Quarterly 13F snapshot: US-listed longs only, no performance figures — 13F data cannot support them.
Reported portfolio value by quarter (53 quarters reported)
$4.72B in Q2 2013 → $5.4B now. Hover for any quarter.
As reported for the quarter ended June 30, 2026. Activity is the change in share count since the prior quarter's filing.
| Holding | % of portfolio | Activity | Shares | Value |
|---|---|---|---|---|
| Edgewise Therapeutics Inc | 11.7% | Unchanged | 15,518,492 | $631M |
| Enliven Therapeutics Inc | 6.4% | Trimmed 15% | 6,776,632 | $344M |
| EL Eli Lilly & Co | 5.7% | Added 8.9% | 257,900 | $309M |
| Mbx Biosciences Inc | 3.5% | Trimmed 5.7% | 3,428,736 | $189M |
| SB Sinovac Biotech Ltd | 3.4% | Unchanged | 2,718,735 | $184M |
| Astrazeneca PLC | 3.2% | Added 37% | 915,700 | $171M |
| Structure Therapeutics Inc | 2.2% | Added 50% | 2,209,400 | $119M |
| Sionna Therapeutics Inc | 2.1% | Trimmed 28% | 2,555,877 | $112M |
| Corvus Pharmaceuticals Inc | 2.0% | Unchanged | 7,165,006 | $107M |
| Arrivent Biopharma Inc | 1.9% | Unchanged | 3,027,328 | $105M |
| Guardant Health Inc | 1.6% | Added 34% | 583,700 | $87.6M |
| Argenx Se | 1.6% | Trimmed 32% | 92,880 | $86.2M |
| Merck & Co Inc | 1.6% | Unchanged | 663,400 | $85.2M |
| UN Uniqure Nv | 1.5% | Trimmed 15% | 1,807,486 | $83.3M |
| PP Praxis Precision Medicines I | 1.4% | Added 33% | 230,100 | $77M |
| Edwards Lifesciences Corp | 1.4% | Trimmed 32% | 834,900 | $75.5M |
| Prelude Therapeutics Inc | 1.4% | Added 26% | 13,724,571 | $73.2M |
| Abivax Sa | 1.3% | Added 17% | 546,522 | $72.8M |
| Dyne Therapeutics Inc | 1.3% | Added 11% | 3,235,684 | $71.9M |
| Natera Inc | 1.3% | Unchanged | 262,000 | $71.1M |
| Cg Oncology Inc | 1.3% | Added 2.6% | 972,800 | $69.1M |
| Unitedhealth Group Inc | 1.2% | New | 161,100 | $67M |
| Ars Pharmaceuticals Inc | 1.2% | Unchanged | 8,288,510 | $66.4M |
| Ascendis Pharma A/s | 1.2% | New | 244,456 | $65.2M |
| Humana Inc | 1.2% | New | 164,100 | $65.2M |
| Cogent Biosciences Inc | 1.2% | Added 422% | 1,681,300 | $65.1M |
| Boston Scientific Corp | 1.2% | Trimmed 38% | 1,483,200 | $63.3M |
| Intuitive Surgical Inc | 1.2% | Trimmed 24% | 157,900 | $62.8M |
| Mineralys Therapeutics Inc | 1.1% | Added 2.8% | 2,110,300 | $56.9M |
| Odyssey Therapeutics Inc | 1.0% | New | 3,001,198 | $56.2M |
| Xenon Pharmaceuticals Inc | 1.0% | Trimmed 16% | 892,471 | $53.9M |
| Arcutis Biotherapeutics Inc | 1.0% | New | 2,042,000 | $53.5M |
| Bristol-myers Squibb Co | 1.0% | Unchanged | 925,000 | $53.3M |
| Q32 Bio Inc | 1.0% | Added 83% | 4,127,987 | $52.6M |
| Stryker Corporation | 0.9% | Trimmed 13% | 159,100 | $50.1M |
| Caris Life Sciences Inc | 0.9% | Unchanged | 2,806,811 | $50M |
| SS SPDR Series Trust Put | 0.9% | New | 300,000 | $47.5M |
| Thermo Fisher Scientific Inc | 0.8% | Added 95% | 90,700 | $45.5M |
| PT Palvella Therapeutics Inc Ne | 0.8% | Added 117% | 292,360 | $44.7M |
| EH Elevance Health Inc Formerly | 0.8% | Unchanged | 114,700 | $44.4M |
| Shattuck Labs Inc | 0.8% | Unchanged | 6,306,127 | $43.8M |
| Upstream Bio Inc | 0.7% | Unchanged | 5,693,589 | $39.4M |
| CP Crinetics Pharmaceuticals In | 0.7% | Unchanged | 999,000 | $37.4M |
| Rhythm Pharmaceuticals Inc | 0.7% | Added 2.8% | 322,900 | $35.9M |
| Syndax Pharmaceuticals Inc | 0.6% | Added 60% | 1,542,000 | $33.7M |
| Forte Biosciences Inc | 0.6% | Added 32% | 1,577,705 | $33.5M |
| Compass Therapeutics Inc | 0.6% | Unchanged | 15,219,994 | $33.3M |
| Nektar Therapeutics | 0.6% | Added 69% | 465,346 | $32.5M |
| Krystal Biotech Inc | 0.6% | Added 20% | 83,200 | $30.9M |
| Prelude Therapeutics Inc | 0.6% | Trimmed 8.5% | 5,680,186 | $30.3M |
| Axsome Therapeutics Inc. | 0.5% | Trimmed 45% | 117,578 | $28.8M |
| KP Kiniksa Pharmaceuticals Intl | 0.5% | Added 133% | 420,600 | $26.9M |
| Trevi Therapeutics Inc | 0.5% | Trimmed 42% | 1,430,293 | $26.7M |
| Abivax Sa Call | 0.5% | New | 200,000 | $26.7M |
| Disc Medicine Inc | 0.5% | Trimmed 67% | 357,535 | $26.2M |
| WP West Pharmaceutical Svsc Inc | 0.5% | New | 70,600 | $25.3M |
| Relmada Therapeutics Inc | 0.5% | Trimmed 23% | 3,631,195 | $25.1M |
| Urogen Pharma Ltd | 0.5% | Trimmed 23% | 676,187 | $24.9M |
| Sutro Biopharma Inc | 0.5% | Trimmed 7.1% | 743,944 | $24.7M |
| Savara Inc | 0.5% | Added 524% | 3,959,900 | $24.4M |
Showing top 60 of 129 positions.
What changed each quarter, from the filings' own share counts. Largest moves first; most recent 8 quarters.
quarter ended June 30, 2026 · filed August 14, 2026
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Mdxhealth Sa | Exited | −124,306,000 | −$286M | — |
| Avita Medical Inc | Exited | −40,966,100 | −$154M | — |
| Myriad Genetics Inc | Exited | −125,000,000 | −$123M | — |
| Unitedhealth Group Inc | New | +161,100 | +$67M | 1.2% |
| Ascendis Pharma A/s | New | +244,456 | +$65.2M | 1.2% |
| Humana Inc | New | +164,100 | +$65.2M | 1.2% |
| Enliven Therapeutics Inc | Trimmed | −1,182,906 | −$60M | 6.4% |
| Odyssey Therapeutics Inc | New | +3,001,198 | +$56.2M | 1.0% |
| Pfizer Inc | Exited | −1,946,500 | −$54.7M | — |
| Arcutis Biotherapeutics Inc | New | +2,042,000 | +$53.5M | 1.0% |
Showing the 10 largest of 126 changes.
quarter ended March 31, 2026 · filed May 15, 2026
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Mdxhealth Sa | New | +124,306,000 | +$286M | 5.7% |
| Avita Medical Inc | New | +40,966,100 | +$154M | 3.1% |
| Astrazeneca PLC | New | +670,200 | +$132M | 2.6% |
| Myriad Genetics Inc | New | +125,000,000 | +$123M | 2.4% |
| Terns Pharmaceuticals Inc | Exited | −2,153,300 | −$87M | — |
| Merck & Co Inc | New | +663,400 | +$79.8M | 1.6% |
| Apellis Pharmaceuticals Inc | Exited | −2,429,868 | −$61M | — |
| EL Eli Lilly & Co | Trimmed | −64,400 | −$59.2M | 4.3% |
| The Cigna Group | Exited | −205,000 | −$56.4M | — |
| Alnylam Pharmaceuticals Inc | Trimmed | −169,800 | −$56.2M | 0.8% |
Showing the 10 largest of 109 changes.
quarter ended December 31, 2025 · filed February 17, 2026
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Terns Pharmaceuticals Inc | Trimmed | −5,409,671 | −$219M | 1.8% |
| Avidity Biosciences Inc | Trimmed | −1,019,356 | −$73.5M | 0.9% |
| Exact Sciences Corp | Trimmed | −642,900 | −$65.3M | 0.7% |
| Axsome Therapeutics Inc | Trimmed | −278,679 | −$50.9M | 0.9% |
| Bristol-myers Squibb Co | New | +775,000 | +$41.8M | 0.9% |
| Pfizer Inc | New | +1,652,900 | +$41.2M | 0.8% |
| Si-bone Inc | Exited | −2,578,979 | −$38M | — |
| EH Elevance Health Inc Formerly | New | +99,100 | +$34.7M | 0.7% |
| Scpharmaceuticals Inc | Exited | −6,059,528 | −$34.4M | — |
| Cybin Inc | New | +3,840,500 | +$31.4M | 0.6% |
Showing the 10 largest of 108 changes.
quarter ended September 30, 2025 · filed November 14, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Unitedhealth Group Inc | Exited | −336,300 | −$105M | — |
| Vertex Pharmaceuticals Inc | Exited | −210,287 | −$93.6M | — |
| Tenet Healthcare Corp | Exited | −465,000 | −$81.8M | — |
| Danaher Corporation | New | +263,100 | +$52.2M | 1.2% |
| UT United Therapeutics Corp Del | New | +114,900 | +$48.2M | 1.1% |
| The Cigna Group | New | +162,800 | +$46.9M | 1.1% |
| Boston Scientific Corp | Trimmed | −383,900 | −$37.5M | 5.6% |
| Cytokinetics Inc | Exited | −1,077,000 | −$35.6M | — |
| Oric Pharmaceuticals Inc | Added | +2,742,475 | +$32.9M | 1.0% |
| Abivax Sa | New | +380,000 | +$32.3M | 0.8% |
Showing the 10 largest of 85 changes.
quarter ended June 30, 2025 · filed August 14, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Pfizer Inc | Exited | −3,850,200 | −$97.6M | — |
| Caris Life Sciences Inc | New | +3,034,858 | +$81.1M | 2.0% |
| Ionis Pharmaceuticals Inc | Exited | −2,540,136 | −$76.6M | — |
| Neurocrine Biosciences Inc | Trimmed | −496,100 | −$62.4M | 1.4% |
| Unitedhealth Group Inc | Added | +135,100 | +$42.1M | 2.6% |
| Springworks Therapeutics Inc | Exited | −950,200 | −$41.9M | — |
| XM Xtant Med Hldgs Inc | Exited | −73,114,592 | −$34.4M | — |
| Thermo Fisher Scientific Inc | Trimmed | −82,500 | −$33.5M | 0.5% |
| Roivant Sciences Ltd | New | +2,779,427 | +$31.3M | 0.8% |
| IH Integer Hldgs Corp | Trimmed | −229,100 | −$28.2M | 1.3% |
Showing the 10 largest of 88 changes.
quarter ended March 31, 2025 · filed May 15, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Sarepta Therapeutics Inc | Exited | −963,400 | −$117M | — |
| Pfizer Inc | New | +3,850,200 | +$97.6M | 2.3% |
| Merck & Co Inc | Exited | −829,900 | −$82.6M | — |
| Biogen Inc | Exited | −509,100 | −$77.9M | — |
| Intuitive Surgical Inc | Trimmed | −110,700 | −$54.8M | 3.4% |
| UH Universal Hlth Svcs Inc | Exited | −269,300 | −$48.3M | — |
| Axsome Therapeutics Inc | New | +386,700 | +$45.1M | 1.1% |
| Tenet Healthcare Corp | Trimmed | −327,000 | −$44M | 1.5% |
| Sionna Therapeutics Inc | New | +3,704,959 | +$38.8M | 0.9% |
| Unitedhealth Group Inc | Added | +70,300 | +$36.8M | 2.5% |
Showing the 10 largest of 72 changes.
quarter ended December 31, 2024 · filed February 14, 2025
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Upstream Bio Inc | New | +5,693,589 | +$93.6M | 1.9% |
| Neurocrine Biosciences Inc | Added | +635,900 | +$86.8M | 2.6% |
| Edwards Lifesciences Corp | New | +1,145,302 | +$84.8M | 1.7% |
| Amgen Inc | Exited | −252,300 | −$81.3M | — |
| Elevance Health Inc | Exited | −106,200 | −$55.2M | — |
| Merck & Co Inc | Trimmed | −486,100 | −$48.4M | 1.7% |
| Regeneron Pharmaceuticals | Exited | −45,200 | −$47.5M | — |
| Evolent Health Inc | Exited | −1,665,115 | −$47.1M | — |
| Biogen Inc | Trimmed | −303,900 | −$46.5M | 1.6% |
| Vaxcyte Inc | Exited | −387,000 | −$44.2M | — |
Showing the 10 largest of 94 changes.
quarter ended September 30, 2024 · filed November 14, 2024
| Company | Action | Shares changed | Value of change | % of portfolio |
|---|---|---|---|---|
| Mbx Biosciences Inc | New | +3,812,215 | +$99M | 1.8% |
| Janux Therapeutics Inc | Trimmed | −1,721,262 | −$78.2M | 1.0% |
| Tenet Healthcare Corp | Trimmed | −391,300 | −$65M | 2.4% |
| Vaxcyte Inc | Trimmed | −408,900 | −$46.7M | 0.8% |
| Verona Pharma PLC | Exited | −2,861,801 | −$41.4M | — |
| Unitedhealth Group Inc | Added | +67,000 | +$39.2M | 1.9% |
| Sarepta Therapeutics Inc | Added | +308,500 | +$38.5M | 2.2% |
| Geron Corp | Exited | −8,930,252 | −$37.9M | — |
| Amgen Inc | Added | +117,400 | +$37.8M | 1.5% |
| UH Universal Hlth Svcs Inc | New | +156,000 | +$35.7M | 0.6% |
Showing the 10 largest of 94 changes.
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