2022 Q1 Form 10-Q Financial Statement
#000117867022000016 Filed on April 28, 2022
Income Statement
Concept | 2022 Q1 | 2021 Q1 |
---|---|---|
Revenue | $213.3M | $177.6M |
YoY Change | 20.1% | 78.5% |
Cost Of Revenue | $23.46M | $23.02M |
YoY Change | 1.89% | 73.08% |
Gross Profit | $189.8M | $154.5M |
YoY Change | 22.82% | 79.34% |
Gross Profit Margin | 89.0% | 87.03% |
Selling, General & Admin | $154.5M | $146.9M |
YoY Change | 5.18% | 15.86% |
% of Gross Profit | 81.39% | 95.03% |
Research & Development | $169.9M | $185.9M |
YoY Change | -8.61% | 9.63% |
% of Gross Profit | 89.51% | 120.29% |
Depreciation & Amortization | $9.460M | $12.60M |
YoY Change | -24.92% | 65.79% |
% of Gross Profit | 4.98% | 8.15% |
Operating Expenses | $324.4M | $332.8M |
YoY Change | -2.52% | 12.29% |
Operating Profit | -$146.7M | -$186.3M |
YoY Change | -21.22% | -11.37% |
Interest Expense | $42.36M | $32.52M |
YoY Change | 30.28% | |
% of Operating Profit | ||
Other Income/Expense, Net | -$92.62M | -$13.02M |
YoY Change | 611.34% | -145.67% |
Pretax Income | -$239.4M | -$199.3M |
YoY Change | 20.11% | 9.71% |
Income Tax | $985.0K | $1.016M |
% Of Pretax Income | ||
Net Earnings | -$240.3M | -$200.3M |
YoY Change | 20.0% | 9.92% |
Net Earnings / Revenue | -112.7% | -112.8% |
Basic Earnings Per Share | -$2.00 | -$1.71 |
Diluted Earnings Per Share | -$2.00 | -$1.71 |
COMMON SHARES | ||
Basic Shares Outstanding | 120.4M shares | 117.1M shares |
Diluted Shares Outstanding | 120.4M shares | 117.1M shares |
Balance Sheet
Concept | 2022 Q1 | 2021 Q1 |
---|---|---|
SHORT-TERM ASSETS | ||
Cash & Short-Term Investments | $2.208B | $1.653B |
YoY Change | 33.58% | 26.72% |
Cash & Equivalents | $534.1M | $379.5M |
Short-Term Investments | $1.673B | $1.273B |
Other Short-Term Assets | $115.1M | $76.00M |
YoY Change | 51.4% | -23.0% |
Inventory | $78.52M | $73.94M |
Prepaid Expenses | ||
Receivables | $156.5M | $110.6M |
Other Receivables | $23.42M | $519.1M |
Total Short-Term Assets | $2.590B | $2.470B |
YoY Change | 4.84% | 55.86% |
LONG-TERM ASSETS | ||
Property, Plant & Equipment | $504.4M | $464.6M |
YoY Change | 8.57% | 8.09% |
Goodwill | ||
YoY Change | ||
Intangibles | ||
YoY Change | ||
Long-Term Investments | ||
YoY Change | ||
Other Assets | $69.82M | $42.68M |
YoY Change | 63.61% | 124.23% |
Total Long-Term Assets | $843.9M | $785.2M |
YoY Change | 7.47% | 13.0% |
TOTAL ASSETS | ||
Total Short-Term Assets | $2.590B | $2.470B |
Total Long-Term Assets | $843.9M | $785.2M |
Total Assets | $3.434B | $3.255B |
YoY Change | 5.48% | 42.8% |
SHORT-TERM LIABILITIES | ||
YoY Change | ||
Accounts Payable | $54.92M | $45.38M |
YoY Change | 21.01% | 12.1% |
Accrued Expenses | $355.9M | $280.5M |
YoY Change | 26.88% | 53.11% |
Deferred Revenue | $131.8M | $116.3M |
YoY Change | 13.32% | 35.21% |
Short-Term Debt | $0.00 | $0.00 |
YoY Change | ||
Long-Term Debt Due | ||
YoY Change | ||
Total Short-Term Liabilities | $606.0M | $494.8M |
YoY Change | 22.46% | 46.06% |
LONG-TERM LIABILITIES | ||
Long-Term Debt | $676.7M | $191.6M |
YoY Change | 253.19% | |
Other Long-Term Liabilities | $120.8M | $60.46M |
YoY Change | 99.84% | 557.33% |
Total Long-Term Liabilities | $120.8M | $60.46M |
YoY Change | 99.84% | 557.33% |
TOTAL LIABILITIES | ||
Total Short-Term Liabilities | $606.0M | $494.8M |
Total Long-Term Liabilities | $120.8M | $60.46M |
Total Liabilities | $3.032B | $2.329B |
YoY Change | 30.2% | 150.47% |
SHAREHOLDERS EQUITY | ||
Retained Earnings | -$5.679B | -$4.786B |
YoY Change | 18.66% | 22.42% |
Common Stock | $6.118B | $5.749B |
YoY Change | 6.42% | 8.65% |
Preferred Stock | ||
YoY Change | ||
Treasury Stock (at cost) | ||
YoY Change | ||
Treasury Stock Shares | ||
Shareholders Equity | $401.2M | $926.2M |
YoY Change | ||
Total Liabilities & Shareholders Equity | $3.434B | $3.255B |
YoY Change | 5.48% | 42.8% |
Cashflow Statement
Concept | 2022 Q1 | 2021 Q1 |
---|---|---|
OPERATING ACTIVITIES | ||
Net Income | -$240.3M | -$200.3M |
YoY Change | 20.0% | 9.92% |
Depreciation, Depletion And Amortization | $9.460M | $12.60M |
YoY Change | -24.92% | 65.79% |
Cash From Operating Activities | -$171.2M | -$235.7M |
YoY Change | -27.36% | -4.27% |
INVESTING ACTIVITIES | ||
Capital Expenditures | $17.86M | $17.18M |
YoY Change | 3.96% | -12.43% |
Acquisitions | ||
YoY Change | ||
Other Investing Activities | $75.00K | $4.198M |
YoY Change | -98.21% | |
Cash From Investing Activities | -$147.4M | $71.35M |
YoY Change | -306.61% | -37.24% |
FINANCING ACTIVITIES | ||
Cash Dividend Paid | ||
YoY Change | ||
Common Stock Issuance & Retirement, Net | ||
YoY Change | ||
Debt Paid & Issued, Net | ||
YoY Change | ||
Cash From Financing Activities | $34.96M | $51.18M |
YoY Change | -31.7% | -5.0% |
NET CHANGE | ||
Cash From Operating Activities | -$171.2M | -$235.7M |
Cash From Investing Activities | -$147.4M | $71.35M |
Cash From Financing Activities | $34.96M | $51.18M |
Net Change In Cash | -$285.9M | -$117.0M |
YoY Change | 144.27% | 47.71% |
FREE CASH FLOW | ||
Cash From Operating Activities | -$171.2M | -$235.7M |
Capital Expenditures | $17.86M | $17.18M |
Free Cash Flow | -$189.1M | -$252.8M |
YoY Change | -25.23% | -4.87% |
Facts In Submission
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|
117080000 | shares |
CY2022Q1 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-240341000 | USD |
CY2022Q1 | us-gaap |
Increase Decrease In Prepaid Deferred Expense And Other Assets
IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
|
29852000 | USD |
CY2021Q1 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-200291000 | USD |
CY2022Q1 | us-gaap |
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
|
-7217000 | USD |
CY2021Q1 | us-gaap |
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
|
-1000 | USD |
CY2022Q1 | us-gaap |
Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax
OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax
|
2376000 | USD |
CY2021Q1 | us-gaap |
Other Comprehensive Income Foreign Currency Transaction And Translation Gain Loss Arising During Period Net Of Tax
OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax
|
6848000 | USD |
CY2022Q1 | us-gaap |
Other Comprehensive Income Loss Pension And Other Postretirement Benefit Plans Adjustment Before Reclassification Adjustments Net Of Tax
OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsNetOfTax
|
-35000 | USD |
CY2021Q1 | us-gaap |
Other Comprehensive Income Loss Pension And Other Postretirement Benefit Plans Adjustment Before Reclassification Adjustments Net Of Tax
OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsNetOfTax
|
-58000 | USD |
CY2022Q1 | us-gaap |
Other Comprehensive Income Loss Net Of Tax
OtherComprehensiveIncomeLossNetOfTax
|
-4806000 | USD |
CY2021Q1 | us-gaap |
Other Comprehensive Income Loss Net Of Tax
OtherComprehensiveIncomeLossNetOfTax
|
6905000 | USD |
CY2022Q1 | us-gaap |
Comprehensive Income Net Of Tax
ComprehensiveIncomeNetOfTax
|
-245147000 | USD |
CY2021Q1 | us-gaap |
Comprehensive Income Net Of Tax
ComprehensiveIncomeNetOfTax
|
-193386000 | USD |
CY2021Q4 | us-gaap |
Stockholders Equity
StockholdersEquity
|
588203000 | USD |
CY2022Q1 | us-gaap |
Stock Issued During Period Value Stock Options Exercised
StockIssuedDuringPeriodValueStockOptionsExercised
|
28059000 | USD |
CY2022Q1 | us-gaap |
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
|
30051000 | USD |
CY2022Q1 | us-gaap |
Other Comprehensive Income Loss Net Of Tax
OtherComprehensiveIncomeLossNetOfTax
|
-4806000 | USD |
CY2022Q1 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-240341000 | USD |
CY2022Q1 | us-gaap |
Stockholders Equity
StockholdersEquity
|
401166000 | USD |
CY2020Q4 | us-gaap |
Stockholders Equity
StockholdersEquity
|
1016247000 | USD |
CY2021Q1 | us-gaap |
Stock Issued During Period Value Stock Options Exercised
StockIssuedDuringPeriodValueStockOptionsExercised
|
47034000 | USD |
CY2021Q1 | us-gaap |
Stock Issued During Period Value Share Based Compensation Gross
StockIssuedDuringPeriodValueShareBasedCompensationGross
|
0 | USD |
CY2021Q1 | us-gaap |
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
|
56295000 | USD |
CY2021Q1 | us-gaap |
Other Comprehensive Income Loss Net Of Tax
OtherComprehensiveIncomeLossNetOfTax
|
6905000 | USD |
CY2021Q1 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-200291000 | USD |
CY2021Q1 | us-gaap |
Stockholders Equity
StockholdersEquity
|
926190000 | USD |
CY2022Q1 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-240341000 | USD |
CY2021Q1 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-200291000 | USD |
CY2022Q1 | us-gaap |
Depreciation Amortization And Accretion Net
DepreciationAmortizationAndAccretionNet
|
9460000 | USD |
CY2021Q1 | us-gaap |
Depreciation Amortization And Accretion Net
DepreciationAmortizationAndAccretionNet
|
12601000 | USD |
CY2022Q1 | alny |
Amortization And Interest Accretion Related To Operating Leases
AmortizationAndInterestAccretionRelatedToOperatingLeases
|
10318000 | USD |
CY2021Q1 | alny |
Amortization And Interest Accretion Related To Operating Leases
AmortizationAndInterestAccretionRelatedToOperatingLeases
|
10261000 | USD |
CY2022Q1 | alny |
Non Cash Interest Expense On Sale Of Future Royalties
NonCashInterestExpenseOnSaleOfFutureRoyalties
|
27702000 | USD |
CY2021Q1 | alny |
Non Cash Interest Expense On Sale Of Future Royalties
NonCashInterestExpenseOnSaleOfFutureRoyalties
|
28184000 | USD |
CY2022Q1 | us-gaap |
Share Based Compensation
ShareBasedCompensation
|
29293000 | USD |
CY2021Q1 | us-gaap |
Share Based Compensation
ShareBasedCompensation
|
55690000 | USD |
CY2022Q1 | us-gaap |
Equity Securities Fv Ni Gain Loss
EquitySecuritiesFvNiGainLoss
|
-31161000 | USD |
CY2021Q1 | us-gaap |
Equity Securities Fv Ni Gain Loss
EquitySecuritiesFvNiGainLoss
|
47016000 | USD |
CY2022Q1 | us-gaap |
Other Operating Activities Cash Flow Statement
OtherOperatingActivitiesCashFlowStatement
|
21177000 | USD |
CY2021Q1 | us-gaap |
Other Operating Activities Cash Flow Statement
OtherOperatingActivitiesCashFlowStatement
|
30777000 | USD |
CY2022Q1 | us-gaap |
Increase Decrease In Accounts Receivable
IncreaseDecreaseInAccountsReceivable
|
-39696000 | USD |
CY2021Q1 | us-gaap |
Increase Decrease In Accounts Receivable
IncreaseDecreaseInAccountsReceivable
|
10709000 | USD |
CY2022Q1 | us-gaap |
Increase Decrease In Inventories
IncreaseDecreaseInInventories
|
-1926000 | USD |
CY2021Q1 | us-gaap |
Increase Decrease In Inventories
IncreaseDecreaseInInventories
|
-1934000 | USD |
CY2021Q1 | us-gaap |
Increase Decrease In Prepaid Deferred Expense And Other Assets
IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
|
13654000 | USD |
CY2022Q1 | us-gaap |
Increase Decrease In Accounts Payable And Accrued Liabilities
IncreaseDecreaseInAccountsPayableAndAccruedLiabilities
|
-48736000 | USD |
CY2021Q1 | us-gaap |
Increase Decrease In Accounts Payable And Accrued Liabilities
IncreaseDecreaseInAccountsPayableAndAccruedLiabilities
|
-66573000 | USD |
CY2022Q1 | us-gaap |
Increase Decrease In Contract With Customer Liability
IncreaseDecreaseInContractWithCustomerLiability
|
-12325000 | USD |
CY2021Q1 | us-gaap |
Increase Decrease In Contract With Customer Liability
IncreaseDecreaseInContractWithCustomerLiability
|
-27804000 | USD |
CY2022Q1 | us-gaap |
Operating Lease Payments
OperatingLeasePayments
|
10672000 | USD |
CY2021Q1 | us-gaap |
Operating Lease Payments
OperatingLeasePayments
|
9060000 | USD |
CY2022Q1 | us-gaap |
Net Cash Provided By Used In Operating Activities
NetCashProvidedByUsedInOperatingActivities
|
-171193000 | USD |
CY2021Q1 | us-gaap |
Net Cash Provided By Used In Operating Activities
NetCashProvidedByUsedInOperatingActivities
|
-235660000 | USD |
CY2022Q1 | us-gaap |
Payments To Acquire Property Plant And Equipment
PaymentsToAcquirePropertyPlantAndEquipment
|
17859000 | USD |
CY2021Q1 | us-gaap |
Payments To Acquire Property Plant And Equipment
PaymentsToAcquirePropertyPlantAndEquipment
|
17178000 | USD |
CY2022Q1 | us-gaap |
Payments To Acquire Available For Sale Securities Debt
PaymentsToAcquireAvailableForSaleSecuritiesDebt
|
634705000 | USD |
CY2021Q1 | us-gaap |
Payments To Acquire Available For Sale Securities Debt
PaymentsToAcquireAvailableForSaleSecuritiesDebt
|
345954000 | USD |
CY2022Q1 | us-gaap |
Proceeds From Sale And Maturity Of Marketable Securities
ProceedsFromSaleAndMaturityOfMarketableSecurities
|
505220000 | USD |
CY2021Q1 | us-gaap |
Proceeds From Sale And Maturity Of Marketable Securities
ProceedsFromSaleAndMaturityOfMarketableSecurities
|
438682000 | USD |
CY2022Q1 | us-gaap |
Payments To Acquire Restricted Investments
PaymentsToAcquireRestrictedInvestments
|
9400000 | USD |
CY2021Q1 | us-gaap |
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect
|
-117041000 | USD |
CY2021Q4 | us-gaap |
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
|
822153000 | USD |
CY2021Q1 | us-gaap |
Payments To Acquire Restricted Investments
PaymentsToAcquireRestrictedInvestments
|
10650000 | USD |
CY2022Q1 | us-gaap |
Proceeds From Sale Of Restricted Investments
ProceedsFromSaleOfRestrictedInvestments
|
9400000 | USD |
CY2021Q1 | us-gaap |
Proceeds From Sale Of Restricted Investments
ProceedsFromSaleOfRestrictedInvestments
|
10650000 | USD |
CY2022Q1 | us-gaap |
Payments For Proceeds From Other Investing Activities
PaymentsForProceedsFromOtherInvestingActivities
|
75000 | USD |
CY2021Q1 | us-gaap |
Payments For Proceeds From Other Investing Activities
PaymentsForProceedsFromOtherInvestingActivities
|
4198000 | USD |
CY2022Q1 | us-gaap |
Net Cash Provided By Used In Investing Activities
NetCashProvidedByUsedInInvestingActivities
|
-147419000 | USD |
CY2021Q1 | us-gaap |
Net Cash Provided By Used In Investing Activities
NetCashProvidedByUsedInInvestingActivities
|
71352000 | USD |
CY2022Q1 | us-gaap |
Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options
ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions
|
27123000 | USD |
CY2021Q1 | us-gaap |
Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options
ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions
|
46977000 | USD |
CY2022Q1 | us-gaap |
Proceeds From Derivative Instrument Financing Activities
ProceedsFromDerivativeInstrumentFinancingActivities
|
7833000 | USD |
CY2021Q1 | us-gaap |
Proceeds From Derivative Instrument Financing Activities
ProceedsFromDerivativeInstrumentFinancingActivities
|
4200000 | USD |
CY2022Q1 | us-gaap |
Net Cash Provided By Used In Financing Activities
NetCashProvidedByUsedInFinancingActivities
|
34956000 | USD |
CY2021Q1 | us-gaap |
Net Cash Provided By Used In Financing Activities
NetCashProvidedByUsedInFinancingActivities
|
51177000 | USD |
CY2022Q1 | us-gaap |
Effect Of Exchange Rate On Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents
|
-2238000 | USD |
CY2021Q1 | us-gaap |
Effect Of Exchange Rate On Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents
|
-3910000 | USD |
CY2022Q1 | us-gaap |
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect
|
-285894000 | USD |
CY2022Q1 | us-gaap |
Capital Expenditures Incurred But Not Yet Paid
CapitalExpendituresIncurredButNotYetPaid
|
8318000 | USD |
CY2021Q1 | us-gaap |
Capital Expenditures Incurred But Not Yet Paid
CapitalExpendituresIncurredButNotYetPaid
|
7289000 | USD |
CY2020Q4 | us-gaap |
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
|
499046000 | USD |
CY2022Q1 | us-gaap |
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
|
536259000 | USD |
CY2021Q1 | us-gaap |
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
|
382005000 | USD |
CY2022Q1 | us-gaap |
Nature Of Operations
NatureOfOperations
|
NATURE OF BUSINESS<div style="margin-top:6pt;text-align:justify;text-indent:18pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:115%">Alnylam Pharmaceuticals, Inc. (also referred to as Alnylam, we, our or us) commenced operations on June 14, 2002 as a biopharmaceutical company seeking to develop and commercialize novel therapeutics based on ribonucleic acid interference, or RNAi. We are committed to the advancement of our company strategy of building a multi-product, global, commercial biopharmaceutical company with a deep and sustainable clinical pipeline of RNAi therapeutics for future growth and a robust, organic research engine for sustainable innovation and great potential for patient impact. Since inception, we have focused on discovering, developing and commercializing RNAi therapeutics by establishing and maintaining a strong intellectual property position in the RNAi field, establishing strategic alliances with leading pharmaceutical and life sciences companies, generating revenues through licensing agreements, and ultimately developing and commercializing RNAi therapeutics globally, either independently or with our strategic partners. We have devoted substantially all of our efforts to business planning, research, development, manufacturing and early commercial efforts, acquiring, filing and expanding intellectual property rights, recruiting management and technical staff, and raising capital. </span></div><div style="margin-top:6pt;text-align:justify;text-indent:18pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:115%">In early 2021, we launched our </span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-style:italic;font-weight:400;line-height:115%">Alnylam P</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:6.5pt;font-style:italic;font-weight:400;line-height:115%;position:relative;top:-3.5pt;vertical-align:baseline">5</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-style:italic;font-weight:400;line-height:115%">x25 </span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:115%">strategy, which focuses on our planned transition to a top five biotech company by the end of 2025. With </span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-style:italic;font-weight:400;line-height:115%">Alnylam P</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:6.5pt;font-style:italic;font-weight:400;line-height:115%;position:relative;top:-3.5pt;vertical-align:baseline">5</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-style:italic;font-weight:400;line-height:115%">x25</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:115%">, we aim to deliver transformative rare and prevalent disease medicines for patients around the world through sustainable innovation, delivering exceptional financial performance and driving profitability.</span></div><div style="margin-top:6pt;text-align:justify;text-indent:18pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:115%">As of March 31, 2022, we have four products that have received marketing approval, including one partnered product, and five late-stage investigational programs advancing towards potential commercialization. We currently generate worldwide product revenues from three commercialized products, ONPATTRO, GIVLAARI and OXLUMO, primarily in the U.S., Europe and Japan.</span></div> | |
CY2022Q1 | alny |
Number Of Marketed Products
NumberOfMarketedProducts
|
4 | product |
CY2022Q1 | alny |
Number Of Partnered Products
NumberOfPartneredProducts
|
1 | product |
CY2022Q1 | alny |
Number Of Clinical Programs In Late Stages
NumberOfClinicalProgramsInLateStages
|
5 | program |
CY2022Q1 | alny |
Number Of Commercialized Products
NumberOfCommercializedProducts
|
3 | product |
CY2022Q1 | us-gaap |
Use Of Estimates
UseOfEstimates
|
<div style="margin-top:6pt;text-align:justify"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-style:italic;font-weight:700;line-height:115%">Use of Estimates</span></div><div style="margin-top:6pt;text-align:justify;text-indent:18pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:115%">The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of revenues and expenses during the reporting period. In our condensed consolidated financial statements, we use estimates and assumptions related to our inventory valuation and related reserves, liability related to the sale of future royalties, development derivative liability, income taxes, revenue recognition, research and development expenses, and stock-based compensation. We base our estimates on historical experience and on various other assumptions that we believe to be reasonable. Actual results could differ from those estimates.</span></div><div style="margin-top:6pt;text-align:justify;text-indent:18pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:115%">The full extent to which the ongoing COVID-19 pandemic will directly or indirectly impact our business, results of operations and financial condition, including sales, expenses, reserves and allowances, the supply of our products and product candidates, clinical trials and research and development costs, will depend on future developments that are highly uncertain, including as a result of new information that may emerge concerning COVID-19 and variants thereof, and the actions taken to contain or treat it or vaccinate against it, as well as the economic impact on local, regional, national and international customers and markets. We have made estimates of the impact of COVID-19 within our financial statements and there may be changes to those estimates in future periods. Actual results may differ from these estimates.</span></div> | |
CY2022Q1 | us-gaap |
Accounts Receivable Net
AccountsReceivableNet
|
23421000 | USD |
CY2021Q4 | us-gaap |
Accounts Receivable Net
AccountsReceivableNet
|
73266000 | USD |
CY2022Q1 | us-gaap |
Contract With Customer Liability
ContractWithCustomerLiability
|
78683000 | USD |
CY2021Q4 | us-gaap |
Contract With Customer Liability
ContractWithCustomerLiability
|
88627000 | USD |
CY2022Q1 | us-gaap |
Contract With Customer Liability Revenue Recognized
ContractWithCustomerLiabilityRevenueRecognized
|
9500000 | USD |
CY2021Q1 | us-gaap |
Contract With Customer Liability Revenue Recognized
ContractWithCustomerLiabilityRevenueRecognized
|
25300000 | USD |
CY2022Q1 | alny |
Increase Decrease In Research And Development Expense
IncreaseDecreaseInResearchAndDevelopmentExpense
|
-3900000 | USD |
CY2021Q1 | alny |
Increase Decrease In Research And Development Expense
IncreaseDecreaseInResearchAndDevelopmentExpense
|
-5400000 | USD |
CY2022Q1 | us-gaap |
Available For Sale Debt Securities Amortized Cost Basis
AvailableForSaleDebtSecuritiesAmortizedCostBasis
|
1736298000 | USD |
CY2022Q1 | us-gaap |
Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax
AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
|
22000 | USD |
CY2022Q1 | us-gaap |
Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax
AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
|
8869000 | USD |
CY2022Q1 | us-gaap |
Available For Sale Securities Debt Securities
AvailableForSaleSecuritiesDebtSecurities
|
1727451000 | USD |
CY2021Q4 | us-gaap |
Available For Sale Debt Securities Amortized Cost Basis
AvailableForSaleDebtSecuritiesAmortizedCostBasis
|
1605245000 | USD |
CY2021Q4 | us-gaap |
Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax
AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
|
9000 | USD |
CY2021Q4 | us-gaap |
Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax
AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
|
1639000 | USD |
CY2021Q4 | us-gaap |
Available For Sale Securities Debt Securities
AvailableForSaleSecuritiesDebtSecurities
|
1603615000 | USD |
CY2022Q1 | us-gaap |
Available For Sale Securities Debt Securities Current
AvailableForSaleSecuritiesDebtSecuritiesCurrent
|
1673485000 | USD |
CY2021Q4 | us-gaap |
Available For Sale Securities Debt Securities Current
AvailableForSaleSecuritiesDebtSecuritiesCurrent
|
1548617000 | USD |
CY2022Q1 | us-gaap |
Cash And Cash Equivalents Fair Value Disclosure
CashAndCashEquivalentsFairValueDisclosure
|
53966000 | USD |
CY2021Q4 | us-gaap |
Cash And Cash Equivalents Fair Value Disclosure
CashAndCashEquivalentsFairValueDisclosure
|
54998000 | USD |
CY2022Q1 | us-gaap |
Available For Sale Securities Debt Securities
AvailableForSaleSecuritiesDebtSecurities
|
1727451000 | USD |
CY2021Q4 | us-gaap |
Available For Sale Securities Debt Securities
AvailableForSaleSecuritiesDebtSecurities
|
1603615000 | USD |
CY2022Q1 | us-gaap |
Inventory Raw Materials
InventoryRawMaterials
|
20372000 | USD |
CY2021Q4 | us-gaap |
Inventory Raw Materials
InventoryRawMaterials
|
14754000 | USD |
CY2022Q1 | us-gaap |
Inventory Work In Process
InventoryWorkInProcess
|
91262000 | USD |
CY2021Q4 | us-gaap |
Inventory Work In Process
InventoryWorkInProcess
|
100942000 | USD |
CY2022Q1 | us-gaap |
Inventory Finished Goods
InventoryFinishedGoods
|
10428000 | USD |
CY2021Q4 | us-gaap |
Inventory Finished Goods
InventoryFinishedGoods
|
7005000 | USD |
CY2022Q1 | alny |
Inventory Current And Noncurrent
InventoryCurrentAndNoncurrent
|
122062000 | USD |
CY2021Q4 | alny |
Inventory Current And Noncurrent
InventoryCurrentAndNoncurrent
|
122701000 | USD |
CY2022Q1 | alny |
Capitalized Inventory
CapitalizedInventory
|
7000000 | USD |
CY2021Q4 | alny |
Capitalized Inventory
CapitalizedInventory
|
7100000 | USD |
CY2022Q1 | us-gaap |
Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
|
534081000 | USD |
CY2021Q1 | us-gaap |
Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
|
379543000 | USD |
CY2022Q1 | us-gaap |
Restricted Cash
RestrictedCash
|
2178000 | USD |
CY2021Q1 | us-gaap |
Restricted Cash
RestrictedCash
|
2462000 | USD |
CY2022Q1 | us-gaap |
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
|
536259000 | USD |
CY2021Q1 | us-gaap |
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
|
382005000 | USD |
CY2022Q1 | us-gaap |
Other Comprehensive Income Loss Before Reclassifications Net Of Tax
OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax
|
2377000 | USD |
CY2022Q1 | us-gaap |
Reclassification From Accumulated Other Comprehensive Income Current Period Net Of Tax
ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax
|
7183000 | USD |
CY2022Q1 | us-gaap |
Other Comprehensive Income Loss Net Of Tax
OtherComprehensiveIncomeLossNetOfTax
|
-4806000 | USD |
CY2021Q1 | us-gaap |
Other Comprehensive Income Loss Before Reclassifications Net Of Tax
OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax
|
6847000 | USD |
CY2021Q1 | us-gaap |
Reclassification From Accumulated Other Comprehensive Income Current Period Net Of Tax
ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax
|
-58000 | USD |
CY2021Q1 | us-gaap |
Other Comprehensive Income Loss Net Of Tax
OtherComprehensiveIncomeLossNetOfTax
|
6905000 | USD |
CY2022Q1 | us-gaap |
Debt Instrument Interest Rate Stated Percentage
DebtInstrumentInterestRateStatedPercentage
|
0.14 | |
CY2022Q1 | us-gaap |
Allocated Share Based Compensation Expense
AllocatedShareBasedCompensationExpense
|
29293000 | USD |
CY2021Q1 | us-gaap |
Allocated Share Based Compensation Expense
AllocatedShareBasedCompensationExpense
|
55690000 | USD |
CY2022Q1 | us-gaap |
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
|
14703000 | shares |
CY2021Q1 | us-gaap |
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
|
15397000 | shares |