2023 Q1 Form 10-K Financial Statement

#000156459023004830 Filed on March 30, 2023

View on sec.gov

Income Statement

Concept 2023 Q1 2022 Q4 2022
Revenue $0.00 $0.00 $794.0K
YoY Change -100.0% -100.0% -89.12%
Cost Of Revenue $0.00 $0.00 $798.0K
YoY Change -100.0% -100.0% -89.19%
Gross Profit $0.00 $0.00 -$4.000K
YoY Change -100.0% -100.0% -90.48%
Gross Profit Margin -0.5%
Selling, General & Admin $3.970M $4.165M $16.97M
YoY Change -13.58% 0.02% -10.53%
% of Gross Profit
Research & Development $588.0K $660.0K $13.04M
YoY Change -93.94% -95.91% -81.08%
% of Gross Profit
Depreciation & Amortization $3.000K $10.00K $230.0K
YoY Change -97.35% -91.3% -20.69%
% of Gross Profit
Operating Expenses -$178.0K $4.825M $9.405M
YoY Change -101.25% -76.23% -86.35%
Operating Profit $178.0K -$4.825M -$8.611M
YoY Change -101.24% -76.25% -87.51%
Interest Expense $96.00K $167.0K $537.0K
YoY Change 4700.0% -283.52% 1276.92%
% of Operating Profit 53.93%
Other Income/Expense, Net $1.000K $0.00
YoY Change -98.67% -100.0%
Pretax Income $274.0K -$40.11M -$7.894M
YoY Change -101.88% 97.28% -91.02%
Income Tax $14.00K $348.0K $348.0K
% Of Pretax Income 5.11%
Net Earnings $260.0K -$40.45M -$8.200M
YoY Change -101.79% 99.0% -90.67%
Net Earnings / Revenue -1032.75%
Basic Earnings Per Share $0.01 -$0.26
Diluted Earnings Per Share $0.01 -$1.27 -$0.26
COMMON SHARES
Basic Shares Outstanding 37.76M 31.49M 31.55M
Diluted Shares Outstanding 37.98M 31.55M

Balance Sheet

Concept 2023 Q1 2022 Q4 2022
SHORT-TERM ASSETS
Cash & Short-Term Investments $8.099M $21.67M $21.67M
YoY Change -76.73% -53.75% -53.76%
Cash & Equivalents $8.100M $21.67M $21.67M
Short-Term Investments $0.00 $0.00
Other Short-Term Assets $915.0K $1.540M $1.540M
YoY Change -30.79% -45.14% -45.14%
Inventory $6.122M
Prepaid Expenses
Receivables $5.000M $5.000M $5.000M
Other Receivables $0.00 $0.00 $0.00
Total Short-Term Assets $14.01M $28.21M $28.21M
YoY Change -61.82% -45.21% -45.21%
LONG-TERM ASSETS
Property, Plant & Equipment $1.000K $4.000K $70.00K
YoY Change -99.97% -99.59% -98.12%
Goodwill
YoY Change
Intangibles
YoY Change
Long-Term Investments
YoY Change
Other Assets $168.0K $168.0K $168.0K
YoY Change -64.41% -64.41% -64.41%
Total Long-Term Assets $4.736M $238.0K $238.0K
YoY Change 32.62% -94.31% -94.31%
TOTAL ASSETS
Total Short-Term Assets $14.01M $28.21M $28.21M
Total Long-Term Assets $4.736M $238.0K $238.0K
Total Assets $18.75M $28.44M $28.44M
YoY Change -53.44% -48.9% -48.9%
SHORT-TERM LIABILITIES
YoY Change
Accounts Payable $16.00K $194.0K $194.0K
YoY Change -99.66% -96.98% -96.98%
Accrued Expenses $1.828M $4.072M $4.072M
YoY Change -78.45% -45.82% -45.82%
Deferred Revenue
YoY Change
Short-Term Debt $0.00 $0.00 $0.00
YoY Change
Long-Term Debt Due
YoY Change
Total Short-Term Liabilities $6.844M $16.82M $16.82M
YoY Change -48.11% 18.77% 18.77%
LONG-TERM LIABILITIES
Long-Term Debt $0.00 $0.00 $0.00
YoY Change
Other Long-Term Liabilities $4.550M $0.00 $0.00
YoY Change -100.0% -100.0%
Total Long-Term Liabilities $4.550M $0.00 $0.00
YoY Change -100.0% -100.0%
TOTAL LIABILITIES
Total Short-Term Liabilities $6.844M $16.82M $16.82M
Total Long-Term Liabilities $4.550M $0.00 $0.00
Total Liabilities $11.39M $16.82M $16.82M
YoY Change -13.62% 15.45% 15.45%
SHAREHOLDERS EQUITY
Retained Earnings -$410.7M -$410.9M
YoY Change -1.56% 2.04%
Common Stock $37.00K $37.00K
YoY Change 19.35%
Preferred Stock
YoY Change
Treasury Stock (at cost)
YoY Change
Treasury Stock Shares
Shareholders Equity -$25.95M -$21.69M $11.62M
YoY Change
Total Liabilities & Shareholders Equity $18.75M $28.44M $28.44M
YoY Change -53.44% -48.9% -48.9%

Cashflow Statement

Concept 2023 Q1 2022 Q4 2022
OPERATING ACTIVITIES
Net Income $260.0K -$40.45M -$8.200M
YoY Change -101.79% 99.0% -90.67%
Depreciation, Depletion And Amortization $3.000K $10.00K $230.0K
YoY Change -97.35% -91.3% -20.69%
Cash From Operating Activities -$6.216M -$1.475M -$33.10M
YoY Change -48.41% -91.66% -60.48%
INVESTING ACTIVITIES
Capital Expenditures $1.742M $0.00 $0.00
YoY Change -100.0%
Acquisitions
YoY Change
Other Investing Activities $411.0K $51.00K $55.43M
YoY Change -83.59% -98.22% 13.05%
Cash From Investing Activities $411.0K $51.00K $55.43M
YoY Change -83.59% -98.22% 15.02%
FINANCING ACTIVITIES
Cash Dividend Paid $7.764M $45.03M
YoY Change
Common Stock Issuance & Retirement, Net
YoY Change
Debt Paid & Issued, Net
YoY Change
Cash From Financing Activities -7.762M 0.000 -45.01M
YoY Change -48612.5% -190.83%
NET CHANGE
Cash From Operating Activities -6.216M -1.475M -33.10M
Cash From Investing Activities 411.0K 51.00K 55.43M
Cash From Financing Activities -7.762M 0.000 -45.01M
Net Change In Cash -13.57M -1.424M -22.68M
YoY Change 42.36% -90.38% -262.16%
FREE CASH FLOW
Cash From Operating Activities -$6.216M -$1.475M -$33.10M
Capital Expenditures $1.742M $0.00 $0.00
Free Cash Flow -$7.958M -$1.475M -$33.10M
YoY Change -91.66% -60.08%

Facts In Submission

Frame Concept Type Concept / XBRL Key Value Unit
CY2021 us-gaap Net Income Loss
NetIncomeLoss
-87933000
CY2021 us-gaap Earnings Per Share Diluted
EarningsPerShareDiluted
-2.87
CY2022Q4 us-gaap Commitments And Contingencies
CommitmentsAndContingencies
CY2022 dei Entity Interactive Data Current
EntityInteractiveDataCurrent
Yes
CY2022 dei Document Transition Report
DocumentTransitionReport
false
CY2022 dei Entity File Number
EntityFileNumber
000-51173
CY2022 dei Entity Incorporation State Country Code
EntityIncorporationStateCountryCode
DE
CY2022 dei Entity Tax Identification Number
EntityTaxIdentificationNumber
56-2020050
CY2022 dei Entity Address Address Line1
EntityAddressAddressLine1
611 Gateway Blvd
CY2022 dei Entity Address Address Line2
EntityAddressAddressLine2
Suite 710
CY2022 dei Entity Address City Or Town
EntityAddressCityOrTown
South San Francisco
CY2022 dei Entity Address State Or Province
EntityAddressStateOrProvince
CA
CY2022 dei Entity Address Postal Zip Code
EntityAddressPostalZipCode
94080
CY2022 dei City Area Code
CityAreaCode
650
CY2022 dei Local Phone Number
LocalPhoneNumber
871-0761
CY2021 us-gaap Operating Expenses
OperatingExpenses
95232000
CY2021 us-gaap Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
-5000
CY2022 dei Auditor Name
AuditorName
EISNERAMPER LLP
CY2022 dei Auditor Location
AuditorLocation
Philadelphia, Pennsylvania
CY2022Q4 us-gaap Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
21666000
CY2021Q4 us-gaap Cash And Cash Equivalents At Carrying Value
CashAndCashEquivalentsAtCarryingValue
44347000
CY2021Q4 us-gaap Short Term Investments
ShortTermInvestments
2504000
CY2021Q4 us-gaap Prepaid Expense And Other Assets Current
PrepaidExpenseAndOtherAssetsCurrent
2807000
CY2021Q4 us-gaap Assets Current
AssetsCurrent
51476000
CY2021Q4 us-gaap Operating Lease Liability Current
OperatingLeaseLiabilityCurrent
1977000
CY2021Q4 us-gaap Liabilities Current
LiabilitiesCurrent
14165000
CY2022Q4 us-gaap Operating Lease Right Of Use Asset
OperatingLeaseRightOfUseAsset
66000
CY2022Q4 us-gaap Property Plant And Equipment Net
PropertyPlantAndEquipmentNet
4000
CY2022Q4 us-gaap Assets
Assets
28444000
CY2022Q4 us-gaap Accounts Payable Current
AccountsPayableCurrent
194000
CY2022Q4 us-gaap Accrued Employee Benefits Current
AccruedEmployeeBenefitsCurrent
2582000
CY2021Q4 us-gaap Deferred Revenue Current
DeferredRevenueCurrent
230000
CY2022Q4 us-gaap Other Accrued Liabilities Current
OtherAccruedLiabilitiesCurrent
1452000
CY2021Q4 us-gaap Other Accrued Liabilities Current
OtherAccruedLiabilitiesCurrent
4072000
CY2022Q4 us-gaap Common Stock Value
CommonStockValue
37000
CY2021Q4 us-gaap Common Stock Value
CommonStockValue
31000
CY2021Q4 us-gaap Additional Paid In Capital
AdditionalPaidInCapital
443752000
CY2022 dei Entity Filer Category
EntityFilerCategory
Non-accelerated Filer
CY2022 dei Entity Shell Company
EntityShellCompany
false
CY2023Q1 dei Entity Common Stock Shares Outstanding
EntityCommonStockSharesOutstanding
37759825
CY2022 us-gaap Comprehensive Income Net Of Tax
ComprehensiveIncomeNetOfTax
-8242000
CY2021 us-gaap Comprehensive Income Net Of Tax
ComprehensiveIncomeNetOfTax
-87938000
CY2022 us-gaap Effective Income Tax Rate Reconciliation Nondeductible Expense Other
EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther
0.0207
CY2021 cbio Effective Income Tax Rate Reconciliation Derecognition
EffectiveIncomeTaxRateReconciliationDerecognition
0.0000
CY2021 us-gaap Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance
-0.2626
CY2021Q4 us-gaap Commitments And Contingencies
CommitmentsAndContingencies
CY2021 us-gaap Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2
P7Y5M15D
CY2022 us-gaap Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2
P7Y5M19D
CY2022 us-gaap Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1
SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1
P5Y11M8D
CY2022 dei Document Annual Report
DocumentAnnualReport
true
CY2022 dei Security12b Title
Security12bTitle
Common stock
CY2022 dei Security Exchange Name
SecurityExchangeName
NASDAQ
CY2022 dei Entity Well Known Seasoned Issuer
EntityWellKnownSeasonedIssuer
No
CY2022 dei Entity Voluntary Filers
EntityVoluntaryFilers
No
CY2022 dei Entity Current Reporting Status
EntityCurrentReportingStatus
Yes
CY2022 dei Entity Small Business
EntitySmallBusiness
true
CY2022 dei Entity Emerging Growth Company
EntityEmergingGrowthCompany
false
CY2022 dei Icfr Auditor Attestation Flag
IcfrAuditorAttestationFlag
false
CY2022Q2 dei Entity Public Float
EntityPublicFloat
55642222
CY2022 dei Auditor Firm
AuditorFirmId
274
CY2022Q4 us-gaap Accounts And Other Receivables Net Current
AccountsAndOtherReceivablesNetCurrent
5000000
CY2021Q4 us-gaap Accounts And Other Receivables Net Current
AccountsAndOtherReceivablesNetCurrent
1818000
CY2022Q4 us-gaap Prepaid Expense And Other Assets Current
PrepaidExpenseAndOtherAssetsCurrent
1540000
CY2022Q4 us-gaap Assets Current
AssetsCurrent
28206000
CY2022Q4 us-gaap Other Assets Noncurrent
OtherAssetsNoncurrent
168000
CY2021Q4 us-gaap Other Assets Noncurrent
OtherAssetsNoncurrent
472000
CY2021Q4 us-gaap Operating Lease Right Of Use Asset
OperatingLeaseRightOfUseAsset
2744000
CY2021Q4 us-gaap Property Plant And Equipment Net
PropertyPlantAndEquipmentNet
970000
CY2021Q4 us-gaap Assets
Assets
55662000
CY2021Q4 us-gaap Accounts Payable Current
AccountsPayableCurrent
6419000
CY2021Q4 us-gaap Accrued Employee Benefits Current
AccruedEmployeeBenefitsCurrent
1467000
CY2022Q4 us-gaap Dividends Payable Current
DividendsPayableCurrent
7558000
CY2022Q4 cbio Contingent Value Rights Derivative Liability
ContingentValueRightsDerivativeLiability
5000000
CY2022Q4 us-gaap Operating Lease Liability Current
OperatingLeaseLiabilityCurrent
38000
CY2022Q4 us-gaap Liabilities Current
LiabilitiesCurrent
16824000
CY2021Q4 us-gaap Operating Lease Liability Noncurrent
OperatingLeaseLiabilityNoncurrent
408000
CY2022Q4 us-gaap Liabilities
Liabilities
16824000
CY2021Q4 us-gaap Liabilities
Liabilities
14573000
CY2022Q4 us-gaap Common Stock Par Or Stated Value Per Share
CommonStockParOrStatedValuePerShare
0.001
CY2021Q4 us-gaap Common Stock Par Or Stated Value Per Share
CommonStockParOrStatedValuePerShare
0.001
CY2022Q4 us-gaap Common Stock Shares Authorized
CommonStockSharesAuthorized
100000000
CY2021Q4 us-gaap Common Stock Shares Authorized
CommonStockSharesAuthorized
100000000
CY2022Q4 us-gaap Common Stock Shares Issued
CommonStockSharesIssued
37756574
CY2022Q4 us-gaap Common Stock Shares Outstanding
CommonStockSharesOutstanding
37756574
CY2021Q4 us-gaap Common Stock Shares Issued
CommonStockSharesIssued
31409707
CY2021Q4 us-gaap Common Stock Shares Outstanding
CommonStockSharesOutstanding
31409707
CY2022Q4 us-gaap Additional Paid In Capital
AdditionalPaidInCapital
389210000
CY2022Q4 us-gaap Retained Earnings Accumulated Deficit
RetainedEarningsAccumulatedDeficit
-410936000
CY2021Q4 us-gaap Retained Earnings Accumulated Deficit
RetainedEarningsAccumulatedDeficit
-402694000
CY2022Q4 us-gaap Stockholders Equity
StockholdersEquity
-21689000
CY2021Q4 us-gaap Stockholders Equity
StockholdersEquity
41089000
CY2022Q4 us-gaap Liabilities And Stockholders Equity
LiabilitiesAndStockholdersEquity
28444000
CY2021Q4 us-gaap Liabilities And Stockholders Equity
LiabilitiesAndStockholdersEquity
55662000
CY2022 us-gaap Research And Development Expense Excluding Acquired In Process Cost
ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost
13037000
CY2021 us-gaap Research And Development Expense Excluding Acquired In Process Cost
ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost
68889000
CY2022 us-gaap General And Administrative Expense
GeneralAndAdministrativeExpense
17366000
CY2021 us-gaap General And Administrative Expense
GeneralAndAdministrativeExpense
18963000
CY2022 us-gaap Research And Development In Process
ResearchAndDevelopmentInProcess
35390000
CY2022 us-gaap Gain Loss On Disposition Of Assets1
GainLossOnDispositionOfAssets1
57186000
CY2022 us-gaap Operating Expenses
OperatingExpenses
9405000
CY2022 us-gaap Operating Income Loss
OperatingIncomeLoss
-8611000
CY2021 us-gaap Operating Income Loss
OperatingIncomeLoss
-87894000
CY2022 cbio Interest And Other Income Expense Net
InterestAndOtherIncomeExpenseNet
717000
CY2021 cbio Interest And Other Income Expense Net
InterestAndOtherIncomeExpenseNet
-39000
CY2022 us-gaap Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest
-7894000
CY2021 us-gaap Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest
-87933000
CY2022 us-gaap Income Tax Expense Benefit
IncomeTaxExpenseBenefit
348000
CY2022 us-gaap Net Income Loss
NetIncomeLoss
-8242000
CY2022 us-gaap Earnings Per Share Diluted
EarningsPerShareDiluted
-0.26
CY2022 us-gaap Earnings Per Share Basic
EarningsPerShareBasic
-0.26
CY2021 us-gaap Earnings Per Share Basic
EarningsPerShareBasic
-2.87
CY2022 us-gaap Weighted Average Number Of Diluted Shares Outstanding
WeightedAverageNumberOfDilutedSharesOutstanding
31545723
CY2022 us-gaap Weighted Average Number Of Shares Outstanding Basic
WeightedAverageNumberOfSharesOutstandingBasic
31545723
CY2021 us-gaap Weighted Average Number Of Diluted Shares Outstanding
WeightedAverageNumberOfDilutedSharesOutstanding
30640977
CY2021 us-gaap Weighted Average Number Of Shares Outstanding Basic
WeightedAverageNumberOfSharesOutstandingBasic
30640977
CY2022 us-gaap Common Stock Dividends Per Share Cash Paid
CommonStockDividendsPerShareCashPaid
1.43
CY2022 us-gaap Common Stock Dividends Per Share Declared
CommonStockDividendsPerShareDeclared
0.24
CY2022 us-gaap Net Income Loss
NetIncomeLoss
-8242000
CY2021 us-gaap Net Income Loss
NetIncomeLoss
-87933000
CY2021 us-gaap Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
-5000
CY2020Q4 us-gaap Stockholders Equity
StockholdersEquity
76069000
CY2021 us-gaap Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
3405000
CY2021 cbio Stock Issued During Period From Stock Grants And Stock Options Exercised Value
StockIssuedDuringPeriodFromStockGrantsAndStockOptionsExercisedValue
303000
CY2021 us-gaap Adjustments To Additional Paid In Capital Stock Issued Issuance Costs
AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts
3563000
CY2021 us-gaap Stock Issued During Period Value New Issues
StockIssuedDuringPeriodValueNewIssues
49250000
CY2021 us-gaap Net Income Loss
NetIncomeLoss
-87933000
CY2021Q4 us-gaap Stockholders Equity
StockholdersEquity
41089000
CY2022 us-gaap Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
1342000
CY2022 cbio Stock Issued During Period From Stock Grants And Stock Options Exercised Value
StockIssuedDuringPeriodFromStockGrantsAndStockOptionsExercisedValue
20000
CY2022 us-gaap Stock Issued During Period Value Acquisitions
StockIssuedDuringPeriodValueAcquisitions
1691000
CY2022 us-gaap Common Stock Dividends Per Share Cash Paid
CommonStockDividendsPerShareCashPaid
1.43
CY2022 us-gaap Dividends Common Stock Cash
DividendsCommonStockCash
45031000
CY2022 us-gaap Common Stock Dividends Per Share Declared
CommonStockDividendsPerShareDeclared
0.24
CY2022 us-gaap Dividends Common Stock Stock
DividendsCommonStockStock
7558000
CY2022 cbio Cvr Derivative Liability
CVRDerivativeLiability
5000000
CY2022 us-gaap Net Income Loss
NetIncomeLoss
-8242000
CY2022Q4 us-gaap Stockholders Equity
StockholdersEquity
-21689000
CY2022 us-gaap Profit Loss
ProfitLoss
-8242000
CY2021 us-gaap Profit Loss
ProfitLoss
-87933000
CY2022 us-gaap Research And Development In Process
ResearchAndDevelopmentInProcess
35390000
CY2022 us-gaap Share Based Compensation
ShareBasedCompensation
1342000
CY2021 us-gaap Share Based Compensation
ShareBasedCompensation
3405000
CY2022 us-gaap Depreciation Depletion And Amortization
DepreciationDepletionAndAmortization
230000
CY2021 us-gaap Depreciation Depletion And Amortization
DepreciationDepletionAndAmortization
290000
CY2022 us-gaap Provision For Doubtful Accounts
ProvisionForDoubtfulAccounts
200000
CY2022 cbio Loss On Lease Termination
LossOnLeaseTermination
115000
CY2022 us-gaap Gain Loss On Disposition Of Assets1
GainLossOnDispositionOfAssets1
57186000
CY2022 us-gaap Increase Decrease In Accounts And Other Receivables
IncreaseDecreaseInAccountsAndOtherReceivables
-1618000
CY2021 us-gaap Increase Decrease In Accounts And Other Receivables
IncreaseDecreaseInAccountsAndOtherReceivables
-1495000
CY2022 us-gaap Increase Decrease In Prepaid Deferred Expense And Other Assets
IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
-1609000
CY2021 us-gaap Increase Decrease In Prepaid Deferred Expense And Other Assets
IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
-3880000
CY2022 us-gaap Increase Decrease In Accounts Payable
IncreaseDecreaseInAccountsPayable
-6225000
CY2021 us-gaap Increase Decrease In Accounts Payable
IncreaseDecreaseInAccountsPayable
500000
CY2022 us-gaap Increase Decrease In Accrued Liabilities
IncreaseDecreaseInAccruedLiabilities
-1895000
CY2021 us-gaap Increase Decrease In Accrued Liabilities
IncreaseDecreaseInAccruedLiabilities
-3680000
CY2022 cbio Increase Decrease In Operating Lease Liability And Right Of Use Asset
IncreaseDecreaseInOperatingLeaseLiabilityAndRightOfUseAsset
178000
CY2021 cbio Increase Decrease In Operating Lease Liability And Right Of Use Asset
IncreaseDecreaseInOperatingLeaseLiabilityAndRightOfUseAsset
41000
CY2022 us-gaap Increase Decrease In Contract With Customer Liability
IncreaseDecreaseInContractWithCustomerLiability
-230000
CY2021 us-gaap Increase Decrease In Contract With Customer Liability
IncreaseDecreaseInContractWithCustomerLiability
-1753000
CY2022 us-gaap Net Cash Provided By Used In Operating Activities
NetCashProvidedByUsedInOperatingActivities
-33096000
CY2021 us-gaap Net Cash Provided By Used In Operating Activities
NetCashProvidedByUsedInOperatingActivities
-83755000
CY2022 us-gaap Proceeds From Sale Maturity And Collection Of Shortterm Investments
ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments
2504000
CY2021 us-gaap Proceeds From Sale Maturity And Collection Of Shortterm Investments
ProceedsFromSaleMaturityAndCollectionOfShorttermInvestments
49028000
CY2021 us-gaap Payments To Acquire Property Plant And Equipment
PaymentsToAcquirePropertyPlantAndEquipment
839000
CY2022 us-gaap Proceeds From Sale Of Property Plant And Equipment
ProceedsFromSaleOfPropertyPlantAndEquipment
498000
CY2022 us-gaap Proceeds From Sale Of Intangible Assets
ProceedsFromSaleOfIntangibleAssets
55000000
CY2022 cbio Payment Of Transaction Costs In Connection With Sale Of Complement Portfolio
PaymentOfTransactionCostsInConnectionWithSaleOfComplementPortfolio
2576000
CY2022 us-gaap Net Cash Provided By Used In Investing Activities
NetCashProvidedByUsedInInvestingActivities
55426000
CY2021 us-gaap Net Cash Provided By Used In Investing Activities
NetCashProvidedByUsedInInvestingActivities
48189000
CY2021 cbio Proceeds From Issuance Of Common Stock For Public Offering Net Of Issuance Costs
ProceedsFromIssuanceOfCommonStockForPublicOfferingNetOfIssuanceCosts
49250000
CY2022 us-gaap Payments Of Dividends
PaymentsOfDividends
45031000
CY2022 cbio Proceeds From Issuance Of Common Stock From Stock Grants And Option Exercises
ProceedsFromIssuanceOfCommonStockFromStockGrantsAndOptionExercises
20000
CY2021 cbio Proceeds From Issuance Of Common Stock From Stock Grants And Option Exercises
ProceedsFromIssuanceOfCommonStockFromStockGrantsAndOptionExercises
303000
CY2022 us-gaap Net Cash Provided By Used In Financing Activities
NetCashProvidedByUsedInFinancingActivities
-45011000
CY2021 us-gaap Net Cash Provided By Used In Financing Activities
NetCashProvidedByUsedInFinancingActivities
49553000
CY2022 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect
-22681000
CY2021 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect
13987000
CY2021Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
44347000
CY2020Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
30360000
CY2022Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
21666000
CY2021Q4 us-gaap Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
44347000
CY2022 cbio Non Cash Or Part Non Cash Dividend Declared Unpaid
NonCashOrPartNonCashDividendDeclaredUnpaid
7558000
CY2022 cbio Cvr Derivative Liability
CVRDerivativeLiability
5000000
CY2021 cbio Non Cash Or Part Non Cash Right Of Use Assets Obtained In Exchange For Operating Lease Liabilities
NonCashOrPartNonCashRightOfUseAssetsObtainedInExchangeForOperatingLeaseLiabilities
1850000
CY2021 cbio Non Cash Or Part Non Cash Remeasurement Of Right Of Use Asset Due To Operating Lease Modification
NonCashOrPartNonCashRemeasurementOfRightOfUseAssetDueToOperatingLeaseModification
624000
CY2022 us-gaap Nature Of Operations
NatureOfOperations
<div style="align:left;"> <table border="0" cellpadding="0" cellspacing="0" style="border-collapse:collapse; width:100%;"> <tr> <td style="width:5.24%;white-space:nowrap" valign="top"> <p style="margin-top:12pt;margin-bottom:0pt;font-weight:bold;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;"><span style="font-weight:bold;font-family:Times New Roman;font-size:10pt;font-style:normal;text-transform:none;font-variant: normal;">1.</span></p></td> <td valign="top"> <p id="NOTES_TO_CONSOLIDATED" style="margin-top:12pt;margin-bottom:0pt;font-weight:bold;font-style:normal;text-transform:none;font-variant: normal;font-family:Times New Roman;font-size:10pt;">Nature of Operations</p></td></tr></table></div> <p style="text-align:justify;margin-top:6pt;margin-bottom:0pt;margin-left:5.24%;text-indent:0%;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Catalyst Biosciences, Inc. and its subsidiary (the “Company” or “Catalyst”) was a <span style="color:#000000;">biopharmaceutical company with expertise in protease engineering. Prior to ceasing research and development activities in March 2022, the Company had several protease assets that were designed to address unmet medical needs in disorders of the complement or coagulation systems. As discussed further below, the Company recently completed a purchase agreement to acquire a clinical-stage drug candidate for the treatment of NASH (nonalcoholic steatohepatitis, a severe form of nonalcoholic fatty liver disease). Concurrent with this purchase agreement, the Company entered into a separate business combination agreement to acquire an indirect controlling interest in a China-based pharmaceutical company. The Company will continue to evaluate the impact of the novel coronavirus disease (“COVID-19”) pandemic on its business, operations, and cash requirements.</span> <span style="color:#000000;">The Company is located in South San Francisco, California and operates in</span> one segment. </p> <p style="text-align:justify;margin-top:12pt;margin-bottom:0pt;margin-left:5.24%;text-indent:0%;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">On May 19, 2022, Catalyst entered into and closed on an asset purchase agreement with Vertex Pharmaceuticals Inc. (“Vertex”), pursuant to which Vertex acquired Catalyst’s complement portfolio, including CB 2782-PEG and CB 4332, as well as its complement-related intellectual property including the ProTUNE<sup style="font-size:85%;line-height:120%;vertical-align:top">TM</sup> and ImmunoTUNE<sup style="font-size:85%;line-height:120%;vertical-align:top">TM</sup> platforms. See Note 16, <span style="font-style:italic;">Restructuring</span>. After the transaction of its complement portfolio, Catalyst’s product candidates consisted of the coagulation related assets marzeptacog alfa (activated) (“MarzAA”), dalcinonacog alfa (“DalcA”), and CB 2679d-GT. MarzAA is a SQ administered next generation engineered coagulation Factor VIIa (“FVIIa”) for the treatment of episodic bleeding and prophylaxis in subjects with rare bleeding disorders. DalcA is a next-generation SQ administered FIX. CB 2679d-GT is an AAV-based gene therapy construct harboring the DalcA sequence. Both MarzAA and DalcA have shown sustained efficacy and safety in mid-stage clinical trials. CB 2679d-GT has obtained preclinical proof-of-concept. Catalyst sold MarzAA, DalcA and CB-2679d-GT in February 2023 to GC Biopharma Corp. (“GCBP”). See Note 17, <span style="font-style:italic;">Subsequent Events.</span></p> <p style="text-align:justify;margin-top:12pt;margin-bottom:0pt;margin-left:5.24%;text-indent:0%;font-weight:bold;font-style:italic;font-family:Times New Roman;font-size:10pt;text-transform:none;font-variant: normal;">F351 Asset Acquisition</p> <p style="text-align:justify;margin-top:6pt;margin-bottom:0pt;margin-left:5.24%;text-indent:0%;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">On December 26, 2022, the Company executed and closed an Asset Purchase Agreement (the “F351 Agreement”), with GNI Group Ltd. and GNI Hong Kong Limited (together “GNI”) to purchase all of the assets and intellectual property rights primarily related to the proprietary Hydronidone compound (collectively, the “F351 Assets”), other than such assets and intellectual property rights located in the People’s Republic of China. At the closing of the agreement on December 26, 2022, the Company paid $35.0 million in the form of 6,266,521 shares of Catalyst common stock and 12,340 shares of newly designated Series X redeemable convertible preferred stock (“Catalyst Convertible Preferred Stock”). Each share of Catalyst Convertible Preferred Stock is convertible into 10,000 shares of common stock, subject to stockholder approval under Nasdaq rules and subject to a beneficial ownership conversion blocker. For additional information, see Note 4, <span style="font-style:italic;">F351 Asset Acquisition </span>and Note<span style="font-style:italic;"> </span>14<span style="font-style:italic;">, Stockholders’ Equity</span>.</p> <p style="text-align:justify;margin-top:12pt;margin-bottom:0pt;margin-left:5.24%;text-indent:0%;font-weight:bold;font-style:italic;font-family:Times New Roman;font-size:10pt;text-transform:none;font-variant: normal;">Business Combination Agreement</p> <p style="text-align:justify;margin-top:6pt;margin-bottom:0pt;margin-left:5.24%;text-indent:0%;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Concurrent with the F351 Asset acquisition, the Company signed a definitive agreement with GNI Group Ltd., GNI Hong Kong Limited, GNI USA, Inc., Continent Pharmaceuticals Inc. and Shanghai Genomics, Inc. (collectively, “GNI”) and other minority stockholders to acquire an indirect controlling interest in Beijing Continent Pharmaceutical Co Ltd. (“BC”), a commercial-stage pharmaceutical company based in China and majority-owned subsidiary of GNI, in exchange for newly issued shares of common stock (the “Business Combination Agreement”). The closing of the Business Combination Agreement will be subject to stockholder approval at a stockholder meeting expected to be held in the third quarter of 2023 and certain customary closing conditions. For additional information, see Note 8, <span style="font-style:italic;">Commitments and Contingencies</span>.</p> <p style="text-align:justify;margin-top:12pt;margin-bottom:0pt;margin-left:5.24%;text-indent:0%;font-weight:bold;font-style:italic;font-family:Times New Roman;font-size:10pt;text-transform:none;font-variant: normal;">Contingent Value Rights Agreement</p> <p style="text-align:justify;margin-top:6pt;margin-bottom:0pt;margin-left:5.24%;text-indent:0%;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">Pursuant to the Business Combination Agreement, on December 26, 2022, Catalyst and the Rights Agent (as defined therein) executed a contingent value rights agreement (the “CVR Agreement”), pursuant to which each holder of Catalyst common stock as of January 5, 2023 (the “CVR Holders”), excluding GNI, received one </p> <p style="text-align:justify;margin-top:6pt;margin-bottom:0pt;margin-left:5.24%;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"><span style="font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">contractual contingent value right</span><span style="font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"> (a “CVR”)</span><span style="font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"> issued by the Company for each share of Catalyst common stock held by such holder. Each </span><span style="font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">CVR </span><span style="font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">entitles the holder thereof to receive</span><span style="font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;"> certain cash payments in the future. For additional information, see Note 8, </span><span style="font-style:italic;">Commitments and Contingencies</span><span style="font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">. </span></p>
CY2022 us-gaap Number Of Operating Segments
NumberOfOperatingSegments
1
CY2022Q3 us-gaap Common Stock Dividends Per Share Cash Paid
CommonStockDividendsPerShareCashPaid
1.43
CY2022Q3 us-gaap Dividends Payable Date Of Record Day Month And Year
DividendsPayableDateOfRecordDayMonthAndYear
2022-09-06
CY2022Q3 us-gaap Payments Of Dividends Common Stock
PaymentsOfDividendsCommonStock
45000000.0
CY2022Q4 us-gaap Payments Of Dividends Common Stock
PaymentsOfDividendsCommonStock
7600000
CY2022Q4 us-gaap Dividends Payable Date Of Record Day Month And Year
DividendsPayableDateOfRecordDayMonthAndYear
2022-01-05
CY2022 us-gaap Net Income Loss
NetIncomeLoss
-8200000
CY2022Q4 us-gaap Retained Earnings Accumulated Deficit
RetainedEarningsAccumulatedDeficit
-410900000
CY2022Q4 us-gaap Cash Cash Equivalents And Short Term Investments
CashCashEquivalentsAndShortTermInvestments
21700000
CY2022 us-gaap Use Of Estimates
UseOfEstimates
<p style="text-align:justify;margin-top:12pt;margin-bottom:0pt;margin-left:5.24%;text-indent:0%;font-weight:bold;font-style:italic;font-family:Times New Roman;font-size:10pt;text-transform:none;font-variant: normal;">Use of Estimates</p> <p style="text-align:justify;margin-top:6pt;margin-bottom:0pt;margin-left:5.24%;text-indent:0%;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">The preparation of consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. On an ongoing basis, management evaluates its estimates, including those related to revenue recognition, allowance of doubtful accounts, contingent value rights, operating lease right-of-use assets and liabilities, accrued expenses, income taxes and stock-based compensation. The Company bases its estimates on various assumptions that the Company believes to be reasonable under the circumstances. Actual results could differ from those estimates.</p>
CY2022 us-gaap Derivatives Methods Of Accounting Hedging Derivatives
DerivativesMethodsOfAccountingHedgingDerivatives
<p style="text-align:justify;margin-top:12pt;margin-bottom:0pt;margin-left:5.48%;text-indent:0%;font-weight:bold;font-style:italic;font-family:Times New Roman;font-size:10pt;text-transform:none;font-variant: normal;">Derivative Financial Instruments</p> <p style="text-align:justify;margin-top:6pt;margin-bottom:0pt;margin-left:5.24%;text-indent:0%;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">The Company evaluates its contracts to determine if those contracts qualify as derivatives under ASC 815, <span style="font-style:italic;">Derivatives and Hedging</span>. For derivative financial instruments that are accounted for as liabilities, the derivative instrument is initially recorded at its fair value and is then re-valued at each reporting date. Any changes in fair value are recorded as non-operating, non-cash other income or expense for each reporting period. Derivative instrument liabilities are classified in the balance sheet as current or non-current based on whether or not net-cash settlement of the derivative instrument is probable within the next 12 months from the balance sheet date.</p> <p style="text-align:justify;margin-top:12pt;margin-bottom:0pt;margin-left:5.24%;text-indent:0%;font-family:Times New Roman;font-size:10pt;font-weight:normal;font-style:normal;text-transform:none;font-variant: normal;">The Company determined that certain contingent payments under the CVR Agreement qualified as derivatives under ASC 815, and as such, were recorded as a liability on the balance sheet as of December 31, 2022. Refer to Note 5, <span style="font-style:italic;">Fair Value Measurement</span> and Note 8, <span style="font-style:italic;">Commitments and Contingencies</span>, for additional information regarding the CVR derivative liability.</p>
CY2022 us-gaap Concentration Risk Credit Risk Financial Instrument Maximum Exposure
ConcentrationRiskCreditRiskFinancialInstrumentMaximumExposure
21400000
CY2022Q4 us-gaap Allowance For Doubtful Accounts Receivable
AllowanceForDoubtfulAccountsReceivable
200000
CY2021Q4 us-gaap Allowance For Doubtful Accounts Receivable
AllowanceForDoubtfulAccountsReceivable
0
CY2022Q4 us-gaap Assets Fair Value Disclosure
AssetsFairValueDisclosure
21666000
CY2022Q4 us-gaap Liabilities Fair Value Disclosure
LiabilitiesFairValueDisclosure
5000000
CY2021Q4 us-gaap Assets Fair Value Disclosure
AssetsFairValueDisclosure
46851000
CY2022Q4 us-gaap Available For Sale Debt Securities Amortized Cost Basis
AvailableForSaleDebtSecuritiesAmortizedCostBasis
21666000
CY2022Q4 us-gaap Available For Sale Securities Debt Securities
AvailableForSaleSecuritiesDebtSecurities
21666000
CY2022Q4 us-gaap Available For Sale Securities Debt Securities
AvailableForSaleSecuritiesDebtSecurities
21666000
CY2021Q4 us-gaap Available For Sale Debt Securities Amortized Cost Basis
AvailableForSaleDebtSecuritiesAmortizedCostBasis
46851000
CY2021Q4 us-gaap Available For Sale Securities Debt Securities
AvailableForSaleSecuritiesDebtSecurities
46851000
CY2021Q4 us-gaap Available For Sale Securities Debt Securities
AvailableForSaleSecuritiesDebtSecurities
46851000
CY2022 us-gaap Debt Securities Available For Sale Realized Gain Loss
DebtSecuritiesAvailableForSaleRealizedGainLoss
0
CY2022Q4 us-gaap Available For Sale Securities Debt Securities Current
AvailableForSaleSecuritiesDebtSecuritiesCurrent
0
CY2022Q4 us-gaap Accrued Professional Fees Current
AccruedProfessionalFeesCurrent
1417000
CY2021Q4 us-gaap Accrued Professional Fees Current
AccruedProfessionalFeesCurrent
509000
CY2022Q4 cbio Accrued Manufacturing Expenses Current
AccruedManufacturingExpensesCurrent
22000
CY2021Q4 cbio Accrued Manufacturing Expenses Current
AccruedManufacturingExpensesCurrent
1381000
CY2021Q4 cbio Accrued Collaboration Expenses Current
AccruedCollaborationExpensesCurrent
868000
CY2021Q4 cbio Accrued Pre Clinical Expenses Current
AccruedPreClinicalExpensesCurrent
773000
CY2021Q4 cbio Accrued Clinical Expenses Current
AccruedClinicalExpensesCurrent
361000
CY2022Q4 cbio Accrued And Other Current Liabilities
AccruedAndOtherCurrentLiabilities
13000
CY2021Q4 cbio Accrued And Other Current Liabilities
AccruedAndOtherCurrentLiabilities
180000
CY2022Q4 us-gaap Other Accrued Liabilities Current
OtherAccruedLiabilitiesCurrent
1452000
CY2021Q4 us-gaap Other Accrued Liabilities Current
OtherAccruedLiabilitiesCurrent
4072000
CY2022Q2 cbio Percentage Of Common Stock Filed Lawsuit
PercentageOfCommonStockFiledLawsuit
0.05
CY2022 us-gaap Lease Expiration Date1
LeaseExpirationDate1
2023-04-30
CY2022 cbio Lessee Operating Lease Renewal Term Description
LesseeOperatingLeaseRenewalTermDescription
no stated renewal options
CY2021Q4 us-gaap Right Of Use Asset Obtained In Exchange For Operating Lease Liability
RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability
600000
CY2022 us-gaap Operating Lease Expense
OperatingLeaseExpense
1700000
CY2021 us-gaap Operating Lease Expense
OperatingLeaseExpense
1700000
CY2022Q4 us-gaap Operating Lease Weighted Average Remaining Lease Term1
OperatingLeaseWeightedAverageRemainingLeaseTerm1
P0Y3M18D
CY2021Q4 us-gaap Operating Lease Weighted Average Remaining Lease Term1
OperatingLeaseWeightedAverageRemainingLeaseTerm1
P1Y3M18D
CY2022Q4 us-gaap Operating Lease Weighted Average Discount Rate Percent
OperatingLeaseWeightedAverageDiscountRatePercent
0.043
CY2021Q4 us-gaap Operating Lease Weighted Average Discount Rate Percent
OperatingLeaseWeightedAverageDiscountRatePercent
0.048
CY2022Q4 us-gaap Lessee Operating Lease Liability Payments Due Next Twelve Months
LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths
38000
CY2022Q4 us-gaap Lessee Operating Lease Liability Payments Due
LesseeOperatingLeaseLiabilityPaymentsDue
38000
CY2022Q4 us-gaap Operating Lease Liability
OperatingLeaseLiability
38000
CY2022 cbio Cash Paid For Amounts Included In The Measurement Of Lease Liabilities
CashPaidForAmountsIncludedInTheMeasurementOfLeaseLiabilities
1512000
CY2021 cbio Cash Paid For Amounts Included In The Measurement Of Lease Liabilities
CashPaidForAmountsIncludedInTheMeasurementOfLeaseLiabilities
1641000
CY2021 cbio Prepaid Cash Payment For Lease Liabilities
PrepaidCashPaymentForLeaseLiabilities
208000
CY2022 us-gaap Operating Lease Payments
OperatingLeasePayments
1512000
CY2021 us-gaap Operating Lease Payments
OperatingLeasePayments
1849000
CY2022Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant
12990839
CY2022 us-gaap Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested Number Of Shares
SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedNumberOfShares
0
CY2022Q3 us-gaap Payments Of Dividends Common Stock
PaymentsOfDividendsCommonStock
45000000.0
CY2022Q3 us-gaap Common Stock Dividends Per Share Cash Paid
CommonStockDividendsPerShareCashPaid
1.43
CY2021Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
2603630
CY2021Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
7.70
CY2022 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross
10270911
CY2022 us-gaap Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice
1.34
CY2022 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriod
4148455
CY2022 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period Weighted Average Exercise Price
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice
4.96
CY2022 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Expirations In Period
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod
47319
CY2022 us-gaap Share Based Compensation Arrangements By Share Based Payment Award Options Expirations In Period Weighted Average Exercise Price
ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice
13.27
CY2022Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
8678767
CY2022Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
1.42
CY2022Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue
1051000
CY2022Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber
4317076
CY2022Q4 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice
2.38
CY2022 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
0.96
CY2021 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
4.00
CY2022 us-gaap Stock Issued During Period Shares Stock Options Exercised
StockIssuedDuringPeriodSharesStockOptionsExercised
0
CY2021 us-gaap Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue
3000
CY2022 us-gaap Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested In Period Fair Value1
SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue1
1900000
CY2021 us-gaap Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested In Period Fair Value1
SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedInPeriodFairValue1
2600000
CY2022 us-gaap Allocated Share Based Compensation Expense
AllocatedShareBasedCompensationExpense
1342000
CY2021 us-gaap Allocated Share Based Compensation Expense
AllocatedShareBasedCompensationExpense
3405000
CY2022 us-gaap Stock Issued During Period Shares Issued For Services
StockIssuedDuringPeriodSharesIssuedForServices
32684
CY2021 us-gaap Stock Issued During Period Shares Issued For Services
StockIssuedDuringPeriodSharesIssuedForServices
56912
CY2022 us-gaap Current Federal Tax Expense Benefit
CurrentFederalTaxExpenseBenefit
341000
CY2022 us-gaap Current State And Local Tax Expense Benefit
CurrentStateAndLocalTaxExpenseBenefit
7000
CY2022 us-gaap Current Federal State And Local Tax Expense Benefit
CurrentFederalStateAndLocalTaxExpenseBenefit
348000
CY2022 us-gaap Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
0.2100
CY2021 us-gaap Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
0.2100
CY2022 us-gaap Effective Income Tax Rate Reconciliation State And Local Income Taxes
EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes
0.0001
CY2021 us-gaap Effective Income Tax Rate Reconciliation State And Local Income Taxes
EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes
0.0000
CY2022 cbio Effective Income Tax Rate Reconciliation Permanent Differences
EffectiveIncomeTaxRateReconciliationPermanentDifferences
-0.0100
CY2021 cbio Effective Income Tax Rate Reconciliation Permanent Differences
EffectiveIncomeTaxRateReconciliationPermanentDifferences
-0.0035
CY2022 us-gaap Effective Income Tax Rate Reconciliation Tax Credits
EffectiveIncomeTaxRateReconciliationTaxCredits
0.4208
CY2021 us-gaap Effective Income Tax Rate Reconciliation Tax Credits
EffectiveIncomeTaxRateReconciliationTaxCredits
0.0586
CY2022 cbio Effective Income Tax Rate Reconciliation Derecognition
EffectiveIncomeTaxRateReconciliationDerecognition
-1.3900
CY2022 us-gaap Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance
0.6924
CY2022 cbio Effective Income Tax Rate Reconciliation Fixed Assets Other Adjustment Percent
EffectiveIncomeTaxRateReconciliationFixedAssetsOtherAdjustmentPercent
0.0119
CY2021 cbio Effective Income Tax Rate Reconciliation Fixed Assets Other Adjustment Percent
EffectiveIncomeTaxRateReconciliationFixedAssetsOtherAdjustmentPercent
0.0000
CY2021 us-gaap Effective Income Tax Rate Reconciliation Nondeductible Expense Other
EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther
-0.0025
CY2022 us-gaap Effective Income Tax Rate Continuing Operations
EffectiveIncomeTaxRateContinuingOperations
0.0441
CY2021 us-gaap Effective Income Tax Rate Continuing Operations
EffectiveIncomeTaxRateContinuingOperations
0.0000
CY2022Q4 us-gaap Deferred Tax Assets Tax Deferred Expense Reserves And Accruals
DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals
1273000
CY2021Q4 us-gaap Deferred Tax Assets Tax Deferred Expense Reserves And Accruals
DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals
1000000
CY2022Q4 us-gaap Deferred Tax Assets Operating Loss Carryforwards
DeferredTaxAssetsOperatingLossCarryforwards
40770000
CY2021Q4 us-gaap Deferred Tax Assets Operating Loss Carryforwards
DeferredTaxAssetsOperatingLossCarryforwards
47541000
CY2022Q4 us-gaap Deferred Tax Assets Tax Credit Carryforwards Research
DeferredTaxAssetsTaxCreditCarryforwardsResearch
4463000
CY2021Q4 us-gaap Deferred Tax Assets Tax Credit Carryforwards Research
DeferredTaxAssetsTaxCreditCarryforwardsResearch
12939000
CY2022Q4 cbio Deferred Tax Assets Fixed Assets And Intangibles
DeferredTaxAssetsFixedAssetsAndIntangibles
9510000
CY2021Q4 cbio Deferred Tax Assets Fixed Assets And Intangibles
DeferredTaxAssetsFixedAssetsAndIntangibles
3000
CY2022Q4 us-gaap Deferred Tax Assets Valuation Allowance
DeferredTaxAssetsValuationAllowance
56016000
CY2021Q4 us-gaap Deferred Tax Assets Valuation Allowance
DeferredTaxAssetsValuationAllowance
61483000
CY2022 us-gaap Valuation Allowances And Reserves Period Increase Decrease
ValuationAllowancesAndReservesPeriodIncreaseDecrease
-5500000
CY2021 us-gaap Valuation Allowances And Reserves Period Increase Decrease
ValuationAllowancesAndReservesPeriodIncreaseDecrease
23100000
CY2022 cbio Research And Development Tax Credit Carry Forwards Derecognized
ResearchAndDevelopmentTaxCreditCarryForwardsDerecognized
26100000
CY2022Q4 us-gaap Unrecognized Tax Benefits
UnrecognizedTaxBenefits
1900000
CY2021Q4 us-gaap Unrecognized Tax Benefits
UnrecognizedTaxBenefits
4700000
CY2020Q4 us-gaap Unrecognized Tax Benefits
UnrecognizedTaxBenefits
2955000
CY2021 us-gaap Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions
UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions
1749000
CY2021Q4 us-gaap Unrecognized Tax Benefits
UnrecognizedTaxBenefits
4704000
CY2022 cbio Unrecognized Tax Benefits Increase Decrease Resulting From Prior Period Tax Positions
UnrecognizedTaxBenefitsIncreaseDecreaseResultingFromPriorPeriodTaxPositions
-2841000
CY2022 us-gaap Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions
UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions
20000
CY2022Q4 us-gaap Unrecognized Tax Benefits
UnrecognizedTaxBenefits
1883000
CY2022Q4 us-gaap Income Tax Examination Penalties And Interest Accrued
IncomeTaxExaminationPenaltiesAndInterestAccrued
0
CY2021Q4 us-gaap Income Tax Examination Penalties And Interest Accrued
IncomeTaxExaminationPenaltiesAndInterestAccrued
0
CY2022Q4 us-gaap Liability For Uncertain Tax Positions Current
LiabilityForUncertainTaxPositionsCurrent
0
CY2021Q4 us-gaap Liability For Uncertain Tax Positions Current
LiabilityForUncertainTaxPositionsCurrent
0
CY2022 us-gaap Deferred Revenue Revenue Recognized1
DeferredRevenueRevenueRecognized1
200000
CY2022 us-gaap Interest Income Expense Nonoperating Net
InterestIncomeExpenseNonoperatingNet
537000
CY2021 us-gaap Interest Income Expense Nonoperating Net
InterestIncomeExpenseNonoperatingNet
39000
CY2022 cbio Gain Loss From Extinguishment Of Liability
GainLossFromExtinguishmentOfLiability
180000
CY2021 us-gaap Other Nonoperating Income Expense
OtherNonoperatingIncomeExpense
-78000
CY2022 cbio Interest And Other Income Expense Net
InterestAndOtherIncomeExpenseNet
717000
CY2021 cbio Interest And Other Income Expense Net
InterestAndOtherIncomeExpenseNet
-39000
CY2022Q4 us-gaap Common Stock Shares Authorized
CommonStockSharesAuthorized
100000000
CY2022Q4 us-gaap Common Stock Par Or Stated Value Per Share
CommonStockParOrStatedValuePerShare
0.001
CY2022 us-gaap Common Stock Voting Rights
CommonStockVotingRights
one vote
CY2022Q4 us-gaap Preferred Stock Shares Authorized
PreferredStockSharesAuthorized
5000000
CY2022Q4 us-gaap Preferred Stock Par Or Stated Value Per Share
PreferredStockParOrStatedValuePerShare
0.001
CY2022 us-gaap Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
132078767
CY2021 us-gaap Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
2603715
CY2021Q4 us-gaap Restructuring And Related Cost Number Of Positions Eliminated Period Percent
RestructuringAndRelatedCostNumberOfPositionsEliminatedPeriodPercent
0.35
CY2021 us-gaap Severance Costs1
SeveranceCosts1
400000
CY2021 cbio Charges Related To Write Off Of Prepaid Manufacturing Cost
ChargesRelatedToWriteOffOfPrepaidManufacturingCost
3800000
CY2021 cbio Restructuring Liability
RestructuringLiability
200000
CY2022Q1 us-gaap Restructuring And Related Cost Number Of Positions Eliminated
RestructuringAndRelatedCostNumberOfPositionsEliminated
22
CY2022Q1 cbio Remaining Number Of Full Time Employees
RemainingNumberOfFullTimeEmployees
5
CY2022 us-gaap Restructuring Charges
RestructuringCharges
1011000
CY2021 us-gaap Restructuring Charges
RestructuringCharges
4168000

Files In Submission

Name View Source Status
0001564590-23-004830-index-headers.html Edgar Link pending
0001564590-23-004830-index.html Edgar Link pending
0001564590-23-004830.txt Edgar Link pending
0001564590-23-004830-xbrl.zip Edgar Link pending
cbio-10k_20221231.htm Edgar Link pending
cbio-20221231.xsd Edgar Link pending
cbio-ex231_8.htm Edgar Link pending
cbio-ex311_6.htm Edgar Link pending
cbio-ex312_10.htm Edgar Link pending
cbio-ex321_9.htm Edgar Link pending
cbio-ex322_11.htm Edgar Link pending
Financial_Report.xlsx Edgar Link pending
garhgr05lopy000001.jpg Edgar Link pending
garhgr05lopy000002.jpg Edgar Link pending
MetaLinks.json Edgar Link pending
cbio-20221231_cal.xml Edgar Link unprocessable
cbio-20221231_def.xml Edgar Link unprocessable
cbio-20221231_lab.xml Edgar Link unprocessable
cbio-20221231_pre.xml Edgar Link unprocessable
FilingSummary.xml Edgar Link unprocessable
cbio-10k_20221231_htm.xml Edgar Link completed
R1.htm Edgar Link pending
R10.htm Edgar Link pending
R11.htm Edgar Link pending
R12.htm Edgar Link pending
R13.htm Edgar Link pending
R14.htm Edgar Link pending
R15.htm Edgar Link pending
R16.htm Edgar Link pending
R17.htm Edgar Link pending
R18.htm Edgar Link pending
R19.htm Edgar Link pending
R2.htm Edgar Link pending
R20.htm Edgar Link pending
R21.htm Edgar Link pending
R22.htm Edgar Link pending
R23.htm Edgar Link pending
R24.htm Edgar Link pending
R25.htm Edgar Link pending
R26.htm Edgar Link pending
R27.htm Edgar Link pending
R28.htm Edgar Link pending
R29.htm Edgar Link pending
R3.htm Edgar Link pending
R30.htm Edgar Link pending
R31.htm Edgar Link pending
R32.htm Edgar Link pending
R33.htm Edgar Link pending
R34.htm Edgar Link pending
R35.htm Edgar Link pending
R36.htm Edgar Link pending
R37.htm Edgar Link pending
R38.htm Edgar Link pending
R39.htm Edgar Link pending
R4.htm Edgar Link pending
R40.htm Edgar Link pending
R41.htm Edgar Link pending
R42.htm Edgar Link pending
R43.htm Edgar Link pending
R44.htm Edgar Link pending
R45.htm Edgar Link pending
R46.htm Edgar Link pending
R47.htm Edgar Link pending
R48.htm Edgar Link pending
R49.htm Edgar Link pending
R5.htm Edgar Link pending
R50.htm Edgar Link pending
R51.htm Edgar Link pending
R52.htm Edgar Link pending
R53.htm Edgar Link pending
R54.htm Edgar Link pending
R55.htm Edgar Link pending
R56.htm Edgar Link pending
R57.htm Edgar Link pending
R58.htm Edgar Link pending
R59.htm Edgar Link pending
R6.htm Edgar Link pending
R60.htm Edgar Link pending
R61.htm Edgar Link pending
R62.htm Edgar Link pending
R63.htm Edgar Link pending
R64.htm Edgar Link pending
R65.htm Edgar Link pending
R66.htm Edgar Link pending
R7.htm Edgar Link pending
R8.htm Edgar Link pending
R9.htm Edgar Link pending
report.css Edgar Link pending
Show.js Edgar Link pending