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$RYTM

$84.01 -$3.86 (4.39%)

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Insider Transactions

Insider Transaction Summary

M JAMES BARRETT

4,909,956 shares

Net: 0 B/S: -

Ravi Viswanathan

4,909,956 shares

Net: 0 B/S: -

SCOTT D SANDELL

4,909,956 shares

Net: 0 B/S: -

PETER J BARRIS

4,909,956 shares

Net: 0 B/S: -

PATRICK J KERINS

4,909,956 shares

Net: 0 B/S: -

ENTERPRISE ASSOCIATES 13 LP NEW

4,909,956 shares

Net: 0 B/S: -

DAVID M MOTT

4,909,956 shares

Net: 0 B/S: -

FOREST BASKETT

4,909,956 shares

Net: 0 B/S: -

CAPITAL MANAGEMENT, L.P. RA

4,557,882 shares

Net: 0 B/S: -

KEVIN P STARR

3,981,437 shares

Net: 0 B/S: -

ROCK VENTURES LP THIRD

2,981,437 shares

Net: 0 B/S: -

SAMUEL D ISALY

2,901,295 shares

Net: 0 B/S: -

ADVISORS LLC ORBIMED

2,751,679 shares

Net: 0 B/S: -

LUKE EVNIN

2,696,392 shares

Net: 0 B/S: -

INC PFIZER

1,427,639 shares

Net: 0 B/S: -

Todd Foley

909,258 shares

Net: 0 B/S: -

S.A. Ipsen,

833,099 shares

Net: 0 B/S: -

Keith Michael Gottesdiener

558,250 shares

Net: 0 B/S: -

Harbor Master Investors (Cayman) L.P. Hadley

545,256 shares

Net: 0 B/S: -

James E Flynn

468,505 shares

Net: 0 B/S: -

FELIX BAKER

170,778 shares

Net: 0 B/S: -

Hunter C Smith

116,611 shares

Net: +66,482 B/S: 2.35

Linda Shapiro Manning

75,000 shares

Net: 0 B/S: -

David P Meeker

71,900 shares

Net: +109,091 B/S: ∞

Yann Mazabraud

66,030 shares

Net: +86,725 B/S: ∞

Nithya Desikan

43,602 shares

Net: 0 B/S: -

der Ploeg Leonardus H.T. Van

42,339 shares

Net: 0 B/S: -

Fred T. Fiedorek

25,000 shares

Net: 0 B/S: -

Jennifer Kayden Lee

21,650 shares

Net: +35,025 B/S: ∞

Alastair Garfield

16,650 shares

Net: +24,419 B/S: 21.14

Joseph Shulman

15,000 shares

Net: +13,438 B/S: 1.45

Edward T Mathers

14,168 shares

Net: +19,434 B/S: ∞

Pamela J. Cramer

11,650 shares

Net: +17,593 B/S: 1.53

Neil Exter

10,000 shares

Net: 0 B/S: -

Murray Stewart

9,375 shares

Net: 0 B/S: -

William T. Roberts

7,872 shares

Net: 0 B/S: -

CHRISTOPHE JEAN

7,037 shares

Net: +11,037 B/S: ∞

Stuart A Arbuckle

7,037 shares

Net: +11,037 B/S: ∞

Camille L Bedrosian

7,037 shares

Net: +11,037 B/S: ∞

JENNIFER L GOOD

7,037 shares

Net: +11,037 B/S: ∞

LYNN A. TETRAULT

7,037 shares

Net: +11,037 B/S: ∞

DAVID W J MCGIRR

7,037 shares

Net: +11,037 B/S: ∞

Kimberly J Popovits

6,808 shares

Net: +6,808 B/S: ∞

Simon Kelner

6,250 shares

Net: 0 B/S: -

Christopher Paul German

5,753 shares

Net: +2,929 B/S: 1.4

Jennifer Chien

4,940 shares

Net: 0 B/S: -

Insider Name	Current Shares	Net Change (1yr)	Buy/Sell Ratio
M JAMES BARRETT	4,909,956	0	-
Ravi Viswanathan	4,909,956	0	-
SCOTT D SANDELL	4,909,956	0	-
PETER J BARRIS	4,909,956	0	-
PATRICK J KERINS	4,909,956	0	-
ENTERPRISE ASSOCIATES 13 LP NEW	4,909,956	0	-
DAVID M MOTT	4,909,956	0	-
FOREST BASKETT	4,909,956	0	-
CAPITAL MANAGEMENT, L.P. RA	4,557,882	0	-
KEVIN P STARR	3,981,437	0	-
ROCK VENTURES LP THIRD	2,981,437	0	-
SAMUEL D ISALY	2,901,295	0	-
ADVISORS LLC ORBIMED	2,751,679	0	-
LUKE EVNIN	2,696,392	0	-
INC PFIZER	1,427,639	0	-
Todd Foley	909,258	0	-
S.A. Ipsen,	833,099	0	-
Keith Michael Gottesdiener	558,250	0	-
Harbor Master Investors (Cayman) L.P. Hadley	545,256	0	-
James E Flynn	468,505	0	-
FELIX BAKER	170,778	0	-
Hunter C Smith	116,611	+66,482	2.35
Linda Shapiro Manning	75,000	0	-
David P Meeker	71,900	+109,091	∞
Yann Mazabraud	66,030	+86,725	∞
Nithya Desikan	43,602	0	-
der Ploeg Leonardus H.T. Van	42,339	0	-
Fred T. Fiedorek	25,000	0	-
Jennifer Kayden Lee	21,650	+35,025	∞
Alastair Garfield	16,650	+24,419	21.14
Joseph Shulman	15,000	+13,438	1.45
Edward T Mathers	14,168	+19,434	∞
Pamela J. Cramer	11,650	+17,593	1.53
Neil Exter	10,000	0	-
Murray Stewart	9,375	0	-
William T. Roberts	7,872	0	-
CHRISTOPHE JEAN	7,037	+11,037	∞
Stuart A Arbuckle	7,037	+11,037	∞
Camille L Bedrosian	7,037	+11,037	∞
JENNIFER L GOOD	7,037	+11,037	∞
LYNN A. TETRAULT	7,037	+11,037	∞
DAVID W J MCGIRR	7,037	+11,037	∞
Kimberly J Popovits	6,808	+6,808	∞
Simon Kelner	6,250	0	-
Christopher Paul German	5,753	+2,929	1.4
Jennifer Chien	4,940	0	-

Individual Transactions

April 01, 2026

Kimberly J Popovits

Grant/Award Acquisition

Change: +6,808

Price: $0.00

Shares: 6,808

Value: +$0

Yann Mazabraud

Option Exercise/Conversion

Change: +12,875

Price: $0.00

Shares: 66,030

Value: +$0

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Kimberly J Popovits	Apr 03	Grant/Award Acquisition (A) Compensation/Award	6,808	+6,808	$0.00	+$0
Yann Mazabraud	Apr 03	Option Exercise/Conversion (M) Compensation/Award	66,030	+12,875	$0.00	+$0

March 12, 2026

Edward T Mathers

Other Transaction

Change: +4,199

Price: $0.00

Shares: 14,168

Value: +$0

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Edward T Mathers	Mar 16	Other Transaction (J) Other	14,168	+4,199	$0.00	+$0

March 04, 2026

Christopher Paul German

Option Exercise/Conversion

Change: +1,500

Price: $17.97

Shares: 5,753

Value: +$26,955

Christopher Paul German

Open Market Sale

Change: -5,614

Price: $89.56

Shares: 160

Value: -$502,789

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Christopher Paul German	Mar 06	Option Exercise/Conversion (M) Compensation/Award	5,753	+1,500	$17.97	+$26,955
Christopher Paul German	Mar 06	Open Market Sale (S) Market Sale	160	-5,614	$89.56	-$502,789

March 02, 2026

Yann Mazabraud

Grant/Award Acquisition

Change: +35,000

Price: $0.00

Shares: 35,000

Value: +$0

Edward T Mathers

Other Transaction

Change: +4,198

Price: $0.00

Shares: 9,969

Value: +$0

Hunter C Smith

Option Exercise/Conversion

Change: +6,099

Price: $6.80

Shares: 116,611

Value: +$41,473

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Yann Mazabraud	Mar 04	Grant/Award Acquisition (A) Compensation/Award	35,000	+35,000	$0.00	+$0
Edward T Mathers	Mar 04	Other Transaction (J) Other	9,969	+4,198	$0.00	+$0
Hunter C Smith	Mar 02	Option Exercise/Conversion (M) Compensation/Award	116,611	+6,099	$6.80	+$41,473

March 01, 2026

Christopher Paul German

Option Exercise/Conversion

Change: +1,162

Price: $0.00

Shares: 4,595

Value: +$0

Christopher Paul German

Tax Payment

Change: -342

Price: $94.94

Shares: 4,253

Value: -$32,469

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Christopher Paul German	Mar 03	Option Exercise/Conversion (M) Compensation/Award	4,595	+1,162	$0.00	+$0
Christopher Paul German	Mar 03	Tax Payment (F) Tax Payment	4,253	-342	$94.94	-$32,469

February 19, 2026

Hunter C Smith

Open Market Sale

Change: -1,308

Price: $100.27

Shares: 113,589

Value: -$131,152

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Hunter C Smith	Feb 19	Open Market Sale (S) Market Sale	113,589	-1,308	$100.27	-$131,152

February 17, 2026

Hunter C Smith

Open Market Sale

Change: -1,200

Price: $99.42

Shares: 117,266

Value: -$119,298

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Hunter C Smith	Feb 19	Open Market Sale (S) Market Sale	117,266	-1,200	$99.42	-$119,298

February 14, 2026

Yann Mazabraud

Option Exercise/Conversion

Change: +10,000

Price: $0.00

Shares: 53,155

Value: +$0

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Yann Mazabraud	Feb 18	Option Exercise/Conversion (M) Compensation/Award	53,155	+10,000	$0.00	+$0

February 12, 2026

Hunter C Smith

Open Market Sale

Change: -292

Price: $96.26

Shares: 119,766

Value: -$28,108

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Hunter C Smith	Feb 12	Open Market Sale (S) Market Sale	119,766	-292	$96.26	-$28,108

February 11, 2026

Joseph Shulman

Grant/Award Acquisition

Change: +15,000

Price: $0.00

Shares: 15,000

Value: +$0

Yann Mazabraud

Grant/Award Acquisition

Change: +23,350

Price: $0.00

Shares: 23,350

Value: +$0

Jennifer Kayden Lee

Grant/Award Acquisition

Change: +21,650

Price: $0.00

Shares: 21,650

Value: +$0

Alastair Garfield

Grant/Award Acquisition

Change: +16,650

Price: $0.00

Shares: 16,650

Value: +$0

Pamela J. Cramer

Grant/Award Acquisition

Change: +11,650

Price: $0.00

Shares: 11,650

Value: +$0

Hunter C Smith

Grant/Award Acquisition

Change: +25,000

Price: $0.00

Shares: 25,000

Value: +$0

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Joseph Shulman	Feb 13	Grant/Award Acquisition (A) Compensation/Award	15,000	+15,000	$0.00	+$0
Yann Mazabraud	Feb 13	Grant/Award Acquisition (A) Compensation/Award	23,350	+23,350	$0.00	+$0
Jennifer Kayden Lee	Feb 13	Grant/Award Acquisition (A) Compensation/Award	21,650	+21,650	$0.00	+$0
Alastair Garfield	Feb 13	Grant/Award Acquisition (A) Compensation/Award	16,650	+16,650	$0.00	+$0
Pamela J. Cramer	Feb 13	Grant/Award Acquisition (A) Compensation/Award	11,650	+11,650	$0.00	+$0
Hunter C Smith	Feb 12	Grant/Award Acquisition (A) Compensation/Award	25,000	+25,000	$0.00	+$0