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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net income (loss) | |||||
| Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: | |||||
| Depreciation and amortization expense | |||||
| Share-based compensation expense | |||||
| Acquired in-process research and development | |||||
| Amortization of research and development cost share liability | |||||
| Unrealized losses on long-term investments | |||||
| Impairment of equity investments | |||||
| Loss on long-term investments | |||||
| Non-cash interest expense | |||||
| Deferred income tax expense | |||||
| Gain on BMS termination settlement | |||||
| Other items, net | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable | |||||
| Inventories | |||||
| Other assets | |||||
| Accounts payable | |||||
| Accrued expenses and other payables | |||||
| Deferred revenue | |||||
| Other liabilities | |||||
| Net cash provided by (used in) operating activities | |||||
| Cash flows from investing activities: | |||||
| Purchases of property and equipment | |||||
| Purchases of short-term investments | |||||
| Purchase of in-process research and development | |||||
| Purchase of intangible assets | |||||
| Purchase of long-term investments | |||||
| Proceeds from sale or maturity of short-term investments | |||||
| Other investing activities | |||||
| Net cash (used in) provided by investing activities | |||||
| Cash flows from financing activities: | |||||
| Proceeds from public offering, net of cost | |||||
| Proceeds from sale of ordinary shares, net of cost | |||||
| Proceeds from sale of future royalties | |||||
| Proceeds from long-term loan | |||||
| Repayment of long-term loan | |||||
| Proceeds from short-term loans | |||||
| Repayment of short-term loans | |||||
| Payments of debt issuance costs | |||||
| Payments of withholding taxes from share-based awards | |||||
| Proceeds from option exercises and employee share purchase plan | |||||
| Repayment of sale of future royalties liability | |||||
| Other financing activities | |||||
| Net cash provided by financing activities | |||||
| Effect of foreign exchange rate changes, net | |||||
| Net increase (decrease) in cash, cash equivalents, and restricted cash | |||||
| Cash, cash equivalents, and restricted cash, beginning of year | |||||
| Cash, cash equivalents, and restricted cash, end of year | |||||
| Supplemental cash flow disclosures: | |||||
| Cash and cash equivalents | |||||
| Short-term restricted cash | |||||
| Long-term restricted cash | |||||
| Income taxes paid | |||||
| Interest paid | |||||
| Supplemental non-cash activities: | |||||
| Accruals for capital expenditures | |||||
| Purchase of in-process research and development included in accounts payable | |||||
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