| Insider Name | Current Shares | Net Change (1yr) | Buy/Sell Ratio |
|---|---|---|---|
| Capital GP V LLC OrbiMed | 8,053,298 | 0 | - |
| ADVISORS LLC ORBIMED | 7,165,006 | +221,352 | 1.19 |
| SAMUEL D ISALY | 5,379,349 | 0 | - |
| A/S Novo | 3,224,046 | 0 | - |
| Holdings A/S Novo | 1,389,498 | 0 | - |
| RICHARD A MD MILLER | 1,000,000 | +1,000,000 | ∞ |
| LEIV LEA | 400,000 | +400,000 | ∞ |
| William Benton Jones | 400,000 | +400,000 | ∞ |
| Jason V Coloma | 200,000 | 0 | - |
| Jeffrey Arcara | 100,000 | +100,000 | ∞ |
| Mehrdad Mobasher | 85,000 | 0 | - |
| Capital, LLC EcoR1 | 81,077 | 0 | - |
| Daniel W. Hunt | 75,000 | 0 | - |
| Erik J. Verner | 50,000 | 0 | - |
| Joseph J Buggy | 40,000 | 0 | - |
| David Scott Moore | 30,000 | +30,000 | ∞ |
| Peter A. Thompson | 30,000 | +266,352 | 1.23 |
| Andrew C. Chan | 30,000 | +30,000 | ∞ |
| den Broek Richard van | 30,000 | 0 | - |
| STREET PARTNERS LLC ADAMS | 15,000 | 0 | - |
| Linda Grais | 15,000 | +15,000 | ∞ |
| Terry P Gould | 15,000 | 0 | - |
| IAN T CLARK | 15,000 | +15,000 | ∞ |
| Edith P. Mitchell | 15,000 | 0 | - |
| Scott W Morrison | 15,000 | +15,000 | ∞ |
| Linda S Grais | 15,000 | 0 | - |
| Steve E. Krognes | 15,000 | 0 | - |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Andrew C. Chan | Apr 27 |
Grant/Award Acquisition (A)
Compensation/Award
|
30,000 | +30,000 | $0.00 | +$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Peter A. Thompson | Jan 30 |
Option Exercise/Conversion (M)
Compensation/Award
|
30,000 | +30,000 | $15.00 | +$450,000 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| William Benton Jones | Dec 08 |
Grant/Award Acquisition (A)
Compensation/Award
|
400,000 | +400,000 | $0.00 | +$0 |
| Jeffrey Arcara | Dec 08 |
Grant/Award Acquisition (A)
Compensation/Award
|
100,000 | +100,000 | $0.00 | +$0 |
| LEIV LEA | Dec 08 |
Grant/Award Acquisition (A)
Compensation/Award
|
400,000 | +400,000 | $0.00 | +$0 |
| RICHARD A MD MILLER | Dec 08 |
Grant/Award Acquisition (A)
Compensation/Award
|
1,000,000 | +1,000,000 | $0.00 | +$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| David Scott Moore | Oct 06 |
Grant/Award Acquisition (A)
Compensation/Award
|
30,000 | +30,000 | $0.00 | +$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| ADVISORS LLC ORBIMED | Jul 01 |
In/At-money Exercise (X)
Derivative Exercise
|
8,341,338 | +1,397,684 | $3.50 | +$4,891,894 |
| Peter A. Thompson | Jul 01 |
In/At-money Exercise (X)
Derivative Exercise
|
8,341,338 | +1,397,684 | $3.50 | +$4,891,894 |
| Peter A. Thompson | Jul 01 |
Open Market Sale (S)
Market Sale
|
7,165,006 | -1,176,332 | $4.16 | -$4,891,894 |
| ADVISORS LLC ORBIMED | Jul 01 |
Open Market Sale (S)
Market Sale
|
7,165,006 | -1,176,332 | $4.16 | -$4,891,894 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Scott W Morrison | Jun 16 |
Grant/Award Acquisition (A)
Compensation/Award
|
15,000 | +15,000 | $0.00 | +$0 |
| Linda Grais | Jun 16 |
Grant/Award Acquisition (A)
Compensation/Award
|
15,000 | +15,000 | $0.00 | +$0 |
| Peter A. Thompson | Jun 16 |
Grant/Award Acquisition (A)
Compensation/Award
|
15,000 | +15,000 | $0.00 | +$0 |
| IAN T CLARK | Jun 16 |
Grant/Award Acquisition (A)
Compensation/Award
|
15,000 | +15,000 | $0.00 | +$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| William Benton Jones | Jun 06 |
Option Exercise/Conversion (M)
Compensation/Award
|
173,130 | +19,357 | $3.50 | +$67,749 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| RICHARD A MD MILLER | May 09 |
Option Exercise/Conversion (M)
Compensation/Award
|
1,136,707 | +559,073 | $3.50 | +$1,956,755 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| den Broek Richard van | Apr 09 |
Grant/Award Acquisition (A)
Compensation/Award
|
30,000 | +30,000 | $0.00 | +$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Jeffrey Arcara | Dec 23 |
Grant/Award Acquisition (A)
Compensation/Award
|
50,000 | +50,000 | $0.00 | +$0 |
| William Benton Jones | Dec 23 |
Grant/Award Acquisition (A)
Compensation/Award
|
300,000 | +300,000 | $0.00 | +$0 |
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