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FY2019
12 months to Dec 31, 2019
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FY2018
12 months to Dec 31, 2018
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FY2017
12 months to Dec 31, 2017
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FY2016
12 months to Dec 31, 2016
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FY2015
12 months to Dec 31, 2015
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|---|---|---|---|---|---|
| Net loss | |||||
| Operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to cash used in operating activities: | |||||
| Depreciation and amortization | |||||
| Amortization of operating lease right-of-use assets | |||||
| Accretion of discount on investment securities | |||||
| Non-cash interest expense | |||||
| Stock-based compensation expense, net of capitalized labor | |||||
| Remeasurement loss on embedded derivatives liabilities | |||||
| Stock-based compensation expense for Lonza liability-classified award | |||||
| Charge associated with our Gen 1 manufacturing process transition | |||||
| Remeasurement (gain) loss on embedded derivatives liabilities | |||||
| Provision for excess and obsolete inventories | |||||
| Loss on impairment and provision for excess and obsolete inventories of Bevyxxa asset group | |||||
| Loss on impairment of SRX intangible asset | |||||
| Others | |||||
| Changes in operating assets and liabilities: | |||||
| Inventories | |||||
| Prepaid research and development | |||||
| Trade and other receivables, net | |||||
| Unbilled - collaboration and license revenue | |||||
| Prepaid and other current assets | |||||
| Prepaid and other long-term assets | |||||
| Accounts payable | |||||
| Accrued compensation and employee benefits | |||||
| Accrued research and development | |||||
| Accrued and other liabilities | |||||
| Deferred revenue | |||||
| Notes payable, long term debt and long term obligation to collaborator | |||||
| Notes payable and long term royalty-based debt | |||||
| Other long-term liabilities | |||||
| Net cash used in operating activities | |||||
| Investing activities | |||||
| Capital expenditures, net | |||||
| Decrease (increase) in restricted cash (SRX Cardio) | |||||
| Purchase of intangible assets | |||||
| Purchases of investments | |||||
| Proceeds from maturities of investments | |||||
| Net cash (used in) provided by investing activities | |||||
| Financing activities | |||||
| Proceeds from debt issuance, net | |||||
| Proceeds from issuance of common stock from public offering, net | |||||
| Debt issuance costs paid | |||||
| Payment of public offering costs | |||||
| Proceeds from issuance of common stock pursuant to equity award plans | |||||
| Dividends to Noncontrolling interest (SRX Cardio)'s shareholders | |||||
| Net increase/(decrease) in cash and cash equivalents | |||||
| Cash and cash equivalents at beginning of year | |||||
| Cash and cash equivalents at end of year | |||||
| Payments of long-term obligation to collaborator | |||||
| Other | |||||
| Net cash provided by financing activities | |||||
| Effect of exchange rate changes on cash, cash equivalents and restricted cash | |||||
| Net increase (decrease) in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash at beginning of period | |||||
| Cash, cash equivalents and restricted cash at end of period | |||||
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