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About Aprea Therapeutics, Inc.
Aprea Therapeutics, Inc. is a clinical-stage biopharmaceutical company, which engages in the provision of cancer therapeutics. The company is headquartered in Doylestown, Pennsylvania and currently employs 7 full-time employees. The company went IPO on 2019-10-03. The firm's advanced synthetic lethality product candidate is ATRN-119, a clinical-stage small molecule inhibitor of ataxia telangiectasia and Rad3-related (ATR) a kinase that plays a critical role in DNA damage response (DDR). ATR and Checkpoint Kinase 1 are critical DDR kinases that prevent the collapse of replication forks into DNA double-strand breaks. The company has completed all IND enabling studies for its oral, small molecule WEE1 inhibitor, APR-1051, and received United States Food and Drug Administration (FDA) clearance of its IND. The company has an early-stage program that is in the lead optimization stage, for an undisclosed DDR target. The firm is evaluating potential combination opportunities within its pipeline, including research on the combination of ATRN-119 and APR-1051 that is supported by a Phase II SBIR grant from the National Cancer Institute.
Industry: Pharmaceutical Preparations Peers: Aridis Pharmaceuticals, Inc. AXIM BIOTECHNOLOGIES, INC. Old Ayala, Inc bioAffinity Technologies, Inc. Vyant Bio, Inc. GYRE THERAPEUTICS, INC. Innovation Pharmaceuticals Inc. Cyclo Therapeutics, Inc. Cyclacel Pharmaceuticals, Inc.
