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Harpoon Therapeutics, Inc.

harpoontx.com

No Longer Reporting

The company has not filed an annual or quarterly report since its Q3 FY2023 10-Q, filed Nov 9, 2023. Its latest SEC filing is a 15-12G from Mar 21, 2024.

The sections below describe the company as of the FY2022 annual report.

What Did They Do?

Develops engineered proteins that direct patients’ immune cells to attack cancer cells, for patients with solid tumors and blood cancers.

How Did They Make Money?

Biopharmaceutical partners pay for licenses and research and development work, with additional payments tied to development, regulatory and commercial milestones and royalties on sales. Distinct license fees are earned when the partner can use the license; research-related payments come as work is carried out.

FY2022 revenue

Who Were Their Customers?

Biopharmaceutical partners work directly with Harpoon through licensing and discovery collaborations; AbbVie is identified as a customer under both the HPN217 development agreement and the research collaborations.

Did Revenues Turn Into Profits?

No. It lost $67.7M in FY2022.

Operating income, FY2022
−214% of revenue
▼ −41% (Loss) vs FY2021 (−$116.8M, −494%)
Net income, FY2022
−212% of revenue
▼ −42% (Loss) vs FY2021 (−$116.7M, −493%)
Free cash flow, FY2022
−281% of revenue
▼ −27% (Loss) vs FY2021 (−$122.3M, −517%)

How Were They Changing?

Since the FY2022 annual report
Latest quarter: Q3 FY2023, the three months to Sep 30, 2023
Revenue
▼ −67%
vs $13.6M in Q3 FY2022
Net income
▼ −85% (Loss)
vs −$11.6M in Q3 FY2022
  • Mar 11, 2024 Merck completed its acquisition of Harpoon Common stockholders became entitled to $23.00 in cash per share, and Harpoon requested Nasdaq delisting.
  • Jan 8, 2024 Agreed to be acquired by Merck for $23.00 per common share
  • Nov 9, 2023 Ended AbbVie’s HPN217 license-option agreement Harpoon retained the program and planned to complete the ongoing Phase 1 trial.

Grew. Revenue grew 6.7x in 4 years, from $4.8M in FY2018 to $31.9M in FY2022, about 61% a year.

Broader drug-candidate platform The earlier report described its candidate pipeline as using TriTAC; the latest report identifies a candidate from the ProTriTAC platform and says additional candidates are moving toward IND-enabling studies.

Two programs discontinued or paused The earlier report described clinical programs for prostate and mesothelin-expressing tumors; the latest report says the prostate-targeting program was discontinued and enrollment in the mesothelin program stopped while it sought a partner.

Who Did They Compete With?

Competes with AbbVie, Amgen, AstraZeneca/MedImmune, Bristol-Myers Squibb, Johnson & Johnson, Merck, Novartis, Pfizer, Roche/Genentech, Boehringer Ingelheim, Allogene Therapeutics, Janssen Pharmaceuticals, Regeneron Pharmaceuticals, Autolus Therapeutics, Arcellx, bluebird bio, Legend Biotech, GlaxoSmithKline, and Celgene/Sutro Pharmaceuticals

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