| Insider Name | Current Shares | Net Change (1yr) | Buy/Sell Ratio |
|---|---|---|---|
| Peter W. Sonsini | 4,186,243 | 0 | - |
| PETER J BARRIS | 4,186,243 | 0 | - |
| JOSHUA MAKOWER | 4,186,243 | 0 | - |
| DAVID M MOTT | 4,186,243 | 0 | - |
| Life Sciences IX, L.P. Frazier | 3,566,912 | 0 | - |
| Holdings A/S Novo | 2,445,147 | 0 | - |
| Carmen Chang | 2,186,243 | 0 | - |
| Paul Edward Walker | 2,186,243 | 0 | - |
| Ali Behbahani | 2,186,243 | 0 | - |
| SCOTT D SANDELL | 2,186,243 | 0 | - |
| Enterprise Associates 16, L.P. New | 2,186,243 | 0 | - |
| Mohamad Makhzoumi | 2,186,243 | 0 | - |
| Partners 16, L.P. NEA | 2,186,243 | 0 | - |
| Anthony A. Jr. Florence | 2,186,243 | 0 | - |
| FOREST BASKETT | 2,186,243 | 0 | - |
| MANAGEMENT COMPANY, L.P. (SERIES C) DEERFIELD | 1,711,324 | 0 | - |
| Niall O'Donnell | 1,621,118 | 0 | - |
| James E Flynn | 1,558,456 | 0 | - |
| Patrick J Heron | 459,010 | +290,702 | ∞ |
| Christopher Peetz | 194,309 | +51,338 | 1.5 |
| Lara Longpre | 104,407 | 0 | - |
| MICHAEL G GREY | 50,000 | 0 | 1.0 |
| ERIC BJERKHOLT | 49,788 | +31,423 | 2.15 |
| Edwin Jonathan Tucker | 45,838 | 0 | - |
| Peter Radovich | 40,272 | +23,498 | 1.95 |
| Ian Clements | 30,011 | 0 | - |
| Pamela Vig | 27,406 | 0 | - |
| Joanne Quan | 18,864 | +31,288 | 2.95 |
| Laura Brege | 17,194 | +1,491 | 1.1 |
| Edward T Mathers | 17,000 | 0 | - |
| Carol L Brosgart | 15,583 | 0 | - |
| Jolanda Howe | 8,429 | +7,683 | 1.42 |
| Laurent Fischer | 6,268 | 0 | - |
| Timothy P Walbert | 6,268 | 0 | - |
| Lon Cardon | 6,268 | 0 | - |
| William Fairey | 2,500 | -3,203 | - |
| Saira Ramasastry | 0 | +1,000 | 1.03 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Saira Ramasastry | Apr 16 |
Option Exercise/Conversion (M)
Compensation/Award
|
2,000 | +2,000 | $23.51 | +$47,020 |
| Saira Ramasastry | Apr 16 |
Open Market Sale (S)
Market Sale
|
0 | -2,000 | $96.90 | -$193,800 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| ERIC BJERKHOLT | Mar 17 |
Open Market Sale (S)
Market Sale
|
49,788 | -7,287 | $91.98 | -$670,242 |
| Jolanda Howe | Mar 17 |
Open Market Sale (S)
Market Sale
|
8,429 | -4,732 | $91.98 | -$435,239 |
| Joanne Quan | Mar 17 |
Open Market Sale (S)
Market Sale
|
18,864 | -7,287 | $91.98 | -$670,242 |
| Peter Radovich | Mar 17 |
Open Market Sale (S)
Market Sale
|
40,272 | -16,515 | $91.98 | -$1,519,015 |
| Christopher Peetz | Mar 17 |
Open Market Sale (S)
Market Sale
|
194,309 | -40,985 | $91.98 | -$3,769,714 |
| Saira Ramasastry | Mar 17 |
Option Exercise/Conversion (M)
Compensation/Award
|
2,000 | +2,000 | $23.51 | +$47,020 |
| Saira Ramasastry | Mar 17 |
Open Market Sale (S)
Market Sale
|
0 | -2,000 | $90.76 | -$181,520 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Jolanda Howe | Mar 17 |
Option Exercise/Conversion (M)
Compensation/Award
|
7,161 | +2,658 | $0.00 | +$0 |
| Peter Radovich | Mar 17 |
Option Exercise/Conversion (M)
Compensation/Award
|
33,787 | +7,220 | $0.00 | +$0 |
| Joanne Quan | Mar 17 |
Option Exercise/Conversion (M)
Compensation/Award
|
26,151 | +13,334 | $0.00 | +$0 |
| Christopher Peetz | Mar 17 |
Option Exercise/Conversion (M)
Compensation/Award
|
185,294 | +25,000 | $0.00 | +$0 |
| ERIC BJERKHOLT | Mar 17 |
Option Exercise/Conversion (M)
Compensation/Award
|
57,075 | +13,334 | $0.00 | +$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Peter Radovich | Mar 11 |
Option Exercise/Conversion (M)
Compensation/Award
|
26,567 | +5,912 | $15.87 | +$93,823 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Saira Ramasastry | Feb 17 |
Option Exercise/Conversion (M)
Compensation/Award
|
2,000 | +2,000 | $23.51 | +$47,020 |
| Saira Ramasastry | Feb 17 |
Open Market Sale (S)
Market Sale
|
0 | -2,000 | $102.09 | -$204,180 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Jolanda Howe | Feb 03 |
Open Market Sale (S)
Market Sale
|
4,503 | -968 | $103.30 | -$99,997 |
| Peter Radovich | Feb 03 |
Open Market Sale (S)
Market Sale
|
20,655 | -2,631 | $103.30 | -$271,791 |
| Christopher Peetz | Feb 03 |
Open Market Sale (S)
Market Sale
|
160,294 | -9,108 | $103.30 | -$940,888 |
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