| Filed On | Filing |
|---|---|
| 02 Apr 2018 | SC 13D |
| 16 Feb 2018 | SC 13D |
| 06 Nov 2015 | SCHEDULE 13D |
| 23 Dec 2005 | SCHEDULE 13D |
| 13 Oct 2005 | SC 13D |
| 26 Feb 2004 | SCHEDULE 13D - ORBIMED CAPITAL LLC |
| 25 Feb 2004 | SCHEDULE 13D - SAMUEL D. ISALY |
| 24 Feb 2004 | SCHEDULE 13D - ORBIMED ADVISORS LLC |
| 01 Jul 2002 | SCHEDULE 13D |
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