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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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FY2020
12 months to Dec 31, 2020
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FY2019
12 months to Dec 31, 2019
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FY2018
12 months to Dec 31, 2018
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| Operating activities: | |||||
| Net (loss) income | |||||
| Adjustments to reconcile net (loss) income to net cash (used) provided by operating activities | |||||
| Share-based compensation | |||||
| Depreciation and amortization | |||||
| Amortization of intangible assets | |||||
| Amortization of right-of-use-assets | |||||
| Amortization of premiums, accretion of discounts, and (gains) losses on debt securities | |||||
| Loss (gain) on equity securities | |||||
| Gain on disposals of property and equipment | |||||
| Deferred income taxes | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable, net | |||||
| Inventories | |||||
| Prepaid expenses and other assets | |||||
| Lease liabilities | |||||
| Deferred revenue | |||||
| Other liabilities | |||||
| Net cash (used) provided by operating activities | |||||
| Investing activities: | |||||
| Purchases of securities | |||||
| Proceeds from maturities of securities | |||||
| Proceeds from sales of securities | |||||
| Payments for lessor-owned assets | |||||
| Purchases of property and equipment | |||||
| Acquisition of Cascadian Therapeutics, Inc., net of cash acquired | |||||
| Net cash provided (used) by investing activities | |||||
| Financing activities: | |||||
| Net proceeds from issuance of common stock | |||||
| Proceeds from exercise of stock options and employee stock purchase plan | |||||
| Net cash provided by financing activities | |||||
| Cash and cash equivalents at end of year | |||||
| Effect of exchange rate changes on cash, cash equivalents, and restricted cash | |||||
| Net (decrease) increase in cash, cash equivalents, and restricted cash | |||||
| Cash, cash equivalents, and restricted cash at beginning of year | |||||
| Cash, cash equivalents, and restricted cash at end of year | |||||
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