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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash provided by (used in) operating activities: | |||||
| Loss from equity method investment | |||||
| Depreciation and amortization | |||||
| Amortization of investment discount (premiums) | |||||
| In-process research and development charge | |||||
| Stock-based compensation expense | |||||
| Amortization of operating lease right-of-use assets | |||||
| Change in operating lease right-of-use assets | |||||
| Change in fair value of derivative liabilities | |||||
| Change in fair value of contingent consideration liabilities | |||||
| Change in fair value of non-controlling equity investments | |||||
| Realized loss (gain) on sale of marketable securities | |||||
| Gain on sale of equity method investment | |||||
| Changes in operating assets and liabilities: | |||||
| Prepaid expenses and other current assets | |||||
| Accounts payable | |||||
| Accrued expenses and other liabilities | |||||
| Operating lease liabilities | |||||
| Collaboration receivable | |||||
| Deferred revenue | |||||
| Other long-term liabilities | |||||
| Net cash provided by (used in) operating activities | |||||
| Investing activities | |||||
| Purchases of property and equipment | |||||
| Purchases of marketable securities | |||||
| Maturities of marketable securities | |||||
| Proceeds from sale of marketable securities | |||||
| Cash paid for acquisition, net | |||||
| Proceeds from sale of equity method investment | |||||
| Net cash provided by (used in) investing activities | |||||
| Financing activities | |||||
| Proceeds from issuance of common shares and pre-funded warrants, net of issuance costs | |||||
| Proceeds from issuance of common shares, net of commissions | |||||
| Proceeds from issuances of stock under ESPP | |||||
| Payment of equity offering costs | |||||
| Equipment financings, net | |||||
| Proceeds from exercise of stock options | |||||
| Proceeds from private stock issuance | |||||
| Net cash provided by (used in) financing activities | |||||
| Net change in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash-beginning of year | |||||
| Cash, cash equivalents and restricted cash-end of year | |||||
| Supplemental disclosure of cash flow information: | |||||
| Cash paid for interest | |||||
| Supplemental disclosure of noncash investing and financing activities: | |||||
| Property and equipment additions in accounts payable and accrued expenses | |||||
| Operating lease liabilities arising from obtaining right-of-use assets | |||||
| Contingent consideration liabilities assumed in acquisition | |||||
| Fair value of equity instruments issued in connection with acquisition | |||||
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