| Insider Name | Current Shares | Net Change (1yr) | Buy/Sell Ratio |
|---|---|---|---|
| Healthcare Partners, L.P. EW | 25,470,390 | 0 | - |
| Asset Management, LP Cormorant | 8,265,000 | -60,000 | - |
| Woodlands Fund IX-GP, L.P. Essex | 3,490,921 | 0 | - |
| Paul Ashton | 450,741 | 0 | - |
| LEONARD M BLUM | 375,000 | 0 | - |
| David Price | 300,000 | 0 | - |
| Nancy Lurker | 294,346 | +97,745 | 13.89 |
| Lori Freedman | 125,000 | 0 | - |
| Therapeutics Ocumension | 100,221 | 0 | - |
| Ye Liu | 100,221 | 0 | - |
| Leonard S Ross | 90,044 | 0 | - |
| George Elston | 87,818 | +67,738 | ∞ |
| Dario A. Paggiarino | 48,056 | 0 | - |
| DEBORA JORN | 45,000 | 0 | - |
| David Scott Jones | 43,572 | 0 | - |
| GORAN ANDO | 41,500 | +41,500 | ∞ |
| Stuart Duty | 40,000 | +40,000 | ∞ |
| Fred Hassan | 40,000 | +40,000 | ∞ |
| WENDY F DICICCO | 40,000 | +40,000 | ∞ |
| Karen L. Zaderej | 40,000 | +42,000 | ∞ |
| MICHAEL W ROGERS | 40,000 | 0 | - |
| Reginald J. Sanders | 40,000 | +40,000 | ∞ |
| John B. Landis | 40,000 | +40,000 | ∞ |
| PETER G SAVAS | 20,000 | 0 | - |
| Kristine Peterson | 19,000 | 0 | - |
| David J Mazzo | 19,000 | 0 | - |
| Michael Craig Pine | 13,662 | 0 | - |
| James J Barry | 12,500 | 0 | - |
| Douglas Evan Godshall | 11,000 | 0 | - |
| ANTHONY P ADAMIS | 4,000 | 0 | - |
| Ramiro Ribeiro | 2,437 | +82,978 | 2.7 |
| DAVID R GUYER | 1,850 | 0 | - |
| Jay S. Duker | 986 | +109,835 | ∞ |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Ramiro Ribeiro | Apr 20 |
Open Market Sale (S)
Market Sale
|
0 | -2,437 | $15.00 | -$36,555 |
| Ramiro Ribeiro | Apr 20 |
Option Exercise/Conversion (M)
Compensation/Award
|
2,437 | +2,437 | $8.26 | +$20,129 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Jay S. Duker | Mar 24 |
Other Transaction (J)
Other
|
986 | -76,766 | $13.11 | -$1,006,402 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Jay S. Duker | Mar 16 |
Open Market Purchase (P)
Market Purchase
|
100,665 | +1,500 | $13.15 | +$19,723 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Ramiro Ribeiro | Mar 05 |
Option Exercise/Conversion (M)
Compensation/Award
|
2,438 | +2,438 | $8.26 | +$20,137 |
| Ramiro Ribeiro | Mar 05 |
Open Market Sale (S)
Market Sale
|
0 | -2,438 | $17.87 | -$43,571 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| George Elston | Mar 06 |
Gift (G)
Non-Market Transfer
|
87,818 | -5,000 | $0.00 | -$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Ramiro Ribeiro | Feb 18 |
Option Exercise/Conversion (M)
Compensation/Award
|
2,437 | +2,437 | $8.26 | +$20,129 |
| Ramiro Ribeiro | Feb 18 |
Open Market Sale (S)
Market Sale
|
0 | -2,437 | $15.00 | -$36,555 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Jay S. Duker | Jan 07 |
Option Exercise/Conversion (M)
Compensation/Award
|
87,806 | +20,793 | $0.00 | +$0 |
| Jay S. Duker | Jan 07 |
Tax Payment (F)
Tax Payment
|
77,752 | -10,054 | $16.86 | -$169,510 |
| Nancy Lurker | Jan 07 |
Option Exercise/Conversion (M)
Compensation/Award
|
294,346 | +75,133 | $0.00 | +$0 |
| George Elston | Jan 07 |
Option Exercise/Conversion (M)
Compensation/Award
|
96,339 | +15,285 | $0.00 | +$0 |
| George Elston | Jan 07 |
Tax Payment (F)
Tax Payment
|
91,852 | -4,487 | $16.86 | -$75,650 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Ramiro Ribeiro | Jan 07 |
Option Exercise/Conversion (M)
Compensation/Award
|
42,544 | +29,250 | $8.26 | +$241,605 |
| Ramiro Ribeiro | Jan 07 |
Open Market Sale (S)
Market Sale
|
0 | -42,544 | $17.10 | -$727,319 |
| Jay S. Duker | Jan 06 |
Option Exercise/Conversion (M)
Compensation/Award
|
81,518 | +30,000 | $0.00 | +$0 |
| Jay S. Duker | Jan 06 |
Tax Payment (F)
Tax Payment
|
67,013 | -14,505 | $17.43 | -$252,822 |
| Nancy Lurker | Jan 06 |
Option Exercise/Conversion (M)
Compensation/Award
|
219,213 | +12,666 | $0.00 | +$0 |
| George Elston | Jan 06 |
Option Exercise/Conversion (M)
Compensation/Award
|
85,457 | +15,000 | $0.00 | +$0 |
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