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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Operating activities | |||||
| Net loss from continuing operations | |||||
| Net income (loss) | |||||
| Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: | |||||
| Depreciation and amortization | |||||
| Amortization and accretion on investment securities, net | |||||
| Future royalty payment contingency interest accretion | |||||
| Share-based compensation | |||||
| Loss on disposal of property and equipment | |||||
| Loss on impairment of long-lived assets | |||||
| Amortization of right-of-use assets | |||||
| Deferred income taxes | |||||
| Other | |||||
| Changes in operating assets and liabilities: | |||||
| Receivables from collaborative and licensing arrangements | |||||
| Prepaid clinical and development services | |||||
| Other prepaid and current assets | |||||
| Right-of-use lease assets | |||||
| Future contingent milestone and royalty assets | |||||
| Other assets | |||||
| Accounts payable | |||||
| Accrued personnel-related expenses, accrued clinical and development expenses, and other accrued liabilities | |||||
| Deferred revenue | |||||
| Operating lease liabilities | |||||
| Unrecognized tax benefits | |||||
| Other long-term liabilities | |||||
| Net cash used in operating activities - continuing operations | |||||
| Net cash provided by (used in) operating activities | |||||
| Investing activities | |||||
| Purchases of property and equipment | |||||
| Purchases of marketable securities | |||||
| Maturities of marketable securities | |||||
| Purchase of derivative | |||||
| Sale of short-term investments and marketable securities | |||||
| Proceeds from the sale of property and equipment | |||||
| Net cash (used in) provided by investing activities - continuing operations | |||||
| Net cash (used in) provided by investing activities | |||||
| Financing activities | |||||
| Ordinary share repurchases | |||||
| Proceeds from the sale of ordinary shares | |||||
| Proceeds from ESPP purchases | |||||
| Proceeds from option exercises | |||||
| Repurchase of shares to satisfy tax withholding | |||||
| Net cash used in financing activities - continuing operations | |||||
| Net cash used in financing activities | |||||
| Net increase (decrease) in cash, cash equivalents, and restricted cash | |||||
| Cash, cash equivalents, and restricted cash at beginning of period | |||||
| Cash, cash equivalents, and restricted cash at end of period | |||||
| Supplemental disclosure of cash flow information | |||||
| Cash paid for income taxes, net | |||||
| Recognition of tenant improvement allowance assigned to sublease | |||||
| Sublease | |||||
| Total recognition of tenant improvement allowance assigned to sublease | |||||
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