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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities | |||||
| Depreciation expense | |||||
| Depreciation and amortization expense | |||||
| Non-cash lease expense | |||||
| Stock-based compensation | |||||
| Non-cash interest expense | |||||
| Non-cash royalty revenue related to the sale of future royalties | |||||
| Gain on sale of equipment | |||||
| Other, net | |||||
| Changes in operating assets and liabilities | |||||
| Accounts receivable | |||||
| Inventory | |||||
| Prepaid commercial manufacturing | |||||
| Prepaid expenses and other assets | |||||
| Accounts payable | |||||
| Accrued compensation and benefits | |||||
| Operating lease liabilities | |||||
| Accrued and other liabilities | |||||
| Deferred revenue | |||||
| Net cash used in operating activities | |||||
| Investing activities | |||||
| Proceeds from maturities and redemptions of investments | |||||
| Purchases of investments | |||||
| Proceeds from sale of property and equipment | |||||
| Purchases of property and equipment | |||||
| Net cash used in investing activities | |||||
| Financing activities | |||||
| Proceeds from issuance of common stock in at the market offering, net of issuance costs | |||||
| Proceeds from 2022 Loan Agreement, net of costs | |||||
| Proceeds from the sale of future royalties, net of issuance costs | |||||
| Proceeds from issuance of common stock under equity incentive plans | |||||
| Payments of the previously outstanding exit fees | |||||
| Payments for the 2018 Loan, net of costs | |||||
| Payments for taxes related to net share settlement of equity awards | |||||
| Net cash provided by financing activities | |||||
| Net increase (decrease) in cash and cash equivalents | |||||
| Cash and cash equivalents at beginning of period | |||||
| Cash and cash equivalents at end of period | |||||
| Supplementary disclosure of cash flow information | |||||
| Cash paid for interest | |||||
| Cash paid for income taxes | |||||
| Supplementary disclosure of non-cash activities | |||||
| Right-of-use assets obtained in exchange for lease obligations | |||||
| Issuance of common stock for services | |||||
| Issuance of derivative in connection with issuance of loan payable | |||||
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