$QURE
uniQure N.V. Stock $qure

$qure Overview Financials Valuation SEC Filings Company Website

2023 Q1 Form 10-K Financial Statement

#000155837023002110 Filed on February 27, 2023

Income Statement

Concept	2023 Q1	2022 Q4	2022
Revenue	$5.325M	$102.7M	$106.5M
YoY Change	197.15%	78.1%	-79.68%
Cost Of Revenue	$2.435M	$1.650M	$1.254M
YoY Change		-8.23%	-94.98%
Gross Profit	$2.890M	$101.1M	$105.2M
YoY Change		80.87%	-78.91%
Gross Profit Margin	54.27%	98.39%	98.82%
Selling, General & Admin	$17.85M	$18.26M	$55.06M
YoY Change	62.45%	30.72%	-2.19%
% of Gross Profit	617.58%	18.06%	52.32%
Research & Development	$60.81M	$58.76M	$197.6M
YoY Change	35.12%	38.78%	37.65%
% of Gross Profit	2104.12%	58.12%	187.77%
Depreciation & Amortization	$2.527M	$2.331M	$8.200M
YoY Change	19.09%	25.86%	34.43%
% of Gross Profit	87.44%	2.31%	7.79%
Operating Expenses	$78.66M	$74.59M	$252.7M
YoY Change	40.48%	38.59%	26.43%
Operating Profit	-$74.17M	$26.50M	-$143.2M
YoY Change	37.15%	1181.48%	-146.09%
Interest Expense	$3.562M	-$22.03M	$11.70M
YoY Change	41.63%	-469.75%	56.6%
% of Operating Profit		-83.11%
Other Income/Expense, Net	$216.0K	$2.125M	$820.0K
YoY Change	11.92%	-1428.13%	-6.39%
Pretax Income	-$78.43M	$6.600M	-$128.3M
YoY Change	65.84%	-16.08%	-138.54%
Income Tax	-$1.207M	-$207.0K	-$1.470M
% Of Pretax Income		-3.14%
Net Earnings	-$77.23M	$6.807M	-$126.8M
YoY Change	65.45%	-17.07%	-138.47%
Net Earnings / Revenue	-1450.27%	6.63%	-119.07%
Basic Earnings Per Share	-$1.63		-$2.71
Diluted Earnings Per Share	-$1.63	$0.15	-$2.71
COMMON SHARES
Basic Shares Outstanding	46.98M	46.82M	46.74M
Diluted Shares Outstanding	47.44M		46.74M

Balance Sheet

Concept	2023 Q1	2022 Q4	2022
SHORT-TERM ASSETS
Cash & Short-Term Investments	$315.3M	$352.8M	$352.8M
YoY Change	-39.92%	-36.57%	-36.57%
Cash & Equivalents	$153.9M	$228.0M	$228.0M
Short-Term Investments	$161.5M	$124.8M	$124.8M
Other Short-Term Assets	$15.04M	$14.63M	$14.63M
YoY Change	2.4%	10.72%	10.72%
Inventory	$7.477M	$6.924M	$6.924M
Prepaid Expenses	$12.57M	$11.82M
Receivables	$104.8M	$102.4M	$102.4M
Other Receivables	$0.00	$0.00	$0.00
Total Short-Term Assets	$442.6M	$476.8M	$476.8M
YoY Change	-23.45%	-24.11%	-24.11%
LONG-TERM ASSETS
Property, Plant & Equipment	$50.07M	$50.53M	$83.26M
YoY Change	11.47%	16.15%	20.53%
Goodwill	$26.00M	$25.58M
YoY Change	-2.13%	-7.43%
Intangibles		$58.78M
YoY Change		-6.23%
Long-Term Investments	$0.00	$39.98M	$39.98M
YoY Change
Other Assets	$6.121M	$6.061M	$20.59M
YoY Change	3.1%	2.78%	-4.43%
Total Long-Term Assets	$188.4M	$228.2M	$228.2M
YoY Change	5.27%	26.11%	26.11%
TOTAL ASSETS
Total Short-Term Assets	$442.6M	$476.8M	$476.8M
Total Long-Term Assets	$188.4M	$228.2M	$228.2M
Total Assets	$631.0M	$705.0M	$705.0M
YoY Change	-16.66%	-12.88%	-12.88%
SHORT-TERM LIABILITIES
YoY Change
Accounts Payable	$8.885M	$10.98M	$10.98M
YoY Change	-10.43%	339.01%	339.01%
Accrued Expenses	$22.53M	$30.57M	$38.95M
YoY Change	12.96%	7.32%	13.69%
Deferred Revenue
YoY Change
Short-Term Debt	$0.00	$0.00	$0.00
YoY Change
Long-Term Debt Due
YoY Change
Total Short-Term Liabilities	$66.34M	$75.92M	$75.92M
YoY Change	48.4%	106.51%	106.51%
LONG-TERM LIABILITIES
Long-Term Debt	$103.3M	$102.8M	$102.8M
YoY Change	1.81%	1.81%	1.81%
Other Long-Term Liabilities	$958.0K	$935.0K	$41.99M
YoY Change	-72.14%	-77.93%	-33.1%
Total Long-Term Liabilities	$151.9M	$153.0M	$144.8M
YoY Change	-8.74%	-13.36%	-11.57%
TOTAL LIABILITIES
Total Short-Term Liabilities	$66.34M	$75.92M	$75.92M
Total Long-Term Liabilities	$151.9M	$153.0M	$144.8M
Total Liabilities	$218.2M	$229.0M	$229.0M
YoY Change	3.35%	7.29%	7.29%
SHAREHOLDERS EQUITY
Retained Earnings	-$659.2M	-$581.9M
YoY Change	31.35%	27.86%
Common Stock	$2.869M	$2.838M
YoY Change	1.7%	1.28%
Preferred Stock
YoY Change
Treasury Stock (at cost)
YoY Change
Treasury Stock Shares
Shareholders Equity	$412.8M	$476.0M	$476.0M
YoY Change
Total Liabilities & Shareholders Equity	$631.0M	$705.0M	$705.0M
YoY Change	-16.66%	-12.88%	-12.88%

Cashflow Statement

Concept	2023 Q1	2022 Q4	2022
OPERATING ACTIVITIES
Net Income	-$77.23M	$6.807M	-$126.8M
YoY Change	65.45%	-17.07%	-138.47%
Depreciation, Depletion And Amortization	$2.527M	$2.331M	$8.200M
YoY Change	19.09%	25.86%	34.43%
Cash From Operating Activities	-$78.30M	-$54.68M	-$145.1M
YoY Change	204.55%	16.12%	-150.38%
INVESTING ACTIVITIES
Capital Expenditures	$2.342M	$5.066M	$17.69M
YoY Change	-42.29%	-242.58%	1.43%
Acquisitions			$1.900M
YoY Change			-96.2%
Other Investing Activities	$5.330M	-$163.1M	-$165.0M
YoY Change	-748.42%		230.43%
Cash From Investing Activities	$2.988M	-$168.2M	-$182.7M
YoY Change	-161.23%	4634.37%	171.17%
FINANCING ACTIVITIES
Cash Dividend Paid
YoY Change
Common Stock Issuance & Retirement, Net
YoY Change
Debt Paid & Issued, Net
YoY Change
Cash From Financing Activities	131.0K	601.0K	1.445M
YoY Change	-72.99%	-97.99%	-98.48%
NET CHANGE
Cash From Operating Activities	-78.30M	-54.68M	-145.1M
Cash From Investing Activities	2.988M	-168.2M	-182.7M
Cash From Financing Activities	131.0K	601.0K	1.445M
Net Change In Cash	-74.15M	-222.3M	-328.2M
YoY Change	137.09%	971.33%	-205.3%
FREE CASH FLOW
Cash From Operating Activities	-$78.30M	-$54.68M	-$145.1M
Capital Expenditures	$2.342M	$5.066M	$17.69M
Free Cash Flow	-$80.64M	-$59.75M	-$162.7M
YoY Change	170.9%	37.23%	-160.16%

Facts In Submission

Frame	Concept Type	Concept / XBRL Key	Value
CY2021	us-gaap	Weighted Average Number Of Diluted Shares Outstanding WeightedAverageNumberOfDilutedSharesOutstanding	46840972
CY2020	us-gaap	Weighted Average Number Of Diluted Shares Outstanding WeightedAverageNumberOfDilutedSharesOutstanding	44466365
CY2022Q4	us-gaap	Commitments And Contingencies CommitmentsAndContingencies
CY2021Q4	us-gaap	Commitments And Contingencies CommitmentsAndContingencies
CY2021	us-gaap	Fair Value Recurring Basis Unobservable Input Reconciliation Liability Gain Loss Statement Of Income Extensible List FairValueRecurringBasisUnobservableInputReconciliationLiabilityGainLossStatementOfIncomeExtensibleList	http://fasb.org/us-gaap/2022#OtherNonoperatingIncomeExpense
CY2022	us-gaap	Fair Value Recurring Basis Unobservable Input Reconciliation Liability Gain Loss Statement Of Income Extensible List FairValueRecurringBasisUnobservableInputReconciliationLiabilityGainLossStatementOfIncomeExtensibleList	http://fasb.org/us-gaap/2022#OtherNonoperatingIncomeExpense
CY2022	dei	Entity Central Index Key EntityCentralIndexKey	0001590560
CY2022	dei	Document Fiscal Year Focus DocumentFiscalYearFocus	2022
CY2022	dei	Document Fiscal Period Focus DocumentFiscalPeriodFocus	FY
CY2022	dei	Entity Tax Identification Number EntityTaxIdentificationNumber	00-0000000
CY2021Q4	us-gaap	Common Stock Shares Issued CommonStockSharesIssued	46298635
CY2022Q4	us-gaap	Common Stock Shares Outstanding CommonStockSharesOutstanding	46968032
CY2020	us-gaap	Fair Value Recurring Basis Unobservable Input Reconciliation Liability Gain Loss Statement Of Income Extensible List FairValueRecurringBasisUnobservableInputReconciliationLiabilityGainLossStatementOfIncomeExtensibleList	http://fasb.org/us-gaap/2022#OtherNonoperatingIncomeExpense
CY2022	dei	Amendment Flag AmendmentFlag	false
CY2022	dei	Document Type DocumentType	10-K
CY2022	dei	Document Annual Report DocumentAnnualReport	true
CY2022	dei	Document Period End Date DocumentPeriodEndDate	2022-12-31
CY2022	dei	Current Fiscal Year End Date CurrentFiscalYearEndDate	--12-31
CY2022	dei	Document Transition Report DocumentTransitionReport	false
CY2022	dei	Entity File Number EntityFileNumber	001-36294
CY2022	dei	Entity Registrant Name EntityRegistrantName	uniQure N.V.
CY2022	dei	Entity Incorporation State Country Code EntityIncorporationStateCountryCode	P7
CY2022	dei	Entity Address Address Line1 EntityAddressAddressLine1	Paasheuvelweg 25
CY2022	dei	Entity Address Postal Zip Code EntityAddressPostalZipCode	1105 BP
CY2022	dei	Entity Address City Or Town EntityAddressCityOrTown	Amsterdam
CY2022	dei	Entity Address Country EntityAddressCountry	NL
CY2022	dei	City Area Code CityAreaCode	31
CY2020	us-gaap	Other Expenses OtherExpenses	1302000
CY2022	qure	Operating Cycle Period OperatingCyclePeriod	P12M
CY2022Q4	us-gaap	Derivative Fair Value Of Derivative Liability DerivativeFairValueOfDerivativeLiability	0
CY2022Q4	qure	Liability Related To Post Acquisition Services LiabilityRelatedToPostAcquisitionServices	300000
CY2021Q4	qure	Liability Related To Post Acquisition Services LiabilityRelatedToPostAcquisitionServices	800000
CY2022Q4	us-gaap	Common Stock Par Or Stated Value Per Share CommonStockParOrStatedValuePerShare	0.05
CY2022	us-gaap	Current Income Tax Expense Benefit CurrentIncomeTaxExpenseBenefit	24000
CY2021	us-gaap	Deferred Federal State And Local Tax Expense Benefit DeferredFederalStateAndLocalTaxExpenseBenefit	3047000
CY2021	us-gaap	Deferred Income Tax Expense Benefit DeferredIncomeTaxExpenseBenefit	3210000
CY2022	us-gaap	Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate	0.258
CY2021	us-gaap	Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate	0.250
CY2020	us-gaap	Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate	0.250
CY2021	us-gaap	Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent	-38763000
CY2022	dei	Local Phone Number LocalPhoneNumber	20-240-6000
CY2022	dei	Security12b Title Security12bTitle	Ordinary shares, par value €0.05 per share
CY2022	dei	Trading Symbol TradingSymbol	QURE
CY2022	dei	Security Exchange Name SecurityExchangeName	NASDAQ
CY2022	dei	Entity Well Known Seasoned Issuer EntityWellKnownSeasonedIssuer	Yes
CY2022	dei	Entity Voluntary Filers EntityVoluntaryFilers	No
CY2022	dei	Entity Current Reporting Status EntityCurrentReportingStatus	Yes
CY2022	dei	Entity Interactive Data Current EntityInteractiveDataCurrent	Yes
CY2022	dei	Entity Filer Category EntityFilerCategory	Large Accelerated Filer
CY2022	dei	Entity Small Business EntitySmallBusiness	false
CY2022	dei	Entity Emerging Growth Company EntityEmergingGrowthCompany	false
CY2022	dei	Icfr Auditor Attestation Flag IcfrAuditorAttestationFlag	true
CY2022	dei	Entity Shell Company EntityShellCompany	false
CY2022Q2	dei	Entity Public Float EntityPublicFloat	870200000
CY2023Q1	dei	Entity Common Stock Shares Outstanding EntityCommonStockSharesOutstanding	46982485
CY2022	dei	Auditor Name AuditorName	KPMG Accountants N.V.
CY2022	dei	Auditor Location AuditorLocation	Amstelveen, The Netherlands
CY2022	dei	Auditor Firm AuditorFirmId	1012
CY2022Q4	us-gaap	Cash And Cash Equivalents At Carrying Value CashAndCashEquivalentsAtCarryingValue	228012000
CY2021Q4	us-gaap	Cash And Cash Equivalents At Carrying Value CashAndCashEquivalentsAtCarryingValue	556256000
CY2022Q4	us-gaap	Debt Securities Held To Maturity Amortized Cost After Allowance For Credit Loss Current DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLossCurrent	124831000
CY2022Q4	qure	Accounts Receivable And Contract With Customer Asset Current AccountsReceivableAndContractWithCustomerAssetCurrent	102376000
CY2021Q4	qure	Accounts Receivable And Contract With Customer Asset Current AccountsReceivableAndContractWithCustomerAssetCurrent	58768000
CY2022Q4	us-gaap	Inventory Net InventoryNet	6924000
CY2022Q4	us-gaap	Prepaid Expense Current PrepaidExpenseCurrent	11817000
CY2021Q4	us-gaap	Prepaid Expense Current PrepaidExpenseCurrent	10540000
CY2022Q4	qure	Other Current Assets And Receivables OtherCurrentAssetsAndReceivables	2814000
CY2021Q4	qure	Other Current Assets And Receivables OtherCurrentAssetsAndReceivables	2675000
CY2022Q4	us-gaap	Assets Current AssetsCurrent	476774000
CY2021Q4	us-gaap	Assets Current AssetsCurrent	628239000
CY2022Q4	us-gaap	Property Plant And Equipment Net PropertyPlantAndEquipmentNet	50532000
CY2021Q4	us-gaap	Property Plant And Equipment Net PropertyPlantAndEquipmentNet	43505000
CY2022Q4	us-gaap	Debt Securities Held To Maturity Amortized Cost After Allowance For Credit Loss Noncurrent DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLossNoncurrent	39984000
CY2022Q4	us-gaap	Operating Lease Right Of Use Asset OperatingLeaseRightOfUseAsset	32726000
CY2021Q4	us-gaap	Operating Lease Right Of Use Asset OperatingLeaseRightOfUseAsset	25573000
CY2022Q4	us-gaap	Finite Lived Intangible Assets Net FiniteLivedIntangibleAssetsNet	58778000
CY2021Q4	us-gaap	Finite Lived Intangible Assets Net FiniteLivedIntangibleAssetsNet	62686000
CY2022Q4	us-gaap	Goodwill Goodwill	25581000
CY2021Q4	us-gaap	Goodwill Goodwill	27633000
CY2022Q4	us-gaap	Deferred Income Tax Assets Net DeferredIncomeTaxAssetsNet	14528000
CY2021Q4	us-gaap	Deferred Income Tax Assets Net DeferredIncomeTaxAssetsNet	15647000
CY2022Q4	us-gaap	Other Assets Noncurrent OtherAssetsNoncurrent	6061000
CY2021Q4	us-gaap	Other Assets Noncurrent OtherAssetsNoncurrent	5897000
CY2022Q4	us-gaap	Assets Noncurrent AssetsNoncurrent	228190000
CY2021Q4	us-gaap	Assets Noncurrent AssetsNoncurrent	180941000
CY2022Q4	us-gaap	Assets Assets	704964000
CY2021Q4	us-gaap	Assets Assets	809180000
CY2022Q4	us-gaap	Accounts Payable Current AccountsPayableCurrent	10984000
CY2021Q4	us-gaap	Accounts Payable Current AccountsPayableCurrent	2502000
CY2022Q4	us-gaap	Accrued Liabilities Current AccruedLiabilitiesCurrent	30571000
CY2021Q4	us-gaap	Accrued Liabilities Current AccruedLiabilitiesCurrent	28487000
CY2022Q4	us-gaap	Business Combination Contingent Consideration Liability Current BusinessCombinationContingentConsiderationLiabilityCurrent	25982000
CY2022Q4	us-gaap	Operating Lease Liability Current OperatingLeaseLiabilityCurrent	8382000
CY2021Q4	us-gaap	Operating Lease Liability Current OperatingLeaseLiabilityCurrent	5774000
CY2022Q4	us-gaap	Liabilities Current LiabilitiesCurrent	75919000
CY2021Q4	us-gaap	Liabilities Current LiabilitiesCurrent	36763000
CY2022Q4	us-gaap	Long Term Debt Noncurrent LongTermDebtNoncurrent	102791000
CY2021Q4	us-gaap	Long Term Debt Noncurrent LongTermDebtNoncurrent	100963000
CY2022Q4	us-gaap	Operating Lease Liability Noncurrent OperatingLeaseLiabilityNoncurrent	31719000
CY2021Q4	us-gaap	Operating Lease Liability Noncurrent OperatingLeaseLiabilityNoncurrent	28987000
CY2022Q4	us-gaap	Business Combination Contingent Consideration Liability Noncurrent BusinessCombinationContingentConsiderationLiabilityNoncurrent	9334000
CY2021Q4	us-gaap	Business Combination Contingent Consideration Liability Noncurrent BusinessCombinationContingentConsiderationLiabilityNoncurrent	29542000
CY2022Q4	us-gaap	Deferred Income Tax Liabilities Net DeferredIncomeTaxLiabilitiesNet	8257000
CY2021Q4	us-gaap	Deferred Income Tax Liabilities Net DeferredIncomeTaxLiabilitiesNet	12913000
CY2022Q4	us-gaap	Other Liabilities Noncurrent OtherLiabilitiesNoncurrent	935000
CY2021Q4	us-gaap	Other Liabilities Noncurrent OtherLiabilitiesNoncurrent	4236000
CY2022Q4	us-gaap	Liabilities Noncurrent LiabilitiesNoncurrent	153036000
CY2021Q4	us-gaap	Liabilities Noncurrent LiabilitiesNoncurrent	176641000
CY2022Q4	us-gaap	Liabilities Liabilities	228955000
CY2021Q4	us-gaap	Liabilities Liabilities	213404000
CY2021Q4	us-gaap	Common Stock Par Or Stated Value Per Share CommonStockParOrStatedValuePerShare	0.05
CY2022Q4	us-gaap	Common Stock Par Or Stated Value Per Share CommonStockParOrStatedValuePerShare	0.05
CY2021Q4	us-gaap	Common Stock Shares Authorized CommonStockSharesAuthorized	80000000
CY2022Q4	us-gaap	Common Stock Shares Authorized CommonStockSharesAuthorized	80000000
CY2022Q4	us-gaap	Common Stock Shares Issued CommonStockSharesIssued	46968032
CY2021Q4	us-gaap	Common Stock Shares Outstanding CommonStockSharesOutstanding	46298635
CY2022Q4	us-gaap	Common Stock Value CommonStockValue	2838000
CY2021Q4	us-gaap	Common Stock Value CommonStockValue	2802000
CY2022Q4	us-gaap	Additional Paid In Capital AdditionalPaidInCapital	1113393000
CY2021Q4	us-gaap	Additional Paid In Capital AdditionalPaidInCapital	1076972000
CY2022Q4	us-gaap	Accumulated Other Comprehensive Income Loss Net Of Tax AccumulatedOtherComprehensiveIncomeLossNetOfTax	-58291000
CY2021Q4	us-gaap	Accumulated Other Comprehensive Income Loss Net Of Tax AccumulatedOtherComprehensiveIncomeLossNetOfTax	-28856000
CY2022Q4	us-gaap	Retained Earnings Accumulated Deficit RetainedEarningsAccumulatedDeficit	-581931000
CY2021Q4	us-gaap	Retained Earnings Accumulated Deficit RetainedEarningsAccumulatedDeficit	-455142000
CY2022Q4	us-gaap	Stockholders Equity StockholdersEquity	476009000
CY2021Q4	us-gaap	Stockholders Equity StockholdersEquity	595776000
CY2022Q4	us-gaap	Liabilities And Stockholders Equity LiabilitiesAndStockholdersEquity	704964000
CY2021Q4	us-gaap	Liabilities And Stockholders Equity LiabilitiesAndStockholdersEquity	809180000
CY2022	us-gaap	Revenue From Contract With Customer Including Assessed Tax RevenueFromContractWithCustomerIncludingAssessedTax	106483000
CY2021	us-gaap	Revenue From Contract With Customer Including Assessed Tax RevenueFromContractWithCustomerIncludingAssessedTax	524002000
CY2020	us-gaap	Revenue From Contract With Customer Including Assessed Tax RevenueFromContractWithCustomerIncludingAssessedTax	37514000
CY2022	us-gaap	Cost Of Goods And Services Sold CostOfGoodsAndServicesSold	1254000
CY2021	us-gaap	Cost Of Goods And Services Sold CostOfGoodsAndServicesSold	24976000
CY2022	qure	Cost Of Contract Manufacturing Revenues CostOfContractManufacturingRevenues	2089000
CY2022	us-gaap	Research And Development Expense ResearchAndDevelopmentExpense	197591000
CY2021	us-gaap	Research And Development Expense ResearchAndDevelopmentExpense	143548000
CY2020	us-gaap	Research And Development Expense ResearchAndDevelopmentExpense	122400000
CY2022	us-gaap	Selling General And Administrative Expense SellingGeneralAndAdministrativeExpense	55059000
CY2021	us-gaap	Selling General And Administrative Expense SellingGeneralAndAdministrativeExpense	56290000
CY2020	us-gaap	Selling General And Administrative Expense SellingGeneralAndAdministrativeExpense	42580000
CY2022	us-gaap	Costs And Expenses CostsAndExpenses	255993000
CY2021	us-gaap	Costs And Expenses CostsAndExpenses	224814000
CY2022	us-gaap	Operating Income Loss OperatingIncomeLoss	-143159000
CY2021	us-gaap	Operating Income Loss OperatingIncomeLoss	310618000
CY2020	us-gaap	Costs And Expenses CostsAndExpenses	164980000
CY2022	us-gaap	Other Income OtherIncome	7171000
CY2021	us-gaap	Other Income OtherIncome	12306000
CY2020	us-gaap	Other Income OtherIncome	3342000
CY2022	us-gaap	Other Expenses OtherExpenses	820000
CY2021	us-gaap	Other Expenses OtherExpenses	876000
CY2020	us-gaap	Operating Income Loss OperatingIncomeLoss	-125426000
CY2022	us-gaap	Investment Income Interest InvestmentIncomeInterest	609000
CY2021	us-gaap	Investment Income Interest InvestmentIncomeInterest	162000
CY2020	us-gaap	Investment Income Interest InvestmentIncomeInterest	938000
CY2022	us-gaap	Interest Expense InterestExpense	11704000
CY2021	us-gaap	Interest Expense InterestExpense	7474000
CY2020	us-gaap	Interest Expense InterestExpense	3825000
CY2022	us-gaap	Foreign Currency Transaction Gain Loss Before Tax ForeignCurrencyTransactionGainLossBeforeTax	23235000
CY2021	us-gaap	Foreign Currency Transaction Gain Loss Before Tax ForeignCurrencyTransactionGainLossBeforeTax	29660000
CY2020	us-gaap	Foreign Currency Transaction Gain Loss Before Tax ForeignCurrencyTransactionGainLossBeforeTax	-13613000
CY2022	us-gaap	Other Nonoperating Income Expense OtherNonoperatingIncomeExpense	2760000
CY2021	us-gaap	Other Nonoperating Income Expense OtherNonoperatingIncomeExpense	-160000
CY2020	us-gaap	Other Nonoperating Income Expense OtherNonoperatingIncomeExpense	483000
CY2022	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-128259000
CY2021	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	332806000
CY2020	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-141443000
CY2022	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	-1470000
CY2021	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	3217000
CY2020	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	-16419000
CY2022	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-126789000
CY2021	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	329589000
CY2020	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-125024000
CY2022	us-gaap	Other Comprehensive Income Foreign Currency Transaction And Translation Adjustment Net Of Tax Portion Attributable To Parent OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent	-29435000
CY2021	us-gaap	Other Comprehensive Income Foreign Currency Transaction And Translation Adjustment Net Of Tax Portion Attributable To Parent OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent	-38763000
CY2020	us-gaap	Other Comprehensive Income Foreign Currency Transaction And Translation Adjustment Net Of Tax Portion Attributable To Parent OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent	16596000
CY2022	us-gaap	Comprehensive Income Net Of Tax ComprehensiveIncomeNetOfTax	-156224000
CY2021	us-gaap	Comprehensive Income Net Of Tax ComprehensiveIncomeNetOfTax	290826000
CY2020	us-gaap	Comprehensive Income Net Of Tax ComprehensiveIncomeNetOfTax	-108428000
CY2022	us-gaap	Earnings Per Share Basic EarningsPerShareBasic	-2.71
CY2021	us-gaap	Earnings Per Share Basic EarningsPerShareBasic	7.17
CY2020	us-gaap	Earnings Per Share Basic EarningsPerShareBasic	-2.81
CY2022	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-2.71
CY2021	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	7.04
CY2020	us-gaap	Earnings Per Share Diluted EarningsPerShareDiluted	-2.81
CY2022	us-gaap	Weighted Average Number Of Shares Outstanding Basic WeightedAverageNumberOfSharesOutstandingBasic	46735045
CY2021	us-gaap	Weighted Average Number Of Shares Outstanding Basic WeightedAverageNumberOfSharesOutstandingBasic	45986467
CY2020	us-gaap	Weighted Average Number Of Shares Outstanding Basic WeightedAverageNumberOfSharesOutstandingBasic	44466365
CY2022	us-gaap	Weighted Average Number Of Diluted Shares Outstanding WeightedAverageNumberOfDilutedSharesOutstanding	46735045
CY2021	us-gaap	Weighted Average Number Of Diluted Shares Outstanding WeightedAverageNumberOfDilutedSharesOutstanding	46840972
CY2020	us-gaap	Weighted Average Number Of Diluted Shares Outstanding WeightedAverageNumberOfDilutedSharesOutstanding	44466365
CY2019Q4	us-gaap	Stockholders Equity StockholdersEquity	323058000
CY2020	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-125024000
CY2020	us-gaap	Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent	16596000
CY2020	us-gaap	Stock Issued During Period Value Stock Options Exercised StockIssuedDuringPeriodValueStockOptionsExercised	7198000
CY2020	us-gaap	Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue	21831000
CY2020	us-gaap	Stock Issued During Period Value Employee Stock Purchase Plan StockIssuedDuringPeriodValueEmployeeStockPurchasePlan	246000
CY2020Q4	us-gaap	Stockholders Equity StockholdersEquity	243905000
CY2021	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	329589000
CY2021	us-gaap	Stock Issued During Period Value New Issues StockIssuedDuringPeriodValueNewIssues	29564000
CY2021	qure	Adjustments To Additional Paid In Capital Stock Issued Issuance Costs Tax Effect Prior Years AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCostsTaxEffectPriorYears	3047000
CY2021	us-gaap	Stock Issued During Period Value Stock Options Exercised StockIssuedDuringPeriodValueStockOptionsExercised	2653000
CY2021	us-gaap	Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue	25635000
CY2021	us-gaap	Stock Issued During Period Value Employee Stock Purchase Plan StockIssuedDuringPeriodValueEmployeeStockPurchasePlan	146000
CY2021Q4	us-gaap	Stockholders Equity StockholdersEquity	595776000
CY2022	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-126789000
CY2022	us-gaap	Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent	-29435000
CY2022	qure	Adjustments To Additional Paid In Capital Stock Issued Issuance Costs Tax Effect Prior Years AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCostsTaxEffectPriorYears	808000
CY2022	us-gaap	Stock Issued During Period Value Stock Options Exercised StockIssuedDuringPeriodValueStockOptionsExercised	1280000
CY2022	us-gaap	Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue	34204000
CY2022	us-gaap	Stock Issued During Period Value Employee Stock Purchase Plan StockIssuedDuringPeriodValueEmployeeStockPurchasePlan	165000
CY2022Q4	us-gaap	Stockholders Equity StockholdersEquity	476009000
CY2022	us-gaap	Profit Loss ProfitLoss	-126789000
CY2021	us-gaap	Profit Loss ProfitLoss	329589000
CY2020	us-gaap	Profit Loss ProfitLoss	-125024000
CY2022	us-gaap	Depreciation And Amortization DepreciationAndAmortization	8537000
CY2021	us-gaap	Depreciation And Amortization DepreciationAndAmortization	7299000
CY2020	us-gaap	Depreciation And Amortization DepreciationAndAmortization	10648000
CY2022	us-gaap	Share Based Compensation ShareBasedCompensation	34204000
CY2021	us-gaap	Share Based Compensation ShareBasedCompensation	25635000
CY2020	us-gaap	Share Based Compensation ShareBasedCompensation	21831000
CY2022	qure	Change In Deferred Tax Expense ChangeInDeferredTaxExpense	-1470000
CY2021	qure	Change In Deferred Tax Expense ChangeInDeferredTaxExpense	3210000
CY2020	qure	Change In Deferred Tax Expense ChangeInDeferredTaxExpense	-16419000
CY2022	qure	Change In Fair Value Of Derivative Financial Instruments And Contingent Consideration ChangeInFairValueOfDerivativeFinancialInstrumentsAndContingentConsideration	4320000
CY2021	qure	Change In Fair Value Of Derivative Financial Instruments And Contingent Consideration ChangeInFairValueOfDerivativeFinancialInstrumentsAndContingentConsideration	6843000
CY2020	qure	Change In Fair Value Of Derivative Financial Instruments And Contingent Consideration ChangeInFairValueOfDerivativeFinancialInstrumentsAndContingentConsideration	-483000
CY2022	us-gaap	Foreign Currency Transaction Gain Loss Unrealized ForeignCurrencyTransactionGainLossUnrealized	22083000
CY2021	us-gaap	Foreign Currency Transaction Gain Loss Unrealized ForeignCurrencyTransactionGainLossUnrealized	31335000
CY2020	us-gaap	Foreign Currency Transaction Gain Loss Unrealized ForeignCurrencyTransactionGainLossUnrealized	-14730000
CY2020	us-gaap	Increase Decrease In Contract With Customer Liability IncreaseDecreaseInContractWithCustomerLiability	-33642000
CY2022	us-gaap	Other Noncash Income Expense OtherNoncashIncomeExpense	-1605000
CY2021	us-gaap	Other Noncash Income Expense OtherNoncashIncomeExpense	2800000
CY2022	qure	Increase Decrease In Accounts Receivable Prepaid Expense And Other Current Assets IncreaseDecreaseInAccountsReceivablePrepaidExpenseAndOtherCurrentAssets	4083000
CY2021	qure	Increase Decrease In Accounts Receivable Prepaid Expense And Other Current Assets IncreaseDecreaseInAccountsReceivablePrepaidExpenseAndOtherCurrentAssets	3959000
CY2020	qure	Increase Decrease In Accounts Receivable Prepaid Expense And Other Current Assets IncreaseDecreaseInAccountsReceivablePrepaidExpenseAndOtherCurrentAssets	6967000
CY2022	us-gaap	Increase Decrease In Contract With Customer Asset IncreaseDecreaseInContractWithCustomerAsset	45000000
CY2021	us-gaap	Increase Decrease In Contract With Customer Asset IncreaseDecreaseInContractWithCustomerAsset	55000000
CY2022	us-gaap	Increase Decrease In Inventories IncreaseDecreaseInInventories	6924000
CY2022	us-gaap	Increase Decrease In Accounts Payable IncreaseDecreaseInAccountsPayable	9238000
CY2021	us-gaap	Increase Decrease In Accounts Payable IncreaseDecreaseInAccountsPayable	-727000
CY2020	us-gaap	Increase Decrease In Accounts Payable IncreaseDecreaseInAccountsPayable	-2701000
CY2022	us-gaap	Increase Decrease In Accrued Liabilities And Other Operating Liabilities IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities	3385000
CY2021	us-gaap	Increase Decrease In Accrued Liabilities And Other Operating Liabilities IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities	9204000
CY2020	us-gaap	Increase Decrease In Accrued Liabilities And Other Operating Liabilities IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities	3199000
CY2022	us-gaap	Net Cash Provided By Used In Operating Activities NetCashProvidedByUsedInOperatingActivities	-145060000
CY2021	us-gaap	Net Cash Provided By Used In Operating Activities NetCashProvidedByUsedInOperatingActivities	287959000
CY2020	us-gaap	Net Cash Provided By Used In Operating Activities NetCashProvidedByUsedInOperatingActivities	-134828000
CY2022	us-gaap	Payments To Acquire Held To Maturity Securities PaymentsToAcquireHeldToMaturitySecurities	163146000
CY2022	us-gaap	Payments To Acquire Property Plant And Equipment PaymentsToAcquirePropertyPlantAndEquipment	17688000
CY2021	us-gaap	Payments To Acquire Property Plant And Equipment PaymentsToAcquirePropertyPlantAndEquipment	17438000
CY2020	us-gaap	Payments To Acquire Property Plant And Equipment PaymentsToAcquirePropertyPlantAndEquipment	7271000
CY2022	us-gaap	Payments To Acquire Businesses Net Of Cash Acquired PaymentsToAcquireBusinessesNetOfCashAcquired	1900000
CY2021	us-gaap	Payments To Acquire Businesses Net Of Cash Acquired PaymentsToAcquireBusinessesNetOfCashAcquired	49949000
CY2020	us-gaap	Payments To Acquire Intangible Assets PaymentsToAcquireIntangibleAssets	2213000
CY2022	us-gaap	Net Cash Provided By Used In Investing Activities NetCashProvidedByUsedInInvestingActivities	-182734000
CY2021	us-gaap	Net Cash Provided By Used In Investing Activities NetCashProvidedByUsedInInvestingActivities	-67387000
CY2020	us-gaap	Net Cash Provided By Used In Investing Activities NetCashProvidedByUsedInInvestingActivities	-9484000
CY2022	us-gaap	Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions	1445000
CY2021	us-gaap	Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions	2798000
CY2020	us-gaap	Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Including Stock Options ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions	7444000
CY2021	us-gaap	Proceeds From Issuance Of Long Term Debt ProceedsFromIssuanceOfLongTermDebt	64067000
CY2021	us-gaap	Proceeds From Issuance Of Common Stock ProceedsFromIssuanceOfCommonStock	30899000
CY2021	us-gaap	Payments Of Stock Issuance Costs PaymentsOfStockIssuanceCosts	1334000
CY2021	us-gaap	Repayments Of Debt RepaymentsOfDebt	1572000
CY2022	us-gaap	Net Cash Provided By Used In Financing Activities NetCashProvidedByUsedInFinancingActivities	1445000
CY2021	us-gaap	Net Cash Provided By Used In Financing Activities NetCashProvidedByUsedInFinancingActivities	94858000
CY2020	us-gaap	Net Cash Provided By Used In Financing Activities NetCashProvidedByUsedInFinancingActivities	7444000
CY2022	us-gaap	Effect Of Exchange Rate On Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	-1831000
CY2021	us-gaap	Effect Of Exchange Rate On Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	-3757000
CY2020	us-gaap	Effect Of Exchange Rate On Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	3822000
CY2022	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect	-328180000
CY2021	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect	311673000
CY2020	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect	-133046000
CY2021Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	559353000
CY2020Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	247680000
CY2019Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	380726000
CY2022Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	231173000
CY2021Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	559353000
CY2020Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	247680000
CY2022Q4	us-gaap	Cash And Cash Equivalents At Carrying Value CashAndCashEquivalentsAtCarryingValue	228012000
CY2021Q4	us-gaap	Cash And Cash Equivalents At Carrying Value CashAndCashEquivalentsAtCarryingValue	556256000
CY2020Q4	us-gaap	Cash And Cash Equivalents At Carrying Value CashAndCashEquivalentsAtCarryingValue	244932000
CY2022Q4	us-gaap	Restricted Cash Noncurrent RestrictedCashNoncurrent	3161000
CY2021Q4	us-gaap	Restricted Cash Noncurrent RestrictedCashNoncurrent	3097000
CY2020Q4	us-gaap	Restricted Cash Noncurrent RestrictedCashNoncurrent	2748000
CY2022Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	231173000
CY2021Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	559353000
CY2020Q4	us-gaap	Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents	247680000
CY2022	us-gaap	Interest Paid Net InterestPaidNet	9247000
CY2021	us-gaap	Interest Paid Net InterestPaidNet	6539000
CY2020	us-gaap	Interest Paid Net InterestPaidNet	4131000
CY2022	qure	Increase Decrease In Accounts Payable And Accrued Liabilities Related To Non Current Assets IncreaseDecreaseInAccountsPayableAndAccruedLiabilitiesRelatedToNonCurrentAssets	-964000
CY2021	qure	Increase Decrease In Accounts Payable And Accrued Liabilities Related To Non Current Assets IncreaseDecreaseInAccountsPayableAndAccruedLiabilitiesRelatedToNonCurrentAssets	1488000
CY2020	qure	Increase Decrease In Accounts Payable And Accrued Liabilities Related To Non Current Assets IncreaseDecreaseInAccountsPayableAndAccruedLiabilitiesRelatedToNonCurrentAssets	630000
CY2022	us-gaap	Nature Of Operations NatureOfOperations	<p style="font-family:'Times New Roman','Times','serif';font-size:10pt;font-weight:bold;margin:0pt;"><span style="display:inline-block;text-indent:0pt;width:36pt;"><b style="font-family:'Times New Roman','Times','serif';font-size:10pt;font-style:normal;font-weight:bold;">1.</b></span>General business information</p><p style="font-family:'Times New Roman','Times','serif';font-size:10pt;margin:0pt;"><span style="visibility:hidden;"></span></p><p style="font-family:'Times New Roman','Times','serif';font-size:10pt;text-align:justify;text-indent:36pt;margin:0pt;">uniQure (the “Company”) was incorporated on January 9, 2012 as a private company with limited liability (<i style="font-style:italic;">besloten vennootschap met beperkte aansprakelijkheid</i>) under the laws of the Netherlands. The Company is a leader in the field of gene therapy and seeks to deliver to patients suffering from rare and other devastating diseases single treatments with potentially curative results. The Company’s business was founded in 1998 and was initially operated through its predecessor company, Amsterdam Molecular Therapeutics Holding N.V (“AMT”). In 2012, AMT undertook a corporate reorganization, pursuant to which uniQure B.V. acquired the entire business and assets of AMT and completed a share-for-share exchange with the shareholders of AMT. Effective February 10, 2014, in connection with its initial public offering, the Company converted into a public company with limited liability (<i style="font-style:italic;">naamloze vennootschap</i>) and changed its legal name from uniQure B.V. to uniQure N.V.</p><p style="font-family:'Times New Roman','Times','serif';font-size:11pt;text-align:justify;margin:0pt 1pt 0pt 1pt;"><span style="font-size:10pt;margin-left:0pt;margin-right:0pt;visibility:hidden;"></span></p><p style="font-family:'Times New Roman','Times','serif';font-size:10pt;text-align:justify;text-indent:36pt;margin:0pt;">The Company is registered in the trade register of the Dutch Chamber of Commerce (<i style="font-style:italic;">Kamer van Koophandel</i>) in Amsterdam, the Netherlands under number 54385229. The Company’s headquarters are in Amsterdam, the Netherlands, and its registered office is located at Paasheuvelweg 25, Amsterdam 1105 BP, the Netherlands and its telephone number is +31 20 240 6000. The Company’s website address is www.uniqure.com. </p><p style="font-family:'Times New Roman','Times','serif';font-size:11pt;text-align:justify;margin:0pt;"><span style="visibility:hidden;"></span></p><p style="font-family:'Times New Roman','Times','serif';font-size:10pt;text-align:justify;text-indent:36pt;margin:0pt;">The Company’s ordinary shares are listed on the Nasdaq Global Select Market and trade under the symbol “QURE.”</p>
CY2022	us-gaap	Use Of Estimates UseOfEstimates	<p style="font-family:'Times New Roman','Times','serif';font-size:10pt;font-weight:bold;margin:0pt;">2.2<span style="font-weight:normal;"> </span>Use of estimates</p><p style="font-family:'Times New Roman','Times','serif';font-size:10pt;margin:0pt;"><span style="visibility:hidden;"></span></p><p style="font-family:'Times New Roman','Times','serif';font-size:10pt;text-align:justify;text-indent:36pt;margin:0pt;">The preparation of consolidated financial statements, in conformity with U.S. GAAP and Securities and Exchange Commission (“SEC”) rules and regulations, requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, disclosure of contingent assets and liabilities at the date of the consolidated financial statements and reported amounts of revenues and expenses during the reporting period. Estimates and assumptions are primarily made in relation to contingent consideration related to the acquisition of Corlieve Therapeutics SAS (“Corlieve”), the treatment of revenue to be recognized under the commercialization and license agreement entered into (“CSL Behring Agreement”) between the Company and CSL Behring LLC (“CSL Behring”), and the assessment of a valuation allowance on the Company’s deferred tax assets in the Netherlands and the U.S. If actual results differ from the Company’s estimates, or to the extent these estimates are adjusted in future periods, the Company’s results of operations could either benefit from, or be adversely affected by, any such change in estimate.</p>
CY2022	us-gaap	Number Of Operating Segments NumberOfOperatingSegments	1
CY2015	qure	License Revenue From Related Parties LicenseRevenueFromRelatedParties	75100000
CY2020	qure	License Revenue From Related Parties LicenseRevenueFromRelatedParties	27800000
CY2022Q4	us-gaap	Debt Securities Held To Maturity Amortized Cost After Allowance For Credit Loss DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLoss	164815000
CY2022Q4	us-gaap	Held To Maturity Securities Accumulated Unrecognized Holding Loss HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss	326000
CY2022Q4	us-gaap	Held To Maturity Securities Fair Value HeldToMaturitySecuritiesFairValue	164489000
CY2021	us-gaap	Payments To Acquire Held To Maturity Securities PaymentsToAcquireHeldToMaturitySecurities	0
CY2022Q4	us-gaap	Inventory Raw Materials Net Of Reserves InventoryRawMaterialsNetOfReserves	3584000
CY2022Q4	us-gaap	Inventory Work In Process Net Of Reserves InventoryWorkInProcessNetOfReserves	1874000
CY2022Q4	us-gaap	Inventory Finished Goods Net Of Reserves InventoryFinishedGoodsNetOfReserves	1466000
CY2022Q4	us-gaap	Inventory Net InventoryNet	6924000
CY2019Q4	us-gaap	Fair Value Measurement With Unobservable Inputs Reconciliations Recurring Basis Liability Value FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue	3075000
CY2020	us-gaap	Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Gain Loss Included In Earnings FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings	-2300000
CY2020	qure	Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Derecognition Of Warrants FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityDerecognitionOfWarrants	796000
CY2020	qure	Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Recognition Of Derivative Liability FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityRecognitionOfDerivativeLiability	2613000
CY2020	qure	Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Currency Translation Effects FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityCurrencyTranslationEffects	53000
CY2020Q4	us-gaap	Fair Value Measurement With Unobservable Inputs Reconciliations Recurring Basis Liability Value FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue	2645000
CY2021	qure	Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Contingent Consideration FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityContingentConsideration	23950000
CY2021	us-gaap	Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Gain Loss Included In Earnings FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings	6843000
CY2021	qure	Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Currency Translation Effects FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityCurrencyTranslationEffects	-1091000
CY2021Q4	us-gaap	Fair Value Measurement With Unobservable Inputs Reconciliations Recurring Basis Liability Value FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue	32347000
CY2022	us-gaap	Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Gain Loss Included In Earnings FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings	4320000
CY2022	qure	Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Currency Translation Effects FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityCurrencyTranslationEffects	-1351000
CY2022Q4	us-gaap	Fair Value Measurement With Unobservable Inputs Reconciliations Recurring Basis Liability Value FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue	35316000
CY2022Q4	us-gaap	Business Combination Contingent Consideration Liability Current BusinessCombinationContingentConsiderationLiabilityCurrent	26000000.0
CY2022Q4	us-gaap	Business Combination Contingent Consideration Liability BusinessCombinationContingentConsiderationLiability	35300000
CY2022	qure	Gain On Sale Of Derivatives GainOnSaleOfDerivatives	2760000
CY2020	qure	Gain On Sale Of Derivatives GainOnSaleOfDerivatives	483000
CY2022	us-gaap	Other Nonoperating Income OtherNonoperatingIncome	2760000
CY2020	us-gaap	Other Nonoperating Income OtherNonoperatingIncome	483000
CY2021	qure	Loss On Sale Of Derivatives LossOnSaleOfDerivatives	160000
CY2022	us-gaap	Other Nonoperating Income Expense OtherNonoperatingIncomeExpense	2760000
CY2021	us-gaap	Other Nonoperating Income Expense OtherNonoperatingIncomeExpense	-160000
CY2020	us-gaap	Other Nonoperating Income Expense OtherNonoperatingIncomeExpense	483000
CY2022Q4	qure	Number Of Warrant Types NumberOfWarrantTypes	2
CY2020Q4	qure	Number Of Collaboration Targets NumberOfCollaborationTargets	4
CY2020Q4	qure	Collaboration Agreement Cash Payable CollaborationAgreementCashPayable	70000000.0
CY2020Q4	qure	Collaboration Agreement Cash Payable CollaborationAgreementCashPayable	70000000.0
CY2020Q4	qure	Collaboration Agreement Cash Payable CollaborationAgreementCashPayable	70000000.0
CY2022Q4	us-gaap	Property Plant And Equipment Gross PropertyPlantAndEquipmentGross	94658000
CY2021Q4	us-gaap	Property Plant And Equipment Gross PropertyPlantAndEquipmentGross	80405000
CY2022Q4	us-gaap	Accumulated Depreciation Depletion And Amortization Property Plant And Equipment AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment	44126000
CY2021Q4	us-gaap	Accumulated Depreciation Depletion And Amortization Property Plant And Equipment AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment	36900000
CY2022Q4	us-gaap	Property Plant And Equipment Net PropertyPlantAndEquipmentNet	50532000
CY2021Q4	us-gaap	Property Plant And Equipment Net PropertyPlantAndEquipmentNet	43505000
CY2022	us-gaap	Depreciation Depreciation	8200000
CY2021	us-gaap	Depreciation Depreciation	6100000
CY2020	us-gaap	Depreciation Depreciation	5700000
CY2022Q4	us-gaap	Property Plant And Equipment Net PropertyPlantAndEquipmentNet	50532000
CY2021Q4	us-gaap	Property Plant And Equipment Net PropertyPlantAndEquipmentNet	43505000
CY2018Q4	us-gaap	Area Of Land AreaOfLand	30655
CY2021Q2	us-gaap	Area Of Land AreaOfLand	1080
CY2022	us-gaap	Operating Lease Cost OperatingLeaseCost	5932000
CY2021	us-gaap	Operating Lease Cost OperatingLeaseCost	5306000
CY2020	us-gaap	Operating Lease Cost OperatingLeaseCost	5052000
CY2022	us-gaap	Variable Lease Cost VariableLeaseCost	785000
CY2021	us-gaap	Variable Lease Cost VariableLeaseCost	698000
CY2020	us-gaap	Variable Lease Cost VariableLeaseCost	607000
CY2022	us-gaap	Sublease Income SubleaseIncome	849000
CY2021	us-gaap	Sublease Income SubleaseIncome	907000
CY2020	us-gaap	Sublease Income SubleaseIncome	904000
CY2022	us-gaap	Lease Cost LeaseCost	5868000
CY2021	us-gaap	Lease Cost LeaseCost	5097000
CY2020	us-gaap	Lease Cost LeaseCost	4755000
CY2022Q4	us-gaap	Operating Lease Right Of Use Asset OperatingLeaseRightOfUseAsset	32726000
CY2021Q4	us-gaap	Operating Lease Right Of Use Asset OperatingLeaseRightOfUseAsset	25573000
CY2022Q4	us-gaap	Operating Lease Liability Current OperatingLeaseLiabilityCurrent	8382000
CY2021Q4	us-gaap	Operating Lease Liability Current OperatingLeaseLiabilityCurrent	5774000
CY2022Q4	us-gaap	Operating Lease Liability Noncurrent OperatingLeaseLiabilityNoncurrent	31719000
CY2021Q4	us-gaap	Operating Lease Liability Noncurrent OperatingLeaseLiabilityNoncurrent	28987000
CY2022Q4	us-gaap	Operating Lease Liability OperatingLeaseLiability	40101000
CY2021Q4	us-gaap	Operating Lease Liability OperatingLeaseLiability	34761000
CY2022Q4	us-gaap	Operating Lease Weighted Average Remaining Lease Term1 OperatingLeaseWeightedAverageRemainingLeaseTerm1	P7Y2M12D
CY2021Q4	us-gaap	Operating Lease Weighted Average Remaining Lease Term1 OperatingLeaseWeightedAverageRemainingLeaseTerm1	P8Y3M18D
CY2022Q4	us-gaap	Operating Lease Weighted Average Discount Rate Percent OperatingLeaseWeightedAverageDiscountRatePercent	0.112
CY2021Q4	us-gaap	Operating Lease Weighted Average Discount Rate Percent OperatingLeaseWeightedAverageDiscountRatePercent	0.113
CY2022	us-gaap	Operating Lease Payments OperatingLeasePayments	7532000
CY2021	us-gaap	Operating Lease Payments OperatingLeasePayments	5738000
CY2020	us-gaap	Operating Lease Payments OperatingLeasePayments	5769000
CY2022	us-gaap	Right Of Use Asset Obtained In Exchange For Operating Lease Liability RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability	9824000
CY2021	us-gaap	Right Of Use Asset Obtained In Exchange For Operating Lease Liability RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability	1699000
CY2022Q4	us-gaap	Lessee Operating Lease Liability Payments Due Next Twelve Months LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths	8382000
CY2022Q4	us-gaap	Lessee Operating Lease Liability Payments Due Year Two LesseeOperatingLeaseLiabilityPaymentsDueYearTwo	7601000
CY2022Q4	us-gaap	Lessee Operating Lease Liability Payments Due Year Three LesseeOperatingLeaseLiabilityPaymentsDueYearThree	7956000
CY2022Q4	us-gaap	Lessee Operating Lease Liability Payments Due Year Four LesseeOperatingLeaseLiabilityPaymentsDueYearFour	8128000
CY2022Q4	us-gaap	Lessee Operating Lease Liability Payments Due Year Five LesseeOperatingLeaseLiabilityPaymentsDueYearFive	8308000
CY2022Q4	us-gaap	Lessee Operating Lease Liability Payments Due After Year Five LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive	17002000
CY2022Q4	us-gaap	Lessee Operating Lease Liability Payments Due LesseeOperatingLeaseLiabilityPaymentsDue	57377000
CY2022Q4	us-gaap	Lessee Operating Lease Liability Undiscounted Excess Amount LesseeOperatingLeaseLiabilityUndiscountedExcessAmount	17276000
CY2022Q4	us-gaap	Operating Lease Liability OperatingLeaseLiability	40101000
CY2022Q4	us-gaap	Operating Lease Liability Current OperatingLeaseLiabilityCurrent	8382000
CY2022Q4	us-gaap	Operating Lease Liability Noncurrent OperatingLeaseLiabilityNoncurrent	31719000
CY2022Q4	us-gaap	Foreign Currency Exchange Rate Translation1 ForeignCurrencyExchangeRateTranslation1	1.07
CY2022Q4	us-gaap	Intangible Assets Net Excluding Goodwill IntangibleAssetsNetExcludingGoodwill	58778000
CY2021Q4	us-gaap	Intangible Assets Net Excluding Goodwill IntangibleAssetsNetExcludingGoodwill	62686000
CY2022	us-gaap	Acquired Finite Lived Intangible Assets Weighted Average Useful Life AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife	P11Y6M
CY2021	us-gaap	Acquired Finite Lived Intangible Assets Weighted Average Useful Life AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife	P10Y9M18D
CY2020	qure	Impairment Of Intangible Asset Finite Lived Statement Of Income Or Comprehensive Income Extensible Enumeration Not Disclosed Flag ImpairmentOfIntangibleAssetFiniteLivedStatementOfIncomeOrComprehensiveIncomeExtensibleEnumerationNotDisclosedFlag	true
CY2021	qure	Impairment Of Intangible Asset Finite Lived Statement Of Income Or Comprehensive Income Extensible Enumeration Not Disclosed Flag ImpairmentOfIntangibleAssetFiniteLivedStatementOfIncomeOrComprehensiveIncomeExtensibleEnumerationNotDisclosedFlag	true
CY2022	qure	Impairment Of Intangible Asset Finite Lived Statement Of Income Or Comprehensive Income Extensible Enumeration Not Disclosed Flag ImpairmentOfIntangibleAssetFiniteLivedStatementOfIncomeOrComprehensiveIncomeExtensibleEnumerationNotDisclosedFlag	true
CY2022Q4	qure	Accruals For Services Provided By Vendors Not Yet Billed Current AccrualsForServicesProvidedByVendorsNotYetBilledCurrent	11120000
CY2021Q4	qure	Accruals For Services Provided By Vendors Not Yet Billed Current AccrualsForServicesProvidedByVendorsNotYetBilledCurrent	13012000
CY2022Q4	us-gaap	Employee Related Liabilities Current EmployeeRelatedLiabilitiesCurrent	17201000
CY2021Q4	us-gaap	Employee Related Liabilities Current EmployeeRelatedLiabilitiesCurrent	12603000
CY2022Q4	us-gaap	Other Liabilities Current OtherLiabilitiesCurrent	2250000
CY2021Q4	us-gaap	Other Liabilities Current OtherLiabilitiesCurrent	2872000
CY2022Q4	us-gaap	Accrued Liabilities Current AccruedLiabilitiesCurrent	30571000
CY2021Q4	us-gaap	Accrued Liabilities Current AccruedLiabilitiesCurrent	28487000
CY2022	qure	Long Term Debt Maturities Coupon Interest Payments And Financing Fees LongTermDebtMaturitiesCouponInterestPaymentsAndFinancingFees	44500000
CY2022Q4	us-gaap	Long Term Debt Maturities Repayments Of Principal In Next Twelve Months LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths	14870000
CY2022Q4	us-gaap	Long Term Debt Maturities Repayments Of Principal In Year Two LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo	12403000
CY2022Q4	us-gaap	Long Term Debt Maturities Repayments Of Principal In Year Three LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree	117219000
CY2022Q4	us-gaap	Long Term Debt LongTermDebt	144492000
CY2022Q4	qure	Common Stock Shares Authorized Value CommonStockSharesAuthorizedValue	4000000.0
CY2022Q4	qure	Common Stock Shares Authorized Value CommonStockSharesAuthorizedValue	4300000
CY2022Q4	us-gaap	Foreign Currency Exchange Rate Translation1 ForeignCurrencyExchangeRateTranslation1	1.07
CY2021Q2	qure	Common Stock Additional Shares Authorized CommonStockAdditionalSharesAuthorized	20000000
CY2022Q4	us-gaap	Common Stock Shares Authorized CommonStockSharesAuthorized	80000000
CY2021Q4	us-gaap	Common Stock Shares Authorized CommonStockSharesAuthorized	80000000
CY2022Q4	us-gaap	Accumulated Other Comprehensive Income Loss Net Of Tax AccumulatedOtherComprehensiveIncomeLossNetOfTax	-58300000
CY2021Q4	us-gaap	Accumulated Other Comprehensive Income Loss Net Of Tax AccumulatedOtherComprehensiveIncomeLossNetOfTax	-28900000
CY2020Q4	us-gaap	Accumulated Other Comprehensive Income Loss Net Of Tax AccumulatedOtherComprehensiveIncomeLossNetOfTax	-9900000
CY2021	qure	Adjustments To Additional Paid In Capital Stock Issued Issuance Costs Tax Effect Prior Years AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCostsTaxEffectPriorYears	3000000.0
CY2022	qure	Adjustments To Additional Paid In Capital Tax Effect Of Issuance Cost AdjustmentsToAdditionalPaidInCapitalTaxEffectOfIssuanceCost	800000
CY2022	us-gaap	Allocated Share Based Compensation Expense AllocatedShareBasedCompensationExpense	34204000
CY2021	us-gaap	Allocated Share Based Compensation Expense AllocatedShareBasedCompensationExpense	25635000
CY2020	us-gaap	Allocated Share Based Compensation Expense AllocatedShareBasedCompensationExpense	21831000
CY2022	us-gaap	Allocated Share Based Compensation Expense AllocatedShareBasedCompensationExpense	34204000
CY2021	us-gaap	Allocated Share Based Compensation Expense AllocatedShareBasedCompensationExpense	25635000
CY2020	us-gaap	Allocated Share Based Compensation Expense AllocatedShareBasedCompensationExpense	21831000
CY2022Q4	us-gaap	Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized	49528000
CY2022	us-gaap	Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1 EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1	P2Y2M4D
CY2021Q3	us-gaap	Deferred Compensation Arrangement With Individual Requisite Service Period1 DeferredCompensationArrangementWithIndividualRequisiteServicePeriod1	P1Y
CY2022	us-gaap	Deferred Compensation Arrangement With Individual Requisite Service Period1 DeferredCompensationArrangementWithIndividualRequisiteServicePeriod1	P3Y
CY2022	us-gaap	Labor And Related Expense LaborAndRelatedExpense	119903000
CY2021	us-gaap	Labor And Related Expense LaborAndRelatedExpense	96161000
CY2020	us-gaap	Labor And Related Expense LaborAndRelatedExpense	75926000
CY2022	qure	Laboratory And Development Expense LaboratoryAndDevelopmentExpense	65964000
CY2021	qure	Laboratory And Development Expense LaboratoryAndDevelopmentExpense	36014000
CY2020	qure	Laboratory And Development Expense LaboratoryAndDevelopmentExpense	35977000
CY2022	qure	Office And Housing Expense OfficeAndHousingExpense	17612000
CY2021	qure	Office And Housing Expense OfficeAndHousingExpense	14638000
CY2020	qure	Office And Housing Expense OfficeAndHousingExpense	13388000
CY2022	qure	Legal And Advisory Professional Fees LegalAndAdvisoryProfessionalFees	15782000
CY2021	qure	Legal And Advisory Professional Fees LegalAndAdvisoryProfessionalFees	24767000
CY2020	qure	Legal And Advisory Professional Fees LegalAndAdvisoryProfessionalFees	17370000
CY2022	us-gaap	Other Cost And Expense Operating OtherCostAndExpenseOperating	8510000
CY2021	us-gaap	Other Cost And Expense Operating OtherCostAndExpenseOperating	10528000
CY2020	us-gaap	Other Cost And Expense Operating OtherCostAndExpenseOperating	8772000
CY2022	qure	Patent And License Expenses PatentAndLicenseExpenses	9548000
CY2021	qure	Patent And License Expenses PatentAndLicenseExpenses	3748000
CY2020	qure	Patent And License Expenses PatentAndLicenseExpenses	2899000
CY2022	qure	Depreciation Amortization And Impairment Charges DepreciationAmortizationAndImpairmentCharges	8250000
CY2021	qure	Depreciation Amortization And Impairment Charges DepreciationAmortizationAndImpairmentCharges	7299000
CY2020	qure	Depreciation Amortization And Impairment Charges DepreciationAmortizationAndImpairmentCharges	10648000
CY2022	qure	Fair Value Loss On Corlieve Contingent Consideration FairValueLossOnCorlieveContingentConsideration	7081000
CY2021	qure	Fair Value Loss On Corlieve Contingent Consideration FairValueLossOnCorlieveContingentConsideration	6683000
CY2022	us-gaap	Operating Costs And Expenses OperatingCostsAndExpenses	252650000
CY2021	us-gaap	Operating Costs And Expenses OperatingCostsAndExpenses	199838000
CY2020	us-gaap	Operating Costs And Expenses OperatingCostsAndExpenses	164980000
CY2022	us-gaap	Salaries Wages And Officers Compensation SalariesWagesAndOfficersCompensation	63704000
CY2021	us-gaap	Salaries Wages And Officers Compensation SalariesWagesAndOfficersCompensation	53078000
CY2020	us-gaap	Salaries Wages And Officers Compensation SalariesWagesAndOfficersCompensation	40919000
CY2022	qure	Share Based Compensation In Employee Benefits ShareBasedCompensationInEmployeeBenefits	33881000
CY2021	qure	Share Based Compensation In Employee Benefits ShareBasedCompensationInEmployeeBenefits	25635000
CY2020	qure	Share Based Compensation In Employee Benefits ShareBasedCompensationInEmployeeBenefits	21831000
CY2022	qure	Social Security Costs SocialSecurityCosts	5179000
CY2021	qure	Social Security Costs SocialSecurityCosts	4496000
CY2020	qure	Social Security Costs SocialSecurityCosts	4068000
CY2022	qure	Health Insurance HealthInsurance	4148000
CY2021	qure	Health Insurance HealthInsurance	3161000
CY2020	qure	Health Insurance HealthInsurance	2271000
CY2022	qure	Contractor Expenses ContractorExpenses	3959000
CY2021	qure	Contractor Expenses ContractorExpenses	3170000
CY2020	qure	Contractor Expenses ContractorExpenses	2423000
CY2022	us-gaap	Other Labor Related Expenses OtherLaborRelatedExpenses	6365000
CY2021	us-gaap	Other Labor Related Expenses OtherLaborRelatedExpenses	4570000
CY2020	us-gaap	Other Labor Related Expenses OtherLaborRelatedExpenses	2635000
CY2022	us-gaap	Pension And Other Postretirement Benefit Expense PensionAndOtherPostretirementBenefitExpense	2667000
CY2021	us-gaap	Pension And Other Postretirement Benefit Expense PensionAndOtherPostretirementBenefitExpense	2051000
CY2020	us-gaap	Pension And Other Postretirement Benefit Expense PensionAndOtherPostretirementBenefitExpense	1779000
CY2022	us-gaap	Labor And Related Expense LaborAndRelatedExpense	119903000
CY2021	us-gaap	Labor And Related Expense LaborAndRelatedExpense	96161000
CY2020	us-gaap	Labor And Related Expense LaborAndRelatedExpense	75926000
CY2022	us-gaap	Other Income OtherIncome	7200000
CY2022	us-gaap	Other Income OtherIncome	7200000
CY2021	us-gaap	Other Income OtherIncome	12300000
CY2020	us-gaap	Other Income OtherIncome	3300000
CY2022	qure	Payments Received From European Authorities PaymentsReceivedFromEuropeanAuthorities	5600000
CY2021	qure	Payments Received From European Authorities PaymentsReceivedFromEuropeanAuthorities	5300000
CY2020	qure	Payments Received From European Authorities PaymentsReceivedFromEuropeanAuthorities	1900000
CY2021	qure	Employee Retention Credit Income EmployeeRetentionCreditIncome	2600000
CY2020	qure	Employee Retention Credit Income EmployeeRetentionCreditIncome	0
CY2022	qure	Employee Retention Credit Income EmployeeRetentionCreditIncome	0
CY2020	qure	Employee Retention Credit Income EmployeeRetentionCreditIncome	0
CY2021Q4	us-gaap	Unrecognized Tax Benefits UnrecognizedTaxBenefits	0
CY2022Q4	us-gaap	Unrecognized Tax Benefits UnrecognizedTaxBenefits	0
CY2022	us-gaap	Income Loss From Continuing Operations Before Income Taxes Domestic IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic	-96872000
CY2021	us-gaap	Income Loss From Continuing Operations Before Income Taxes Domestic IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic	348400000
CY2020	us-gaap	Income Loss From Continuing Operations Before Income Taxes Domestic IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic	-130493000
CY2022	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-128259000
CY2021	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	332806000
CY2020	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-141443000
CY2022	us-gaap	Deferred Income Tax Expense Benefit DeferredIncomeTaxExpenseBenefit	-1494000
CY2020	us-gaap	Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate	-35361000
CY2022	us-gaap	Income Tax Reconciliation Nondeductible Expense IncomeTaxReconciliationNondeductibleExpense	11129000
CY2021	us-gaap	Income Tax Reconciliation Nondeductible Expense IncomeTaxReconciliationNondeductibleExpense	9182000
CY2020	us-gaap	Income Tax Reconciliation Nondeductible Expense IncomeTaxReconciliationNondeductibleExpense	5041000
CY2021	us-gaap	Current Income Tax Expense Benefit CurrentIncomeTaxExpenseBenefit	7000
CY2022	us-gaap	Deferred Federal State And Local Tax Expense Benefit DeferredFederalStateAndLocalTaxExpenseBenefit	808000
CY2021	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	332806000
CY2020	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-141443000
CY2022	us-gaap	Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate	-33091000
CY2021	us-gaap	Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate	83201000
CY2020	us-gaap	Deferred Income Tax Expense Benefit DeferredIncomeTaxExpenseBenefit	-16419000
CY2022	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	-1470000
CY2021	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	3217000
CY2020	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	-16419000
CY2022	us-gaap	Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest	-128259000
CY2022	us-gaap	Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance	20591000
CY2021	us-gaap	Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance	-88857000
CY2020	us-gaap	Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance	30568000
CY2022	us-gaap	Income Tax Reconciliation Foreign Income Tax Rate Differential IncomeTaxReconciliationForeignIncomeTaxRateDifferential	-99000
CY2021	us-gaap	Income Tax Reconciliation Foreign Income Tax Rate Differential IncomeTaxReconciliationForeignIncomeTaxRateDifferential	-309000
CY2020	us-gaap	Income Tax Reconciliation Foreign Income Tax Rate Differential IncomeTaxReconciliationForeignIncomeTaxRateDifferential	-247000
CY2022	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	-1470000
CY2021	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	3217000
CY2020	us-gaap	Income Tax Expense Benefit IncomeTaxExpenseBenefit	-16419000
CY2022	us-gaap	Income Tax Reconciliation Nondeductible Expense Share Based Compensation Cost IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost	8500000
CY2021	us-gaap	Income Tax Reconciliation Nondeductible Expense Share Based Compensation Cost IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost	6700000
CY2020	us-gaap	Income Tax Reconciliation Nondeductible Expense Share Based Compensation Cost IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost	5800000
CY2022	qure	Effective Income Tax Rate Reconciliation Nondeductible Expense Contingent Consideration Amount EffectiveIncomeTaxRateReconciliationNondeductibleExpenseContingentConsiderationAmount	1900000
CY2021	qure	Effective Income Tax Rate Reconciliation Nondeductible Expense Contingent Consideration Amount EffectiveIncomeTaxRateReconciliationNondeductibleExpenseContingentConsiderationAmount	2000000.0
CY2020	qure	Effective Income Tax Rate Reconciliation Nondeductible Expense Contingent Consideration Amount EffectiveIncomeTaxRateReconciliationNondeductibleExpenseContingentConsiderationAmount	0
CY2022Q4	us-gaap	Deferred Tax Assets Operating Loss Carryforwards DeferredTaxAssetsOperatingLossCarryforwards	84633000
CY2021Q4	us-gaap	Deferred Tax Assets Operating Loss Carryforwards DeferredTaxAssetsOperatingLossCarryforwards	71917000
CY2022Q4	qure	Deferred Tax Assets Lease Liability DeferredTaxAssetsLeaseLiability	10612000
CY2021Q4	qure	Deferred Tax Assets Lease Liability DeferredTaxAssetsLeaseLiability	9300000
CY2022Q4	us-gaap	Deferred Tax Assets Goodwill And Intangible Assets DeferredTaxAssetsGoodwillAndIntangibleAssets	3826000
CY2021Q4	us-gaap	Deferred Tax Assets Goodwill And Intangible Assets DeferredTaxAssetsGoodwillAndIntangibleAssets	2039000
CY2022Q4	us-gaap	Deferred Tax Assets Tax Deferred Expense DeferredTaxAssetsTaxDeferredExpense	1862000
CY2021Q4	us-gaap	Deferred Tax Assets Tax Deferred Expense DeferredTaxAssetsTaxDeferredExpense	1312000
CY2022Q4	us-gaap	Deferred Tax Assets Property Plant And Equipment DeferredTaxAssetsPropertyPlantAndEquipment	510000
CY2021Q4	us-gaap	Deferred Tax Assets Property Plant And Equipment DeferredTaxAssetsPropertyPlantAndEquipment	971000
CY2021Q4	us-gaap	Deferred Tax Assets Inventory DeferredTaxAssetsInventory	148000
CY2022Q4	us-gaap	Deferred Tax Assets Tax Credit Carryforwards Research DeferredTaxAssetsTaxCreditCarryforwardsResearch	144000
CY2021Q4	us-gaap	Deferred Tax Assets Tax Credit Carryforwards Research DeferredTaxAssetsTaxCreditCarryforwardsResearch	105000
CY2022Q4	us-gaap	Deferred Tax Asset Interest Carryforward DeferredTaxAssetInterestCarryforward	3697000
CY2022Q4	us-gaap	Deferred Tax Assets Gross DeferredTaxAssetsGross	105284000
CY2021Q4	us-gaap	Deferred Tax Assets Gross DeferredTaxAssetsGross	85792000
CY2022Q4	us-gaap	Deferred Tax Assets Valuation Allowance DeferredTaxAssetsValuationAllowance	74547000
CY2021Q4	us-gaap	Deferred Tax Assets Valuation Allowance DeferredTaxAssetsValuationAllowance	60289000
CY2022Q4	us-gaap	Deferred Tax Assets Net DeferredTaxAssetsNet	30737000
CY2021Q4	us-gaap	Deferred Tax Assets Net DeferredTaxAssetsNet	25503000
CY2022Q4	qure	Deferred Tax Liabilities In Process Research And Development DeferredTaxLiabilitiesInProcessResearchAndDevelopment	15033000
CY2021Q4	qure	Deferred Tax Liabilities In Process Research And Development DeferredTaxLiabilitiesInProcessResearchAndDevelopment	15189000
CY2022Q4	qure	Deferred Tax Liability Right Of Use Asset DeferredTaxLiabilityRightOfUseAsset	9323000
CY2021Q4	qure	Deferred Tax Liability Right Of Use Asset DeferredTaxLiabilityRightOfUseAsset	7493000
CY2022Q4	qure	Deferred Tax Liability Other Current Assets And Receivables DeferredTaxLiabilityOtherCurrentAssetsAndReceivables	110000
CY2021Q4	qure	Deferred Tax Liability Other Current Assets And Receivables DeferredTaxLiabilityOtherCurrentAssetsAndReceivables	87000
CY2022Q4	us-gaap	Deferred Income Tax Liabilities DeferredIncomeTaxLiabilities	24466000
CY2021Q4	us-gaap	Deferred Income Tax Liabilities DeferredIncomeTaxLiabilities	22769000
CY2022Q4	us-gaap	Deferred Tax Assets Liabilities Net DeferredTaxAssetsLiabilitiesNet	6271000
CY2021Q4	us-gaap	Deferred Tax Assets Liabilities Net DeferredTaxAssetsLiabilitiesNet	2734000
CY2021Q4	us-gaap	Deferred Tax Assets Valuation Allowance DeferredTaxAssetsValuationAllowance	60289000
CY2020Q4	us-gaap	Deferred Tax Assets Valuation Allowance DeferredTaxAssetsValuationAllowance	150113000
CY2019Q4	us-gaap	Deferred Tax Assets Valuation Allowance DeferredTaxAssetsValuationAllowance	109856000
CY2022	qure	Valuation Allowance Deferred Tax Asset Changes Recorded In Profit And Loss ValuationAllowanceDeferredTaxAssetChangesRecordedInProfitAndLoss	20593000
CY2021	qure	Valuation Allowance Deferred Tax Asset Changes Recorded In Profit And Loss ValuationAllowanceDeferredTaxAssetChangesRecordedInProfitAndLoss	-88858000
CY2020	qure	Valuation Allowance Deferred Tax Asset Changes Recorded In Profit And Loss ValuationAllowanceDeferredTaxAssetChangesRecordedInProfitAndLoss	30568000
CY2022	qure	Valuation Allowance Deferred Tax Asset Changes Recorded In Equity ValuationAllowanceDeferredTaxAssetChangesRecordedInEquity	-972000
CY2021	qure	Valuation Allowance Deferred Tax Asset Changes Recorded In Profit And Loss Related To Tax Reform ValuationAllowanceDeferredTaxAssetChangesRecordedInProfitAndLossRelatedToTaxReform	1897000
CY2020	qure	Valuation Allowance Deferred Tax Asset Changes Recorded In Profit And Loss Related To Tax Reform ValuationAllowanceDeferredTaxAssetChangesRecordedInProfitAndLossRelatedToTaxReform	18287000
CY2021	qure	Valuation Allowance Deferred Tax Assets On Acquisition ValuationAllowanceDeferredTaxAssetsOnAcquisition	545000
CY2022	qure	Valuation Allowance Deferred Tax Asset Currency Translation Effects ValuationAllowanceDeferredTaxAssetCurrencyTranslationEffects	-5363000
CY2021	qure	Valuation Allowance Deferred Tax Asset Currency Translation Effects ValuationAllowanceDeferredTaxAssetCurrencyTranslationEffects	-3408000
CY2020	qure	Valuation Allowance Deferred Tax Asset Currency Translation Effects ValuationAllowanceDeferredTaxAssetCurrencyTranslationEffects	7821000
CY2022Q4	us-gaap	Deferred Tax Assets Valuation Allowance DeferredTaxAssetsValuationAllowance	74547000
CY2021Q4	us-gaap	Deferred Tax Assets Valuation Allowance DeferredTaxAssetsValuationAllowance	60289000
CY2020Q4	us-gaap	Deferred Tax Assets Valuation Allowance DeferredTaxAssetsValuationAllowance	150113000
CY2020	qure	Operating Loss Carryforwards Realized OperatingLossCarryforwardsRealized	1200000
CY2022Q4	us-gaap	Operating Loss Carryforwards OperatingLossCarryforwards	264000000.0
CY2021Q4	us-gaap	Operating Loss Carryforwards OperatingLossCarryforwards	228500000
CY2020Q4	us-gaap	Operating Loss Carryforwards OperatingLossCarryforwards	588200000
CY2021	qure	Adjustments To Additional Paid In Capital Stock Issued Issuance Costs Tax Effect Prior Years AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCostsTaxEffectPriorYears	3000000.0
CY2022	qure	Adjustments To Additional Paid In Capital Stock Issued Issuance Costs Tax Effect Prior Years AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCostsTaxEffectPriorYears	800000
CY2022Q4	qure	Valuation Allowance For Deferred Tax Assets Within Contributed Capital As It Relates To Follow On Offering Costs ValuationAllowanceForDeferredTaxAssetsWithinContributedCapitalAsItRelatesToFollowOnOfferingCosts	3300000
CY2021Q4	qure	Valuation Allowance For Deferred Tax Assets Within Contributed Capital As It Relates To Follow On Offering Costs ValuationAllowanceForDeferredTaxAssetsWithinContributedCapitalAsItRelatesToFollowOnOfferingCosts	4500000
CY2020	us-gaap	Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate	0.250
CY2021	us-gaap	Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate	0.250
CY2021	us-gaap	Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate	0.250
CY2022	us-gaap	Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate	0.258
CY2022	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-126789000
CY2021	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	329589000
CY2020	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-125024000
CY2022	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	-126789000
CY2021	us-gaap	Net Income Loss Available To Common Stockholders Basic NetIncomeLossAvailableToCommonStockholdersBasic	329589000
CY2022	us-gaap	Weighted Average Number Of Shares Outstanding Basic WeightedAverageNumberOfSharesOutstandingBasic	46735045
CY2021	us-gaap	Weighted Average Number Of Shares Outstanding Basic WeightedAverageNumberOfSharesOutstandingBasic	45986467
CY2020	us-gaap	Weighted Average Number Of Shares Outstanding Basic WeightedAverageNumberOfSharesOutstandingBasic	44466365
CY2022	us-gaap	Weighted Average Number Of Diluted Shares Outstanding WeightedAverageNumberOfDilutedSharesOutstanding	46735045
CY2022	us-gaap	Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount	6458429
CY2021	us-gaap	Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount	3814508
CY2020	us-gaap	Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount	3353797

Files In Submission

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report.css	Edgar Link	pending
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2023 Q1 Form 10-K Financial Statement

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2023 Q1 Form 10-K Financial Statement

#000155837023002110 Filed on February 27, 2023

Income Statement

Balance Sheet

Cashflow Statement

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Files In Submission

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