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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net income (loss) to net cash used in operating activities: | |||||
| Acquired in-process research and development | |||||
| Depreciation and amortization | |||||
| Noncash interest expense | |||||
| Share-based compensation expense | |||||
| Write-off of acquired intangible asset | |||||
| Write-off of goodwill | |||||
| Deferred tax benefit | |||||
| Change in fair value of warrants | |||||
| Gain on sale of dismutase mimetics assets | |||||
| Gain on extinguishment of debt | |||||
| Loss on disposal of property and equipment | |||||
| Changes in operating assets and liabilities: | |||||
| Refundable PDUFA fee | |||||
| Prepaid expenses and other current assets | |||||
| Other assets | |||||
| Accounts payable | |||||
| Accrued expenses | |||||
| Other liabilities | |||||
| Cash used in operating activities | |||||
| Investing activities: | |||||
| Purchases of short-term investments | |||||
| Proceeds from sales of short-term investments | |||||
| Cash paid for acquisition of Nova | |||||
| Purchase of property and equipment | |||||
| Proceeds from sale of property and equipment | |||||
| Proceeds from sale of dismutase mimetics asset | |||||
| Cash provided by investing activities | |||||
| Financing activities: | |||||
| Proceeds from the sale of common stock and common stock warrants in private placement, net of issuance costs | |||||
| Proceeds from the sale of common stock and common stock warrants in registered direct offering, net of issuance costs | |||||
| Proceeds from the sale of common stock under the Open Market Sale Agreement, net of issuance costs | |||||
| Proceeds from the exercise of common stock warrants | |||||
| Proceeds from exercise of stock options | |||||
| Cash provided by financing activities | |||||
| Net decrease in cash and cash equivalents | |||||
| Cash and cash equivalents at beginning of year | |||||
| Cash and cash equivalents at end of year | |||||
| Supplemental schedule of non-cash investing and financing activities: | |||||
| Extinguishment of royalty purchase liability upon sale of dismutase mimetics assets | |||||
| Issuance of Series B redeemable convertible preferred stock in asset acquisition | |||||
| Accretion (amortization) of redeemable convertible preferred stock to redemption value | |||||
| Subscription receivable in connection with private placement | |||||
| Derecognition of lease liability and right-of-use asset due to lease termination | |||||
| Acquisition costs in accounts payable | |||||
| Right-of-use asset obtained in exchange for lease obligation | |||||
| Sale of property and equipment in exchange for prepaid future services | |||||
| Reclassification of warrant liability to additional paid-in capital | |||||
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