| Insider Name | Current Shares | Net Change (1yr) | Buy/Sell Ratio |
|---|---|---|---|
| IV Associates, LLC Montreux | 3,209,812 | 0 | - |
| PAUL S MADERA | 2,972,501 | 0 | - |
| George Bischof | 2,972,501 | 0 | - |
| ROSS A MD JAFFE | 2,884,835 | 0 | - |
| VENTURE CAPITAL I LP VERSANT | 2,884,835 | 0 | - |
| Douglas A Pepper | 2,603,362 | 0 | - |
| V, LP FHM | 2,603,362 | 0 | - |
| REBECCA B ROBERTSON | 2,379,539 | 0 | - |
| DONALD B MILDER | 2,379,539 | 0 | - |
| KATHLEEN K SCHOEMAKER | 2,068,960 | 0 | - |
| Capital GP III LLC OrbiMed | 1,725,265 | 0 | - |
| SAMUEL D ISALY | 1,076,444 | 0 | - |
| Chris M. Calcaterra | 181,594 | 0 | - |
| Tomas Navratil | 91,226 | -12,700 | 1.75 |
| Thomas William Burns | 80,494 | -77,334 | 1.71 |
| Joseph E Gilliam | 73,419 | -30,455 | 0.7 |
| JONATHAN SILVERSTEIN | 66,790 | 0 | - |
| ADVISORS LLC ORBIMED | 66,790 | 0 | - |
| Mark J Foley | 60,267 | +3,046 | ∞ |
| Alex R. Thurman | 53,681 | -3,462 | 1.13 |
| David F Hoffmeister | 49,549 | +17,631 | ∞ |
| Marc Stapley | 39,327 | +13,793 | 4.62 |
| Gilbert H Kliman | 37,406 | +2,501 | 1.17 |
| OLAV BERGHEIM | 25,000 | 0 | - |
| Denice Torres | 24,212 | +2,501 | ∞ |
| LEANA WEN | 21,617 | +801 | 1.47 |
| AIMEE S WEISNER | 20,684 | +14,368 | 8.13 |
| WILLIAM J PHD LINK | 17,821 | 0 | - |
| BRIAN H DOVEY | 14,041 | 0 | - |
| Brian K Halak | 6,501 | 0 | - |
| ROBERT J MORE | 5,000 | 0 | - |
| RICHARD L HARRISON | 1,388 | 0 | - |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| AIMEE S WEISNER | Jun 01 |
Grant/Award Acquisition (A)
Compensation/Award
|
20,684 | +1,878 | $0.00 | +$0 |
| Gilbert H Kliman | Jun 01 |
Grant/Award Acquisition (A)
Compensation/Award
|
37,406 | +1,878 | $0.00 | +$0 |
| David F Hoffmeister | Jun 01 |
Grant/Award Acquisition (A)
Compensation/Award
|
49,549 | +1,878 | $0.00 | +$0 |
| Mark J Foley | Jun 01 |
Grant/Award Acquisition (A)
Compensation/Award
|
60,267 | +1,878 | $0.00 | +$0 |
| Marc Stapley | Jun 01 |
Grant/Award Acquisition (A)
Compensation/Award
|
39,327 | +1,878 | $0.00 | +$0 |
| Denice Torres | Jun 01 |
Grant/Award Acquisition (A)
Compensation/Award
|
24,212 | +1,878 | $0.00 | +$0 |
| LEANA WEN | Jun 01 |
Grant/Award Acquisition (A)
Compensation/Award
|
21,617 | +1,878 | $0.00 | +$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| David F Hoffmeister | May 28 |
Option Exercise/Conversion (M)
Compensation/Award
|
47,671 | +15,000 | $24.69 | +$370,350 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Gilbert H Kliman | May 18 |
Open Market Sale (S)
Market Sale
|
35,528 | -5,000 | $140.76 | -$703,800 |
| Gilbert H Kliman | May 18 |
Option Exercise/Conversion (M)
Compensation/Award
|
40,528 | +5,000 | $24.69 | +$123,450 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Gilbert H Kliman | May 13 |
Open Market Sale (S)
Market Sale
|
35,528 | -5,000 | $135.00 | -$675,000 |
| Gilbert H Kliman | May 13 |
Option Exercise/Conversion (M)
Compensation/Award
|
40,528 | +5,000 | $24.69 | +$123,450 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Joseph E Gilliam | May 04 |
Open Market Sale (S)
Market Sale
|
73,419 | -19,573 | $143.54 | -$2,809,508 |
| LEANA WEN | May 04 |
Open Market Sale (S)
Market Sale
|
19,739 | -1,700 | $143.35 | -$243,695 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Alex R. Thurman | May 04 |
Open Market Sale (S)
Market Sale
|
43,681 | -10,000 | $140.00 | -$1,400,000 |
| Alex R. Thurman | May 04 |
Option Exercise/Conversion (M)
Compensation/Award
|
53,681 | +10,000 | $38.68 | +$386,800 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Tomas Navratil | Apr 14 |
Open Market Sale (S)
Market Sale
|
91,226 | -1,237 | $116.72 | -$144,382 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Thomas William Burns | Apr 03 |
Tax Payment (F)
Tax Payment
|
80,494 | -2,469 | $109.60 | -$270,602 |
| Joseph E Gilliam | Apr 03 |
Tax Payment (F)
Tax Payment
|
92,992 | -3,169 | $109.60 | -$347,322 |
| Tomas Navratil | Apr 03 |
Tax Payment (F)
Tax Payment
|
94,294 | -1,146 | $109.60 | -$125,601 |
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