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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation on property and equipment | |||||
| Amortization of intangible assets | |||||
| Inventory reserves and write-offs | |||||
| Loss on disposal of property and equipment | |||||
| Share-based compensation net of amounts capitalized | |||||
| Interest expense accrued on liabilities related to future royalties and milestones, net | |||||
| Accretion of available-for-sale securities | |||||
| Foreign exchange differences | |||||
| Non-cash operating lease expense | |||||
| Loss on lease incentive and reassessment | |||||
| Loss on termination of operating lease | |||||
| Impairment of operating lease right-of-use assets and related property and equipment | |||||
| Deferred income tax | |||||
| Changes in operating assets and liabilities | |||||
| Increase in prepaid expenses and other current assets | |||||
| (Increase) decrease in prepaid expenses and other non-current assets | |||||
| Increase in inventories, net | |||||
| Increase in accounts receivable, net | |||||
| Decrease in long-term deposits | |||||
| Increase in accounts payable | |||||
| Increase in accrued expenses and other liabilities | |||||
| Increase (decrease) in operating lease liability | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities: | |||||
| Acquisition of property and equipment | |||||
| Acquisition of intangibles assets | |||||
| Purchases of marketable securities: available-for-sale debt securities | |||||
| Proceeds from maturities and redemptions of marketable securities: available-for-sale debt securities | |||||
| Net cash provided by (used in) investing activities | |||||
| Cash flows from financing activities: | |||||
| Proceeds from issuance of ordinary shares | |||||
| Proceeds from exercise of share options | |||||
| Proceeds from liabilities related to future royalties and milestones, net | |||||
| Payments of issuance costs related to the liabilities related to future royalties and milestones, net | |||||
| Payments of revenue share | |||||
| Net cash (used in) provided by financing activities | |||||
| Effect of exchange rate changes on cash, cash equivalents and restricted cash | |||||
| Net decrease in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash, beginning of period | |||||
| Cash, cash equivalents and restricted cash, end of period | |||||
| Supplemental cash flow information | |||||
| Cash paid for taxes - primarily related to the United States of America | |||||
| Cash paid for income taxes | |||||
| Unrealized gains on marketable securities: available-for-sale debt securities | |||||
| Supplemental non-cash flow information | |||||
| Property and equipment purchases included in accounts payable or accrued expenses | |||||
| Leased assets terminated and obtained in exchange for operating lease liabilities, net | |||||
| Leased assets obtained in exchange for operating lease liabilities | |||||
| Capitalized share-based compensation, net of forfeitures | |||||
| Capitalized implementation costs included in accrued expenses | |||||
| Issuance costs included in accounts payable and accrued expenses | |||||
| Warrants issued in relation to Blackstone Agreements at relative fair value | |||||
| Reconciliation of cash, cash equivalents and restricted cash reported within the consolidated balance sheets: | |||||
| Cash and cash equivalents | |||||
| Restricted cash | |||||
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