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FY2021
12 months to Dec 31, 2021
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FY2020
12 months to Dec 31, 2020
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FY2019
12 months to Dec 31, 2019
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FY2018
12 months to Dec 31, 2018
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|---|---|---|---|---|
| Operating activities: | ||||
| Net loss | ||||
| Adjustments to reconcile net loss to net cash used in operating activities: | ||||
| Depreciation and amortization | ||||
| Non-cash restructuring costs | ||||
| Non-cash operating lease costs | ||||
| Amortization of premiums and accretion of discounts on investments, net | ||||
| Accretion of Term Loan and Convertible Senior Notes | ||||
| Loss on early extinguishment of Term Loan | ||||
| Stock-based compensation | ||||
| Changes in compound derivative liability | ||||
| Changes in fair value of preferred stock tranche obligation | ||||
| Realized gains on sale of investments | ||||
| Other non-cash items | ||||
| Changes in operating assets and liabilities: | ||||
| Prepaid expenses and other assets | ||||
| Accounts payable | ||||
| Accrued expenses and other liabilities | ||||
| Operating lease liabilities | ||||
| Net cash used in operating activities | ||||
| Investing activities: | ||||
| Purchase of investments | ||||
| Proceeds from maturities of investments | ||||
| Proceeds from sale of investments | ||||
| Purchase of property and equipment | ||||
| Net cash provided by investing activities | ||||
| Financing activities: | ||||
| Proceeds from equity offerings, net of offering costs | ||||
| Payments of offering costs | ||||
| Proceeds from issuance of common stock under equity incentive plans | ||||
| Proceeds from issuance of convertible preferred stock, net | ||||
| Proceeds from Convertible Senior Notes, net | ||||
| Proceeds from leasehold improvement loan | ||||
| Repayments of leasehold improvement loan | ||||
| Cash paid for early extinguishment of Term Loan | ||||
| Proceeds from Term Loan, net | ||||
| Net cash provided by (used in) financing activities | ||||
| Net increase (decrease) in cash and cash equivalents | ||||
| Cash and cash equivalents at beginning of year | ||||
| Cash and cash equivalents at end of year | ||||
| Supplemental disclosures | ||||
| Cash paid for interest | ||||
| Supplemental disclosures of non-cash investing and financing activities | ||||
| Right-of-use assets obtained in exchange for lease obligations | ||||
| Deferred equity offering costs incurred but not paid | ||||
| Payments for taxes related to net share settlement of equity awards not remitted | ||||
| Warrants and compound derivative liability related to Term Loan | ||||
| Purchases of property and equipment included in accounts payable and accrued expenses | ||||
| Series C fair value of preferred stock obligation upon closing | ||||
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