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FY2021
12 months to Dec 31, 2021
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FY2020
12 months to Dec 31, 2020
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FY2019
12 months to Dec 31, 2019
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FY2018
12 months to Dec 31, 2018
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FY2017
12 months to Dec 31, 2017
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|---|---|---|---|---|---|
| Operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation and amortization | |||||
| Stock-based compensation expense | |||||
| Amortization of premiums on investments | |||||
| Amortization of deferred lease incentive | |||||
| Non-cash license consideration (Note 12) | |||||
| Non-cash lease expense | |||||
| Other non-cash items | |||||
| Unrealized loss on marketable equity securities | |||||
| Unrealized loss on warrant liabilities (Note 14) | |||||
| Loss (gain) on disposal of asset | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable | |||||
| Contract asset | |||||
| Interest receivable | |||||
| Prepaid expenses and other current assets | |||||
| Other assets | |||||
| Accounts payable | |||||
| Accrued expenses and other liabilities | |||||
| Income taxes receivable | |||||
| Income taxes payable | |||||
| Deferred rent | |||||
| Operating lease liability | |||||
| Deferred revenue | |||||
| Net cash used in operating activities | |||||
| Investing activities | |||||
| Purchases of property and equipment | |||||
| Purchases of investments | |||||
| Maturities of investments | |||||
| Net cash provided by investing activities | |||||
| Financing activities | |||||
| Proceeds from exercise of warrants | |||||
| Repurchase of common stock pursuant to share surrender | |||||
| Proceeds from at-the-market offering, net of issuance costs | |||||
| Proceeds from exercise of stock options | |||||
| Cash and cash equivalents at beginning of period | |||||
| Cash and cash equivalents at end of period | |||||
| Proceeds from common and preferred stock, warrants and royalty interest sold, net of issuance costs | |||||
| Net cash provided by financing activities | |||||
| Net increase in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash at beginning of period | |||||
| Cash, cash equivalents and restricted cash at end of period | |||||
| Supplemental cash flow information: | |||||
| Cash paid for income taxes | |||||
| Purchases of property and equipment unpaid at period end | |||||
| Tenant improvements paid by landlord (Note 11) | |||||
| Public offering costs unpaid at period end | |||||
| Cash paid included in measurement of lease liabilities | |||||
| Warrants issued | |||||
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