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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net income (loss) | |||||
| Adjustments to reconcile consolidated net income (loss) to cash flows from operating activities: | |||||
| Depreciation of property and equipment | |||||
| Amortization of intangible assets | |||||
| Deferred income tax benefit | |||||
| Amortization and depreciation | |||||
| Share-based compensation | |||||
| Foreign exchange loss (gain) on revaluation of Monoplant finance lease liability | |||||
| Net amortization of premiums and discounts on investments | |||||
| Upfront license and milestone expense | |||||
| Non-cash write-down of inventory | |||||
| Other, net | |||||
| Net changes in operating assets and liabilities: | |||||
| Accounts receivable, net | |||||
| Inventory | |||||
| Prepaid expenses and other current assets | |||||
| Other noncurrent operating assets | |||||
| Accounts payable, accrued and other liabilities | |||||
| Accounts payable | |||||
| Accrued expenses and other liabilities | |||||
| Total accounts payable, accrued and other liabilities | |||||
| Deferred revenue | |||||
| Operating lease liabilities | |||||
| Cash flows from operating activities | |||||
| Cash flows from investing activities: | |||||
| Proceeds from the sale and maturities of investments | |||||
| Purchases of investments | |||||
| Upfront lease payments | |||||
| Upfront license payment | |||||
| Purchases of property, equipment and intangible assets | |||||
| Additions to internal use-software implementation costs | |||||
| Cash flows from investing activities | |||||
| Cash flows from financing activities: | |||||
| Repurchase of common shares | |||||
| Principal portion of finance lease payments | |||||
| Proceeds from issuance of common shares from exercise of stock options and vesting of RSUs and performance awards | |||||
| Proceeds from issuance of common shares under ESPP | |||||
| Taxes paid related to net settlement of exercises of stock options and vesting of RSUs and performance awards | |||||
| Cash flows from financing activities | |||||
| Net (decrease) increase in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash, beginning of the period | |||||
| Cash, cash equivalents and restricted cash, end of the period | |||||
| Supplemental cash flow disclosure: | |||||
| Finance lease liability arising from obtaining right-of-use assets | |||||
| Cash paid for income taxes | |||||
| Supplemental disclosure of non-cash financing activities: | |||||
| Taxes withheld related to vesting of performance awards | |||||
| Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets | |||||
| Cash and cash equivalents | |||||
| Restricted cash | |||||
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