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$SION

$36.01 -$0.69 (1.88%)

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Insider Transactions

Insider Transaction Summary

Capital Healthcare Fund LP RA

6,897,623 shares

Net: -3,931 B/S: 0.84

JAMES G COULTER

6,494,962 shares

Net: -190,000 B/S: 0.24

Peter A. Thompson

2,964,774 shares

Net: -720,226 B/S: 0.03

ADVISORS LLC ORBIMED

2,964,774 shares

Net: -740,185 B/S: -

Bruce Booth

2,360,156 shares

Net: -293,276 B/S: 0.06

Michael Cloonan

436,100 shares

Net: +436,100 B/S: 4.85

Elena Ridloff

165,440 shares

Net: +80,440 B/S: 1.95

Charlotte McKee

155,700 shares

Net: +155,700 B/S: ∞

Caroline Stark Beer

139,340 shares

Net: +394,340 B/S: ∞

Harold Edward Fleming

19,959 shares

Net: +19,959 B/S: ∞

Joanne L. Viney

19,959 shares

Net: +19,959 B/S: ∞

Marcella K. Ruddy

19,959 shares

Net: +19,959 B/S: ∞

Laurie Stelzer

19,959 shares

Net: +19,959 B/S: ∞

Joshua Resnick

19,959 shares

Net: +19,959 B/S: ∞

Paul J Clancy

19,959 shares

Net: +19,959 B/S: ∞

Jennifer Fitzpatrick

10,250 shares

Net: +103,140 B/S: 4.35

Insider Name	Current Shares	Net Change (1yr)	Buy/Sell Ratio
Capital Healthcare Fund LP RA	6,897,623	-3,931	0.84
JAMES G COULTER	6,494,962	-190,000	0.24
Peter A. Thompson	2,964,774	-720,226	0.03
ADVISORS LLC ORBIMED	2,964,774	-740,185	-
Bruce Booth	2,360,156	-293,276	0.06
Michael Cloonan	436,100	+436,100	4.85
Elena Ridloff	165,440	+80,440	1.95
Charlotte McKee	155,700	+155,700	∞
Caroline Stark Beer	139,340	+394,340	∞
Harold Edward Fleming	19,959	+19,959	∞
Joanne L. Viney	19,959	+19,959	∞
Marcella K. Ruddy	19,959	+19,959	∞
Laurie Stelzer	19,959	+19,959	∞
Joshua Resnick	19,959	+19,959	∞
Paul J Clancy	19,959	+19,959	∞
Jennifer Fitzpatrick	10,250	+103,140	4.35

Individual Transactions

April 18, 2026

ADVISORS LLC ORBIMED

Open Market Sale

Change: -2,948

Price: $44.52

Shares: 2,964,774

Value: -$131,244

Peter A. Thompson

Open Market Sale

Change: -2,948

Price: $44.52

Shares: 2,964,774

Value: -$131,244

Insider	Filing Date	Transaction	Shares	Change	Price	Value
ADVISORS LLC ORBIMED	Apr 21	Open Market Sale (S) Market Sale	2,964,774	-2,948	$44.52	-$131,244
Peter A. Thompson	Apr 21	Open Market Sale (S) Market Sale	2,964,774	-2,948	$44.52	-$131,244

April 17, 2026

ADVISORS LLC ORBIMED

Open Market Sale

Change: -52,397

Price: $44.68

Shares: 2,967,722

Value: -$2,341,097

Peter A. Thompson

Open Market Sale

Change: -52,397

Price: $44.68

Shares: 2,967,722

Value: -$2,341,097

Insider	Filing Date	Transaction	Shares	Change	Price	Value
ADVISORS LLC ORBIMED	Apr 21	Open Market Sale (S) Market Sale	2,967,722	-52,397	$44.68	-$2,341,097
Peter A. Thompson	Apr 21	Open Market Sale (S) Market Sale	2,967,722	-52,397	$44.68	-$2,341,097

April 16, 2026

Peter A. Thompson

Open Market Sale

Change: -226,906

Price: $45.34

Shares: 3,020,119

Value: -$10,287,918

ADVISORS LLC ORBIMED

Open Market Sale

Change: -226,906

Price: $45.34

Shares: 3,020,119

Value: -$10,287,918

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Peter A. Thompson	Apr 16	Open Market Sale (S) Market Sale	3,020,119	-226,906	$45.34	-$10,287,918
ADVISORS LLC ORBIMED	Apr 16	Open Market Sale (S) Market Sale	3,020,119	-226,906	$45.34	-$10,287,918

April 15, 2026

ADVISORS LLC ORBIMED

Open Market Sale

Change: -235,863

Price: $44.64

Shares: 3,247,025

Value: -$10,528,924

Peter A. Thompson

Open Market Sale

Change: -235,863

Price: $44.64

Shares: 3,247,025

Value: -$10,528,924

Insider	Filing Date	Transaction	Shares	Change	Price	Value
ADVISORS LLC ORBIMED	Apr 16	Open Market Sale (S) Market Sale	3,247,025	-235,863	$44.64	-$10,528,924
Peter A. Thompson	Apr 16	Open Market Sale (S) Market Sale	3,247,025	-235,863	$44.64	-$10,528,924

April 14, 2026

ADVISORS LLC ORBIMED

Open Market Sale

Change: -47,814

Price: $44.51

Shares: 3,482,888

Value: -$2,128,201

Peter A. Thompson

Open Market Sale

Change: -47,814

Price: $44.51

Shares: 3,482,888

Value: -$2,128,201

Insider	Filing Date	Transaction	Shares	Change	Price	Value
ADVISORS LLC ORBIMED	Apr 16	Open Market Sale (S) Market Sale	3,482,888	-47,814	$44.51	-$2,128,201
Peter A. Thompson	Apr 16	Open Market Sale (S) Market Sale	3,482,888	-47,814	$44.51	-$2,128,201

March 05, 2026

Jennifer Fitzpatrick

Option Exercise/Conversion

Change: +10,250

Price: $6.11

Shares: 10,250

Value: +$62,627

Jennifer Fitzpatrick

Open Market Sale

Change: -10,250

Price: $33.86

Shares: 0

Value: -$347,018

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Jennifer Fitzpatrick	Mar 06	Option Exercise/Conversion (M) Compensation/Award	10,250	+10,250	$6.11	+$62,627
Jennifer Fitzpatrick	Mar 06	Open Market Sale (S) Market Sale	0	-10,250	$33.86	-$347,018

February 03, 2026

Peter A. Thompson

Open Market Sale

Change: -29,063

Price: $44.58

Shares: 3,530,702

Value: -$1,295,628

ADVISORS LLC ORBIMED

Open Market Sale

Change: -29,063

Price: $44.58

Shares: 3,530,702

Value: -$1,295,628

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Peter A. Thompson	Feb 04	Open Market Sale (S) Market Sale	3,530,702	-29,063	$44.58	-$1,295,628
ADVISORS LLC ORBIMED	Feb 04	Open Market Sale (S) Market Sale	3,530,702	-29,063	$44.58	-$1,295,628

February 02, 2026

Peter A. Thompson

Open Market Sale

Change: -1,890

Price: $44.57

Shares: 3,559,765

Value: -$84,237

ADVISORS LLC ORBIMED

Open Market Sale

Change: -1,890

Price: $44.57

Shares: 3,559,765

Value: -$84,237

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Peter A. Thompson	Feb 04	Open Market Sale (S) Market Sale	3,559,765	-1,890	$44.57	-$84,237
ADVISORS LLC ORBIMED	Feb 04	Open Market Sale (S) Market Sale	3,559,765	-1,890	$44.57	-$84,237

January 22, 2026

JAMES G COULTER

Open Market Sale

Change: -250,000

Price: $40.00

Shares: 6,494,962

Value: -$10,000,000

Insider	Filing Date	Transaction	Shares	Change	Price	Value
JAMES G COULTER	Jan 26	Open Market Sale (S) Market Sale	6,494,962	-250,000	$40.00	-$10,000,000

January 02, 2026

Caroline Stark Beer

Grant/Award Acquisition

Change: +139,340

Price: $0.00

Shares: 139,340

Value: +$0

Jennifer Fitzpatrick

Grant/Award Acquisition

Change: +103,140

Price: $0.00

Shares: 103,140

Value: +$0

Charlotte McKee

Grant/Award Acquisition

Change: +155,700

Price: $0.00

Shares: 155,700

Value: +$0

Insider	Filing Date	Transaction	Shares	Change	Price	Value
Caroline Stark Beer	Jan 06	Grant/Award Acquisition (A) Compensation/Award	139,340	+139,340	$0.00	+$0
Jennifer Fitzpatrick	Jan 06	Grant/Award Acquisition (A) Compensation/Award	103,140	+103,140	$0.00	+$0
Charlotte McKee	Jan 06	Grant/Award Acquisition (A) Compensation/Award	155,700	+155,700	$0.00	+$0