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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Stock-based compensation | |||||
| Loss on extinguishments of debt | |||||
| Accretion of debt | |||||
| Fair value adjustment of warrants | |||||
| Noncash interest expense on deferred royalty obligations | |||||
| Amortization of debt discount and issuance costs | |||||
| Financing Agreement | |||||
| Funding Agreement | |||||
| Total financing Agreement | |||||
| Total amortization of debt discount and issuance costs | |||||
| Depreciation and amortization | |||||
| Noncash lease expense | |||||
| Net loss from equity method investments | |||||
| Change in fair value of the embedded derivative associated with the deferred royalty obligation | |||||
| Noncash income from equity method investments | |||||
| (Gain) loss on deconsolidation of subsidiaries | |||||
| Gain from investment in equity securities, net | |||||
| Fair value of shares issued under a license agreement | |||||
| Loss on sale of certain assets | |||||
| Impairment of long-lived assets | |||||
| Gain from sale of priority review voucher, excluding transaction costs | |||||
| Gain from recognition of receivable from licensing and collaboration agreement | |||||
| LEO call option income | |||||
| Accrual of payment-in-kind interest on term loan | |||||
| Other noncash adjustments, net | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable, net | |||||
| Inventories | |||||
| Prepaid expenses and other current assets | |||||
| Other assets | |||||
| Accounts payable | |||||
| Accrued compensation and benefits | |||||
| Accrued research and development liabilities | |||||
| Operating lease liabilities | |||||
| Deferred revenue | |||||
| Other liabilities | |||||
| Net cash used in operating activities | |||||
| Investing activities: | |||||
| Sales of marketable securities | |||||
| Purchases of marketable securities | |||||
| Maturities of marketable securities | |||||
| Purchases of investments in equity securities | |||||
| Proceeds from sales of investments in equity securities | |||||
| Proceeds from special cash dividends received from an investment in equity securities | |||||
| Payment for intangible assets | |||||
| Proceeds from sale of priority review voucher | |||||
| Proceeds from sale of certain assets | |||||
| Purchases of property and equipment | |||||
| Increase in cash and cash equivalents from consolidation of PellePharm | |||||
| Decrease in cash and cash equivalents resulting from deconsolidation of subsidiaries | |||||
| Net cash provided by (used in) investing activities | |||||
| Financing activities: | |||||
| Proceeds from issuance of common stock through Private Placement offering, net | |||||
| Proceeds from royalty obligation under Funding Agreement | |||||
| Issuance costs and discounts associated with royalty obligation under Funding Agreement | |||||
| Proceeds from issuance of 2031 Notes | |||||
| 2031 Notes, net | |||||
| Total proceeds from issuance of 2031 Notes | |||||
| Issuance costs and discounts associated with 2031 Notes/ Issuance costs and discounts associated with term loan under Amended Financing Agreement | |||||
| 2031 Notes, net | |||||
| Financing Agreement | |||||
| Total issuance costs and discounts associated with 2031 Notes/ Issuance costs and discounts associated with term loan under Amended Financing Agreement | |||||
| Purchase of capped calls | |||||
| Repurchase of common stock | |||||
| Proceeds from royalty obligation | |||||
| Royalty Interest Purchase and Sale Agreement | |||||
| Funding Agreement | |||||
| Issuance costs and discounts associated with a royalty obligation | |||||
| Royalty Interest Purchase and Sale Agreement | |||||
| Funding Agreement | |||||
| Proceeds from term loan under the Amended Financing Agreement | |||||
| Repayment of term loans | |||||
| Funding Agreement | |||||
| Total repayment of term loans | |||||
| Repayments of deferred royalty obligations | |||||
| Proceeds from issuance of common stock through public offerings, net | |||||
| Proceeds from issuance of common stock through ATM offering, net | |||||
| Proceeds from common stock issuances under ESPP | |||||
| Proceeds from stock option exercises, net of repurchases | |||||
| Repurchase of Eidos noncontrolling interest, including direct transaction costs | |||||
| Transactions with noncontrolling interests | |||||
| Repurchase of RSU shares to satisfy tax withholding | |||||
| Other financing activities | |||||
| Net cash provided by financing activities | |||||
| Net increase (decrease) in cash, cash equivalents, and restricted cash | |||||
| Cash, cash equivalents, and restricted cash at beginning of year | |||||
| Cash, cash equivalents, and restricted cash at end of year | |||||
| Supplemental Disclosure of Cash Flow Information: | |||||
| Cash paid for interest | |||||
| Cash paid for income taxes | |||||
| Supplemental Disclosures of Noncash Investing and Financing Information: | |||||
| Unpaid property and equipment | |||||
| Leasehold improvements paid by landlord | |||||
| Transfers to noncontrolling interests | |||||
| Noncash contribution by a noncontrolling interest | |||||
| Recognized intangible asset recorded in "Accrued research and development liabilities" | |||||
| Payment-in-kind interest added to principal of term loan | |||||
| Unpaid debt issuance costs | |||||
| Net noncash portion of repurchase of Eidos noncontrolling interests | |||||
| Direct transaction costs in the repurchase of Eidos recorded in additional paid-in capital previously classified in prepaid expenses and other current assets | |||||
| Reconciliation of Cash, Cash Equivalents and Restricted Cash: | |||||
| Cash and cash equivalents | |||||
| Restricted cash — Included in “Prepaid expenses and other current assets” | |||||
| Restricted cash — Included in “Other assets” | |||||
| Total cash, cash equivalents and restricted cash at end of years shown on the consolidated statements of cash flows | |||||
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