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Super Investors Stonepine Capital Management, LLC
SC

Stonepine Capital Management, LLC

Quarterly 13F snapshot: US-listed longs only, no performance figures — 13F data cannot support them.

Portfolio value
$177M
Positions
87
Quarter ended
June 30, 2026
Filed
August 17, 2026

Reported portfolio value by quarter (43 quarters reported)

$301M $51.6M
Q4 15 Q1 18 Q2 20 Q3 22 Q4 24 Q2 26

$85.4M in Q4 2015 → $177M now. Hover for any quarter.

Holdings

As reported for the quarter ended June 30, 2026. Activity is the change in share count since the prior quarter's filing.

Holding % of portfolio Activity Shares Value
Verastem Inc 7.2% Added 1.4% 3,349,627 $12.8M
Evolus Inc 6.2% Trimmed 9.6% 1,590,162 $11M
Tenax Therapeutics Inc 5.4% Trimmed 32% 660,000 $9.6M
Nektar Therapeutics 4.8% Added 42% 120,654 $8.42M
Adma Biologics Inc Call 4.5% Trimmed 43% 650,000 $7.95M
Adma Biologics Inc 3.5% Unchanged 740,000 $6.19M
Camp4 Therapeutics Corp 3.4% Unchanged 1,389,622 $6.07M
Insmed Inc Call 3.2% New 40,000 $5.6M
Eloxx Pharmaceuticals Inc 3.1% New 397,160 $5.51M
UP Ultragenyx Pharmaceutical In Call 3.1% New 200,000 $5.5M
Kazia Therapeutics Ltd 2.7% Unchanged 345,179 $4.86M
Medtronic PLC Call 2.5% New 50,000 $4.38M
Indivior Pharmaceuticals Inc 2.3% New 100,000 $4.1M
CP Corbus Pharmaceuticals Hldgs 2.2% Added 11% 425,000 $3.99M
Abbott Laboratories Call 2.1% New 40,000 $3.8M
Satellos Bioscience Inc 2.1% Added 392% 491,624 $3.72M
Zevra Therapeutics Inc 2.1% Trimmed 46% 258,701 $3.71M
Abeona Therapeutics Inc 1.9% Trimmed 25% 557,284 $3.44M
Boston Scientific Corp Call 1.8% New 50,000 $3.25M
Edesa Biotech Inc 1.8% Added 1421% 456,439 $3.19M
Evolus Inc Call 1.8% Unchanged 420,000 $3.15M
Biomarin Pharmaceutical Inc Call 1.8% New 50,000 $3.13M
Cabaletta Bio Inc 1.6% Added 1734% 917,100 $2.85M
An2 Therapeutics Inc 1.5% Trimmed 23% 551,692 $2.67M
Xilio Therapeutics Inc 1.2% Added 252% 225,994 $2.17M
Adicet Bio Inc 1.2% Added 11% 245,518 $2.12M
Xeris Biopharma Holdings Inc Call 1.2% Unchanged 280,000 $2.1M
Tela Bio Inc 1.1% Added 1.7% 2,662,427 $2M
Aytu Biopharma Inc 1.1% Added 15% 912,921 $1.96M
Curis Inc 1.0% Trimmed 11% 3,312,185 $1.73M
Spruce Biosciences Inc 0.9% New 28,795 $1.55M
Heron Therapeutics Inc Call 0.8% Unchanged 1,000,000 $1.5M
Si Bone Inc Call 0.8% Unchanged 100,000 $1.5M
Okyo Pharma Ltd 0.7% Added 1.5% 862,996 $1.29M
Neumora Therapeutics Inc. Call 0.7% Unchanged 500,000 $1.25M
Pasithea Therapeutics Corp 0.6% Added 165% 2,201,468 $1.13M
Sol-gel Technologies Ltd 0.6% Trimmed 48% 14,469 $1.07M
Pulmonx Corp 0.6% Added 6.1% 815,436 $1.06M
X4 Pharmaceuticals Inc 0.6% Trimmed 33% 224,989 $1.05M
Ardelyx Inc Call 0.6% Unchanged 150,000 $1.05M
DS Delcath Sys Inc Call 0.6% Unchanged 100,000 $1M
In8bio Inc 0.6% Added 4.8% 695,287 $980K
Moonlake Immunotherapeutics 0.5% New 50,000 $974K
Quoin Pharmaceuticals Ltd 0.5% Added 273% 199,486 $966K
Maxcyte Inc 0.5% Trimmed 25% 751,606 $924K
Phathom Pharmaceuticals Inc 0.5% Added 70% 85,010 $922K
Azitra Inc 0.5% New 5,285,476 $887K
CB Connect Biopharma Hldgs Ltd 0.5% Added 18% 364,254 $867K
Cybin Inc 0.5% Trimmed 3.6% 129,280 $855K
UP Ultragenyx Pharmaceutical In 0.5% New 25,000 $835K
Inhibikase Therapeutics Inc 0.5% Trimmed 59% 396,179 $804K
Zentalis Pharmaceuticals Inc 0.4% Trimmed 40% 161,583 $784K
Cytomx Therapeutics Inc. 0.4% Added 2.5% 205,000 $769K
Mannkind Corp Call 0.4% Trimmed 50% 250,000 $750K
Nuvectis Pharma Inc 0.4% New 40,000 $736K
Crescent Biopharma Inc. 0.4% Trimmed 53% 40,000 $720K
Pmv Pharmaceuticals Inc 0.4% Trimmed 24% 536,086 $718K
Oruka Therapeutics Inc 0.4% New 7,500 $714K
Radiopharm Theranostics Ltd 0.4% Unchanged 51,000,000 $671K
Onkure Therapeutics Inc 0.3% Trimmed 1.4% 130,684 $596K

Showing top 60 of 87 positions.

Timeline of changes

What changed each quarter, from the filings' own share counts. Largest moves first; most recent 8 quarters.

Q2 2026

quarter ended June 30, 2026 · filed August 17, 2026

Company Action Shares changed Value of change % of portfolio
SS SPDR Series Trust Exited −400,000 −$51.1M —
SS SPDR Series Trust Exited −400,000 −$51.1M —
Adma Biologics Inc Trimmed −500,000 −$6.12M 4.5%
Insmed Inc New +40,000 +$5.6M 3.2%
Eloxx Pharmaceuticals Inc New +397,160 +$5.51M 3.1%
UP Ultragenyx Pharmaceutical In New +200,000 +$5.5M 3.1%
Terns Pharmaceuticals Inc Exited −100,000 −$5.27M —
Tenax Therapeutics Inc Trimmed −315,200 −$4.59M 5.4%
Medtronic PLC New +50,000 +$4.38M 2.5%
Indivior Pharmaceuticals Inc New +100,000 +$4.1M 2.3%

Showing the 10 largest of 96 changes.

Q1 2026

quarter ended March 31, 2026 · filed May 14, 2026

Company Action Shares changed Value of change % of portfolio
SS SPDR Series Trust New +400,000 +$51.1M 20.5%
SS SPDR Series Trust New +400,000 +$51.1M 20.5%
Tenax Therapeutics Inc Added +963,316 +$15.4M 6.2%
Adma Biologics Inc New +1,150,000 +$10.4M 4.1%
Terns Pharmaceuticals Inc New +100,000 +$5.27M 2.1%
Camp4 Therapeutics Corp Added +1,160,728 +$5.12M 2.5%
IP Indivior PLC Exited −100,000 −$3.59M —
Edesa Biotech Inc Trimmed −657,500 −$3.44M 0.1%
Verastem Inc Added +570,221 +$3.02M 7.0%
EL Establishment Labs Hldgs Inc New +50,000 +$2.84M 1.1%

Showing the 10 largest of 96 changes.

Q4 2025

quarter ended December 31, 2025 · filed February 13, 2026

Company Action Shares changed Value of change % of portfolio
DO Day One Biopharmaceuticals I Trimmed −447,382 −$4.17M 1.4%
Inhibikase Therapeutics Inc Added +1,613,128 +$3.31M 3.5%
Enanta Pharmaceuticals Inc Trimmed −205,000 −$3.23M 1.2%
CP Corbus Pharmaceuticals Hldgs New +389,916 +$3.17M 2.3%
Kazia Therapeutics Ltd New +460,359 +$3.17M 2.3%
Surrozen Inc Trimmed −136,515 −$3.09M 1.9%
Verrica Pharmaceuticals Inc New +353,669 +$2.94M 2.1%
Cybin Inc New +339,902 +$2.78M 2.0%
Omniab Inc Trimmed −1,441,857 −$2.67M 0.9%
Crispr Therapeutics Ag New +50,000 +$2.62M 1.9%

Showing the 10 largest of 86 changes.

Q3 2025

quarter ended September 30, 2025 · filed November 13, 2025

Company Action Shares changed Value of change % of portfolio
Verastem Inc Added +1,309,646 +$11.6M 19.2%
IP Indivior PLC Trimmed −250,000 −$6.03M 2.0%
Evolus Inc Added +619,891 +$3.81M 7.7%
X4 Pharmaceuticals Inc New +1,056,338 +$3.61M 2.9%
Enanta Pharmaceuticals Inc Trimmed −299,066 −$3.58M 3.0%
Omniab Inc New +2,142,857 +$3.43M 2.8%
Iteos Therapeutics Inc Exited −310,033 −$3.09M —
Ani Pharmaceuticals Inc Exited −38,597 −$2.52M —
Abeona Therapeutics Inc Added +405,970 +$2.14M 1.9%
Anika Therapeutics Inc Exited −190,590 −$2.02M —

Showing the 10 largest of 78 changes.

Q2 2025

quarter ended June 30, 2025 · filed August 13, 2025

Company Action Shares changed Value of change % of portfolio
Optinose Inc Exited −788,647 −$7.23M —
Urogen Pharma Ltd Exited −333,400 −$3.69M —
Verastem Inc Added +747,386 +$3.1M 5.5%
Aquestive Therapeutics Inc Exited −200,000 −$3.04M —
EL Establishment Labs Hldgs Inc Trimmed −67,500 −$2.88M 0.3%
Acadia Pharmaceuticals Inc Added +131,607 +$2.84M 4.8%
Galapagos Nv Exited −93,968 −$2.36M —
Ardelyx Inc New +555,000 +$2.18M 2.1%
Evolus Inc Trimmed −218,074 −$2.01M 8.3%
Iteos Therapeutics Inc Added +200,033 +$1.99M 3.0%

Showing the 10 largest of 87 changes.

Q1 2025

quarter ended March 31, 2025 · filed May 14, 2025

Company Action Shares changed Value of change % of portfolio
Ani Pharmaceuticals Inc Added +27,600 +$7.85M 13.3%
Ironwood Pharmaceuticals Inc Exited −648,785 −$2.87M —
Galapagos Nv Trimmed −106,032 −$2.66M 2.3%
Optinose Inc Added +199,990 +$1.83M 7.0%
Surrozen Inc Added +148,582 +$1.73M 3.2%
Edesa Biotech Inc New +687,500 +$1.68M 1.6%
Evolus Inc Trimmed −130,077 −$1.56M 13.3%
Verastem Inc Trimmed −257,000 −$1.55M 3.6%
Enanta Pharmaceuticals Inc Added +258,842 +$1.43M 3.2%
JP Jazz Pharmaceuticals PLC Us Listed Exited −10,000 −$1.23M —

Showing the 10 largest of 74 changes.

Q4 2024

quarter ended December 31, 2024 · filed February 14, 2025

Company Action Shares changed Value of change % of portfolio
Adma Biologics Inc Trimmed −628,968 −$10.8M 17.2%
GN Galapagos Nv-spon ADR Trimmed −278,659 −$7.66M 4.4%
Royalty Pharma PLC Exited −212,000 −$6M —
JP Jazz Pharmaceuticals PLC Us Listed Trimmed −45,000 −$5.54M 1.0%
Rigel Pharmaceuticals Inc Exited −309,100 −$5M —
Aclaris Therapeutics Inc Trimmed −1,795,468 −$4.45M 1.3%
Optinose Inc New +588,657 +$3.93M 3.2%
Optinose Inc Exited −5,688,590 −$3.81M —
Tela Bio Inc Added +1,243,099 +$3.75M 5.7%
Inhibikase Therapeutics Inc New +1,132,388 +$3.68M 3.0%

Showing the 10 largest of 59 changes.

Q3 2024

quarter ended September 30, 2024 · filed November 13, 2024

Company Action Shares changed Value of change % of portfolio
Alimera Sciences Inc Exited −3,511,816 −$19.5M —
RT Revance Therapeutics Inc Trimmed −1,980,000 −$10.3M 2.7%
JP Jazz Pharmaceuticals PLC Us Listed New +55,000 +$6.13M 3.9%
Royalty Pharma PLC New +212,000 +$6M 3.8%
Zevra Therapeutics Inc New +700,000 +$4.86M 3.1%
Evolus Inc Trimmed −287,790 −$4.66M 14.0%
Ironwood Pharmaceuticals Inc Added +951,988 +$3.92M 2.6%
Verastem Inc New +1,310,287 +$3.92M 2.5%
Urogen Pharma Ltd New +280,345 +$3.56M 2.2%
Establishment Labs Holdings New +75,000 +$3.25M 2.1%

Showing the 10 largest of 38 changes.

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