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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Stock-based compensation expense | |||||
| Issuance of common stock to Alexion Pharmaceuticals, Inc | |||||
| Net amortization of investment discounts and premiums | |||||
| Changes in operating assets and liabilities, net | |||||
| Other current assets | |||||
| Accounts payable, accrued expenses and other current liabilities | |||||
| In-process R&D accrued expenses | |||||
| Operating lease right-of-use assets and liabilities, net | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities: | |||||
| Purchase of short-term investments | |||||
| Maturities of short-term investments | |||||
| Net cash used in investing activities | |||||
| Cash flows from financing activities: | |||||
| Cash proceeds from the sales of common stock under a Capital on DemandTM Sales Agreement, net of commissions, fees and expenses | |||||
| Taxes paid related to net share settlement of vested restricted stock units | |||||
| Cash proceeds from the issuance of common stock upon exercise of stock options | |||||
| Net proceeds from issuance of common stock upon public offering, net of offering costs | |||||
| Net proceeds from issuance of common stock and concurrent private placement of pre-funded warrants upon registered offering, net of offering costs | |||||
| Net proceeds from issuance of common stock and concurrent issuance of pre-funded warrants upon public offering, net of offering costs | |||||
| Repurchase of common stock | |||||
| Net cash provided by financing activities | |||||
| Net increase in cash and cash equivalents | |||||
| Cash and cash equivalents at beginning of period | |||||
| Cash and cash equivalents at end of period | |||||
| Effect of exchange rate and valuation changes on cash equivalents | |||||
| Supplemental non-cash flow information: | |||||
| Lease liability arising out of obtaining right-of-use asset | |||||
| Accrued financing fees | |||||
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