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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Depreciation and amortization | |||||
| Stock-based compensation expense | |||||
| Non-cash payments for acquired manufacturing rights | |||||
| Loss on disposal of assets | |||||
| Asset impairment charges | |||||
| Amortization of operating lease right-of-use assets | |||||
| Net accretion of discounts on investments | |||||
| Unrealized foreign exchange loss (gain) | |||||
| Changes in operating assets and liabilities: | |||||
| Prepaid expenses and other current assets | |||||
| Operating lease right-of-use assets | |||||
| Other assets | |||||
| Operating lease liabilities | |||||
| Accounts payable | |||||
| Accrued compensation | |||||
| Accrued contract manufacturing expenses | |||||
| Accrued expenses | |||||
| Net cash used in operating activities | |||||
| Cash flows from investing activities: | |||||
| Purchases of property and equipment | |||||
| Purchases of manufacturing facility build-out and equipment construction-in-progress | |||||
| Purchases of investments | |||||
| Maturities of investments | |||||
| Sales of investments | |||||
| Proceeds from sales of property and equipment | |||||
| Net cash provided by (used in) investing activities | |||||
| Cash flows from financing activities: | |||||
| Proceeds from issuance of common stock and pre-funded warrants from follow-on offerings, net of issuance costs | |||||
| Proceeds from exercise of common stock options | |||||
| Proceeds from issuance of common stock under at-the-market offering, net of issuance costs | |||||
| Proceeds from issuance of shares through employee equity incentive plans | |||||
| Taxes paid related to the net share settlement of equity awards | |||||
| Net cash provided by financing activities | |||||
| Effect of exchange rate changes on cash and cash equivalents | |||||
| Net decrease in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash, beginning of period | |||||
| Cash, cash equivalents and restricted cash, end of period | |||||
| Cash paid for interest | |||||
| Supplemental disclosures of non-cash investing and financing activities: | |||||
| Purchases of property and equipment recorded in accounts payable and accrued expenses | |||||
| Issuance of common stock for acquired manufacturing rights | |||||
| Stock issued for payment of accounts payable | |||||
| Cash and cash equivalents | |||||
| Restricted cash | |||||
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