharmaceuticals Inc | New | +2,378,655 | +$50.8M | 1.5% |
| AB Adaptive Biotechnologies Cor | Trimmed | −3,127,093 | −$46.8M | 0.3% |
| Hinge Health Inc | New | +910,476 | +$44.7M | 1.3% |
| Guardant Health Inc | Exited | −837,800 | −$43.6M | — |
| Neurocrine Biosciences Inc | Trimmed | −280,143 | −$39.3M | 3.7% |
| Krystal Biotech Inc | Trimmed | −207,410 | −$36.6M | 2.7% |
| Cvs Health Corp | New | +438,600 | +$33.1M | 1.0% |
Showing the 10 largest of 64 changes.
quarter ended June 30, 2025 · filed August 14, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Caris Life Sciences Inc | New | +7,316,142 | +$195M | 6.7% |
| Transmedics Group Inc | Trimmed | −599,836 | −$80.4M | 1.2% |
| Bridgebio Pharma Inc | Exited | −62,838,000 | −$72M | — |
| Krystal Biotech Inc | Added | +327,067 | +$45M | 3.4% |
| Bridgebio Pharma Inc | Exited | −48,594,000 | −$43.8M | — |
| IT Irhythm Technologies Inc | Trimmed | −256,362 | −$39.5M | 1.6% |
| Blueprint Medicines Corp | Exited | −439,968 | −$38.9M | — |
| Edgewise Therapeutics Inc | Added | +2,752,023 | +$36.1M | 2.3% |
| Karyopharm Therapeutics Inc | New | +48,482,000 | +$35.5M | 1.2% |
| IM Inspire Med Sys Inc | Added | +220,000 | +$28.5M | 2.3% |
Showing the 10 largest of 56 changes.
quarter ended March 31, 2025 · filed May 15, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Guardant Health Inc | New | +219,454,000 | +$227M | 8.0% |
| Guardant Health Inc | Exited | −268,252,000 | −$226M | — |
| N Nuvasive Inc | Exited | −114,206,000 | −$113M | — |
| IT Irhythm Technologies Inc | New | +86,000,000 | +$89.7M | 3.2% |
| Bridgebio Pharma Inc | Trimmed | −78,000,000 | −$89.4M | 2.5% |
| Guardant Health Inc | Trimmed | −1,520,604 | −$64.8M | 2.0% |
| Danaher Corporation | New | +309,339 | +$63.4M | 2.2% |
| AH Alphatec Hldgs Inc | Trimmed | −52,399,000 | −$52.2M | 0.2% |
| Dexcom Inc | Trimmed | −57,250,000 | −$51.3M | 0.8% |
| Argenx Se | Added | +80,083 | +$47.4M | 3.3% |
Showing the 10 largest of 72 changes.
quarter ended December 31, 2024 · filed February 14, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Repligen Corp | New | +112,000,000 | +$115M | 3.4% |
| Insulet Corp | Exited | −63,800,000 | −$76.4M | — |
| Transmedics Group Inc | New | +922,100 | +$57.5M | 1.7% |
| Travere Therapeutics Inc | Exited | −56,031,000 | −$53.5M | — |
| Dexcom Inc | Trimmed | −55,000,000 | −$53.1M | 0.5% |
| Legend Biotech Corp | Added | +1,436,400 | +$46.7M | 2.9% |
| Thermo Fisher Scientific Inc | New | +89,754 | +$46.7M | 1.4% |
| Penumbra Inc | Trimmed | −177,600 | −$42.2M | 1.3% |
| Madrigal Pharmaceuticals Inc | Exited | −183,818 | −$39M | — |
| Apellis Pharmaceuticals Inc | Trimmed | −1,026,317 | −$32.7M | 2.0% |
Showing the 10 largest of 76 changes.
quarter ended September 30, 2024 · filed November 14, 2024
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Apellis Pharmaceuticals Inc | Added | +2,513,383 | +$72.5M | 2.6% |
| Vaxcyte Inc | Trimmed | −510,735 | −$58.4M | 1.0% |
| Exact Sciences Corp | Trimmed | −855,500 | −$58.3M | 0.6% |
| Sarepta Therapeutics Inc | Exited | −43,066,000 | −$55.5M | — |
| Edgewise Therapeutics Inc | New | +1,958,310 | +$52.3M | 1.5% |
| Apogee Therapeutics Inc | Trimmed | −748,816 | −$44M | 2.7% |
| Bicara Therapeutics Inc | New | +1,657,600 | +$42.2M | 1.2% |
| Madrigal Pharmaceuticals Inc | New | +183,818 | +$39M | 1.1% |
| Thermo Fisher Scientific Inc | Exited | −70,449 | −$39M | — |
| Argenx Se | Trimmed | −70,200 | −$38.1M | 1.5% |
Showing the 10 largest of 76 changes.
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