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FY2018
12 months to Dec 31, 2018
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FY2017
12 months to Dec 31, 2017
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FY2016
12 months to Dec 31, 2016
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FY2015
12 months to Dec 31, 2015
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FY2014
12 months to Dec 31, 2014
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|---|---|---|---|---|---|
| Net loss | |||||
| Cash flows from operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation and amortization | |||||
| Stock-based compensation | |||||
| Acquired in-process research and development | |||||
| Amortization of discount for payments related to acquired in-process research and development | |||||
| Net amortization of premiums on available-for-sale securities | |||||
| Amortization of convertible note discount and issuance costs | |||||
| Common stock issued in connection with license agreement | |||||
| Impairment of intangible assets | |||||
| Changes in assets and liabilities: | |||||
| Trade and other receivables, net | |||||
| Inventory | |||||
| Prepaid expenses and other current assets | |||||
| Other assets | |||||
| Accounts payable | |||||
| Accrued liabilities | |||||
| Refund liability | |||||
| Other long-term liabilities | |||||
| Deferred revenue | |||||
| Deferred taxes | |||||
| Purchases of available-for-sale securities | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities | |||||
| Purchases of available-for-sale securities | |||||
| Maturities of available-for-sale securities | |||||
| Acquisition of in-process research and development | |||||
| Increase in restricted cash | |||||
| Purchase of property and equipment | |||||
| Net cash used in investing activities | |||||
| Cash flows from financing activities | |||||
| Net proceeds from issuance of common stock in connection with equity financings | |||||
| Net proceeds from issuance of convertible notes | |||||
| Net proceeds from issuance of common stock in connection with equity awards | |||||
| Net increase (decrease) in cash and cash equivalents | |||||
| Cash and cash equivalents at beginning of year | |||||
| Cash and cash equivalents at end of year | |||||
| Net cash provided by financing activities | |||||
| Net proceeds from term loan | |||||
| Net increase (decrease) in cash and cash equivalents and restricted cash | |||||
| Cash and cash equivalents and restricted cash at beginning of year | |||||
| Cash and cash equivalents and restricted cash at end of year | |||||
| Supplemental disclosure of cash flow information | |||||
| Interest paid | |||||
| Supplemental disclosure of noncash investing activities | |||||
| Acquisition of in-process research and development | |||||
| Acquisition of property and equipment under accounts payable and accrued liabilities | |||||
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