2020 Q1 Form 10-K Financial Statement

#000156459020007350 Filed on February 27, 2020

View on sec.gov

Income Statement

Concept 2020 Q1 2018 Q4 2018 Q3
Revenue $0.00 $0.00 $0.00
YoY Change
Cost Of Revenue
YoY Change
Gross Profit
YoY Change
Gross Profit Margin
Selling, General & Admin $46.20M $6.400M $6.300M
YoY Change 463.41% 30.61% 200.0%
% of Gross Profit
Research & Development $69.28M $30.80M $29.54M
YoY Change 71.15% 135.11% 210.36%
% of Gross Profit
Depreciation & Amortization $85.00K
YoY Change 107.32%
% of Gross Profit
Operating Expenses $69.28M $37.20M $29.54M
YoY Change 71.15% 106.67% 210.36%
Operating Profit -$98.79M -$37.20M -$35.80M
YoY Change 103.05% 106.73% 208.94%
Interest Expense -$70.10M $800.0K $280.9K
YoY Change 13920.0% -366.67% 1567.31%
% of Operating Profit
Other Income/Expense, Net $14.00K $0.00 -$22.23K
YoY Change -105.53% 2675.78%
Pretax Income -$168.8M -$36.50M -$35.50M
YoY Change 233.6% 99.45% 206.03%
Income Tax $0.00
% Of Pretax Income
Net Earnings -$168.8M -$36.46M -$35.97M
YoY Change 233.81% 99.71% 210.82%
Net Earnings / Revenue
Basic Earnings Per Share -$2.29
Diluted Earnings Per Share -$2.29 -$648.3K -$631.7K
COMMON SHARES
Basic Shares Outstanding 75.32M
Diluted Shares Outstanding

Balance Sheet

Concept 2020 Q1 2018 Q4 2018 Q3
SHORT-TERM ASSETS
Cash & Short-Term Investments $646.7M $176.3M $220.6M
YoY Change 124.39% 0.4% 1583.97%
Cash & Equivalents $417.9M $176.3M $220.6M
Short-Term Investments $228.8M
Other Short-Term Assets $25.70M $1.838M $16.90M
YoY Change 164961.01% 12297.65% 362.57%
Inventory
Prepaid Expenses $24.33M
Receivables
Other Receivables
Total Short-Term Assets $672.4M $202.4M $238.9M
YoY Change 116.53% 11.22% 1155.19%
LONG-TERM ASSETS
Property, Plant & Equipment $15.70M $977.9K
YoY Change 1408.07%
Goodwill
YoY Change
Intangibles
YoY Change
Long-Term Investments
YoY Change
Other Assets $800.0K $116.4K $200.0K
YoY Change 392.78% 0.23% 84.59%
Total Long-Term Assets $16.50M $1.094M $200.0K
YoY Change 110.86% 842.18% 84.59%
TOTAL ASSETS
Total Short-Term Assets $672.4M $202.4M $238.9M
Total Long-Term Assets $16.50M $1.094M $200.0K
Total Assets $688.9M $203.5M $239.1M
YoY Change 116.39% 11.75% 1149.13%
SHORT-TERM LIABILITIES
YoY Change
Accounts Payable $3.100M $10.25M $5.500M
YoY Change -73.98% 179.94% 37.46%
Accrued Expenses $44.93M $5.103M $10.60M
YoY Change 511.91% 76.53% 260.93%
Deferred Revenue
YoY Change
Short-Term Debt $0.00 $0.00 $0.00
YoY Change
Long-Term Debt Due $1.667M
YoY Change
Total Short-Term Liabilities $50.70M $17.02M $16.00M
YoY Change 148.69% 159.76% 130.62%
LONG-TERM LIABILITIES
Long-Term Debt $144.6M $25.40M $26.90M
YoY Change 2058.21% -3.79%
Other Long-Term Liabilities $234.6M $158.8K $300.0K
YoY Change 99758.68% -20.61%
Total Long-Term Liabilities $379.2M $158.8K $27.20M
YoY Change 161308.41% -99.4%
TOTAL LIABILITIES
Total Short-Term Liabilities $50.70M $17.02M $16.00M
Total Long-Term Liabilities $379.2M $158.8K $27.20M
Total Liabilities $429.9M $42.56M $43.20M
YoY Change 359.3% 28.24% 526.09%
SHAREHOLDERS EQUITY
Retained Earnings -$276.8M -$240.3M
YoY Change 85.42% 83.43%
Common Stock $5.628K
YoY Change 11.82%
Preferred Stock
YoY Change
Treasury Stock (at cost)
YoY Change
Treasury Stock Shares
Shareholders Equity $259.0M $161.0M $196.0M
YoY Change
Total Liabilities & Shareholders Equity $688.9M $203.5M $239.1M
YoY Change 116.39% 11.75% 1149.37%

Cashflow Statement

Concept 2020 Q1 2018 Q4 2018 Q3
OPERATING ACTIVITIES
Net Income -$168.8M -$36.46M -$35.97M
YoY Change 233.81% 99.71% 210.82%
Depreciation, Depletion And Amortization $85.00K
YoY Change 107.32%
Cash From Operating Activities -$108.3M -$44.48M -$33.13M
YoY Change 204.69% 186.23% 197.4%
INVESTING ACTIVITIES
Capital Expenditures $435.0K
YoY Change -50.29%
Acquisitions
YoY Change
Other Investing Activities -$227.4M
YoY Change
Cash From Investing Activities -$227.9M
YoY Change 25940.46%
FINANCING ACTIVITIES
Cash Dividend Paid
YoY Change
Common Stock Issuance & Retirement, Net $381.6M
YoY Change 247.13%
Debt Paid & Issued, Net
YoY Change
Cash From Financing Activities 403.3M 110.0K -40.00K
YoY Change 171.71% -99.94% -100.21%
NET CHANGE
Cash From Operating Activities -108.3M -44.48M -33.13M
Cash From Investing Activities -227.9M
Cash From Financing Activities 403.3M 110.0K -40.00K
Net Change In Cash 66.91M -44.37M -33.17M
YoY Change -40.25% -127.3% -505.01%
FREE CASH FLOW
Cash From Operating Activities -$108.3M -$44.48M -$33.13M
Capital Expenditures $435.0K
Free Cash Flow -$108.8M
YoY Change 198.57%

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CY2019 us-gaap Increase Decrease In Other Current Assets
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CY2019 us-gaap Increase Decrease In Prepaid Expense
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CY2019 apls Amortization Of Discounts For Convertible Notes Net Of Financing Costs
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CY2017 us-gaap Increase Decrease In Prepaid Expense
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CY2017 us-gaap Increase Decrease In Other Noncurrent Assets
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CY2018 us-gaap Increase Decrease In Other Noncurrent Assets
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CY2019 us-gaap Increase Decrease In Other Noncurrent Assets
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CY2017 us-gaap Increase Decrease In Accounts Payable
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CY2019 us-gaap Increase Decrease In Other Noncurrent Liabilities
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CY2017 us-gaap Net Cash Provided By Used In Financing Activities
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CY2018 us-gaap Net Cash Provided By Used In Financing Activities
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CY2019 us-gaap Net Cash Provided By Used In Financing Activities
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CY2018 us-gaap Effect Of Exchange Rate On Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
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CY2019 us-gaap Effect Of Exchange Rate On Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
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CY2017 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
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CY2018 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
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CY2019 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
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CY2016Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
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CY2019 us-gaap Increase Decrease In Accounts Payable
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CY2017 us-gaap Increase Decrease In Accrued Liabilities
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CY2018 us-gaap Increase Decrease In Accrued Liabilities
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CY2019 us-gaap Increase Decrease In Accrued Liabilities
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CY2017 us-gaap Increase Decrease In Other Noncurrent Liabilities
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CY2018 us-gaap Increase Decrease In Other Noncurrent Liabilities
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CY2017 us-gaap Net Cash Provided By Used In Operating Activities
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CY2018 us-gaap Net Cash Provided By Used In Operating Activities
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CY2019 us-gaap Net Cash Provided By Used In Operating Activities
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CY2019 us-gaap Payments To Acquire Property Plant And Equipment
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CY2019 us-gaap Net Cash Provided By Used In Investing Activities
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CY2017 us-gaap Proceeds From Issuance Of Convertible Preferred Stock
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CY2018 us-gaap Payments Of Stock Issuance Costs
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CY2017 us-gaap Proceeds From Issuance Of Debt
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CY2017 us-gaap Proceeds From Notes Payable
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CY2017 us-gaap Proceeds From Issuance Of Common Stock
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CY2018 us-gaap Proceeds From Issuance Of Common Stock
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CY2019 us-gaap Proceeds From Issuance Of Common Stock
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CY2019 apls Proceeds From Development Derivative Liability
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CY2019 apls Payments For Capped Call Transactions And Associated Costs
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28380000
CY2019 apls Proceeds From Issuance Of Convertible Notes Net Of Issuance Costs
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CY2017 apls Proceeds From Issuance Of Stock Options And Warrants
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CY2017 apls Proceeds From Stock Options And Warrants Exercised
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CY2018 apls Proceeds From Stock Options And Warrants Exercised
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CY2019 apls Proceeds From Stock Options And Warrants Exercised
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CY2019 us-gaap Repayments Of Notes Payable
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CY2019 us-gaap Repayments Of Long Term Lines Of Credit
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CY2017Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
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CY2018Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
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CY2017Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
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CY2018Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
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CY2019Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
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CY2017 us-gaap Conversion Of Stock Amount Converted1
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CY2017 us-gaap Interest Paid Net
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CY2018 us-gaap Interest Paid Net
InterestPaidNet
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CY2019 us-gaap Interest Paid Net
InterestPaidNet
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CY2019 apls Equity Component Of Convertible Notes
EquityComponentOfConvertibleNotes
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CY2019 us-gaap Nature Of Operations
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<p style="margin-bottom:0pt;margin-top:6pt;text-indent:0%;font-weight:bold;font-size:10pt;font-family:Times New Roman;font-style:normal;text-transform:none;font-variant: normal;">1. Nature of Organization and Operations </p> <p style="margin-bottom:0pt;margin-top:6pt;text-indent:4.54%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Apellis Pharmaceuticals, Inc. (the “Company”) is a clinical-stage biopharmaceutical company focused on the development of novel therapeutic compounds to treat disease through the inhibition of the complement system, which is an integral component of the immune system, at the level of C3, the central protein in the complement cascade. </p> <p style="margin-bottom:0pt;margin-top:12pt;text-indent:4.54%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">The Company was incorporated in September 2009 under the laws of the State of Delaware. The Company’s principal executive offices are located in Waltham, Massachusetts, effective January 1, 2020. Prior to that date, the Company’s principal offices were in Crestwood, Kentucky.</p> <p style="margin-bottom:0pt;margin-top:12pt;text-indent:4.54%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">The Company’s operations since inception have been limited to organizing and staffing the Company, acquiring rights to product candidates, business planning, raising capital and developing its product candidates. </p> <p style="margin-bottom:0pt;margin-top:12pt;text-indent:4.54%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">The Company is subject to risks common in the biotechnology industry including, but not limited to, raising additional capital, development by its competitors of new technological innovations, its ability to successfully complete preclinical and clinical development of product candidates and receive timely regulatory approval of products, market acceptance of the Company’s products, protection of proprietary technology, healthcare cost containment initiatives, and compliance with governmental regulations, including those of the U.S. Food and Drug Administration (“FDA”). </p> <p style="margin-bottom:0pt;margin-top:12pt;text-indent:4.54%;font-weight:bold;font-style:italic;font-size:10pt;font-family:Times New Roman;text-transform:none;font-variant: normal;">Convertible Notes Offering</p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">On September 16, 2019, the Company completed a private offering of $220,000,000 aggregate principal amount of 3.5% convertible senior notes due 2026 (the “Convertible Notes”).</p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;font-family:Times New Roman;font-size:11pt;"> </p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;color:#000000;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">The net proceeds from the sale of the Convertible Notes were approximately $212,912,000 after deducting the initial purchasers’ discounts and commissions of $6,600,000 and offering expenses of $487,763 paid by the Company. The Company used $28,380,000 of the net proceeds from the sale of the Convertible Notes to pay the cost of the capped call transactions described below in Note 7. </p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;font-family:Times New Roman;font-size:11pt;"> </p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;color:#000000;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"> <span style="color:#000000;">On September 16, 2019, the Company entered into an indenture (the “Indenture”) with respect to the Convertible Notes with U.S. Bank National Association, as trustee (the “Trustee”). The Convertible Notes are senior unsecured obligations of the Company and bear interest at a rate of 3.5% per year payable semiannually in arrears on March 15 and September 15 of each year, beginning on March 15, 2020. The Convertible Notes will mature on September 15, 2026, unless converted earlier, redeemed or repurchased in accordance with the terms of the Convertible Notes</span>. See Note 7 – Long-term Debt for additional information.</p> <p style="margin-bottom:0pt;margin-top:12pt;text-indent:4.54%;font-weight:bold;font-style:italic;font-size:10pt;font-family:Times New Roman;text-transform:none;font-variant: normal;"> Development Derivative Liability </p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">On February 28, 2019, the Company entered into a development funding agreement with SFJ Pharmaceuticals Group (“SFJ”) under which SFJ agreed to provide funding to the Company to support the development of pegcetacoplan for the treatment of patients with <span style="color:#000000;">paroxysmal nocturnal hemoglobinuria (“PNH”). Pursuant to the agreement, SFJ paid the Company $60,000,000 following the signing of the agreement, and agreed to pay the Company up to an additional $60,000,000 in the aggregate in three equal installments upon the achievement of specified development milestones with respect to the Company’s Phase 3 program for </span>pegcetacoplan<span style="color:#000000;"> in PNH and subject to the Company having cash resources at the time sufficient to fund at least ten months of the Company’s operations. In addition, upon the mutual agreement of the Company and SFJ, at any time after the earlier of the date that the Company has reviewed the primary endpoint data from its PEGASUS Phase 3 trial of </span>pegcetacoplan<span style="color:#000000;"> in patients with PNH and March 31, 2020, SFJ may fund an additional $50,000,000 of the Company’s development costs (the “Additional SFJ Funding”).</span></p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;font-family:Times New Roman;font-size:11pt;"> </p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;color:#000000;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">On June 7, 2019, the Company and SFJ amended the development funding agreement (the “SFJ amendment”). Under the SFJ amendment, SFJ agreed to make an additional $20,000,000 funding payment to the Company to support the development of <span style="color:#000000;">pegcetacoplan</span> for the treatment of patients with PNH. This additional $20,000,000 payment is in addition to and not part of the Additional SFJ Funding. </p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;font-family:Times New Roman;font-size:11pt;"> </p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;color:#000000;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">On June 27, 2019, the Company received $40,000,000 from SFJ, consisting of $20,000,000 as the first installment of the additional $60,000,000 upon the achievement of a milestone and the $20,000,000 payable under the SFJ amendment. </p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;font-family:Times New Roman;font-size:11pt;"> </p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;color:#000000;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">On September 23, 2019, the Company received $20,000,000 from SFJ as the second installment of the additional $60,000,000 upon the achievement of a milestone.</p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;font-family:Times New Roman;font-size:11pt;"> </p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;color:#000000;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">The Company met the remaining development milestone under the SFJ agreement upon the Company’s announcement of the primary endpoint data from its PEGASUS Phase 3 trial on January 7, 2020 and the final installment of $20,000,000 of the additional $60,000,000 was paid on January 29, 2020.</p> <p style="margin-bottom:0pt;margin-top:12pt;margin-left:4.54%;text-indent:0%;font-weight:bold;font-style:italic;font-size:10pt;font-family:Times New Roman;text-transform:none;font-variant: normal;">Follow-on Public Offering</p> <p style="margin-bottom:0pt;margin-top:12pt;text-indent:4.54%;color:#000000;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">On March 11, 2019, the Company issued and sold 6,900,000 shares of its common stock at a price per share of $17.00 in a follow-on public offering <span style="color:#000000;">(“2019 follow-on offering”)</span>. The Company received net proceeds of approximately $109,581,000 after deducting underwriting discounts and commissions of approximately $7,038,000 and offering costs of $680,891.  </p> <p style="margin-top:6pt;margin-bottom:0pt;text-indent:4.54%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">On April 23, 2018, the Company issued and sold 5,500,000 shares of its common stock at a price per share of $25.50 in a follow-on public offering. The Company received net proceeds of $131,324,477 after deducting underwriting discounts and commissions of $8,415,000 and offering costs of $509,973. </p> <p style="margin-bottom:0pt;margin-top:6pt;text-indent:4.54%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">         </p> <p style="margin-bottom:0pt;margin-top:0pt;text-indent:4.54%;font-weight:bold;font-style:italic;font-size:10pt;font-family:Times New Roman;text-transform:none;font-variant: normal;">Liquidity and Going Concern </p> <p style="margin-top:12pt;margin-bottom:0pt;text-indent:4.54%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"> The accompanying consolidated financial statements have been prepared on the basis of the realization of assets and the satisfaction of liabilities and commitments in the normal course of business. Subsequent to December 31, 2019, on January 13, 2020, the Company issued and sold 10,925,000 shares of its common stock at a price per share to the public of $37.00 in a follow-on public offering, including an additional 1,425,000 shares of its common stock that were sold at the follow-on public offering price of $37.00 per share pursuant to the underwriters’ in full exercise of their option to purchase additional shares of common stock.  The Company received net proceeds of approximately $381,374,000 from the sale of shares in the follow on offering after deducting underwriting discounts and commissions of approximately $22,233,000 and offering costs of approximately $618,000. As of February 27, 2020, the date of issuance of these consolidated financial statements, the Company believes that its cash and cash equivalents as of       December 31, 2019 of $351,985,085, together with the net proceeds of its follow-on offering of approximately $381,374,000 in January 2020 and the $20,000,000 received from SFJ in January 2020, will be sufficient to fund its operations and capital expenditures for at least the next twelve months from the date of issuance of these consolidated financial statements. The Company’s future viability beyond that point is dependent on its ability to raise additional capital to finance its operations.</p> <p style="margin-bottom:0pt;margin-top:12pt;text-indent:4.54%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">The Company is subject to risks common to other life science companies in the development stage including, but not limited to, uncertainty of product development and commercialization, lack of marketing and sales history, development by its competitors of new technological innovations, dependence on key personnel, market acceptance of products, product liability, protection of proprietary technology, ability to raise additional financing, and compliance with FDA and other government regulations. If the Company does not successfully commercialize any of its product candidates, it will be unable to generate recurring product revenue or achieve profitability. Management’s plans in order to meet its short-term and longer-term operating cash flow requirements include obtaining additional funding. </p> <p style="margin-bottom:0pt;margin-top:12pt;text-indent:4.54%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">There are uncertainties associated with the Company’s ability to (1) obtain additional debt or equity financing on terms that are favorable to the Company, (2) enter into collaborative agreements with strategic partners, and (3) succeed in its future operations. If the Company is not able to obtain the required funding for its operations, or is not able to obtain funding on terms that are favorable to the Company, it could be forced to delay, reduce or eliminate its research and development programs or future commercialization efforts and its business could be materially harmed. </p>
CY2019Q4 us-gaap Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
351985085
CY2018Q4 apls Prepaid Research And Development Cost Current
PrepaidResearchAndDevelopmentCostCurrent
23053511
CY2019Q1 apls Additional Operating Lease Liability
AdditionalOperatingLeaseLiability
9838982
CY2019 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate
0
CY2019 us-gaap Prior Period Reclassification Adjustment Description
PriorPeriodReclassificationAdjustmentDescription
<p style="margin-bottom:0pt;margin-top:6pt;margin-left:2.26%;text-indent:2.28%;font-size:5pt;"> </p> <p style="margin-bottom:0pt;margin-top:6pt;margin-left:2.26%;text-indent:2.28%;font-weight:bold;font-style:italic;font-size:10pt;font-family:Times New Roman;text-transform:none;font-variant: normal;">Reclassifications</p> <p style="margin-bottom:0pt;margin-top:6pt;margin-left:2.26%;text-indent:2.28%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Certain prior year amounts have been reclassified to conform to the 2019 presentation. </p>
CY2019 us-gaap Number Of Operating Segments
NumberOfOperatingSegments
1
CY2019 us-gaap Use Of Estimates
UseOfEstimates
<p style="margin-bottom:0pt;margin-top:18pt;margin-left:2.26%;text-indent:2.28%;font-weight:bold;font-style:italic;font-size:10pt;font-family:Times New Roman;text-transform:none;font-variant: normal;">Use of Estimates </p> <p style="margin-bottom:0pt;margin-top:12pt;text-indent:4.54%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results may differ from those estimates. Management considers many factors in selecting appropriate financial accounting policies and controls, and in developing the estimates and assumptions that are used in the preparation of these financial statements. Management must apply significant judgment in this process. In addition, other factors may affect estimates, including expected business and operational changes, sensitivity and volatility associated with the assumptions used in developing estimates, and whether historical trends are expected to be representative of future trends. The estimation process often may yield a range of potentially reasonable estimates of the ultimate future outcomes, and management must select an amount that falls within that range of reasonable estimates. Estimates are used in the following areas, among others: share-based compensation expense, fair value of common stock and preferred stock, development derivative liability, accrued expenses, prepaid expenses and convertible debt. </p> <p style="margin-bottom:0pt;margin-top:12pt;text-indent:4.54%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Historically for all periods prior to the IPO, the Company utilized various valuation methodologies in accordance with the framework of the American Institute of Certified Public Accountants Technical Practice Aid, <span style="font-style:italic;">Valuation of Privately-Held Company Equity Securities Issued as Compensation</span>, to estimate the retrospective fair value of its common stock during all periods presented. The methodologies include a probability analysis including both a potential public trading scenario and potential sale scenario. In both scenarios, value is estimated using the guideline public company method. The sale scenario includes an adjustment for a market participant acquisition premium. Value is allocated among the preferred and common shares according to the rights associated with each type of security. Valuation methodologies include estimates and assumptions that require the Company’s judgment. These estimates include assumptions regarding future performance. Significant changes to the key assumptions used in the valuations could result in different fair values of common stock and the associated fair value of stock options granted at each valuation date. Since the completion of the IPO, the Company’s board of directors determines the fair value of underlying common stock based upon the closing price of the Company’s common stock as reported on the date of grant. </p>
CY2019 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Payments
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendPayments
0
CY2019 us-gaap Concentration Risk Credit Risk
ConcentrationRiskCreditRisk
<p style="margin-bottom:0pt;margin-top:18pt;margin-left:2.26%;text-indent:2.28%;font-weight:bold;font-style:italic;font-size:10pt;font-family:Times New Roman;text-transform:none;font-variant: normal;">Concentrations of Credit Risk </p> <p style="margin-bottom:0pt;margin-top:6pt;text-indent:4.54%;font-size:10pt;font-family:Times New Roman;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Cash and cash equivalents are the only financial instruments that potentially subject the Company to concentrations of credit risk. <span style="color:#000000;">Cash and cash equivalents are held at financial institutions in the United States, Australia and Switzerland. The Company is exposed to credit risk in the event of default by the financial institution to the extent that cash and cash equivalent balances recorded in the balance sheets are in excess of the amounts that are insured by the Federal Deposit Insurance Corporation. The Company has not experienced any losses on its deposits since inception, and management believes that minimal credit risk exists with respect to these financial institutions. </span> </p>
CY2019Q1 us-gaap Operating Lease Right Of Use Asset
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5511865
CY2019Q1 apls Additional Operating Lease Right Of Use Asset
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9838982
CY2017 us-gaap Debt Conversion Converted Instrument Warrants Or Options Issued1
DebtConversionConvertedInstrumentWarrantsOrOptionsIssued1
14064
CY2018 us-gaap Debt Conversion Converted Instrument Warrants Or Options Issued1
DebtConversionConvertedInstrumentWarrantsOrOptionsIssued1
14064
CY2019Q4 apls Prepaid Research And Development Cost Current
PrepaidResearchAndDevelopmentCostCurrent
18102049
CY2019Q4 us-gaap Common Stock Capital Shares Reserved For Future Issuance
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CY2017Q4 us-gaap Common Stock Capital Shares Reserved For Future Issuance
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7983327
CY2018Q4 us-gaap Common Stock Capital Shares Reserved For Future Issuance
CommonStockCapitalSharesReservedForFutureIssuance
10031771
CY2018Q4 us-gaap Preferred Stock Shares Authorized
PreferredStockSharesAuthorized
10000000
CY2019Q4 us-gaap Preferred Stock Shares Authorized
PreferredStockSharesAuthorized
10000000
CY2019 apls Minimum Payment Of Additional Funding Amount
MinimumPaymentOfAdditionalFundingAmount
120000000
CY2019 us-gaap Derivative Gain Loss On Derivative Net
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-14839000
CY2019Q4 apls Development Derivative Liabilities Noncurrent
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134839000
CY2018Q4 apls Accrued Research And Development Current
AccruedResearchAndDevelopmentCurrent
3481570
CY2019Q4 apls Accrued Research And Development Current
AccruedResearchAndDevelopmentCurrent
36449386
CY2018Q4 apls Accrued Payroll Liabilities Current
AccruedPayrollLiabilitiesCurrent
269046
CY2019Q4 apls Accrued Payroll Liabilities Current
AccruedPayrollLiabilitiesCurrent
11442889
CY2018Q4 us-gaap Other Accrued Liabilities Current
OtherAccruedLiabilitiesCurrent
1352386
CY2019Q4 us-gaap Other Accrued Liabilities Current
OtherAccruedLiabilitiesCurrent
6890676
CY2018Q4 us-gaap Accrued Liabilities Current
AccruedLiabilitiesCurrent
5103002
CY2019Q4 us-gaap Accrued Liabilities Current
AccruedLiabilitiesCurrent
54782951
CY2017 us-gaap Effective Income Tax Rate Reconciliation Tax Credits
EffectiveIncomeTaxRateReconciliationTaxCredits
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28380000
CY2019Q4 us-gaap Operating Lease Weighted Average Remaining Lease Term1
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P5Y3D
CY2019 us-gaap Lessee Operating Lease Description
LesseeOperatingLeaseDescription
The Company enters into lease agreements with terms generally ranging from 2-7 years. Some of the Company’s lease agreements include Company options to extend the lease on a month to month basis or for set periods for up to five years. Many leases also include options to terminate the leases within one year or per other contractual terms. Renewal and termination options were generally not included in the lease term for the Company’s existing operating leases.
CY2019 apls Lessee Operating Lease Maximum Term Of Options To Terminate Lease
LesseeOperatingLeaseMaximumTermOfOptionsToTerminateLease
P1Y
CY2019Q4 us-gaap Operating Lease Right Of Use Asset
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14110209
CY2019Q4 us-gaap Operating Lease Liability
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14465975
CY2019 us-gaap Operating Lease Cost
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2369000
CY2018Q4 apls Operating Leases Future Minimum Payments Due In Five Years And Thereafter
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2341219
CY2018Q4 us-gaap Operating Leases Future Minimum Payments Due
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6859064
CY2018Q4 us-gaap Operating Leases Future Minimum Payments Due Current
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1251720
CY2019 us-gaap Operating Lease Payments
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2013273
CY2019 us-gaap Right Of Use Asset Obtained In Exchange For Operating Lease Liability
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10201170
CY2019Q4 us-gaap Lessee Operating Lease Liability Payments Due Next Twelve Months
LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths
3679786
CY2019Q4 us-gaap Lessee Operating Lease Liability Payments Due Year Two
LesseeOperatingLeaseLiabilityPaymentsDueYearTwo
3336325
CY2019Q4 us-gaap Lessee Operating Lease Liability Payments Due Year Three
LesseeOperatingLeaseLiabilityPaymentsDueYearThree
3269202
CY2019Q4 us-gaap Lessee Operating Lease Liability Payments Due Year Four
LesseeOperatingLeaseLiabilityPaymentsDueYearFour
3287748
CY2019Q4 us-gaap Lessee Operating Lease Liability Payments Due After Year Five
LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive
4106743
CY2019Q4 us-gaap Lessee Operating Lease Liability Payments Due
LesseeOperatingLeaseLiabilityPaymentsDue
17679804
CY2019Q4 us-gaap Lessee Operating Lease Liability Undiscounted Excess Amount
LesseeOperatingLeaseLiabilityUndiscountedExcessAmount
3213829
CY2019Q4 us-gaap Operating Lease Liability
OperatingLeaseLiability
14465975
CY2018 us-gaap Operating Lease Expense
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798760
CY2018Q4 us-gaap Operating Leases Future Minimum Payments Due In Two Years
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1292025
CY2018Q4 us-gaap Operating Leases Future Minimum Payments Due In Three Years
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975750
CY2018Q4 us-gaap Operating Leases Future Minimum Payments Due In Four Years
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998350
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-26775461
CY2018 us-gaap Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
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0.210
CY2018 us-gaap Income Tax Reconciliation Tax Credits
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6149021
CY2019 us-gaap Defined Contribution Plan Plan Name
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401(k) Plan
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123624
CY2018 us-gaap Defined Contribution Plan Cost Recognized
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322459
CY2019 us-gaap Defined Contribution Plan Cost Recognized
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806915
CY2017 us-gaap Income Loss From Continuing Operations Before Income Taxes Domestic
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-47523183
CY2018 us-gaap Income Loss From Continuing Operations Before Income Taxes Domestic
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-122900285
CY2019 us-gaap Income Loss From Continuing Operations Before Income Taxes Domestic
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-297127180
CY2017 us-gaap Income Loss From Continuing Operations Before Income Taxes Foreign
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-3482911
CY2018 us-gaap Income Loss From Continuing Operations Before Income Taxes Foreign
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-4601909
CY2019 us-gaap Income Loss From Continuing Operations Before Income Taxes Foreign
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-7579433
CY2017 us-gaap Income Loss From Continuing Operations Before Income Taxes Minority Interest And Income Loss From Equity Method Investments
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-51006094
CY2018 us-gaap Income Loss From Continuing Operations Before Income Taxes Minority Interest And Income Loss From Equity Method Investments
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-127502194
CY2019 us-gaap Income Loss From Continuing Operations Before Income Taxes Minority Interest And Income Loss From Equity Method Investments
IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments
-304706613
CY2018 us-gaap Current Income Tax Expense Benefit
CurrentIncomeTaxExpenseBenefit
0
CY2019 us-gaap Current Income Tax Expense Benefit
CurrentIncomeTaxExpenseBenefit
0
CY2018 us-gaap Deferred Income Tax Expense Benefit
DeferredIncomeTaxExpenseBenefit
0
CY2019 us-gaap Deferred Income Tax Expense Benefit
DeferredIncomeTaxExpenseBenefit
0
CY2017 us-gaap Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate
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-17852133
CY2017 us-gaap Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
0.350
CY2019 us-gaap Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate
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-63988409
CY2019 us-gaap Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
0.210
CY2017 us-gaap Income Tax Reconciliation State And Local Income Taxes
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-1634924
CY2017 us-gaap Effective Income Tax Rate Reconciliation State And Local Income Taxes
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0.033
CY2018 us-gaap Income Tax Reconciliation State And Local Income Taxes
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-6397993
CY2018 us-gaap Effective Income Tax Rate Reconciliation State And Local Income Taxes
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0.050
CY2019 us-gaap Income Tax Reconciliation State And Local Income Taxes
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-16423857
CY2019 us-gaap Effective Income Tax Rate Reconciliation State And Local Income Taxes
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0.054
CY2017 us-gaap Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance
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11176291
CY2017 us-gaap Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
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-0.208
CY2018 us-gaap Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance
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38156506
CY2018 us-gaap Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
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-0.299
CY2019 us-gaap Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance
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90300408
CY2019 us-gaap Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
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-0.296
CY2019 us-gaap Income Tax Reconciliation Tax Credits
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6113296
CY2019 us-gaap Effective Income Tax Rate Reconciliation Tax Credits
EffectiveIncomeTaxRateReconciliationTaxCredits
0.020
CY2018 apls Tax Cuts And Jobs Act Of2017 Change In State Apportionment Tax Reform And Other
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873508
CY2019 apls Tax Cuts And Jobs Act Of2017 Change In State Apportionment Tax Reform And Other
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-16861
CY2019 apls Effective Income Tax Rate Reconciliation Change In State Apportionment Tax Reform And Other
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0.000
CY2017 apls Tax Cuts And Jobs Act Of2017 Re Measurement Of Deferred Taxes
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15659916
CY2017 apls Effective Income Tax Rate Change In Re Measurement Of Deferred Taxes
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-0.319
CY2017 us-gaap Income Tax Reconciliation Tax Credits
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3316729
CY2017 apls Income Tax Reconciliation Change In Permanent And Other
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-4032421
CY2019 apls Income Tax Reconciliation Change In Permanent And Other
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-3757985
CY2019 apls Effective Income Tax Rate Change In Permanent And Other
EffectiveIncomeTaxRateChangeInPermanentAndOther
0.012
CY2019Q4 us-gaap Unrecognized Tax Benefits Income Tax Penalties And Interest Accrued
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0
CY2018Q4 us-gaap Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
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2914583
CY2019Q4 us-gaap Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
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6624638
CY2019Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
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6.94
CY2018 us-gaap Effective Income Tax Rate Reconciliation Tax Credits
EffectiveIncomeTaxRateReconciliationTaxCredits
0.048
CY2017 apls Effective Income Tax Rate Change In Permanent And Other
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0.067
CY2018 apls Effective Income Tax Rate Reconciliation Change In State Apportionment Tax Reform And Other
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-0.007
CY2018 apls Income Tax Reconciliation Change In Permanent And Other
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292461
CY2018 apls Effective Income Tax Rate Change In Permanent And Other
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CY2019Q4 apls Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Grant Date Fair Value
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4.62
CY2019Q4 us-gaap Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
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113868890
CY2019Q4 us-gaap Deferred Tax Assets Goodwill And Intangible Assets
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15519
CY2018Q4 us-gaap Deferred Tax Assets Goodwill And Intangible Assets
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19616
CY2017 apls Tax Cuts And Jobs Act Of2017 Re Measurement Of Deferred Taxes
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15659916
CY2018 us-gaap Unrecognized Tax Benefits Income Tax Penalties And Interest Expense
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0
CY2019 us-gaap Unrecognized Tax Benefits Income Tax Penalties And Interest Expense
UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense
0
CY2018Q4 us-gaap Unrecognized Tax Benefits Income Tax Penalties And Interest Accrued
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0
CY2018Q4 apls Deferred Tax Assets Deferred Interest Expense
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135585
CY2018Q4 apls Deferred Tax Assets Contribution Carryforwards
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36759
CY2019Q4 apls Deferred Tax Assets Contribution Carryforwards
DeferredTaxAssetsContributionCarryforwards
41409
CY2018Q4 us-gaap Deferred Tax Assets Operating Loss Carryforwards
DeferredTaxAssetsOperatingLossCarryforwards
64296165
CY2019Q4 us-gaap Deferred Tax Assets Operating Loss Carryforwards
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102623330
CY2018Q4 us-gaap Deferred Tax Assets Tax Credit Carryforwards Research
DeferredTaxAssetsTaxCreditCarryforwardsResearch
7269624
CY2019Q4 us-gaap Deferred Tax Assets Tax Credit Carryforwards Research
DeferredTaxAssetsTaxCreditCarryforwardsResearch
14476348
CY2018Q4 apls Deferred Tax Assets Orphan Drug Credits
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7165354
CY2019Q4 apls Deferred Tax Assets Orphan Drug Credits
DeferredTaxAssetsOrphanDrugCredits
9380475
CY2019Q4 us-gaap Deferred Tax Assets Derivative Instruments
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35874491
CY2019Q4 us-gaap Deferred Tax Assets Tax Deferred Expense Reserves And Accruals
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2259190
CY2019Q4 us-gaap Deferred Tax Assets Other
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11250
CY2018Q4 us-gaap Deferred Tax Assets Gross
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81837686
CY2019Q4 us-gaap Deferred Tax Assets Gross
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171306650
CY2018Q4 us-gaap Deferred Tax Liabilities Deferred Expense Reserves And Accruals
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2463715
CY2018Q4 us-gaap Deferred Tax Liabilities Unrealized Currency Transaction Gains
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12094
CY2019Q4 us-gaap Deferred Tax Liabilities Financing Arrangements
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11479891
CY2019Q4 apls Deferred Tax Liabilities Section481 A Adjustment
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2891490
CY2018Q4 us-gaap Deferred Income Tax Liabilities
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2475809
CY2019Q4 us-gaap Deferred Income Tax Liabilities
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14371381
CY2018Q4 apls Net Deferred Tax Assets Before Valuation Allowance
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79361877
CY2019Q4 apls Net Deferred Tax Assets Before Valuation Allowance
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CY2018Q4 us-gaap Deferred Tax Assets Valuation Allowance
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79361877
CY2019Q4 us-gaap Deferred Tax Assets Valuation Allowance
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156935269
CY2019 apls Net Operating Loss Carryforward Expiration Year
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2024
CY2019 apls Research And Development Tax Credit Carryforward Expiration Year
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2024
CY2019Q4 us-gaap Equity Method Investment Ownership Percentage
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0.50
CY2015Q3 apls Minimum Increase In Ownership Percentage
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0.05
CY2019Q4 us-gaap Equity Method Investment Ownership Percentage
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0.50
CY2017 us-gaap Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
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0.35
CY2019 us-gaap Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
0.21
CY2019 us-gaap Income Tax Examination Description
IncomeTaxExaminationDescription
The Company’s earliest tax years open and subject to examination by taxing authorities are 2016, for the U.S. federal jurisdiction, and 2015, for U.S. states’ and Australia’s federal jurisdiction
CY2019Q4 apls Estimated Termination Costs And Other Fees
EstimatedTerminationCostsAndOtherFees
1789000
CY2019 us-gaap Long Term Purchase Commitment Amount
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35300000
CY2019 us-gaap Litigation Settlement Amount Awarded To Other Party
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0
CY2019Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Number
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6045707
CY2019 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1
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P48M
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3.85
CY2019 apls Share Based Compensation Arrangement By Share Based Payment Award Options Exercised In Period Weighted Average Grant Date Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedInPeriodWeightedAverageGrantDateFairValue
2.81
CY2019 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue
15659119
CY2019 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period
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261681
CY2019 us-gaap Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price
ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice
12.67
CY2019 apls Share Based Compensation Arrangement By Share Based Payment Award Options Forfeited In Period Weighted Average Grant Date Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeitedInPeriodWeightedAverageGrantDateFairValue
10.34
CY2019Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
10854437
CY2019Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
13.52
CY2019Q4 us-gaap Sharebased Compensation Arrangement By Sharebased Payment Award Options Nonvested Weighted Average Grant Date Fair Value
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10.43
CY2019Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
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185847165
CY2019Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
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4808730
CY2019 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Rights
ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingRights
Options granted to employees on or after December 5, 2013 generally vest in installments of (i) 25% at the one year anniversary and (ii) in either 36 equal monthly or 12 equal quarterly installments beginning in the thirteenth month after the initial vesting commencement date (as defined) subject to the employee’s continuous service with the Company.
CY2017Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
6355581
CY2017Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
4.78
CY2017Q4 us-gaap Sharebased Compensation Arrangement By Sharebased Payment Award Options Nonvested Weighted Average Grant Date Fair Value
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2.66
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ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue
107534863
CY2018 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
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2060685
CY2018 us-gaap Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
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15.86
CY2018 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
13.13
CY2018 us-gaap Stock Issued During Period Shares Stock Options Exercised
StockIssuedDuringPeriodSharesStockOptionsExercised
468263
CY2018 us-gaap Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price
ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice
2.61
CY2018 apls Share Based Compensation Arrangement By Share Based Payment Award Options Exercised In Period Weighted Average Grant Date Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedInPeriodWeightedAverageGrantDateFairValue
1.46
CY2018 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue
4953187
CY2018 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod
450269
CY2018 us-gaap Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price
ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice
6.58
CY2018 apls Share Based Compensation Arrangement By Share Based Payment Award Options Forfeited In Period Weighted Average Grant Date Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeitedInPeriodWeightedAverageGrantDateFairValue
4.27
CY2018Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
7497734
CY2018Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
8.09
CY2018Q4 us-gaap Sharebased Compensation Arrangement By Sharebased Payment Award Options Nonvested Weighted Average Grant Date Fair Value
SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedWeightedAverageGrantDateFairValue
5.52
CY2018Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue
45706169
CY2019 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross
4365520
CY2019 us-gaap Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice
21.15
CY2019 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
17.31
CY2019 us-gaap Stock Issued During Period Shares Stock Options Exercised
StockIssuedDuringPeriodSharesStockOptionsExercised
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CY2019Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Exercise Price
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice
18.76
CY2019Q4 apls Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Grant Date Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageGrantDateFairValue
15.04
CY2019Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Aggregate Intrinsic Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue
71978275
CY2010Q2 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Exercise Price
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExercisePrice
1.71
CY2017Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Exercise Price
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExercisePrice
14.00
CY2017Q4 apls Share Based Compensation Arrangement By Share Based Payment Award Actual Fair Value Exercise Price
ShareBasedCompensationArrangementByShareBasedPaymentAwardActualFairValueExercisePrice
11.47
CY2019Q4 apls Share Based Compensation Arrangement By Share Based Payment Award Actual Fair Value Exercise Price
ShareBasedCompensationArrangementByShareBasedPaymentAwardActualFairValueExercisePrice
32.18
CY2018 us-gaap Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested In Period Fair Value1
SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue1
5062428
CY2019 us-gaap Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested In Period Fair Value1
SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue1
12906436
CY2017 us-gaap Allocated Share Based Compensation Expense
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5418710
CY2018 us-gaap Allocated Share Based Compensation Expense
AllocatedShareBasedCompensationExpense
7733256
CY2019 us-gaap Allocated Share Based Compensation Expense
AllocatedShareBasedCompensationExpense
21144029
CY2017Q4 us-gaap Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions
10415787
CY2018Q4 us-gaap Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions
27266206
CY2019Q4 us-gaap Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions
79291036
CY2019 us-gaap Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1
P3Y2M26D
CY2017 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate
0
CY2018 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate
0
CY2019 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate
0
CY2017 us-gaap Net Income Loss
NetIncomeLoss
-51006094
CY2018 us-gaap Net Income Loss
NetIncomeLoss
-127502194
CY2019 us-gaap Net Income Loss
NetIncomeLoss
-304706613
CY2017 us-gaap Weighted Average Number Of Share Outstanding Basic And Diluted
WeightedAverageNumberOfShareOutstandingBasicAndDiluted
13870949
CY2018 us-gaap Weighted Average Number Of Share Outstanding Basic And Diluted
WeightedAverageNumberOfShareOutstandingBasicAndDiluted
54396483
CY2019 us-gaap Weighted Average Number Of Share Outstanding Basic And Diluted
WeightedAverageNumberOfShareOutstandingBasicAndDiluted
62228601
CY2017 us-gaap Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
-3.68
CY2018 us-gaap Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
-2.34
CY2019 us-gaap Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
-4.90
CY2019Q1 us-gaap Operating Income Loss
OperatingIncomeLoss
-48650570
CY2019Q2 us-gaap Operating Income Loss
OperatingIncomeLoss
-63476438
CY2019Q3 us-gaap Operating Income Loss
OperatingIncomeLoss
-69947962
CY2019Q4 us-gaap Operating Income Loss
OperatingIncomeLoss
-105940283
CY2018Q3 us-gaap Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
-0.64
CY2018Q4 us-gaap Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
-0.65
CY2017 us-gaap Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
6369645
CY2018 us-gaap Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
7511798
CY2019 us-gaap Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
10854437
CY2018Q1 us-gaap Operating Income Loss
OperatingIncomeLoss
-21438145
CY2018Q2 us-gaap Operating Income Loss
OperatingIncomeLoss
-33485442
CY2018Q3 us-gaap Operating Income Loss
OperatingIncomeLoss
-35804581
CY2018Q4 us-gaap Operating Income Loss
OperatingIncomeLoss
-37196592
CY2018Q1 us-gaap Net Income Loss
NetIncomeLoss
-21736304
CY2018Q2 us-gaap Net Income Loss
NetIncomeLoss
-33334300
CY2018Q3 us-gaap Net Income Loss
NetIncomeLoss
-35972115
CY2018Q4 us-gaap Net Income Loss
NetIncomeLoss
-36459475
CY2018Q1 us-gaap Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
-0.43
CY2018Q2 us-gaap Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
-0.61
CY2019Q1 us-gaap Net Income Loss
NetIncomeLoss
-50574367
CY2019Q2 us-gaap Net Income Loss
NetIncomeLoss
-71090164
CY2019Q3 us-gaap Net Income Loss
NetIncomeLoss
-69824659
CY2019Q4 us-gaap Net Income Loss
NetIncomeLoss
-113217423
CY2019Q1 us-gaap Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
-0.87
CY2019Q2 us-gaap Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
-1.12
CY2019Q3 us-gaap Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
-1.10
CY2019Q4 us-gaap Earnings Per Share Basic And Diluted
EarningsPerShareBasicAndDiluted
-1.77

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