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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows from operating activities | |||||
| Net Income Loss | |||||
| Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: | |||||
| Depreciation and amortization | |||||
| Non-cash operating lease expense | |||||
| Non-cash royalty revenue related to sale of future royalties | |||||
| Non-cash interest expense on liability related to sale of future royalties | |||||
| Intangible asset impairment | |||||
| Change in valuation of contingent consideration | |||||
| Tangible asset impairment | |||||
| Loss on sale of fixed assets | |||||
| Gain on lease terminations | |||||
| Gain on lease modification | |||||
| Gain on sale of priority review voucher | |||||
| Unrealized (gain) loss on ClearPoint Equity Investments | |||||
| Unrealized loss on ClearPoint convertible debt security | |||||
| Realized loss on sale of ClearPoint Equity Investment | |||||
| Realized loss on ClearPoint convertible debt security | |||||
| Realized gain on sale of marketable securities - equity investments | |||||
| Unrealized gain on marketable securities - equity investments | |||||
| Non-cash stock consideration, milestone payment | |||||
| Disposal of asset | |||||
| Deferred income taxes | |||||
| Amortization of discounts on investments, net | |||||
| Amortization of debt issuance costs | |||||
| Loss on extinguishment of debt | |||||
| Share-based compensation expense | |||||
| Unrealized foreign currency transaction losses (gains), net | |||||
| Changes in operating assets and liabilities: | |||||
| Inventory, net | |||||
| Prepaid expenses and other current assets | |||||
| Trade and royalty receivables, net | |||||
| Deposits and other assets | |||||
| Accounts payable and accrued expenses | |||||
| Other liabilities | |||||
| Deferred revenue | |||||
| Payments on contingent consideration | |||||
| Net cash provided by (used in) operating activities | |||||
| Cash flows from investing activities | |||||
| Purchases of fixed assets | |||||
| Proceeds from sale of fixed assets | |||||
| Proceeds from sale of priority review voucher | |||||
| Purchases of marketable securities- available for sale | |||||
| Purchases of marketable securities- equity investments | |||||
| Sale of marketable securities- available for sale | |||||
| Sale of marketable securities- equity investments | |||||
| Sale of ClearPoint Equity Investments | |||||
| Proceeds from settlement of Clearpoint convertible debt security | |||||
| Acquisition of product rights and licenses | |||||
| Net cash (used in) provided by investing activities | |||||
| Cash flows from financing activities | |||||
| Proceeds from exercise of options | |||||
| Proceeds from employee stock purchase plan | |||||
| Repayment of senior secured term loan | |||||
| Debt extinguishment costs related to senior secured term loan | |||||
| Cash consideration received from A&R Royalty Purchase Agreement | |||||
| Debt issuance costs related to senior secured term loan | |||||
| Payments on contingent consideration obligation | |||||
| Payment of finance lease principal | |||||
| Net cash provided by financing activities | |||||
| Effect of exchange rate changes on cash | |||||
| Net increase in cash and cash equivalents | |||||
| Cash and cash equivalents, and restricted cash beginning of period | |||||
| Cash and cash equivalents, and restricted cash end of period | |||||
| Supplemental disclosure of cash information | |||||
| Cash paid for interest | |||||
| Total income taxes paid, net of refunds recieved: | |||||
| Federal | |||||
| State: | |||||
| Income tax paid, State | |||||
| Illinois | |||||
| Other State | |||||
| Foreign: | |||||
| Income tax paid, Foreign | |||||
| Brazil | |||||
| Other Foreign | |||||
| Total income taxes paid, net of refunds recieved | |||||
| Supplemental disclosure of non-cash investing and financing activity | |||||
| Unrealized gain (loss) on marketable securities, net of tax | |||||
| Right-of-use assets obtained in exchange for operating lease obligations | |||||
| Acquisition of product rights and licenses | |||||
| Fixed asset additions through tenant improvement allowance | |||||
| Accrued brokerage fees in connection with sale of priority review voucher | |||||
| Milestone payable | |||||
| Capital expenditures unpaid at the end of period | |||||
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