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FY2019
12 months to Dec 31, 2019
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FY2018
12 months to Dec 31, 2018
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FY2017
12 months to Dec 31, 2017
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|---|---|---|---|
| Operating activities: | |||
| Net income (loss) | |||
| Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: | |||
| Depreciation | |||
| Amortization of right-of-use operating lease assets | |||
| Amortization of intangibles | |||
| Amortization of discount/premium on investment securities, net | |||
| Non-cash interest expense for line of credit with Ionis Pharmaceuticals, Inc. | |||
| Non-cash sublicensing expense | |||
| Stock-based compensation expense | |||
| Changes in operating assets and liabilities: | |||
| Contracts receivable | |||
| Accounts receivable | |||
| Other current and long-term assets | |||
| Inventory | |||
| Accounts payable | |||
| Receivable/payable to Ionis Pharmaceuticals, Inc. | |||
| Long-term income tax receivable | |||
| Accrued compensation | |||
| Deferred rent | |||
| Accrued liabilities | |||
| Income taxes payable | |||
| Deferred revenue | |||
| Net cash provided by (used in) operating activities | |||
| Investing activities: | |||
| Purchases of short-term investments | |||
| Proceeds from maturity of short-term investments | |||
| Purchase of property, plant and equipment | |||
| Net cash provided by (used in) investing activities | |||
| Financing activities: | |||
| Proceeds from issuance of Series A convertible preferred stock to Ionis Pharmaceuticals, Inc. | |||
| Proceeds from issuance of common stock, net of underwriters' discounts | |||
| Proceeds from exercise of common stock options and employee stock purchase plan issuances | |||
| Payments of tax withholdings related to exercise of employee stock awards | |||
| Distribution to Ionis Pharmaceuticals, Inc. | |||
| Proceeds from issuance of common stock to Ionis Pharmaceuticals in TTR transaction | |||
| Proceeds from issuance of common stock, net of underwriters' discount | |||
| Proceeds from line of credit from Ionis Pharmaceuticals, Inc. | |||
| Offering costs paid | |||
| Net cash (used in) provided by financing activities | |||
| Effect of exchange rates on cash | |||
| Cash and cash equivalents | |||
| Net increase in cash and cash equivalents | |||
| Cash, cash equivalents and restricted cash at beginning of period | |||
| Cash, cash equivalents and restricted cash at end of period | |||
| Supplemental disclosures of non-cash investing and financing activities: | |||
| Unpaid deferred offering costs | |||
| Right-of-use assets obtained in exchange for lease liabilities | |||
| Purchase of property, plant and equipment included in accounts payable | |||
| Purchase of property, plant and equipment included in long-term deferred rent liability | |||
| Acquisition of research and development licenses and milestone payments | |||
| Capital contribution from Ionis Pharmaceuticals, Inc. | |||
| Conversion of preferred stock to common stock upon initial public offering | |||
| Conversion of line of credit from Ionis Pharmaceuticals, Inc. into common stock | |||
| Cash, cash equivalents and restricted cash reported within the condensed consolidated balance sheets: | |||
| Cash and cash equivalents | |||
| Restricted cash included in deposits and other assets |
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