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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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FY2020
12 months to Dec 31, 2020
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FY2019
12 months to Dec 31, 2019
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FY2018
12 months to Dec 31, 2018
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| Cash flows from operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Stock-based compensation expense | |||||
| Depreciation and amortization expense | |||||
| Amortization (accretion) of premium (discount) on investments | |||||
| Non-cash interest expense | |||||
| Impairment charges | |||||
| Gain on debt extinguishment | |||||
| Changes in operating assets and liabilities: | |||||
| Prepaid expenses and other current assets | |||||
| Operating lease, right-of-use-asset | |||||
| Other assets | |||||
| Accounts payable | |||||
| Accrued expenses and other current liabilities | |||||
| Other long-term liabilities | |||||
| Operating lease liabilities | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities: | |||||
| Purchases of property, plant and equipment | |||||
| Proceeds from sale of property, plant and equipment | |||||
| Purchases of investments | |||||
| Sales and maturities of investments | |||||
| Net cash provided by investing activities | |||||
| Cash flows from financing activities: | |||||
| Proceeds from underwritten public offering of common stock, net of commissions and underwriting discounts | |||||
| Payments of offering costs | |||||
| Payments of debt issuance costs | |||||
| Proceeds from borrowings under loan and security agreement | |||||
| Payment of long-term debt | |||||
| Proceeds from issuance of common stock upon exercise of stock options and under employee stock purchase plan | |||||
| Net cash provided by (used in) financing activities | |||||
| Net increase (decrease) in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash at beginning of period | |||||
| Cash, cash equivalents and restricted cash at end of period | |||||
| Supplemental cash flow information: | |||||
| Cash paid for interest | |||||
| Cash paid for leases | |||||
| Supplemental disclosure of non-cash investing and financing information: | |||||
| Purchases of property, plant and equipment included in accounts payable or accrued expenses | |||||
| Offering costs included in accounts payable and accrued expenses | |||||
| Lease assets obtained in exchange for new operating lease liabilities | |||||
| Lease asset derecognized upon lease cancellation | |||||
| Remeasurement of operating lease liabilities and right-of-use assets due to lease modification | |||||
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