| Insider Name | Current Shares | Net Change (1yr) | Buy/Sell Ratio |
|---|---|---|---|
| Venture Fund III, L.P. RiverVest | 5,750,506 | 0 | - |
| RiverVest Fund II-B, L.P. 3x5 | 4,887,932 | 0 | - |
| HOLDING LTD ROCHE | 4,610,723 | 0 | - |
| Partners NextGen Fund I Management, LLC Alta | 2,071,147 | 0 | - |
| Group, LLC Redmile | 1,009,090 | 0 | - |
| Craig A. Paterson | 323,472 | 0 | - |
| Chin Hyok Lee | 275,046 | 0 | - |
| Mark Asbury | 226,935 | 0 | - |
| Everett Rand Sutherland | 154,786 | 0 | - |
| Margaret Nell Fitzgerald | 153,128 | 0 | - |
| JOHN P MCKEARN | 99,590 | 0 | - |
| HENRIK S MD RASMUSSEN | 98,550 | 0 | - |
| DANIEL JANNEY | 86,762 | 0 | - |
| Leo Redmond | 51,958 | 0 | - |
| GUY P NOHRA | 23,468 | 0 | - |
| Peter A Hudson | 18,220 | 0 | - |
| ROBERT J MORE | 10,076 | 0 | - |
| Natalie C. Holles | 7,700 | 0 | - |
| Robert E Andreatta | 0 | 0 | - |
| Paul Edward Walker | 0 | 0 | - |
| Robert Alexander | 0 | 0 | - |
| VALUE FUND L P BIOTECHNOLOGY | 0 | 0 | - |
| Adam Tomasi | 0 | 0 | - |
| Dolca Thomas | 0 | 0 | - |
| Harlan Baird Radford | 0 | 0 | - |
| Partners VIII, L.P. Alta | 0 | 0 | - |
| Steven P James | 0 | 0 | - |
| Amy L Ladd | 0 | 0 | - |
| Neil Murray Hamilton Graham | 0 | 0 | - |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Robert E Andreatta | May 15 |
Disposition to Issuer (D)
Payment to Issuer
|
0 | -37,600 | $0.00 | -$0 |
| VALUE FUND L P BIOTECHNOLOGY | May 19 |
Disposition to Issuer (D)
Payment to Issuer
|
0 | -8,679,726 | $0.00 | -$0 |
| Dolca Thomas | May 15 |
Disposition to Issuer (D)
Payment to Issuer
|
0 | -154,786 | $0.00 | -$0 |
| Neil Murray Hamilton Graham | May 15 |
Disposition to Issuer (D)
Payment to Issuer
|
0 | -154,786 | $0.00 | -$0 |
| Paul Edward Walker | May 15 |
Disposition to Issuer (D)
Payment to Issuer
|
0 | -2,760,860 | $0.00 | -$0 |
| Harlan Baird Radford | May 15 |
Disposition to Issuer (D)
Payment to Issuer
|
0 | -163,426 | $0.00 | -$0 |
| Adam Tomasi | May 15 |
Disposition to Issuer (D)
Payment to Issuer
|
0 | -512,630 | $0.00 | -$0 |
| Steven P James | May 15 |
Disposition to Issuer (D)
Payment to Issuer
|
0 | -55,380 | $0.00 | -$0 |
| Robert Alexander | May 15 |
Disposition to Issuer (D)
Payment to Issuer
|
0 | -738,104 | $0.00 | -$0 |
| Amy L Ladd | May 15 |
Disposition to Issuer (D)
Payment to Issuer
|
0 | -233,177 | $0.00 | -$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Robert Alexander | Mar 07 |
Tax Payment (F)
Tax Payment
|
738,104 | -31,370 | $0.26 | -$8,156 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Adam Tomasi | Mar 07 |
Tax Payment (F)
Tax Payment
|
512,630 | -20,017 | $0.26 | -$5,204 |
| Harlan Baird Radford | Mar 07 |
Tax Payment (F)
Tax Payment
|
163,426 | -14,161 | $0.26 | -$3,681 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Adam Tomasi | Dec 09 |
Tax Payment (F)
Tax Payment
|
532,647 | -21,116 | $1.10 | -$23,227 |
| Harlan Baird Radford | Dec 09 |
Tax Payment (F)
Tax Payment
|
177,587 | -13,138 | $1.10 | -$14,451 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Robert Alexander | Dec 06 |
Tax Payment (F)
Tax Payment
|
769,474 | -32,466 | $1.10 | -$35,712 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Chin Hyok Lee | Dec 06 |
Tax Payment (F)
Tax Payment
|
275,046 | -10,634 | $1.13 | -$12,016 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Robert Alexander | Sep 12 |
Tax Payment (F)
Tax Payment
|
801,940 | -37,311 | $0.58 | -$21,640 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Chin Hyok Lee | Sep 11 |
Tax Payment (F)
Tax Payment
|
285,680 | -45,320 | $0.65 | -$29,458 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Harlan Baird Radford | Sep 10 |
Tax Payment (F)
Tax Payment
|
190,725 | -13,665 | $0.65 | -$8,882 |
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