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$HOWL

$0.35 -$0.04 (9.83%)

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Insider Transactions

Insider Transaction Summary

Capital Healthcare Fund LP RA

5,076,685 shares

Net: -1,160,797 B/S: -

ANSBERT GADICKE

4,784,111 shares

Net: -1,934,559 B/S: -

BioVentures 2014, L.P. MPM

4,784,111 shares

Net: -1,934,559 B/S: -

Todd Foley

3,208,793 shares

Net: 0 B/S: -

MANAGEMENT COMPANY, L.P. (SERIES C) DEERFIELD

2,552,787 shares

Net: 0 B/S: -

Ventures LLC Taiho

2,068,909 shares

Net: 0 B/S: -

Sakae Asanuma

2,068,909 shares

Net: 0 B/S: -

Moshe Arkin

2,046,634 shares

Net: 0 B/S: -

Fund III, L.P. Longwood

1,677,082 shares

Net: 0 B/S: -

UPMC

823,945 shares

Net: 0 B/S: -

FUNDS MANAGEMENT LTD. SPHERA

787,997 shares

Net: 0 B/S: -

Healthcare Investments (Cayman) Ltd. HBM

625,995 shares

Net: 0 B/S: -

DANIEL J HICKLIN

592,690 shares

Net: 0 B/S: -

LUKE EVNIN

300,283 shares

Net: -4,009,577 B/S: -

Steven H. Bloom

201,720 shares

Net: 0 B/S: -

Randi Isaacs

187,500 shares

Net: 0 B/S: -

Timothy W. Trost

150,000 shares

Net: 0 B/S: -

Chulani Karunatilake

150,000 shares

Net: 0 B/S: -

Cynthia Seidel-Dugan

150,000 shares

Net: 0 B/S: -

Ellen Lubman

131,900 shares

Net: 0 B/S: -

Reid Leonard

93,600 shares

Net: 0 B/S: -

Briggs Morrison

27,000 shares

Net: 0 B/S: -

Michael B. Atkins

27,000 shares

Net: 0 B/S: -

Meeta Chatterjee

27,000 shares

Net: 0 B/S: -

Michael A. Sherman

27,000 shares

Net: 0 B/S: -

Alon Lazarus

27,000 shares

Net: 0 B/S: -

Derek DiRocco

17,500 shares

Net: 0 B/S: -

Anil K. Singhal

8,358 shares

Net: 0 B/S: -

Insider Name	Current Shares	Net Change (1yr)	Buy/Sell Ratio
Capital Healthcare Fund LP RA	5,076,685	-1,160,797	-
ANSBERT GADICKE	4,784,111	-1,934,559	-
BioVentures 2014, L.P. MPM	4,784,111	-1,934,559	-
Todd Foley	3,208,793	0	-
MANAGEMENT COMPANY, L.P. (SERIES C) DEERFIELD	2,552,787	0	-
Ventures LLC Taiho	2,068,909	0	-
Sakae Asanuma	2,068,909	0	-
Moshe Arkin	2,046,634	0	-
Fund III, L.P. Longwood	1,677,082	0	-
UPMC	823,945	0	-
FUNDS MANAGEMENT LTD. SPHERA	787,997	0	-
Healthcare Investments (Cayman) Ltd. HBM	625,995	0	-
DANIEL J HICKLIN	592,690	0	-
LUKE EVNIN	300,283	-4,009,577	-
Steven H. Bloom	201,720	0	-
Randi Isaacs	187,500	0	-
Timothy W. Trost	150,000	0	-
Chulani Karunatilake	150,000	0	-
Cynthia Seidel-Dugan	150,000	0	-
Ellen Lubman	131,900	0	-
Reid Leonard	93,600	0	-
Briggs Morrison	27,000	0	-
Michael B. Atkins	27,000	0	-
Meeta Chatterjee	27,000	0	-
Michael A. Sherman	27,000	0	-
Alon Lazarus	27,000	0	-
Derek DiRocco	17,500	0	-
Anil K. Singhal	8,358	0	-

Individual Transactions

June 11, 2026

Capital Healthcare Fund LP RA

Open Market Sale

Change: -245,066

Price: $0.38

Shares: 5,076,685

Value: -$93,125

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Capital Healthcare Fund LP RA	Jun 11	Open Market Sale (S) Market Sale	5,076,685	-245,066	$0.38	-$93,125

June 10, 2026

Capital Healthcare Fund LP RA

Open Market Sale

Change: -42,872

Price: $0.37

Shares: 5,321,751

Value: -$15,862

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Capital Healthcare Fund LP RA	Jun 11	Open Market Sale (S) Market Sale	5,321,751	-42,872	$0.37	-$15,862

June 09, 2026

Capital Healthcare Fund LP RA

Open Market Sale

Change: -345,235

Price: $0.37

Shares: 5,364,623

Value: -$127,736

LUKE EVNIN

Open Market Sale

Change: -76,928

Price: $0.37

Shares: 300,283

Value: -$28,463

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Capital Healthcare Fund LP RA	Jun 11	Open Market Sale (S) Market Sale	5,364,623	-345,235	$0.37	-$127,736
LUKE EVNIN	Jun 10	Open Market Sale (S) Market Sale	300,283	-76,928	$0.37	-$28,463

June 08, 2026

LUKE EVNIN

Open Market Sale

Change: -60,547

Price: $0.40

Shares: 377,211

Value: -$24,218

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	Jun 08	Open Market Sale (S) Market Sale	377,211	-60,547	$0.40	-$24,218

June 05, 2026

LUKE EVNIN

Open Market Sale

Change: -24,946

Price: $0.40

Shares: 437,758

Value: -$9,978

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	Jun 08	Open Market Sale (S) Market Sale	437,758	-24,946	$0.40	-$9,978

June 04, 2026

LUKE EVNIN

Open Market Sale

Change: -20,072

Price: $0.44

Shares: 462,704

Value: -$8,831

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	Jun 08	Open Market Sale (S) Market Sale	462,704	-20,072	$0.44	-$8,831

June 03, 2026

LUKE EVNIN

Open Market Sale

Change: -29,749

Price: $0.42

Shares: 482,776

Value: -$12,494

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	Jun 03	Open Market Sale (S) Market Sale	482,776	-29,749	$0.42	-$12,494

June 02, 2026

LUKE EVNIN

Open Market Sale

Change: -29,595

Price: $0.45

Shares: 512,525

Value: -$13,317

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	Jun 03	Open Market Sale (S) Market Sale	512,525	-29,595	$0.45	-$13,317

June 01, 2026

LUKE EVNIN

Open Market Sale

Change: -80,459

Price: $0.47

Shares: 542,120

Value: -$37,815

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	Jun 03	Open Market Sale (S) Market Sale	542,120	-80,459	$0.47	-$37,815

May 29, 2026

LUKE EVNIN

Open Market Sale

Change: -32,556

Price: $0.45

Shares: 622,579

Value: -$14,650

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	May 29	Open Market Sale (S) Market Sale	622,579	-32,556	$0.45	-$14,650

May 28, 2026

LUKE EVNIN

Open Market Sale

Change: -27,698

Price: $0.46

Shares: 655,135

Value: -$12,741

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	May 29	Open Market Sale (S) Market Sale	655,135	-27,698	$0.46	-$12,741

May 27, 2026

LUKE EVNIN

Open Market Sale

Change: -80,852

Price: $0.48

Shares: 682,833

Value: -$38,808

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	May 29	Open Market Sale (S) Market Sale	682,833	-80,852	$0.48	-$38,808

May 26, 2026

LUKE EVNIN

Open Market Sale

Change: -67,950

Price: $0.47

Shares: 763,685

Value: -$31,936

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	May 26	Open Market Sale (S) Market Sale	763,685	-67,950	$0.47	-$31,936

May 22, 2026

LUKE EVNIN

Open Market Sale

Change: -87,425

Price: $0.45

Shares: 831,635

Value: -$39,341

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	May 26	Open Market Sale (S) Market Sale	831,635	-87,425	$0.45	-$39,341

May 21, 2026

LUKE EVNIN

Open Market Sale

Change: -36,387

Price: $0.42

Shares: 919,060

Value: -$15,282

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	May 26	Open Market Sale (S) Market Sale	919,060	-36,387	$0.42	-$15,282

May 20, 2026

LUKE EVNIN

Open Market Sale

Change: -85,895

Price: $0.43

Shares: 955,447

Value: -$36,934

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	May 20	Open Market Sale (S) Market Sale	955,447	-85,895	$0.43	-$36,934

May 19, 2026

LUKE EVNIN

Open Market Sale

Change: -62,970

Price: $0.45

Shares: 1,041,342

Value: -$28,336

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	May 20	Open Market Sale (S) Market Sale	1,041,342	-62,970	$0.45	-$28,336

May 18, 2026

LUKE EVNIN

Open Market Sale

Change: -22,184

Price: $0.50

Shares: 1,104,312

Value: -$11,092

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	May 20	Open Market Sale (S) Market Sale	1,104,312	-22,184	$0.50	-$11,092

May 13, 2026

LUKE EVNIN

Open Market Sale

Change: -44,679

Price: $0.54

Shares: 1,126,496

Value: -$24,126

Insider	Filing Date	Transaction	Shares	Change	Price	Value
LUKE EVNIN	May 13	Open Market Sale (S) Market Sale	1,126,496	-44,679	$0.54	-$24,126