| Insider Name | Current Shares | Net Change (1yr) | Buy/Sell Ratio |
|---|---|---|---|
| ADVISORS LLC ORBIMED | 6,066,343 | -583,657 | - |
| Patrick J Heron | 5,009,219 | 0 | - |
| IX, L.L.C. FHMLS | 5,009,219 | 0 | - |
| Capital GP VII LLC OrbiMed | 4,094,852 | 0 | - |
| Weston Nichols | 623,704 | +160,856 | ∞ |
| Jill M. Quigley | 368,754 | 0 | - |
| Edgar B. Cale | 278,386 | 0 | - |
| Mark S Forman | 203,000 | 0 | - |
| Sandip Kapadia | 201,857 | 0 | - |
| Saqib Islam | 201,857 | 0 | - |
| MAXINE GOWEN | 201,857 | 0 | - |
| Derrell Porter | 201,857 | 0 | - |
| Athena Countouriotis | 201,857 | 0 | - |
| Dolan Sondhi | 201,857 | 0 | - |
| STEPHEN P SQUINTO | 185,776 | 0 | - |
| Alexandros Fotopoulos | 175,000 | 0 | - |
| Eliseo Oreste Salinas | 157,500 | 0 | - |
| Thomas Richard Kassberg | 143,789 | 0 | - |
| Bruce A Goldsmith | 100,000 | 0 | - |
| William Chou | 58,000 | +63,924 | 16.68 |
| Thomas Woiwode | 24,000 | 0 | - |
| Simona King | 23,994 | 0 | - |
| Michael E. Kamarck | 21,567 | 0 | - |
| Liam Ratcliffe | 16,918 | 0 | - |
| Tadataka Yamada | 16,918 | 0 | - |
| Kathleen Borthwick | 15,610 | +18,548 | 10.0 |
| Richard Steven Morris | 5,454 | 0 | - |
| Monika Maria Toernsen | 3,319 | 0 | - |
| Gary Romano | 1,617 | 0 | - |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| William Chou | Mar 18 |
Grant/Award Acquisition (A)
Compensation/Award
|
58,000 | +58,000 | $0.00 | +$0 |
| Kathleen Borthwick | Mar 18 |
Grant/Award Acquisition (A)
Compensation/Award
|
15,610 | +15,610 | $0.00 | +$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Kathleen Borthwick | Jan 12 |
Option Exercise/Conversion (M)
Compensation/Award
|
7,464 | +5,000 | $0.00 | +$0 |
| Kathleen Borthwick | Jan 12 |
Open Market Sale (S)
Market Sale
|
5,402 | -2,062 | $18.44 | -$38,022 |
| William Chou | Jan 12 |
Option Exercise/Conversion (M)
Compensation/Award
|
10,600 | +10,000 | $0.00 | +$0 |
| William Chou | Jan 12 |
Open Market Sale (S)
Market Sale
|
6,524 | -4,076 | $18.44 | -$75,158 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Weston Nichols | Sep 15 |
Open Market Purchase (P)
Market Purchase
|
623,704 | +11,900 | $6.99 | +$83,175 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Weston Nichols | Sep 15 |
Open Market Purchase (P)
Market Purchase
|
611,804 | +19,783 | $6.99 | +$138,298 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Weston Nichols | Sep 15 |
Open Market Purchase (P)
Market Purchase
|
592,021 | +325 | $6.96 | +$2,260 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Weston Nichols | Jul 24 |
Open Market Purchase (P)
Market Purchase
|
591,696 | +66,423 | $5.71 | +$379,454 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Weston Nichols | Jul 24 |
Open Market Purchase (P)
Market Purchase
|
525,273 | +49,302 | $5.74 | +$283,032 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Weston Nichols | Jul 24 |
Open Market Purchase (P)
Market Purchase
|
475,971 | +13,123 | $5.44 | +$71,337 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| ADVISORS LLC ORBIMED | Jun 26 |
Open Market Sale (S)
Market Sale
|
6,066,343 | -213,257 | $0.33 | -$70,374 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| ADVISORS LLC ORBIMED | Jun 26 |
Open Market Sale (S)
Market Sale
|
6,279,600 | -138,800 | $0.33 | -$45,804 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| ADVISORS LLC ORBIMED | Jun 26 |
Open Market Sale (S)
Market Sale
|
6,418,400 | -231,600 | $0.35 | -$81,060 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Dolan Sondhi | May 30 |
Grant/Award Acquisition (A)
Compensation/Award
|
201,857 | +201,857 | $0.00 | +$0 |
| Derrell Porter | May 30 |
Grant/Award Acquisition (A)
Compensation/Award
|
201,857 | +201,857 | $0.00 | +$0 |
| Sandip Kapadia | May 30 |
Grant/Award Acquisition (A)
Compensation/Award
|
201,857 | +201,857 | $0.00 | +$0 |
| Saqib Islam | May 30 |
Grant/Award Acquisition (A)
Compensation/Award
|
201,857 | +201,857 | $0.00 | +$0 |
| Athena Countouriotis | May 30 |
Grant/Award Acquisition (A)
Compensation/Award
|
201,857 | +201,857 | $0.00 | +$0 |
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