2016 Q1 Form 10-K Financial Statement
#000119312516462538 Filed on February 12, 2016
Income Statement
Concept | 2016 Q1 | 2015 | 2014 Q4 |
---|---|---|---|
Revenue | $7.300M | $41.10M | $24.00M |
YoY Change | -60.54% | -18.77% | 122.22% |
Cost Of Revenue | |||
YoY Change | |||
Gross Profit | |||
YoY Change | |||
Gross Profit Margin | |||
Selling, General & Admin | $21.10M | $60.60M | $14.20M |
YoY Change | 66.14% | 36.18% | 71.08% |
% of Gross Profit | |||
Research & Development | $96.27M | $276.5M | $55.50M |
YoY Change | 65.89% | 45.33% | 72.9% |
% of Gross Profit | |||
Depreciation & Amortization | $4.601M | $19.05M | $3.300M |
YoY Change | 24.69% | 59.74% | 26.92% |
% of Gross Profit | |||
Operating Expenses | $117.4M | $337.1M | $69.73M |
YoY Change | 65.88% | -26.0% | 72.44% |
Operating Profit | -$110.0M | -$296.0M | |
YoY Change | 110.69% | -26.91% | |
Interest Expense | $1.800M | $5.900M | $800.0K |
YoY Change | 80.0% | 126.92% | 166.67% |
% of Operating Profit | |||
Other Income/Expense, Net | $7.054M | $5.935M | $1.500M |
YoY Change | 595.66% | 35.63% | |
Pretax Income | -$103.0M | -$290.1M | -$43.50M |
YoY Change | 101.09% | -27.59% | 48.46% |
Income Tax | $0.00 | $0.00 | -$22.10M |
% Of Pretax Income | |||
Net Earnings | -$103.0M | -$290.1M | -$21.39M |
YoY Change | 102.8% | -19.51% | -33.9% |
Net Earnings / Revenue | -1410.6% | -705.77% | -89.12% |
Basic Earnings Per Share | |||
Diluted Earnings Per Share | -$1.208M | -$3.454M | -$277.9K |
COMMON SHARES | |||
Basic Shares Outstanding | 85.14M shares | 76.93M shares | |
Diluted Shares Outstanding |
Balance Sheet
Concept | 2016 Q1 | 2015 | 2014 Q4 |
---|---|---|---|
SHORT-TERM ASSETS | |||
Cash & Short-Term Investments | $979.7M | $1.081B | $602.1M |
YoY Change | 1.32% | 55.09% | 144.89% |
Cash & Equivalents | $231.3M | $180.9M | $75.18M |
Short-Term Investments | $748.4M | $899.6M | $526.9M |
Other Short-Term Assets | $27.60M | $16.60M | $9.700M |
YoY Change | 109.09% | 71.13% | 148.72% |
Inventory | |||
Prepaid Expenses | |||
Receivables | $8.800M | $8.300M | $39.90M |
Other Receivables | $0.00 | $0.00 | $0.00 |
Total Short-Term Assets | $1.050B | $1.105B | $746.4M |
YoY Change | -3.68% | 48.1% | 193.81% |
LONG-TERM ASSETS | |||
Property, Plant & Equipment | $36.81M | $27.80M | $21.74M |
YoY Change | 73.93% | 28.11% | 32.17% |
Goodwill | |||
YoY Change | |||
Intangibles | |||
YoY Change | |||
Long-Term Investments | $228.6M | $251.8M | $279.8M |
YoY Change | -52.75% | -10.01% | 86.41% |
Other Assets | $1.471M | $1.500M | $31.70M |
YoY Change | -95.64% | -95.27% | |
Total Long-Term Assets | $266.9M | $281.1M | $333.2M |
YoY Change | -50.45% | -15.64% | 100.13% |
TOTAL ASSETS | |||
Total Short-Term Assets | $1.050B | $1.105B | $746.4M |
Total Long-Term Assets | $266.9M | $281.1M | $333.2M |
Total Assets | $1.317B | $1.387B | $1.080B |
YoY Change | -19.15% | 28.43% | 156.72% |
SHORT-TERM LIABILITIES | |||
YoY Change | |||
Accounts Payable | $17.44M | $16.80M | $15.11M |
YoY Change | 12.63% | 11.26% | 156.29% |
Accrued Expenses | $30.81M | $28.80M | $23.68M |
YoY Change | 113.52% | 21.52% | 67.23% |
Deferred Revenue | |||
YoY Change | |||
Short-Term Debt | $0.00 | $0.00 | $0.00 |
YoY Change | |||
Long-Term Debt Due | |||
YoY Change | |||
Total Short-Term Liabilities | $66.37M | $62.10M | $95.33M |
YoY Change | -17.75% | -34.84% | 76.99% |
LONG-TERM LIABILITIES | |||
Long-Term Debt | $0.00 | $0.00 | $0.00 |
YoY Change | |||
Other Long-Term Liabilities | $1.373M | $59.70M | $48.00M |
YoY Change | -97.34% | 24.38% | -50.16% |
Total Long-Term Liabilities | $1.373M | $59.70M | $48.00M |
YoY Change | -97.34% | 24.38% | -50.16% |
TOTAL LIABILITIES | |||
Total Short-Term Liabilities | $66.37M | $62.10M | $95.33M |
Total Long-Term Liabilities | $1.373M | $59.70M | $48.00M |
Total Liabilities | $127.9M | $121.8M | $143.3M |
YoY Change | -3.31% | -15.0% | -4.56% |
SHAREHOLDERS EQUITY | |||
Retained Earnings | -$1.350B | -$956.6M | |
YoY Change | 33.98% | 60.45% | |
Common Stock | $2.548B | $1.844B | |
YoY Change | 3.92% | 117.76% | |
Preferred Stock | |||
YoY Change | |||
Treasury Stock (at cost) | |||
YoY Change | |||
Treasury Stock Shares | |||
Shareholders Equity | $1.189B | $1.265B | $936.3M |
YoY Change | |||
Total Liabilities & Shareholders Equity | $1.317B | $1.387B | $1.080B |
YoY Change | -19.15% | 28.43% | 156.72% |
Cashflow Statement
Concept | 2016 Q1 | 2015 | 2014 Q4 |
---|---|---|---|
OPERATING ACTIVITIES | |||
Net Income | -$103.0M | -$290.1M | -$21.39M |
YoY Change | 102.8% | -19.51% | -33.9% |
Depreciation, Depletion And Amortization | $4.601M | $19.05M | $3.300M |
YoY Change | 24.69% | 59.74% | 26.92% |
Cash From Operating Activities | -$83.60M | -$189.1M | -$36.60M |
YoY Change | 217.87% | 14.19% | 63.39% |
INVESTING ACTIVITIES | |||
Capital Expenditures | $2.759M | $12.95M | -$3.600M |
YoY Change | 30.76% | 44.52% | 300.0% |
Acquisitions | |||
YoY Change | |||
Other Investing Activities | $129.8M | -$308.4M | $24.90M |
YoY Change | -138.27% | -40.1% | -56.24% |
Cash From Investing Activities | $117.9M | -$321.3M | $21.40M |
YoY Change | -134.54% | -41.45% | -61.85% |
FINANCING ACTIVITIES | |||
Cash Dividend Paid | |||
YoY Change | |||
Common Stock Issuance & Retirement, Net | $496.4M | ||
YoY Change | |||
Debt Paid & Issued, Net | |||
YoY Change | |||
Cash From Financing Activities | 16.10M | 616.2M | 7.700M |
YoY Change | -97.31% | -16.33% | 1.32% |
NET CHANGE | |||
Cash From Operating Activities | -83.60M | -189.1M | -36.60M |
Cash From Investing Activities | 117.9M | -321.3M | 21.40M |
Cash From Financing Activities | 16.10M | 616.2M | 7.700M |
Net Change In Cash | 50.40M | 105.8M | -7.500M |
YoY Change | -78.22% | 378.73% | -118.16% |
FREE CASH FLOW | |||
Cash From Operating Activities | -$83.60M | -$189.1M | -$36.60M |
Capital Expenditures | $2.759M | $12.95M | -$3.600M |
Free Cash Flow | -$86.36M | -$202.1M | -$33.00M |
YoY Change | 203.97% | 15.75% | 53.49% |
Facts In Submission
Frame | Concept Type | Concept / XBRL Key | Value | Unit |
---|---|---|---|---|
CY2013Q1 | us-gaap |
Shares Issued Price Per Share
SharesIssuedPricePerShare
|
20.13 | |
CY2015Q1 | us-gaap |
Shares Issued Price Per Share
SharesIssuedPricePerShare
|
95.00 | |
CY2015Q2 | dei |
Entity Public Float
EntityPublicFloat
|
10043526713 | |
CY2012Q4 | us-gaap |
Stockholders Equity
StockholdersEquity
|
134053000 | |
CY2012Q4 | us-gaap |
Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
|
51405000 | |
CY2013Q4 | us-gaap |
Incentive From Lessor
IncentiveFromLessor
|
200000 | |
CY2013Q4 | us-gaap |
Stockholders Equity
StockholdersEquity
|
270347000 | |
CY2013Q4 | us-gaap |
Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
|
53169000 | |
CY2014Q4 | us-gaap |
Common Stock Par Or Stated Value Per Share
CommonStockParOrStatedValuePerShare
|
0.01 | |
CY2014Q4 | us-gaap |
Common Stock Shares Authorized
CommonStockSharesAuthorized
|
125000000 | shares |
CY2014Q4 | us-gaap |
Common Stock Shares Outstanding
CommonStockSharesOutstanding
|
77202753 | shares |
CY2014Q4 | us-gaap |
Preferred Stock Shares Authorized
PreferredStockSharesAuthorized
|
5000000 | shares |
CY2014Q4 | us-gaap |
Preferred Stock Shares Issued
PreferredStockSharesIssued
|
0 | shares |
CY2014Q4 | us-gaap |
Common Stock Shares Issued
CommonStockSharesIssued
|
77202753 | shares |
CY2014Q4 | us-gaap |
Preferred Stock Shares Outstanding
PreferredStockSharesOutstanding
|
0 | shares |
CY2014Q4 | us-gaap |
Preferred Stock Par Or Stated Value Per Share
PreferredStockParOrStatedValuePerShare
|
0.01 | |
CY2014Q4 | us-gaap |
Incentive From Lessor
IncentiveFromLessor
|
1900000 | |
CY2014Q4 | us-gaap |
Liabilities Current
LiabilitiesCurrent
|
95334000 | |
CY2014Q4 | us-gaap |
Deferred Tax Liabilities Current
DeferredTaxLiabilitiesCurrent
|
31667000 | |
CY2014Q4 | us-gaap |
Employee Related Liabilities Current
EmployeeRelatedLiabilitiesCurrent
|
7357000 | |
CY2014Q4 | us-gaap |
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment
|
46093000 | |
CY2014Q4 | us-gaap |
Deferred Revenue Noncurrent
DeferredRevenueNoncurrent
|
42983000 | |
CY2014Q4 | us-gaap |
Accrued Liabilities Current
AccruedLiabilitiesCurrent
|
23680000 | |
CY2014Q4 | us-gaap |
Liabilities
Liabilities
|
143328000 | |
CY2014Q4 | us-gaap |
Deferred Rent Credit Current
DeferredRentCreditCurrent
|
1005000 | |
CY2014Q4 | us-gaap |
Common Stock Value
CommonStockValue
|
772000 | |
CY2014Q4 | us-gaap |
Additional Paid In Capital Common Stock
AdditionalPaidInCapitalCommonStock
|
1843362000 | |
CY2014Q4 | us-gaap |
Deferred Tax Liabilities Other Comprehensive Income
DeferredTaxLiabilitiesOtherComprehensiveIncome
|
32793000 | |
CY2014Q4 | us-gaap |
Available For Sale Securities Accumulated Gross Unrealized Gain Before Tax
AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
|
28000 | |
CY2014Q4 | us-gaap |
Deferred Revenue Current
DeferredRevenueCurrent
|
23871000 | |
CY2014Q4 | us-gaap |
Accumulated Other Comprehensive Income Loss Net Of Tax
AccumulatedOtherComprehensiveIncomeLossNetOfTax
|
48763000 | |
CY2014Q4 | us-gaap |
Commitments And Contingencies
CommitmentsAndContingencies
|
||
CY2014Q4 | us-gaap |
Deferred Tax Assets Valuation Allowance
DeferredTaxAssetsValuationAllowance
|
268416000 | |
CY2014Q4 | us-gaap |
Accrued Professional Fees Current
AccruedProfessionalFeesCurrent
|
3886000 | |
CY2014Q4 | us-gaap |
Preferred Stock Value
PreferredStockValue
|
||
CY2014Q4 | us-gaap |
Other Accrued Liabilities Current
OtherAccruedLiabilitiesCurrent
|
3808000 | |
CY2014Q4 | us-gaap |
Retained Earnings Accumulated Deficit
RetainedEarningsAccumulatedDeficit
|
-956630000 | |
CY2014Q4 | us-gaap |
Deferred Rent Credit Noncurrent
DeferredRentCreditNoncurrent
|
5011000 | |
CY2014Q4 | us-gaap |
Stockholders Equity
StockholdersEquity
|
936267000 | |
CY2014Q4 | us-gaap |
Liabilities And Stockholders Equity
LiabilitiesAndStockholdersEquity
|
1079595000 | |
CY2014Q4 | us-gaap |
Accounts Payable Current
AccountsPayableCurrent
|
15111000 | |
CY2014Q4 | us-gaap |
Deferred Tax Assets Tax Credit Carryforwards
DeferredTaxAssetsTaxCreditCarryforwards
|
788000 | |
CY2014Q4 | us-gaap |
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits
DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits
|
24516000 | |
CY2014Q4 | us-gaap |
Property Plant And Equipment Net
PropertyPlantAndEquipmentNet
|
21740000 | |
CY2014Q4 | us-gaap |
Available For Sale Securities Debt Securities Noncurrent
AvailableForSaleSecuritiesDebtSecuritiesNoncurrent
|
279821000 | |
CY2014Q4 | us-gaap |
Furniture And Fixtures Gross
FurnitureAndFixturesGross
|
1999000 | |
CY2014Q4 | us-gaap |
Assets Current
AssetsCurrent
|
746367000 | |
CY2014Q4 | us-gaap |
Deferred Tax Assets In Process Research And Development
DeferredTaxAssetsInProcessResearchAndDevelopment
|
19246000 | |
CY2014Q4 | us-gaap |
Deferred Tax Assets Deferred Income
DeferredTaxAssetsDeferredIncome
|
14273000 | |
CY2014Q4 | us-gaap |
Deferred Tax Assets Other
DeferredTaxAssetsOther
|
5871000 | |
CY2014Q4 | us-gaap |
Deferred Tax Assets Equity Method Investments
DeferredTaxAssetsEquityMethodInvestments
|
689000 | |
CY2014Q4 | us-gaap |
Deferred Tax Assets Tax Credit Carryforwards Foreign
DeferredTaxAssetsTaxCreditCarryforwardsForeign
|
3196000 | |
CY2014Q4 | us-gaap |
Deferred Tax Assets Liabilities Net
DeferredTaxAssetsLiabilitiesNet
|
0 | |
CY2014Q4 | us-gaap |
Available For Sale Securities Equity Securities Current
AvailableForSaleSecuritiesEquitySecuritiesCurrent
|
94583000 | |
CY2014Q4 | us-gaap |
Deferred Tax Assets Goodwill And Intangible Assets
DeferredTaxAssetsGoodwillAndIntangibleAssets
|
17637000 | |
CY2014Q4 | us-gaap |
Leasehold Improvements Gross
LeaseholdImprovementsGross
|
30853000 | |
CY2014Q4 | us-gaap |
Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
|
75179000 | |
CY2014Q4 | us-gaap |
Available For Sale Securities Debt Securities
AvailableForSaleSecuritiesDebtSecurities
|
806750000 | |
CY2014Q4 | us-gaap |
Receivables Net Current
ReceivablesNetCurrent
|
39937000 | |
CY2014Q4 | us-gaap |
Assets
Assets
|
1079595000 | |
CY2014Q4 | us-gaap |
Deferred Tax Assets Net Noncurrent
DeferredTaxAssetsNetNoncurrent
|
31667000 | |
CY2014Q4 | us-gaap |
Deferred Tax Assets Gross
DeferredTaxAssetsGross
|
301209000 | |
CY2014Q4 | us-gaap |
Available For Sale Securities Accumulated Gross Unrealized Loss Before Tax
AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
|
1121000 | |
CY2014Q4 | us-gaap |
Deferred Tax Assets Operating Loss Carryforwards
DeferredTaxAssetsOperatingLossCarryforwards
|
176789000 | |
CY2014Q4 | us-gaap |
Prepaid Expense And Other Assets Current
PrepaidExpenseAndOtherAssetsCurrent
|
9739000 | |
CY2014Q4 | us-gaap |
Property Plant And Equipment Gross
PropertyPlantAndEquipmentGross
|
67833000 | |
CY2014Q4 | us-gaap |
Available For Sale Debt Securities Amortized Cost Basis
AvailableForSaleDebtSecuritiesAmortizedCostBasis
|
807843000 | |
CY2014Q4 | us-gaap |
Construction In Progress Gross
ConstructionInProgressGross
|
1982000 | |
CY2014Q4 | us-gaap |
Deferred Tax Assets Tax Credit Carryforwards Research
DeferredTaxAssetsTaxCreditCarryforwardsResearch
|
38204000 | |
CY2014Q4 | us-gaap |
Available For Sale Securities Debt Securities Current
AvailableForSaleSecuritiesDebtSecuritiesCurrent
|
526929000 | |
CY2014Q4 | us-gaap |
Machinery And Equipment Gross
MachineryAndEquipmentGross
|
28559000 | |
CY2014Q4 | alny |
Accrued Clinical Trial And Manufacturing Current
AccruedClinicalTrialAndManufacturingCurrent
|
5548000 | |
CY2014Q4 | alny |
Computer Equipment And Software Gross
ComputerEquipmentAndSoftwareGross
|
4440000 | |
CY2014Q4 | alny |
Accrued Preclinical Services Current
AccruedPreclinicalServicesCurrent
|
3081000 | |
CY2015Q4 | us-gaap |
Common Stock Par Or Stated Value Per Share
CommonStockParOrStatedValuePerShare
|
0.01 | |
CY2015Q4 | us-gaap |
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant
|
13626583 | shares |
CY2015Q4 | us-gaap |
Common Stock Shares Authorized
CommonStockSharesAuthorized
|
125000000 | shares |
CY2015Q4 | us-gaap |
Common Stock Shares Outstanding
CommonStockSharesOutstanding
|
85090968 | shares |
CY2015Q4 | us-gaap |
Preferred Stock Shares Authorized
PreferredStockSharesAuthorized
|
5000000 | shares |
CY2015Q4 | us-gaap |
Preferred Stock Shares Issued
PreferredStockSharesIssued
|
0 | shares |
CY2015Q4 | us-gaap |
Common Stock Shares Issued
CommonStockSharesIssued
|
85090968 | shares |
CY2015Q4 | us-gaap |
Preferred Stock Shares Outstanding
PreferredStockSharesOutstanding
|
0 | shares |
CY2015Q4 | us-gaap |
Preferred Stock Par Or Stated Value Per Share
PreferredStockParOrStatedValuePerShare
|
0.01 | |
CY2015Q4 | us-gaap |
Incentive From Lessor
IncentiveFromLessor
|
400000 | |
CY2015Q4 | us-gaap |
Liabilities Current
LiabilitiesCurrent
|
62099000 | |
CY2015Q4 | us-gaap |
Employee Related Liabilities Current
EmployeeRelatedLiabilitiesCurrent
|
11157000 | |
CY2015Q4 | us-gaap |
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment
|
51494000 | |
CY2015Q4 | us-gaap |
Contractual Obligation Due After Fifth Year
ContractualObligationDueAfterFifthYear
|
7819000 | |
CY2015Q4 | us-gaap |
Contractual Obligation Due In Second Year
ContractualObligationDueInSecondYear
|
741000 | |
CY2015Q4 | us-gaap |
Deferred Revenue Noncurrent
DeferredRevenueNoncurrent
|
52965000 | |
CY2015Q4 | us-gaap |
Contractual Obligation Due In Fourth Year
ContractualObligationDueInFourthYear
|
761000 | |
CY2015Q4 | us-gaap |
Accrued Liabilities Current
AccruedLiabilitiesCurrent
|
28798000 | |
CY2015Q4 | us-gaap |
Liabilities
Liabilities
|
121796000 | |
CY2015Q4 | us-gaap |
Contractual Obligation
ContractualObligation
|
19567000 | |
CY2015Q4 | us-gaap |
Deferred Rent Credit Current
DeferredRentCreditCurrent
|
1162000 | |
CY2015Q4 | us-gaap |
Contractual Obligation Due In Fifth Year
ContractualObligationDueInFifthYear
|
761000 | |
CY2015Q4 | us-gaap |
Purchase Obligation Due In Next Twelve Months
PurchaseObligationDueInNextTwelveMonths
|
87500000 | |
CY2015Q4 | us-gaap |
Common Stock Value
CommonStockValue
|
851000 | |
CY2015Q4 | us-gaap |
Additional Paid In Capital Common Stock
AdditionalPaidInCapitalCommonStock
|
2506197000 | |
CY2015Q4 | us-gaap |
Contractual Obligation Due In Third Year
ContractualObligationDueInThirdYear
|
751000 | |
CY2015Q4 | us-gaap |
Deferred Tax Liabilities Other Comprehensive Income
DeferredTaxLiabilitiesOtherComprehensiveIncome
|
14947000 | |
CY2015Q4 | us-gaap |
Available For Sale Securities Accumulated Gross Unrealized Gain Before Tax
AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
|
32000 | |
CY2015Q4 | us-gaap |
Other Liabilities Noncurrent
OtherLiabilitiesNoncurrent
|
1301000 | |
CY2015Q4 | us-gaap |
Deferred Revenue Current
DeferredRevenueCurrent
|
15352000 | |
CY2015Q4 | us-gaap |
Accumulated Other Comprehensive Income Loss Net Of Tax
AccumulatedOtherComprehensiveIncomeLossNetOfTax
|
4369000 | |
CY2015Q4 | us-gaap |
Commitments And Contingencies
CommitmentsAndContingencies
|
||
CY2015Q4 | us-gaap |
Deferred Tax Assets Valuation Allowance
DeferredTaxAssetsValuationAllowance
|
397498000 | |
CY2015Q4 | us-gaap |
Accrued Professional Fees Current
AccruedProfessionalFeesCurrent
|
892000 | |
CY2015Q4 | us-gaap |
Preferred Stock Value
PreferredStockValue
|
||
CY2015Q4 | us-gaap |
Other Accrued Liabilities Current
OtherAccruedLiabilitiesCurrent
|
4965000 | |
CY2015Q4 | us-gaap |
Retained Earnings Accumulated Deficit
RetainedEarningsAccumulatedDeficit
|
-1246703000 | |
CY2015Q4 | us-gaap |
Contractual Obligation Due In Next Twelve Months
ContractualObligationDueInNextTwelveMonths
|
8734000 | |
CY2015Q4 | us-gaap |
Deferred Rent Credit Noncurrent
DeferredRentCreditNoncurrent
|
5431000 | |
CY2015Q4 | us-gaap |
Stockholders Equity
StockholdersEquity
|
1264714000 | |
CY2015Q4 | us-gaap |
Liabilities And Stockholders Equity
LiabilitiesAndStockholdersEquity
|
1386510000 | |
CY2015Q4 | us-gaap |
Purchase Obligation
PurchaseObligation
|
150200000 | |
CY2015Q4 | us-gaap |
Accounts Payable Current
AccountsPayableCurrent
|
16787000 | |
CY2015Q4 | us-gaap |
Deferred Tax Assets Tax Credit Carryforwards
DeferredTaxAssetsTaxCreditCarryforwards
|
788000 | |
CY2015Q4 | us-gaap |
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits
DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits
|
33397000 | |
CY2015Q4 | us-gaap |
Property Plant And Equipment Net
PropertyPlantAndEquipmentNet
|
27812000 | |
CY2015Q4 | us-gaap |
Available For Sale Securities Debt Securities Noncurrent
AvailableForSaleSecuritiesDebtSecuritiesNoncurrent
|
251839000 | |
CY2015Q4 | us-gaap |
Furniture And Fixtures Gross
FurnitureAndFixturesGross
|
2906000 | |
CY2015Q4 | us-gaap |
Assets Current
AssetsCurrent
|
1105388000 | |
CY2015Q4 | us-gaap |
Available For Sale Securities Debt Maturities After One Through Five Years Amortized Cost
AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost
|
253091000 | |
CY2015Q4 | us-gaap |
Deferred Tax Assets In Process Research And Development
DeferredTaxAssetsInProcessResearchAndDevelopment
|
19075000 | |
CY2015Q4 | us-gaap |
Available For Sale Securities Debt Maturities Within One Year Amortized Cost
AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost
|
849288000 | |
CY2015Q4 | us-gaap |
Deferred Tax Assets Deferred Income
DeferredTaxAssetsDeferredIncome
|
17279000 | |
CY2015Q4 | us-gaap |
Deferred Tax Assets Other
DeferredTaxAssetsOther
|
6508000 | |
CY2015Q4 | us-gaap |
Deferred Tax Assets Equity Method Investments
DeferredTaxAssetsEquityMethodInvestments
|
689000 | |
CY2015Q4 | us-gaap |
Available For Sale Securities Debt Maturities Within One Year Fair Value
AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue
|
848217000 | |
CY2015Q4 | us-gaap |
Deferred Tax Assets Tax Credit Carryforwards Foreign
DeferredTaxAssetsTaxCreditCarryforwardsForeign
|
3196000 | |
CY2015Q4 | us-gaap |
Deferred Tax Assets Liabilities Net
DeferredTaxAssetsLiabilitiesNet
|
0 | |
CY2015Q4 | us-gaap |
Available For Sale Securities Equity Securities Current
AvailableForSaleSecuritiesEquitySecuritiesCurrent
|
51419000 | |
CY2015Q4 | us-gaap |
Deferred Tax Assets Goodwill And Intangible Assets
DeferredTaxAssetsGoodwillAndIntangibleAssets
|
16181000 | |
CY2015Q4 | us-gaap |
Leasehold Improvements Gross
LeaseholdImprovementsGross
|
35825000 | |
CY2015Q4 | us-gaap |
Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
|
180895000 | |
CY2015Q4 | us-gaap |
Available For Sale Securities Debt Securities
AvailableForSaleSecuritiesDebtSecurities
|
1100056000 | |
CY2015Q4 | us-gaap |
Receivables Net Current
ReceivablesNetCurrent
|
8298000 | |
CY2015Q4 | us-gaap |
Assets
Assets
|
1386510000 | |
CY2015Q4 | us-gaap |
Deferred Tax Assets Gross
DeferredTaxAssetsGross
|
412445000 | |
CY2015Q4 | us-gaap |
Available For Sale Securities Accumulated Gross Unrealized Loss Before Tax
AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
|
2355000 | |
CY2015Q4 | us-gaap |
Available For Sale Securities Debt Maturities After One Through Five Years Fair Value
AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue
|
251839000 | |
CY2015Q4 | us-gaap |
Deferred Tax Assets Operating Loss Carryforwards
DeferredTaxAssetsOperatingLossCarryforwards
|
253908000 | |
CY2015Q4 | us-gaap |
Prepaid Expense And Other Assets Current
PrepaidExpenseAndOtherAssetsCurrent
|
16559000 | |
CY2015Q4 | us-gaap |
Property Plant And Equipment Gross
PropertyPlantAndEquipmentGross
|
79306000 | |
CY2015Q4 | us-gaap |
Available For Sale Debt Securities Amortized Cost Basis
AvailableForSaleDebtSecuritiesAmortizedCostBasis
|
1102379000 | |
CY2015Q4 | us-gaap |
Other Assets Noncurrent
OtherAssetsNoncurrent
|
1471000 | |
CY2015Q4 | us-gaap |
Construction In Progress Gross
ConstructionInProgressGross
|
1285000 | |
CY2015Q4 | us-gaap |
Deferred Tax Assets Tax Credit Carryforwards Research
DeferredTaxAssetsTaxCreditCarryforwardsResearch
|
61424000 | |
CY2015Q4 | us-gaap |
Available For Sale Securities Debt Securities Current
AvailableForSaleSecuritiesDebtSecuritiesCurrent
|
848217000 | |
CY2015Q4 | us-gaap |
Machinery And Equipment Gross
MachineryAndEquipmentGross
|
33558000 | |
CY2015Q4 | alny |
Purchase Obligation Thereafter
PurchaseObligationThereafter
|
62700000 | |
CY2015Q4 | alny |
Accrued Clinical Trial And Manufacturing Current
AccruedClinicalTrialAndManufacturingCurrent
|
10885000 | |
CY2015Q4 | alny |
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Percentage On First Anniversary
ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPercentageOnFirstAnniversary
|
0.25 | pure |
CY2015Q4 | alny |
Computer Equipment And Software Gross
ComputerEquipmentAndSoftwareGross
|
5732000 | |
CY2015Q4 | alny |
Share Based Compensation Arrangement By Share Based Payment Award Options Vesting Percentage In Each Quarter
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestingPercentageInEachQuarter
|
0.0625 | pure |
CY2015Q4 | alny |
Net Rentable Area Under Lease
NetRentableAreaUnderLease
|
15000 | sqft |
CY2015Q4 | alny |
Accrued Preclinical Services Current
AccruedPreclinicalServicesCurrent
|
899000 | |
CY2015Q4 | alny |
Facility Leases Future Minimum Payments Due
FacilityLeasesFutureMinimumPaymentsDue
|
451866000 | |
CY2015Q4 | alny |
Facility Leases Future Minimum Payments Due In Two Years
FacilityLeasesFutureMinimumPaymentsDueInTwoYears
|
13152000 | |
CY2015Q4 | alny |
Facility Leases Future Minimum Payments Due In Three Years
FacilityLeasesFutureMinimumPaymentsDueInThreeYears
|
13055000 | |
CY2015Q4 | alny |
Facility Leases Future Minimum Payments Due In Four Years
FacilityLeasesFutureMinimumPaymentsDueInFourYears
|
30955000 | |
CY2015Q4 | alny |
Facility Leases Future Minimum Payments Due In Five Years
FacilityLeasesFutureMinimumPaymentsDueInFiveYears
|
33035000 | |
CY2015Q4 | alny |
Facility Leases Future Minimum Payments Due Thereafter
FacilityLeasesFutureMinimumPaymentsDueThereafter
|
350148000 | |
CY2015Q4 | alny |
Facility Leases Future Minimum Payments Due Current
FacilityLeasesFutureMinimumPaymentsDueCurrent
|
11521000 | |
CY2016Q1 | dei |
Entity Common Stock Shares Outstanding
EntityCommonStockSharesOutstanding
|
85138602 | shares |
CY2014Q1 | us-gaap |
Research And Development Asset Acquired Other Than Through Business Combination Written Off
ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff
|
199300000 | |
CY2015Q4 | alny |
Litigation Damages Sought
LitigationDamagesSought
|
8000000 | |
CY2013Q1 | us-gaap |
Stock Issued During Period Shares New Issues
StockIssuedDuringPeriodSharesNewIssues
|
9200000 | shares |
CY2013Q1 | us-gaap |
Stock Issued During Period Value New Issues
StockIssuedDuringPeriodValueNewIssues
|
173600000 | |
CY2013Q1 | us-gaap |
Payments Of Stock Issuance Costs
PaymentsOfStockIssuanceCosts
|
11600000 | |
CY2015Q1 | us-gaap |
Stock Issued During Period Shares New Issues
StockIssuedDuringPeriodSharesNewIssues
|
5447368 | shares |
CY2015Q1 | us-gaap |
Stock Issued During Period Value New Issues
StockIssuedDuringPeriodValueNewIssues
|
496400000 | |
CY2015Q1 | us-gaap |
Payments Of Stock Issuance Costs
PaymentsOfStockIssuanceCosts
|
21100000 | |
CY2011Q2 | us-gaap |
Stock Issued During Period Value Restricted Stock Award Gross
StockIssuedDuringPeriodValueRestrictedStockAwardGross
|
2300000 | |
CY2010Q4 | us-gaap |
Stock Issued During Period Value Restricted Stock Award Gross
StockIssuedDuringPeriodValueRestrictedStockAwardGross
|
1400000 | |
CY2013 | us-gaap |
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1
|
P5Y7M6D | |
CY2013 | us-gaap |
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Minimum
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum
|
0.55 | pure |
CY2013 | us-gaap |
Effective Income Tax Rate Reconciliation State And Local Income Taxes
EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes
|
0.043 | pure |
CY2013 | us-gaap |
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
|
9213000 | shares |
CY2013 | us-gaap |
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Maximum
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum
|
0.56 | pure |
CY2013 | us-gaap |
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance
|
-0.385 | pure |
CY2013 | us-gaap |
Effective Income Tax Rate Continuing Operations
EffectiveIncomeTaxRateContinuingOperations
|
0.030 | pure |
CY2013 | us-gaap |
Effective Income Tax Rate Reconciliation Tax Credits
EffectiveIncomeTaxRateReconciliationTaxCredits
|
0.085 | pure |
CY2013 | us-gaap |
Effective Income Tax Rate Reconciliation Foreign Income Tax Rate Differential
EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential
|
-0.041 | pure |
CY2013 | us-gaap |
Net Cash Provided By Used In Operating Activities Continuing Operations
NetCashProvidedByUsedInOperatingActivitiesContinuingOperations
|
-68657000 | |
CY2013 | us-gaap |
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Minimum
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum
|
0.010 | pure |
CY2013 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-1.45 | |
CY2013 | us-gaap |
Effective Income Tax Rate Reconciliation Nondeductible Expense Share Based Compensation Cost
EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost
|
0.008 | pure |
CY2013 | us-gaap |
Weighted Average Number Of Share Outstanding Basic And Diluted
WeightedAverageNumberOfShareOutstandingBasicAndDiluted
|
61551000 | shares |
CY2013 | us-gaap |
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Maximum
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum
|
0.020 | pure |
CY2013 | us-gaap |
Effective Income Tax Rate Reconciliation Nondeductible Expense Other
EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther
|
-0.003 | pure |
CY2013 | us-gaap |
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
|
0.350 | pure |
CY2013 | us-gaap |
Payments To Acquire Available For Sale Securities Debt
PaymentsToAcquireAvailableForSaleSecuritiesDebt
|
364305000 | |
CY2013 | us-gaap |
Comprehensive Income Net Of Tax
ComprehensiveIncomeNetOfTax
|
-85170000 | |
CY2013 | us-gaap |
Capital Expenditures Incurred But Not Yet Paid
CapitalExpendituresIncurredButNotYetPaid
|
161000 | |
CY2013 | us-gaap |
Payments To Acquire Property Plant And Equipment
PaymentsToAcquirePropertyPlantAndEquipment
|
4006000 | |
CY2013 | us-gaap |
Stock Issued During Period Value New Issues
StockIssuedDuringPeriodValueNewIssues
|
173572000 | |
CY2013 | us-gaap |
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
|
20703000 | |
CY2013 | us-gaap |
Other Nonoperating Income Expense
OtherNonoperatingIncomeExpense
|
-47000 | |
CY2013 | us-gaap |
Operating Income Loss
OperatingIncomeLoss
|
-92942000 | |
CY2013 | us-gaap |
Increase Decrease In Receivables
IncreaseDecreaseInReceivables
|
4144000 | |
CY2013 | us-gaap |
Income Loss From Continuing Operations Before Income Taxes Foreign
IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign
|
-10811000 | |
CY2013 | us-gaap |
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest
|
-91920000 | |
CY2013 | us-gaap |
Income Taxes Paid Net
IncomeTaxesPaidNet
|
-11000 | |
CY2013 | us-gaap |
Payments For Proceeds From Tenant Allowance
PaymentsForProceedsFromTenantAllowance
|
-204000 | |
CY2013 | us-gaap |
License And Services Revenue
LicenseAndServicesRevenue
|
47167000 | |
CY2013 | us-gaap |
Investment Income Net
InvestmentIncomeNet
|
1069000 | |
CY2013 | us-gaap |
Stock Issued During Period Value Other
StockIssuedDuringPeriodValueOther
|
1184000 | |
CY2013 | us-gaap |
Payments Related To Tax Withholding For Share Based Compensation
PaymentsRelatedToTaxWithholdingForShareBasedCompensation
|
1389000 | |
CY2013 | us-gaap |
Nonoperating Income Expense
NonoperatingIncomeExpense
|
1022000 | |
CY2013 | us-gaap |
Valuation Allowance Deferred Tax Asset Change In Amount
ValuationAllowanceDeferredTaxAssetChangeInAmount
|
29700000 | |
CY2013 | us-gaap |
Stock Issued During Period Value Stock Options Exercised
StockIssuedDuringPeriodValueStockOptionsExercised
|
27994000 | |
CY2013 | us-gaap |
Income Loss From Continuing Operations Before Income Taxes Domestic
IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic
|
-81109000 | |
CY2013 | us-gaap |
Increase Decrease In Prepaid Deferred Expense And Other Assets
IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
|
1356000 | |
CY2013 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-89225000 | |
CY2013 | us-gaap |
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
|
4055000 | |
CY2013 | us-gaap |
Proceeds From Issuance Of Common Stock
ProceedsFromIssuanceOfCommonStock
|
173572000 | |
CY2013 | us-gaap |
Proceeds From Sale And Maturity Of Available For Sale Securities
ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities
|
237806000 | |
CY2013 | us-gaap |
Operating Leases Rent Expense Net
OperatingLeasesRentExpenseNet
|
4900000 | |
CY2013 | us-gaap |
Operating Expenses
OperatingExpenses
|
140109000 | |
CY2013 | us-gaap |
Deferred Foreign Income Tax Expense Benefit
DeferredForeignIncomeTaxExpenseBenefit
|
-34000 | |
CY2013 | us-gaap |
Depreciation
Depreciation
|
6100000 | |
CY2013 | us-gaap |
Net Cash Provided By Used In Financing Activities Continuing Operations
NetCashProvidedByUsedInFinancingActivitiesContinuingOperations
|
200926000 | |
CY2013 | us-gaap |
Depreciation Depletion And Amortization
DepreciationDepletionAndAmortization
|
10229000 | |
CY2013 | us-gaap |
Income Tax Expense Benefit
IncomeTaxExpenseBenefit
|
-2695000 | |
CY2013 | us-gaap |
Increase Decrease In Other Accrued Liabilities
IncreaseDecreaseInOtherAccruedLiabilities
|
1547000 | |
CY2013 | us-gaap |
Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options
ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions
|
28743000 | |
CY2013 | us-gaap |
Federal Income Tax Expense Benefit Continuing Operations
FederalIncomeTaxExpenseBenefitContinuingOperations
|
-2661000 | |
CY2013 | us-gaap |
General And Administrative Expense
GeneralAndAdministrativeExpense
|
27152000 | |
CY2013 | us-gaap |
Deferred Federal Income Tax Expense Benefit
DeferredFederalIncomeTaxExpenseBenefit
|
-2695000 | |
CY2013 | us-gaap |
Increase Decrease In Deferred Revenue
IncreaseDecreaseInDeferredRevenue
|
-6201000 | |
CY2013 | us-gaap |
Cash And Cash Equivalents Period Increase Decrease
CashAndCashEquivalentsPeriodIncreaseDecrease
|
1764000 | |
CY2013 | us-gaap |
Adjustments Related To Tax Withholding For Share Based Compensation
AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation
|
1989000 | |
CY2013 | us-gaap |
Pension And Other Postretirement Benefit Expense
PensionAndOtherPostretirementBenefitExpense
|
449000 | |
CY2013 | us-gaap |
Income Tax Expense Benefit Intraperiod Tax Allocation
IncomeTaxExpenseBenefitIntraperiodTaxAllocation
|
-2695000 | |
CY2013 | us-gaap |
Current Federal Tax Expense Benefit
CurrentFederalTaxExpenseBenefit
|
34000 | |
CY2013 | us-gaap |
Increase Decrease In Accounts Payable
IncreaseDecreaseInAccountsPayable
|
1832000 | |
CY2013 | us-gaap |
Foreign Income Tax Expense Benefit Continuing Operations
ForeignIncomeTaxExpenseBenefitContinuingOperations
|
-34000 | |
CY2013 | us-gaap |
Share Based Compensation
ShareBasedCompensation
|
20703000 | |
CY2013 | us-gaap |
Net Cash Provided By Used In Investing Activities Continuing Operations
NetCashProvidedByUsedInInvestingActivitiesContinuingOperations
|
-130505000 | |
CY2013 | us-gaap |
Research And Development Expense
ResearchAndDevelopmentExpense
|
112957000 | |
CY2013 | us-gaap |
Current Foreign Tax Expense Benefit
CurrentForeignTaxExpenseBenefit
|
0 | |
CY2013 | alny |
Effective Income Tax Rate Reconciliation Deductions Orphan Drug Credit
EffectiveIncomeTaxRateReconciliationDeductionsOrphanDrugCredit
|
-0.027 | pure |
CY2013 | alny |
Stock Repurchased To Satisfy Employees Tax Withholding
StockRepurchasedToSatisfyEmployeesTaxWithholding
|
600000 | |
CY2014 | us-gaap |
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Minimum
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum
|
0.53 | pure |
CY2014 | us-gaap |
Effective Income Tax Rate Reconciliation State And Local Income Taxes
EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes
|
0.018 | pure |
CY2014 | us-gaap |
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
|
8199000 | shares |
CY2014 | us-gaap |
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Maximum
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum
|
0.57 | pure |
CY2014 | us-gaap |
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance
|
-0.118 | pure |
CY2014 | us-gaap |
Effective Income Tax Rate Continuing Operations
EffectiveIncomeTaxRateContinuingOperations
|
0.100 | pure |
CY2014 | us-gaap |
Effective Income Tax Rate Reconciliation Tax Credits
EffectiveIncomeTaxRateReconciliationTaxCredits
|
0.035 | pure |
CY2014 | us-gaap |
Effective Income Tax Rate Reconciliation Foreign Income Tax Rate Differential
EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential
|
-0.025 | pure |
CY2014 | us-gaap |
Net Cash Provided By Used In Operating Activities Continuing Operations
NetCashProvidedByUsedInOperatingActivitiesContinuingOperations
|
-165641000 | |
CY2014 | us-gaap |
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Minimum
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum
|
0.017 | pure |
CY2014 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-4.85 | |
CY2014 | us-gaap |
Effective Income Tax Rate Reconciliation Nondeductible Expense Share Based Compensation Cost
EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost
|
-0.002 | pure |
CY2014 | us-gaap |
Weighted Average Number Of Share Outstanding Basic And Diluted
WeightedAverageNumberOfShareOutstandingBasicAndDiluted
|
74278000 | shares |
CY2014 | us-gaap |
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Maximum
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum
|
0.023 | pure |
CY2014 | us-gaap |
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
|
0.350 | pure |
CY2014 | us-gaap |
Payments To Acquire Available For Sale Securities Debt
PaymentsToAcquireAvailableForSaleSecuritiesDebt
|
977775000 | |
CY2014 | us-gaap |
Availableforsale Securities Gross Realized Gain Loss Excluding Other Than Temporary Impairments
AvailableforsaleSecuritiesGrossRealizedGainLossExcludingOtherThanTemporaryImpairments
|
2081000 | |
CY2014 | us-gaap |
Comprehensive Income Net Of Tax
ComprehensiveIncomeNetOfTax
|
-331349000 | |
CY2014 | us-gaap |
Capital Expenditures Incurred But Not Yet Paid
CapitalExpendituresIncurredButNotYetPaid
|
1526000 | |
CY2014 | us-gaap |
Payments To Acquire Property Plant And Equipment
PaymentsToAcquirePropertyPlantAndEquipment
|
8961000 | |
CY2014 | us-gaap |
Stock Issued1
StockIssued1
|
51450000 | |
CY2014 | us-gaap |
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
|
33061000 | |
CY2014 | us-gaap |
Other Nonoperating Income Expense
OtherNonoperatingIncomeExpense
|
1817000 | |
CY2014 | us-gaap |
Operating Income Loss
OperatingIncomeLoss
|
-404980000 | |
CY2014 | us-gaap |
Increase Decrease In Receivables
IncreaseDecreaseInReceivables
|
35689000 | |
CY2014 | us-gaap |
Income Loss From Continuing Operations Before Income Taxes Foreign
IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign
|
-28467000 | |
CY2014 | us-gaap |
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest
|
-400604000 | |
CY2014 | us-gaap |
Income Taxes Paid Net
IncomeTaxesPaidNet
|
517000 | |
CY2014 | us-gaap |
Payments For Proceeds From Tenant Allowance
PaymentsForProceedsFromTenantAllowance
|
-1941000 | |
CY2014 | us-gaap |
License And Services Revenue
LicenseAndServicesRevenue
|
50561000 | |
CY2014 | us-gaap |
Investment Income Net
InvestmentIncomeNet
|
2559000 | |
CY2014 | alny |
Noncash Stock Option Exercises
NoncashStockOptionExercises
|
1219000 | |
CY2015 | us-gaap |
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Maximum
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum
|
0.60 | pure |
CY2015 | dei |
Document Fiscal Period Focus
DocumentFiscalPeriodFocus
|
FY | |
CY2014 | us-gaap |
Income Loss From Continuing Operations Before Income Taxes Domestic
IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic
|
-372137000 | |
CY2014 | us-gaap |
Stock Issued During Period Value Other
StockIssuedDuringPeriodValueOther
|
1581000 | |
CY2014 | us-gaap |
Payments Related To Tax Withholding For Share Based Compensation
PaymentsRelatedToTaxWithholdingForShareBasedCompensation
|
15992000 | |
CY2014 | us-gaap |
Nonoperating Income Expense
NonoperatingIncomeExpense
|
4376000 | |
CY2014 | us-gaap |
Valuation Allowance Deferred Tax Asset Change In Amount
ValuationAllowanceDeferredTaxAssetChangeInAmount
|
46000000 | |
CY2014 | us-gaap |
Stock Issued During Period Value Stock Options Exercised
StockIssuedDuringPeriodValueStockOptionsExercised
|
28449000 | |
CY2014 | us-gaap |
Increase Decrease In Prepaid Deferred Expense And Other Assets
IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
|
5829000 | |
CY2014 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-360395000 | |
CY2014 | us-gaap |
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
|
31127000 | |
CY2014 | us-gaap |
Payments To Acquire Intangible Assets
PaymentsToAcquireIntangibleAssets
|
25000000 | |
CY2014 | us-gaap |
Stock Issued During Period Value Purchase Of Assets
StockIssuedDuringPeriodValuePurchaseOfAssets
|
195766000 | |
CY2014 | us-gaap |
Proceeds From Sale And Maturity Of Available For Sale Securities
ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities
|
462922000 | |
CY2014 | us-gaap |
Operating Leases Rent Expense Net
OperatingLeasesRentExpenseNet
|
8900000 | |
CY2014 | us-gaap |
Operating Expenses
OperatingExpenses
|
455541000 | |
CY2014 | us-gaap |
Noncash Or Part Noncash Acquisition Value Of Assets Acquired1
NoncashOrPartNoncashAcquisitionValueOfAssetsAcquired1
|
195766000 | |
CY2014 | us-gaap |
Depreciation
Depreciation
|
5000000 | |
CY2014 | us-gaap |
Net Cash Provided By Used In Financing Activities Continuing Operations
NetCashProvidedByUsedInFinancingActivitiesContinuingOperations
|
736465000 | |
CY2014 | us-gaap |
Other Comprehensive Income Loss Reclassification Adjustment From Aoci For Sale Of Securities Net Of Tax
OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax
|
2081000 | |
CY2014 | us-gaap |
Depreciation Depletion And Amortization
DepreciationDepletionAndAmortization
|
11926000 | |
CY2014 | us-gaap |
Income Tax Expense Benefit
IncomeTaxExpenseBenefit
|
-40209000 | |
CY2014 | us-gaap |
Increase Decrease In Other Accrued Liabilities
IncreaseDecreaseInOtherAccruedLiabilities
|
9122000 | |
CY2014 | us-gaap |
Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options
ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions
|
29420000 | |
CY2014 | us-gaap |
Federal Income Tax Expense Benefit Continuing Operations
FederalIncomeTaxExpenseBenefitContinuingOperations
|
-40209000 | |
CY2014 | us-gaap |
General And Administrative Expense
GeneralAndAdministrativeExpense
|
44526000 | |
CY2014 | us-gaap |
Deferred Federal Income Tax Expense Benefit
DeferredFederalIncomeTaxExpenseBenefit
|
-40209000 | |
CY2014 | us-gaap |
Tax Adjustments Settlements And Unusual Provisions
TaxAdjustmentsSettlementsAndUnusualProvisions
|
20683000 | |
CY2014 | us-gaap |
Increase Decrease In Deferred Revenue
IncreaseDecreaseInDeferredRevenue
|
-7786000 | |
CY2014 | us-gaap |
Proceeds From Issuance Of Private Placement
ProceedsFromIssuanceOfPrivatePlacement
|
723037000 | |
CY2014 | us-gaap |
Research And Development Asset Acquired Other Than Through Business Combination Written Off
ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff
|
220766000 | |
CY2014 | us-gaap |
Cash And Cash Equivalents Period Increase Decrease
CashAndCashEquivalentsPeriodIncreaseDecrease
|
22010000 | |
CY2014 | us-gaap |
Adjustments Related To Tax Withholding For Share Based Compensation
AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation
|
15392000 | |
CY2014 | us-gaap |
Pension And Other Postretirement Benefit Expense
PensionAndOtherPostretirementBenefitExpense
|
692000 | |
CY2014 | us-gaap |
Income Tax Expense Benefit Intraperiod Tax Allocation
IncomeTaxExpenseBenefitIntraperiodTaxAllocation
|
-40209000 | |
CY2014 | us-gaap |
Increase Decrease In Accounts Payable
IncreaseDecreaseInAccountsPayable
|
8840000 | |
CY2014 | us-gaap |
Share Based Compensation
ShareBasedCompensation
|
33061000 | |
CY2014 | us-gaap |
Net Cash Provided By Used In Investing Activities Continuing Operations
NetCashProvidedByUsedInInvestingActivitiesContinuingOperations
|
-548814000 | |
CY2014 | us-gaap |
Research And Development Expense
ResearchAndDevelopmentExpense
|
190249000 | |
CY2014 | us-gaap |
Current Foreign Tax Expense Benefit
CurrentForeignTaxExpenseBenefit
|
0 | |
CY2014 | alny |
Effective Income Tax Rate Reconciliation Nondeductible Expense In Process Research And Development
EffectiveIncomeTaxRateReconciliationNondeductibleExpenseInProcessResearchAndDevelopment
|
-0.194 | pure |
CY2014 | alny |
Effective Income Tax Rate Reconciliation Nondeductible Expense Tax Basis In Intangible Assets
EffectiveIncomeTaxRateReconciliationNondeductibleExpenseTaxBasisInIntangibleAssets
|
0.042 | pure |
CY2014 | alny |
Effective Income Tax Rate Reconciliation Deductions Orphan Drug Credit
EffectiveIncomeTaxRateReconciliationDeductionsOrphanDrugCredit
|
-0.006 | pure |
CY2015 | us-gaap |
Concentration Risk Credit Risk
ConcentrationRiskCreditRisk
|
<div> <p style="MARGIN-BOTTOM: 0px; MARGIN-LEFT: 2%; MARGIN-TOP: 12px"> <font style="FONT-FAMILY: Times New Roman" size="2"><b><i>Concentrations of Credit Risk and Significant Customers</i></b></font></p> <p style="MARGIN-BOTTOM: 0px; MARGIN-TOP: 6px; TEXT-INDENT: 4%"> <font style="FONT-FAMILY: Times New Roman" size="2">Financial instruments that potentially expose us to concentrations of credit risk consist primarily of cash, cash equivalents and fixed income marketable securities. At December 31, 2015 and 2014, substantially all of our cash, cash equivalents and fixed income marketable securities were invested in money market funds, certificates of deposit, commercial paper, corporate notes, municipal debt securities, U.S. government-sponsored enterprise securities and U.S. treasury securities through highly rated financial institutions. Corporate notes also include foreign bonds denominated in U.S. dollars. Investments are restricted, in accordance with our investment policy, to a concentration limit per issuer.</font></p> <p style="MARGIN-BOTTOM: 0px; MARGIN-TOP: 6px; TEXT-INDENT: 4%"> <font style="FONT-FAMILY: Times New Roman" size="2">In recent periods, our revenues from collaborations have been generated primarily from Sanofi Genzyme, the specialty care global business unit of Sanofi, or Sanofi Genzyme, Takeda Pharmaceutical Company Limited, or Takeda, Monsanto Company, or Monsanto, The Medicines Company, or MDCO, and Cubist Pharmaceuticals, Inc., or Cubist (now a wholly-owned subsidiary of Merck & Co., Inc.). For the year ended December 31, 2015, our billed and unbilled collaboration receivables were composed primarily of amounts of expense reimbursement due from Sanofi Genzyme and certain milestones due from Ionis Pharmaceuticals, Inc., or Ionis (formerly Isis Pharmaceuticals, Inc.). For the year ended December 31, 2014, our billed and unbilled collaboration receivables were composed primarily of amounts due from Sanofi Genzyme and MDCO based upon the achievement of certain milestones and also, with respect to MDCO, expense reimbursement.</font></p> <p style="MARGIN-BOTTOM: 0px; FONT-SIZE: 1px; MARGIN-TOP: 6px">  </p> <p style="MARGIN-BOTTOM: 0px; MARGIN-TOP: 0px; TEXT-INDENT: 4%"> <font style="FONT-FAMILY: Times New Roman" size="2">The following table summarizes customers that represent greater than 10% of our net revenues from collaborators, for the periods indicated:</font></p> <p style="MARGIN-BOTTOM: 0px; FONT-SIZE: 12px; MARGIN-TOP: 0px">  </p> <table style="BORDER-COLLAPSE: collapse" cellspacing="0" cellpadding="0" width="100%" align="center" border="0"> <tr> <td width="85%"></td> <td valign="bottom" width="4%"></td> <td></td> <td></td> <td></td> <td valign="bottom" width="4%"></td> <td></td> <td></td> <td></td> <td valign="bottom" width="4%"></td> <td></td> <td></td> <td></td> </tr> <tr> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1">  </font></td> <td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="10" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>Year Ended</b></font><br /> <font style="FONT-FAMILY: Times New Roman" size="1"><b>December 31,</b></font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <tr> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1">  </font></td> <td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2015</b></font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2014</b></font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2013</b></font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <tr bgcolor="#CCEEFF"> <td valign="top"> <p style="MARGIN-LEFT: 1em; TEXT-INDENT: -1em"><font style="FONT-FAMILY: Times New Roman" size="2">Sanofi Genzyme</font></p> </td> <td valign="bottom"><font size="1">  </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">27</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">*</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">*</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td> </tr> <tr> <td valign="top"> <p style="MARGIN-LEFT: 1em; TEXT-INDENT: -1em"><font style="FONT-FAMILY: Times New Roman" size="2">MDCO</font></p> </td> <td valign="bottom"><font size="1">  </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">25</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">21</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">*</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td> </tr> <tr bgcolor="#CCEEFF"> <td valign="top"> <p style="MARGIN-LEFT: 1em; TEXT-INDENT: -1em"><font style="FONT-FAMILY: Times New Roman" size="2">Takeda</font></p> </td> <td valign="bottom"><font size="1">  </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">22</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">43</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">47</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td> </tr> <tr> <td valign="top"> <p style="MARGIN-LEFT: 1em; TEXT-INDENT: -1em"><font style="FONT-FAMILY: Times New Roman" size="2">Monsanto</font></p> </td> <td valign="bottom"><font size="1">  </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">14</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">30</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">12</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td> </tr> <tr bgcolor="#CCEEFF"> <td valign="top"> <p style="MARGIN-LEFT: 1em; TEXT-INDENT: -1em"><font style="FONT-FAMILY: Times New Roman" size="2">Cubist</font></p> </td> <td valign="bottom"><font size="1">  </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">*</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">*</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">21</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td> </tr> </table> <p style="MARGIN-BOTTOM: 0px; MARGIN-TOP: 6px; TEXT-INDENT: 4%"> <font style="FONT-FAMILY: Times New Roman" size="2">The following table summarizes customers with amounts due that represent greater than 10% of our billed and unbilled collaboration receivables balance, at the periods indicated:</font></p> <p style="MARGIN-BOTTOM: 0px; FONT-SIZE: 12px; MARGIN-TOP: 0px">  </p> <table style="BORDER-COLLAPSE: collapse" cellspacing="0" cellpadding="0" width="100%" align="center" border="0"> <tr> <td width="86%"></td> <td valign="bottom" width="6%"></td> <td></td> <td></td> <td></td> <td valign="bottom" width="6%"></td> <td></td> <td></td> <td></td> </tr> <tr> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1">  </font></td> <td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="6" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>At December 31,</b></font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <tr> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1">  </font></td> <td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2015</b></font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font size="1"> </font></td> <td style="BORDER-BOTTOM: #000000 1px solid" valign="bottom" colspan="2" align="center"><font style="FONT-FAMILY: Times New Roman" size="1"><b>2014</b></font></td> <td valign="bottom"><font size="1"> </font></td> </tr> <tr bgcolor="#CCEEFF"> <td valign="top"> <p style="MARGIN-LEFT: 1em; TEXT-INDENT: -1em"><font style="FONT-FAMILY: Times New Roman" size="2">Sanofi Genzyme</font></p> </td> <td valign="bottom"><font size="1">  </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">88</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">63</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td> </tr> <tr> <td valign="top"> <p style="MARGIN-LEFT: 1em; TEXT-INDENT: -1em"><font style="FONT-FAMILY: Times New Roman" size="2">Ionis</font></p> </td> <td valign="bottom"><font size="1">  </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">12</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">*</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td> </tr> <tr bgcolor="#CCEEFF"> <td valign="top"> <p style="MARGIN-LEFT: 1em; TEXT-INDENT: -1em"><font style="FONT-FAMILY: Times New Roman" size="2">MDCO</font></p> </td> <td valign="bottom"><font size="1">  </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">*</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">  </font></td> <td valign="bottom"><font size="1"> </font></td> <td valign="bottom"><font style="FONT-FAMILY: Times New Roman" size="2"> </font></td> <td valign="bottom" align="right"><font style="FONT-FAMILY: Times New Roman" size="2">37</font></td> <td valign="bottom" nowrap="nowrap"><font style="FONT-FAMILY: Times New Roman" size="2">% </font></td> </tr> </table> <p style="MARGIN-BOTTOM: 2px; BORDER-BOTTOM: #000000 0.5pt solid; MARGIN-TOP: 0px; LINE-HEIGHT: 8px; WIDTH: 13%">  </p> <table style="BORDER-COLLAPSE: collapse" cellspacing="0" cellpadding="0" width="100%" border="0"> <tr> <td valign="top" width="2%" align="left"><font style="FONT-FAMILY: Times New Roman" size="2">*</font></td> <td valign="top" align="left"><font style="FONT-FAMILY: Times New Roman" size="2">Represents 10% or less</font></td> </tr> </table> </div> | |
CY2015 | dei |
Document Type
DocumentType
|
10-K | |
CY2015 | dei |
Trading Symbol
TradingSymbol
|
ALNY | |
CY2015 | dei |
Entity Voluntary Filers
EntityVoluntaryFilers
|
No | |
CY2015 | dei |
Entity Central Index Key
EntityCentralIndexKey
|
0001178670 | |
CY2015 | dei |
Document Period End Date
DocumentPeriodEndDate
|
2015-12-31 | |
CY2015 | us-gaap |
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Minimum
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum
|
0.53 | pure |
CY2015 | dei |
Entity Filer Category
EntityFilerCategory
|
Large Accelerated Filer | |
CY2015 | us-gaap |
Lease Expiration Date1
LeaseExpirationDate1
|
2017-08-31 | |
CY2015 | us-gaap |
Effective Income Tax Rate Reconciliation State And Local Income Taxes
EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes
|
0.040 | pure |
CY2015 | us-gaap |
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
|
9979000 | shares |
CY2015 | dei |
Current Fiscal Year End Date
CurrentFiscalYearEndDate
|
--12-31 | |
CY2015 | us-gaap |
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance
|
-0.384 | pure |
CY2015 | us-gaap |
Effective Income Tax Rate Reconciliation Tax Credits
EffectiveIncomeTaxRateReconciliationTaxCredits
|
0.080 | pure |
CY2015 | dei |
Document Fiscal Year Focus
DocumentFiscalYearFocus
|
2015 | |
CY2015 | us-gaap |
Increase Decrease In Receivables
IncreaseDecreaseInReceivables
|
-31639000 | |
CY2015 | us-gaap |
Effective Income Tax Rate Reconciliation Foreign Income Tax Rate Differential
EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential
|
-0.054 | pure |
CY2015 | us-gaap |
Net Cash Provided By Used In Operating Activities Continuing Operations
NetCashProvidedByUsedInOperatingActivitiesContinuingOperations
|
-189140000 | |
CY2015 | dei |
Entity Registrant Name
EntityRegistrantName
|
ALNYLAM PHARMACEUTICALS, INC. | |
CY2015 | us-gaap |
Effective Income Tax Rate Reconciliation Nondeductible Expense Share Based Compensation Cost
EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost
|
-0.011 | pure |
CY2015 | dei |
Entity Current Reporting Status
EntityCurrentReportingStatus
|
Yes | |
CY2015 | dei |
Amendment Flag
AmendmentFlag
|
false | |
CY2015 | us-gaap |
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Minimum
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum
|
0.010 | pure |
CY2015 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-3.45 | |
CY2015 | dei |
Entity Well Known Seasoned Issuer
EntityWellKnownSeasonedIssuer
|
Yes | |
CY2015 | us-gaap |
Use Of Estimates
UseOfEstimates
|
<div> <p style="margin-top:12px;margin-bottom:0px; margin-left:2%"> <font style="font-family:Times New Roman" size="2"><b><i>Use of Estimates</i></b></font></p> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"> <font style="font-family:Times New Roman" size="2">The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America, or GAAP, requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the consolidated financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.</font></p> </div> | |
CY2015 | us-gaap |
Weighted Average Number Of Share Outstanding Basic And Diluted
WeightedAverageNumberOfShareOutstandingBasicAndDiluted
|
83992000 | shares |
CY2015 | us-gaap |
Nature Of Operations
NatureOfOperations
|
<div> <table style="BORDER-COLLAPSE:COLLAPSE" border="0" cellpadding="0" cellspacing="0" width="100%"> <tr> <td width="3%" valign="top" align="left"><font style="font-family:Times New Roman" size="2"><b>1.</b></font></td> <td align="left" valign="top"><font style="font-family:Times New Roman" size="2"><b>NATURE OF BUSINESS</b></font></td> </tr> </table> <p style="margin-top:6px;margin-bottom:0px; text-indent:4%"> <font style="font-family:Times New Roman" size="2">We commenced operations on June 14, 2002 as a biopharmaceutical company seeking to develop and commercialize novel therapeutics based on RNA interference, or RNAi. We are focused on discovering, developing and commercializing RNAi therapeutics by establishing strategic alliances with leading pharmaceutical and life sciences companies, establishing and maintaining a strong intellectual property position in the RNAi field, generating revenues through licensing agreements, and ultimately developing and commercializing RNAi therapeutics for our own account. We have devoted substantially all of our efforts to business planning, research and development, acquiring, filing and expanding intellectual property rights, recruiting management and technical staff, and raising capital.</font></p> </div> | |
CY2015 | us-gaap |
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Maximum
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum
|
0.020 | pure |
CY2015 | us-gaap |
Effective Income Tax Rate Reconciliation Nondeductible Expense Other
EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther
|
-0.001 | pure |
CY2015 | us-gaap |
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
|
0.350 | pure |
CY2015 | us-gaap |
Payments To Acquire Available For Sale Securities Debt
PaymentsToAcquireAvailableForSaleSecuritiesDebt
|
1033843000 | |
CY2015 | us-gaap |
Availableforsale Securities Gross Realized Gain Loss Excluding Other Than Temporary Impairments
AvailableforsaleSecuritiesGrossRealizedGainLossExcludingOtherThanTemporaryImpairments
|
0 | |
CY2015 | us-gaap |
Comprehensive Income Net Of Tax
ComprehensiveIncomeNetOfTax
|
-334467000 | |
CY2015 | us-gaap |
Capital Expenditures Incurred But Not Yet Paid
CapitalExpendituresIncurredButNotYetPaid
|
1333000 | |
CY2015 | us-gaap |
Payments To Acquire Property Plant And Equipment
PaymentsToAcquirePropertyPlantAndEquipment
|
12950000 | |
CY2015 | us-gaap |
Stock Issued During Period Value New Issues
StockIssuedDuringPeriodValueNewIssues
|
496400000 | |
CY2015 | us-gaap |
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
|
45783000 | |
CY2015 | us-gaap |
Other Nonoperating Income Expense
OtherNonoperatingIncomeExpense
|
76000 | |
CY2015 | us-gaap |
Operating Income Loss
OperatingIncomeLoss
|
-296008000 | |
CY2015 | us-gaap |
Income Taxes Paid Net
IncomeTaxesPaidNet
|
-66000 | |
CY2015 | us-gaap |
Payments For Proceeds From Tenant Allowance
PaymentsForProceedsFromTenantAllowance
|
-374000 | |
CY2015 | us-gaap |
Income Loss From Continuing Operations Before Income Taxes Foreign
IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign
|
-44392000 | |
CY2015 | us-gaap |
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest
|
-290073000 | |
CY2015 | us-gaap |
License And Services Revenue
LicenseAndServicesRevenue
|
41097000 | |
CY2015 | us-gaap |
Increase Decrease In Restricted Cash
IncreaseDecreaseInRestrictedCash
|
1471000 | |
CY2015 | us-gaap |
Investment Income Net
InvestmentIncomeNet
|
5859000 | |
CY2015 | us-gaap |
Stock Issued During Period Value Other
StockIssuedDuringPeriodValueOther
|
2666000 | |
CY2015 | us-gaap |
Payments Related To Tax Withholding For Share Based Compensation
PaymentsRelatedToTaxWithholdingForShareBasedCompensation
|
378000 | |
CY2015 | us-gaap |
Nonoperating Income Expense
NonoperatingIncomeExpense
|
5935000 | |
CY2015 | us-gaap |
Valuation Allowance Deferred Tax Asset Change In Amount
ValuationAllowanceDeferredTaxAssetChangeInAmount
|
129100000 | |
CY2015 | us-gaap |
Stock Issued During Period Value Stock Options Exercised
StockIssuedDuringPeriodValueStockOptionsExercised
|
29425000 | |
CY2015 | us-gaap |
Income Loss From Continuing Operations Before Income Taxes Domestic
IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic
|
-245681000 | |
CY2015 | us-gaap |
Increase Decrease In Prepaid Deferred Expense And Other Assets
IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
|
6820000 | |
CY2015 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-290073000 | |
CY2015 | us-gaap |
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
|
-44394000 | |
CY2015 | us-gaap |
Proceeds From Issuance Of Common Stock
ProceedsFromIssuanceOfCommonStock
|
496400000 | |
CY2015 | us-gaap |
Proceeds From Sale And Maturity Of Available For Sale Securities
ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities
|
726943000 | |
CY2015 | us-gaap |
Operating Leases Rent Expense Net
OperatingLeasesRentExpenseNet
|
10500000 | |
CY2015 | us-gaap |
Operating Expenses
OperatingExpenses
|
337105000 | |
CY2015 | us-gaap |
Depreciation
Depreciation
|
6700000 | |
CY2015 | us-gaap |
Net Cash Provided By Used In Financing Activities Continuing Operations
NetCashProvidedByUsedInFinancingActivitiesContinuingOperations
|
616177000 | |
CY2015 | us-gaap |
Depreciation Depletion And Amortization
DepreciationDepletionAndAmortization
|
19050000 | |
CY2015 | us-gaap |
Income Tax Expense Benefit
IncomeTaxExpenseBenefit
|
0 | |
CY2015 | us-gaap |
Increase Decrease In Other Accrued Liabilities
IncreaseDecreaseInOtherAccruedLiabilities
|
6343000 | |
CY2015 | us-gaap |
Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options
ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions
|
31137000 | |
CY2015 | us-gaap |
General And Administrative Expense
GeneralAndAdministrativeExpense
|
60610000 | |
CY2015 | us-gaap |
Increase Decrease In Deferred Revenue
IncreaseDecreaseInDeferredRevenue
|
1904000 | |
CY2015 | us-gaap |
Proceeds From Issuance Of Private Placement
ProceedsFromIssuanceOfPrivatePlacement
|
89018000 | |
CY2015 | us-gaap |
Cash And Cash Equivalents Period Increase Decrease
CashAndCashEquivalentsPeriodIncreaseDecrease
|
105716000 | |
CY2015 | us-gaap |
Adjustments Related To Tax Withholding For Share Based Compensation
AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation
|
378000 | |
CY2015 | us-gaap |
Pension And Other Postretirement Benefit Expense
PensionAndOtherPostretirementBenefitExpense
|
984000 | |
CY2015 | us-gaap |
Increase Decrease In Accounts Payable
IncreaseDecreaseInAccountsPayable
|
1676000 | |
CY2015 | us-gaap |
Share Based Compensation
ShareBasedCompensation
|
45783000 | |
CY2015 | us-gaap |
Net Cash Provided By Used In Investing Activities Continuing Operations
NetCashProvidedByUsedInInvestingActivitiesContinuingOperations
|
-321321000 | |
CY2015 | us-gaap |
Research And Development Expense
ResearchAndDevelopmentExpense
|
276495000 | |
CY2015 | us-gaap |
Current Foreign Tax Expense Benefit
CurrentForeignTaxExpenseBenefit
|
0 | |
CY2015 | alny |
Number Of Lease Extension Options
NumberOfLeaseExtensionOptions
|
2 | RenewalOptions |
CY2015 | alny |
Investment Maturity Period Minimum
InvestmentMaturityPeriodMinimum
|
P90D | |
CY2015Q1 | us-gaap |
License And Services Revenue
LicenseAndServicesRevenue
|
18537000 | |
CY2015Q1 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-50777000 | |
CY2015Q1 | us-gaap |
Operating Expenses
OperatingExpenses
|
70759000 | |
CY2015 | alny |
Employee Stock Purchase Plan Offered Period
EmployeeStockPurchasePlanOfferedPeriod
|
P6M | |
CY2015 | alny |
Lease Extension Period
LeaseExtensionPeriod
|
P5Y | |
CY2015 | alny |
Effective Income Tax Rate Reconciliation Deductions Orphan Drug Credit
EffectiveIncomeTaxRateReconciliationDeductionsOrphanDrugCredit
|
-0.020 | pure |
CY2015 | alny |
Investments Classified As Cash And Cash Equivalent Original Maturities
InvestmentsClassifiedAsCashAndCashEquivalentOriginalMaturities
|
P90D | |
CY2015 | alny |
Operating Loss Carryforward Expiration Year
OperatingLossCarryforwardExpirationYear
|
2035 | |
CY2015 | alny |
Noncash Stock Option Exercises
NoncashStockOptionExercises
|
686000 | |
CY2014Q1 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-3.70 | |
CY2014Q1 | us-gaap |
Weighted Average Number Of Share Outstanding Basic And Diluted
WeightedAverageNumberOfShareOutstandingBasicAndDiluted
|
67786000 | shares |
CY2014Q1 | us-gaap |
License And Services Revenue
LicenseAndServicesRevenue
|
8275000 | |
CY2014Q1 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-250943000 | |
CY2014Q1 | us-gaap |
Operating Expenses
OperatingExpenses
|
277339000 | |
CY2015Q1 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.62 | |
CY2015Q1 | us-gaap |
Weighted Average Number Of Share Outstanding Basic And Diluted
WeightedAverageNumberOfShareOutstandingBasicAndDiluted
|
82074000 | shares |
CY2014Q2 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.58 | |
CY2014Q2 | us-gaap |
Weighted Average Number Of Share Outstanding Basic And Diluted
WeightedAverageNumberOfShareOutstandingBasicAndDiluted
|
75835000 | shares |
CY2014Q2 | us-gaap |
License And Services Revenue
LicenseAndServicesRevenue
|
7295000 | |
CY2014Q2 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-44074000 | |
CY2014Q2 | us-gaap |
Operating Expenses
OperatingExpenses
|
52300000 | |
CY2014Q2 | alny |
Research And Development In Process Credit
ResearchAndDevelopmentInProcessCredit
|
3900000 | |
CY2015Q2 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.85 | |
CY2015Q2 | us-gaap |
Weighted Average Number Of Share Outstanding Basic And Diluted
WeightedAverageNumberOfShareOutstandingBasicAndDiluted
|
84353000 | shares |
CY2015Q2 | us-gaap |
License And Services Revenue
LicenseAndServicesRevenue
|
8685000 | |
CY2015Q2 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-71783000 | |
CY2015Q2 | us-gaap |
Operating Expenses
OperatingExpenses
|
81629000 | |
CY2014Q3 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.58 | |
CY2014Q3 | us-gaap |
Weighted Average Number Of Share Outstanding Basic And Diluted
WeightedAverageNumberOfShareOutstandingBasicAndDiluted
|
76408000 | shares |
CY2014Q3 | us-gaap |
License And Services Revenue
LicenseAndServicesRevenue
|
10972000 | |
CY2014Q3 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-43989000 | |
CY2014Q3 | us-gaap |
Operating Expenses
OperatingExpenses
|
56171000 | |
CY2015Q3 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.91 | |
CY2015Q3 | us-gaap |
Weighted Average Number Of Share Outstanding Basic And Diluted
WeightedAverageNumberOfShareOutstandingBasicAndDiluted
|
84633000 | shares |
CY2015Q3 | us-gaap |
License And Services Revenue
LicenseAndServicesRevenue
|
6324000 | |
CY2015Q3 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-76792000 | |
CY2015Q3 | us-gaap |
Operating Expenses
OperatingExpenses
|
84654000 | |
CY2014Q4 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-0.28 | |
CY2014Q4 | us-gaap |
Weighted Average Number Of Share Outstanding Basic And Diluted
WeightedAverageNumberOfShareOutstandingBasicAndDiluted
|
76957000 | shares |
CY2014Q4 | us-gaap |
License And Services Revenue
LicenseAndServicesRevenue
|
24019000 | |
CY2014Q4 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-21389000 | |
CY2014Q4 | us-gaap |
Operating Expenses
OperatingExpenses
|
69731000 | |
CY2015Q4 | us-gaap |
Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
|
-1.07 | |
CY2015Q4 | us-gaap |
Weighted Average Number Of Share Outstanding Basic And Diluted
WeightedAverageNumberOfShareOutstandingBasicAndDiluted
|
84871000 | shares |
CY2015Q4 | us-gaap |
License And Services Revenue
LicenseAndServicesRevenue
|
7551000 | |
CY2015Q4 | us-gaap |
Net Income Loss
NetIncomeLoss
|
-90721000 | |
CY2015Q4 | us-gaap |
Operating Expenses
OperatingExpenses
|
100063000 |