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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Share-based compensation expense | |||||
| Depreciation and amortization expense | |||||
| Accretion of discount and amortization of premium on investments, net | |||||
| Non-cash lease expense | |||||
| Realized gain on investments | |||||
| Impairment of right-of-use asset | |||||
| Changes in operating assets and liabilities: | |||||
| Prepaid expenses and other assets | |||||
| Operating lease liabilities | |||||
| Accounts payable and accrued and other liabilities | |||||
| Other long-term liabilities | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities: | |||||
| Purchases of investments | |||||
| Proceeds from maturities of investments | |||||
| Purchases of property and equipment | |||||
| Net cash provided by (used in) investing activities | |||||
| Cash flows from financing activities: | |||||
| Proceeds from issuance of common stock and pre-funded warrants, net of issuance costs | |||||
| Proceeds from employee stock purchase plan purchases | |||||
| Proceeds from stock option exercises | |||||
| Net cash provided by financing activities | |||||
| Net increase (decrease) in cash and cash equivalents | |||||
| Cash, cash equivalents and restricted cash at beginning of year | |||||
| Cash, cash equivalents and restricted cash at end of year | |||||
| Reconciliation of cash, cash equivalents and restricted cash to the balance sheets: | |||||
| Cash and cash equivalents | |||||
| Restricted cash | |||||
| Total cash, cash equivalents and restricted cash | |||||
| Supplemental disclosures of non-cash investing activities: | |||||
| Acquisitions of property and equipment recorded in accounts payable and accrued and other current liabilities | |||||
| Right-of-use assets obtained in exchange for operating lease liabilities resulting from modified leases | |||||
| Right-of-use assets recognized in exchange for operating lease liability | |||||
| Decrease in right-of-use asset and lease liability due to termination | |||||
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