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FY2018
12 months to Dec 31, 2018
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FY2017
12 months to Dec 31, 2017
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FY2016
12 months to Dec 31, 2016
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FY2015
12 months to Dec 31, 2015
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FY2014
12 months to Dec 31, 2014
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|---|---|---|---|---|---|
| Operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities | |||||
| Non-cash gain on license of clazakizumab in exchange for investment in unconsolidated entity | |||||
| Equity in net loss of unconsolidated entity | |||||
| Depreciation and amortization | |||||
| Stock-based compensation | |||||
| Accretion of discount on convertible notes | |||||
| Non-cash change in fair value of derivative liability | |||||
| Other non-cash charges, net | |||||
| Changes in operating assets and liabilities | |||||
| Prepaid expenses and other assets | |||||
| Inventory | |||||
| Accounts payable | |||||
| Accrued liabilities | |||||
| Deferred rent | |||||
| Purchases of investments | |||||
| Proceeds from maturities of investments | |||||
| Proceeds from sales of investments | |||||
| Net cash used in operating activities | |||||
| Investing activities | |||||
| Purchases of investments | |||||
| Proceeds from maturities of investments | |||||
| Proceeds from sales of investments | |||||
| Purchases of property and equipment | |||||
| Proceeds from sale of property and equipment | |||||
| Net cash provided by (used in) investing activities | |||||
| Financing activities | |||||
| Proceeds from issuance of 2025 convertible senior notes, net of offering costs | |||||
| Proceeds from issuance of convertible preferred stock, net of offering costs | |||||
| Proceeds from issuance of common stock, net of offering costs | |||||
| Proceeds from exercise of stock options and employee stock purchase plan | |||||
| Effect of exchange rate changes on cash | |||||
| Net increase (decrease) in cash and cash equivalents | |||||
| Beginning of period | |||||
| End of period | |||||
| Net cash provided by financing activities | |||||
| Effect of exchange rate changes on cash, cash equivalents and restricted cash | |||||
| Net increase (decrease) in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash | |||||
| Beginning of period | |||||
| End of period | |||||
| Supplemental disclosures: | |||||
| Purchases of property and equipment included in accounts payable and accrued liabilities | |||||
| Cash paid for interest | |||||
| Dividends on convertible preferred stock paid in kind | |||||
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