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FY2015
12 months to Dec 31, 2015
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FY2014
12 months to Dec 31, 2014
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FY2013
12 months to Dec 31, 2013
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FY2012
12 months to Dec 31, 2012
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FY2011
12 months to Dec 31, 2011
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|---|---|---|---|---|---|
| Operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation and amortization | |||||
| Accretion of investment discounts and amortization of investment premiums, net | |||||
| Amortization of discount and debt issuance costs on convertible senior notes | |||||
| Stock-based compensation expense | |||||
| Changes in assets and liabilities: | |||||
| Accounts receivable | |||||
| Prepaids and other current and noncurrent assets | |||||
| Inventories | |||||
| Accounts payable | |||||
| Accrued compensation | |||||
| Accrued restructuring charges | |||||
| Accrued preclinical and clinical costs | |||||
| Other accrued liabilities, current and noncurrent | |||||
| Deferred revenue, current and noncurrent | |||||
| Net cash used in operating activities | |||||
| Investing activities | |||||
| Purchases of investments | |||||
| Proceeds from maturities of investments | |||||
| Purchases of property and equipment | |||||
| Net cash provided by (used in) investing activities | |||||
| Financing activities | |||||
| Proceeds from issuance of convertible senior notes, net of discount and debt issuance costs | |||||
| Net cash proceeds provided by (used in) issuance of common stock and exercise of stock options | |||||
| Net cash provided by (used in) financing activities | |||||
| Net increase (decrease) in cash and cash equivalents | |||||
| Cash and cash equivalents at beginning of period | |||||
| Cash and cash equivalents at end of period | |||||
| Supplemental Disclosure of Cash Flow Information | |||||
| Cash paid during the period for: | |||||
| Interest expense | |||||
| Non-cash investing activity: | |||||
| Inventories | |||||
| Manufacturing property and equipment | |||||
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