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Insider Transactions

Insider Transaction Summary

PATRICK G ENRIGHT

4,174,379 shares

Net: 0 B/S: -

bioVenture Partners Fund I, L.P. Pivotal

2,923,110 shares

Net: 0 B/S: -

FOREST BASKETT

2,437,689 shares

Net: 0 B/S: -

Peter W. Sonsini

2,437,689 shares

Net: 0 B/S: -

SCOTT D SANDELL

2,437,689 shares

Net: 0 B/S: -

Mohamad Makhzoumi

2,437,689 shares

Net: 0 B/S: -

Anthony A. Jr. Florence

2,437,689 shares

Net: 0 B/S: -

JOSHUA MAKOWER

2,437,689 shares

Net: 0 B/S: -

Holdings A/S Novo

2,194,379 shares

Net: 0 B/S: -

Capital Partners III, LLC Longitude

2,007,225 shares

Net: 0 B/S: -

Enterprise Associates 15, L.P. New

2,000,533 shares

Net: 0 B/S: -

Venture Partners X, L.P. Sofinnova

1,590,808 shares

Net: 0 B/S: -

CAPITAL MANAGEMENT, L.P. RA

1,403,653 shares

Net: 0 B/S: -

PHARMACEUTICALS, INC. ALEXION

1,109,910 shares

Net: 0 B/S: -

Springs Capital Management LP Rock

467,884 shares

Net: 0 B/S: -

Sanofi

438,875 shares

Net: 0 B/S: -

Axel Bolte

419,519 shares

Net: 0 B/S: -

Joseph Schlessinger

286,479 shares

Net: 0 B/S: -

Henric Bjorn Bjarke

105,441 shares

Net: 0 B/S: -

Deborah Wenkert

100,000 shares

Net: 0 B/S: -

Erik Harris

56,000 shares

Net: 0 B/S: -

Steven J Jungles

42,000 shares

Net: 0 B/S: -

Douglas A Treco

41,046 shares

Net: 0 B/S: -

Pedro Huertas

36,074 shares

Net: 0 B/S: -

Sanjay Subramanian

32,888 shares

Net: 0 B/S: -

Robert Lorne Hopfner

28,000 shares

Net: 0 B/S: -

Martin Edwards

28,000 shares

Net: 0 B/S: -

Sarah M Bhagat

28,000 shares

Net: 0 B/S: -

Lynne Marie Sullivan

28,000 shares

Net: 0 B/S: -

REINALDO M DIAZ

28,000 shares

Net: 0 B/S: -

Edward T Mathers

28,000 shares

Net: 0 B/S: -

Stephen J. DiPalma

15,000 shares

Net: 0 B/S: -

Stephen Basso

13,000 shares

Net: 0 B/S: -

Pharma, Inc. Inozyme

9,367 shares

Net: 0 B/S: -

Matthew Winton

7,388 shares

Net: 0 B/S: -

Insider Name	Current Shares	Buy/Sell Ratio
PATRICK G ENRIGHT	4,174,379	-
bioVenture Partners Fund I, L.P. Pivotal	2,923,110	-
FOREST BASKETT	2,437,689	-
Peter W. Sonsini	2,437,689	-
SCOTT D SANDELL	2,437,689	-
Mohamad Makhzoumi	2,437,689	-
Anthony A. Jr. Florence	2,437,689	-
JOSHUA MAKOWER	2,437,689	-
Holdings A/S Novo	2,194,379	-
Capital Partners III, LLC Longitude	2,007,225	-
Enterprise Associates 15, L.P. New	2,000,533	-
Venture Partners X, L.P. Sofinnova	1,590,808	-
CAPITAL MANAGEMENT, L.P. RA	1,403,653	-
PHARMACEUTICALS, INC. ALEXION	1,109,910	-
Springs Capital Management LP Rock	467,884	-
Sanofi	438,875	-
Axel Bolte	419,519	-
Joseph Schlessinger	286,479	-
Henric Bjorn Bjarke	105,441	-
Deborah Wenkert	100,000	-
Erik Harris	56,000	-
Steven J Jungles	42,000	-
Douglas A Treco	41,046	-
Pedro Huertas	36,074	-
Sanjay Subramanian	32,888	-
Robert Lorne Hopfner	28,000	-
Martin Edwards	28,000	-
Sarah M Bhagat	28,000	-
Lynne Marie Sullivan	28,000	-
REINALDO M DIAZ	28,000	-
Edward T Mathers	28,000	-
Stephen J. DiPalma	15,000	-
Stephen Basso	13,000	-
Pharma, Inc. Inozyme	9,367	-
Matthew Winton	7,388	-

Individual Transactions

May 15, 2025

Axel Bolte

Option Exercise/Conversion

Change: +152,823

Price: $0.98

Shares: 419,519

Value: +$149,766

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Axel Bolte	May 20	Option Exercise/Conversion (M) Compensation/Award	419,519	+152,823	$0.98	+$149,766

April 02, 2025

Douglas A Treco

Open Market Sale

Change: -8,819

Price: $0.89

Shares: 41,046

Value: -$7,848

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Douglas A Treco	Apr 03	Open Market Sale (S) Market Sale	41,046	-8,819	$0.89	-$7,848

April 01, 2025

Douglas A Treco

Option Exercise/Conversion

Change: +25,000

Price: $0.00

Shares: 49,865

Value: +$0

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Douglas A Treco	Apr 03	Option Exercise/Conversion (M) Compensation/Award	49,865	+25,000	$0.00	+$0

March 31, 2025

Matthew Winton

Grant/Award Acquisition

Change: +2,490

Price: $0.77

Shares: 7,388

Value: +$1,917

Sanjay Subramanian

Grant/Award Acquisition

Change: +2,490

Price: $0.77

Shares: 32,888

Value: +$1,917

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Matthew Winton	Apr 02	Grant/Award Acquisition (A) Compensation/Award	7,388	+2,490	$0.77	+$1,917
Sanjay Subramanian	Apr 02	Grant/Award Acquisition (A) Compensation/Award	32,888	+2,490	$0.77	+$1,917

March 11, 2025

Matthew Winton

Grant/Award Acquisition

Change: +145,000

Price: $0.00

Shares: 145,000

Value: +$0

Douglas A Treco

Grant/Award Acquisition

Change: +400,000

Price: $0.00

Shares: 400,000

Value: +$0

Sanjay Subramanian

Grant/Award Acquisition

Change: +145,000

Price: $0.00

Shares: 145,000

Value: +$0

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Matthew Winton	Mar 17	Grant/Award Acquisition (A) Compensation/Award	145,000	+145,000	$0.00	+$0
Douglas A Treco	Mar 17	Grant/Award Acquisition (A) Compensation/Award	400,000	+400,000	$0.00	+$0
Sanjay Subramanian	Mar 17	Grant/Award Acquisition (A) Compensation/Award	145,000	+145,000	$0.00	+$0

October 03, 2024

Erik Harris

Grant/Award Acquisition

Change: +56,000

Price: $0.00

Shares: 56,000

Value: +$0

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Erik Harris	Oct 07	Grant/Award Acquisition (A) Compensation/Award	56,000	+56,000	$0.00	+$0

September 30, 2024

Douglas A Treco

Grant/Award Acquisition

Change: +1,710

Price: $4.45

Shares: 22,375

Value: +$7,609

Matthew Winton

Grant/Award Acquisition

Change: +1,710

Price: $4.45

Shares: 4,898

Value: +$7,609

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Douglas A Treco	Oct 03	Grant/Award Acquisition (A) Compensation/Award	22,375	+1,710	$4.45	+$7,609
Matthew Winton	Oct 03	Grant/Award Acquisition (A) Compensation/Award	4,898	+1,710	$4.45	+$7,609

June 18, 2024

Edward T Mathers

Grant/Award Acquisition

Change: +28,000

Price: $0.00

Shares: 28,000

Value: +$0

Robert Lorne Hopfner

Grant/Award Acquisition

Change: +28,000

Price: $0.00

Shares: 28,000

Value: +$0

Axel Bolte

Grant/Award Acquisition

Change: +28,000

Price: $0.00

Shares: 28,000

Value: +$0

Martin Edwards

Grant/Award Acquisition

Change: +28,000

Price: $0.00

Shares: 28,000

Value: +$0

REINALDO M DIAZ

Grant/Award Acquisition

Change: +28,000

Price: $0.00

Shares: 28,000

Value: +$0

Lynne Marie Sullivan

Grant/Award Acquisition

Change: +28,000

Price: $0.00

Shares: 28,000

Value: +$0

Sarah M Bhagat

Grant/Award Acquisition

Change: +28,000

Price: $0.00

Shares: 28,000

Value: +$0

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Edward T Mathers	Jun 20	Grant/Award Acquisition (A) Compensation/Award	28,000	+28,000	$0.00	+$0
Robert Lorne Hopfner	Jun 20	Grant/Award Acquisition (A) Compensation/Award	28,000	+28,000	$0.00	+$0
Axel Bolte	Jun 20	Grant/Award Acquisition (A) Compensation/Award	28,000	+28,000	$0.00	+$0
Martin Edwards	Jun 20	Grant/Award Acquisition (A) Compensation/Award	28,000	+28,000	$0.00	+$0
REINALDO M DIAZ	Jun 20	Grant/Award Acquisition (A) Compensation/Award	28,000	+28,000	$0.00	+$0
Lynne Marie Sullivan	Jun 20	Grant/Award Acquisition (A) Compensation/Award	28,000	+28,000	$0.00	+$0
Sarah M Bhagat	Jun 20	Grant/Award Acquisition (A) Compensation/Award	28,000	+28,000	$0.00	+$0

April 02, 2024

Douglas A Treco

Open Market Sale

Change: -7,523

Price: $6.94

Shares: 20,665

Value: -$52,209

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Douglas A Treco	Apr 03	Open Market Sale (S) Market Sale	20,665	-7,523	$6.94	-$52,209

April 01, 2024

Douglas A Treco

Option Exercise/Conversion

Change: +25,000

Price: $0.00

Shares: 28,188

Value: +$0

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Douglas A Treco	Apr 03	Option Exercise/Conversion (M) Compensation/Award	28,188	+25,000	$0.00	+$0