| Insider Name | Current Shares | Net Change (1yr) | Buy/Sell Ratio |
|---|---|---|---|
| IV Associates, LLC Montreux | 3,209,812 | 0 | - |
| George Bischof | 2,972,501 | 0 | - |
| PAUL S MADERA | 2,972,501 | 0 | - |
| VENTURE CAPITAL I LP VERSANT | 2,884,835 | 0 | - |
| ROSS A MD JAFFE | 2,884,835 | 0 | - |
| V, LP FHM | 2,603,362 | 0 | - |
| Douglas A Pepper | 2,603,362 | 0 | - |
| DONALD B MILDER | 2,379,539 | 0 | - |
| REBECCA B ROBERTSON | 2,379,539 | 0 | - |
| KATHLEEN K SCHOEMAKER | 2,068,960 | 0 | - |
| Capital GP III LLC OrbiMed | 1,725,265 | 0 | - |
| SAMUEL D ISALY | 1,076,444 | 0 | - |
| Chris M. Calcaterra | 181,594 | 0 | - |
| Tomas Navratil | 91,226 | -12,700 | 1.75 |
| Thomas William Burns | 80,494 | -77,334 | 1.71 |
| Joseph E Gilliam | 73,419 | -30,455 | 0.7 |
| JONATHAN SILVERSTEIN | 66,790 | 0 | - |
| ADVISORS LLC ORBIMED | 66,790 | 0 | - |
| Mark J Foley | 58,389 | +1,168 | ∞ |
| Alex R. Thurman | 53,681 | -3,462 | 1.13 |
| Marc Stapley | 48,637 | +11,915 | 4.13 |
| Gilbert H Kliman | 35,528 | +623 | 1.12 |
| David F Hoffmeister | 32,671 | +25,753 | ∞ |
| AIMEE S WEISNER | 31,653 | +12,490 | 7.26 |
| OLAV BERGHEIM | 25,000 | 0 | - |
| Denice Torres | 22,334 | +623 | ∞ |
| LEANA WEN | 19,739 | -1,077 | 0.37 |
| WILLIAM J PHD LINK | 17,821 | 0 | - |
| BRIAN H DOVEY | 14,041 | 0 | - |
| Brian K Halak | 6,501 | 0 | - |
| ROBERT J MORE | 5,000 | 0 | - |
| RICHARD L HARRISON | 1,388 | 0 | - |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Joseph E Gilliam | May 04 |
Open Market Sale (S)
Market Sale
|
73,419 | -19,573 | $143.54 | -$2,809,508 |
| LEANA WEN | May 04 |
Open Market Sale (S)
Market Sale
|
19,739 | -1,700 | $143.35 | -$243,695 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Alex R. Thurman | May 04 |
Open Market Sale (S)
Market Sale
|
43,681 | -10,000 | $140.00 | -$1,400,000 |
| Alex R. Thurman | May 04 |
Option Exercise/Conversion (M)
Compensation/Award
|
53,681 | +10,000 | $38.68 | +$386,800 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Tomas Navratil | Apr 14 |
Open Market Sale (S)
Market Sale
|
91,226 | -1,237 | $116.72 | -$144,382 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Thomas William Burns | Apr 03 |
Tax Payment (F)
Tax Payment
|
80,494 | -2,469 | $109.60 | -$270,602 |
| Joseph E Gilliam | Apr 03 |
Tax Payment (F)
Tax Payment
|
92,992 | -3,169 | $109.60 | -$347,322 |
| Tomas Navratil | Apr 03 |
Tax Payment (F)
Tax Payment
|
94,294 | -1,146 | $109.60 | -$125,601 |
| Alex R. Thurman | Apr 03 |
Tax Payment (F)
Tax Payment
|
43,681 | -1,589 | $109.60 | -$174,154 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Thomas William Burns | Apr 03 |
Gift (G)
Non-Market Transfer
|
82,963 | -180,308 | $0.00 | -$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Tomas Navratil | Apr 02 |
Tax Payment (F)
Tax Payment
|
95,440 | -5,798 | $109.60 | -$635,460 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Tomas Navratil | Mar 27 |
Grant/Award Acquisition (A)
Compensation/Award
|
73,079 | +4,622 | $0.00 | +$0 |
| Alex R. Thurman | Mar 27 |
Grant/Award Acquisition (A)
Compensation/Award
|
45,270 | +3,303 | $0.00 | +$0 |
| Alex R. Thurman | Mar 27 |
Open Market Sale (S)
Market Sale
|
41,967 | -2,511 | $106.46 | -$267,321 |
| Joseph E Gilliam | Mar 27 |
Grant/Award Acquisition (A)
Compensation/Award
|
78,369 | +5,829 | $0.00 | +$0 |
| Thomas William Burns | Mar 27 |
Grant/Award Acquisition (A)
Compensation/Award
|
249,087 | +9,380 | $0.00 | +$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Alex R. Thurman | Mar 25 |
Tax Payment (F)
Tax Payment
|
44,478 | -2,020 | $105.23 | -$212,564 |
| Alex R. Thurman | Mar 25 |
Open Market Sale (S)
Market Sale
|
46,498 | -1,521 | $105.24 | -$160,070 |
| Tomas Navratil | Mar 25 |
Tax Payment (F)
Tax Payment
|
68,457 | -2,546 | $105.23 | -$267,915 |
| Joseph E Gilliam | Mar 25 |
Tax Payment (F)
Tax Payment
|
79,928 | -4,926 | $105.23 | -$518,362 |
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