| Insider Name | Current Shares | Net Change (1yr) | Buy/Sell Ratio |
|---|---|---|---|
| Peter W. Sonsini | 4,186,243 | 0 | - |
| JOSHUA MAKOWER | 4,186,243 | 0 | - |
| DAVID M MOTT | 4,186,243 | 0 | - |
| PETER J BARRIS | 4,186,243 | 0 | - |
| Life Sciences IX, L.P. Frazier | 3,566,912 | 0 | - |
| Holdings A/S Novo | 2,445,147 | 0 | - |
| Enterprise Associates 16, L.P. New | 2,186,243 | 0 | - |
| Carmen Chang | 2,186,243 | 0 | - |
| Mohamad Makhzoumi | 2,186,243 | 0 | - |
| Ali Behbahani | 2,186,243 | 0 | - |
| Anthony A. Jr. Florence | 2,186,243 | 0 | - |
| Paul Edward Walker | 2,186,243 | 0 | - |
| FOREST BASKETT | 2,186,243 | 0 | - |
| SCOTT D SANDELL | 2,186,243 | 0 | - |
| Partners 16, L.P. NEA | 2,186,243 | 0 | - |
| MANAGEMENT COMPANY, L.P. (SERIES C) DEERFIELD | 1,711,324 | 0 | - |
| Niall O'Donnell | 1,621,118 | 0 | - |
| James E Flynn | 1,558,456 | 0 | - |
| Patrick J Heron | 459,010 | +290,702 | ∞ |
| Christopher Peetz | 224,309 | +78,736 | 1.68 |
| Lara Longpre | 104,407 | 0 | - |
| Peter Radovich | 57,260 | +40,486 | 2.64 |
| MICHAEL G GREY | 50,000 | 0 | 1.0 |
| ERIC BJERKHOLT | 47,181 | +31,558 | 2.07 |
| Edwin Jonathan Tucker | 45,838 | 0 | - |
| Ian Clements | 30,011 | 0 | - |
| Pamela Vig | 27,406 | 0 | - |
| Joanne Quan | 18,864 | +31,288 | 2.95 |
| Laura Brege | 17,194 | +1,491 | 1.1 |
| Edward T Mathers | 17,000 | 0 | - |
| Carol L Brosgart | 15,583 | 0 | - |
| Laurent Fischer | 10,727 | +3,977 | ∞ |
| Timothy P Walbert | 9,680 | +3,977 | ∞ |
| Lon Cardon | 9,680 | +3,977 | ∞ |
| Jolanda Howe | 8,429 | +7,683 | 1.44 |
| William Fairey | 2,500 | 0 | - |
| Saira Ramasastry | 0 | +1,000 | 1.03 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| ERIC BJERKHOLT | Jun 09 |
Option Exercise/Conversion (M)
Compensation/Award
|
47,181 | +2,393 | $26.49 | +$63,390 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| ERIC BJERKHOLT | Jun 09 |
Open Market Sale (S)
Market Sale
|
47,530 | -2,258 | $92.84 | -$209,632 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Peter Radovich | Jun 08 |
Option Exercise/Conversion (M)
Compensation/Award
|
57,260 | +16,988 | $19.19 | +$325,999 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Christopher Peetz | Jun 02 |
Open Market Sale (S)
Market Sale
|
221,707 | -2,602 | $94.64 | -$246,253 |
| Christopher Peetz | Jun 02 |
Option Exercise/Conversion (M)
Compensation/Award
|
224,309 | +30,000 | $2.94 | +$88,080 |
| Saira Ramasastry | Jun 02 |
Open Market Sale (S)
Market Sale
|
0 | -3,977 | $100.00 | -$397,700 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Timothy P Walbert | Jun 02 |
Option Exercise/Conversion (M)
Compensation/Award
|
9,680 | +3,977 | $0.00 | +$0 |
| Laurent Fischer | Jun 02 |
Option Exercise/Conversion (M)
Compensation/Award
|
10,727 | +3,977 | $0.00 | +$0 |
| Saira Ramasastry | Jun 02 |
Option Exercise/Conversion (M)
Compensation/Award
|
3,977 | +3,977 | $0.00 | +$0 |
| Lon Cardon | Jun 02 |
Option Exercise/Conversion (M)
Compensation/Award
|
9,680 | +3,977 | $0.00 | +$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Saira Ramasastry | May 18 |
Open Market Sale (S)
Market Sale
|
0 | -2,000 | $109.47 | -$218,940 |
| Saira Ramasastry | May 18 |
Option Exercise/Conversion (M)
Compensation/Award
|
2,000 | +2,000 | $23.51 | +$47,020 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Saira Ramasastry | Apr 16 |
Option Exercise/Conversion (M)
Compensation/Award
|
2,000 | +2,000 | $23.51 | +$47,020 |
| Saira Ramasastry | Apr 16 |
Open Market Sale (S)
Market Sale
|
0 | -2,000 | $96.90 | -$193,800 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| ERIC BJERKHOLT | Mar 17 |
Open Market Sale (S)
Market Sale
|
49,788 | -7,287 | $91.98 | -$670,242 |
| Jolanda Howe | Mar 17 |
Open Market Sale (S)
Market Sale
|
8,429 | -4,732 | $91.98 | -$435,239 |
| Joanne Quan | Mar 17 |
Open Market Sale (S)
Market Sale
|
18,864 | -7,287 | $91.98 | -$670,242 |
| Peter Radovich | Mar 17 |
Open Market Sale (S)
Market Sale
|
40,272 | -16,515 | $91.98 | -$1,519,015 |
| Christopher Peetz | Mar 17 |
Open Market Sale (S)
Market Sale
|
194,309 | -40,985 | $91.98 | -$3,769,714 |
| Saira Ramasastry | Mar 17 |
Option Exercise/Conversion (M)
Compensation/Award
|
2,000 | +2,000 | $23.51 | +$47,020 |
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