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FY2018
12 months to Dec 31, 2018
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FY2017
12 months to Dec 31, 2017
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FY2016
12 months to Dec 31, 2016
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FY2015
12 months to Dec 31, 2015
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FY2014
12 months to Dec 31, 2014
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|---|---|---|---|---|---|
| Cash flows from operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Stock-based compensation expense | |||||
| Depreciation and amortization expense | |||||
| Impairment of intangible assets | |||||
| Gain on deconsolidation of a variable interest entity | |||||
| Non-cash interest expense | |||||
| Market value adjustments to inventories | |||||
| (Gain) loss on disposition of property and equipment | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable, net | |||||
| Inventories | |||||
| Prepaid expenses and other current assets | |||||
| Other assets | |||||
| Accounts payable | |||||
| Accrued expenses and other liabilities | |||||
| Licensing and collaboration commitment | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities | |||||
| Milestone payments for intangible assets | |||||
| Purchases of property and equipment, net | |||||
| Purchase of investments | |||||
| Proceeds from maturities of investments | |||||
| Cash contributed as investment in a noncontrolled entity | |||||
| Net cash provided by (used in) investing activities | |||||
| Cash flows from financing activities | |||||
| Payments for debt issuance costs | |||||
| Payments on loans payable | |||||
| Payment for loans payable final payment fee, termination fee and other fees | |||||
| Taxes paid for awards vested under equity incentive plans | |||||
| Proceeds from stock option exercises | |||||
| Proceeds from issuance of common stock, net of commissions and underwriter fees | |||||
| Net cash provided by (used in) financing activities | |||||
| Net increase (decrease) in cash and cash equivalents | |||||
| Cash and cash equivalents, beginning of period | |||||
| Cash and cash equivalents, end of period | |||||
| Effect of exchange rate on cash | |||||
| Net decrease in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash, beginning of period | |||||
| Cash, cash equivalents and restricted cash, end of period | |||||
| Supplemental disclosure of cash flow information | |||||
| Cash paid for interest | |||||
| Supplemental disclosure of noncash investing and financing activities: | |||||
| Stock issuance costs included in accounts payable | |||||
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