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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Cash flows used in operating activities: | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash used in operating activities: | |||||
| Gain on remeasurement of liabilities | |||||
| Non-cash interest expense | |||||
| Amortization of discount on short-term investments | |||||
| Unrealized foreign exchange loss (gain) | |||||
| Impairment of fixed assets | |||||
| Amortization of operating right-of-use assets | |||||
| Depreciation | |||||
| Amortization of intangible assets | |||||
| Impairment of intangible assets | |||||
| Stock-based compensation | |||||
| Loss on disposal of assets | |||||
| Acquired in-process research and development expense | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable | |||||
| Prepaid expenses | |||||
| Prepaid expenses and other current assets | |||||
| Other assets | |||||
| Research and development tax credit receivable | |||||
| Deferred revenue and other income | |||||
| Accounts payable | |||||
| Accrued liabilities and other current liabilities | |||||
| Accrued compensation | |||||
| Other long-term liabilities | |||||
| Operating lease right-of-use assets and lease liabilities, net | |||||
| Net cash used in operating activities | |||||
| Cash flows used in investing activities: | |||||
| Maturities and sales of short-term investments | |||||
| Purchase of short-term investments | |||||
| Purchase of property and equipment | |||||
| Proceeds from sale of property, plant and equipment | |||||
| Payments to Akeso for upfront milestone payments and associated direct transaction costs | |||||
| Net cash used in investing activities | |||||
| Cash flows provided by financing activities: | |||||
| Proceeds from the issuance of common stock via private placements, net of offering costs | |||||
| Proceeds from exercise of warrants | |||||
| Proceeds received related to employee stock purchase plan and exercise of stock options | |||||
| Proceeds from related party promissory notes | |||||
| Payments of related party promissory notes issuance costs | |||||
| Net cash provided by financing activities | |||||
| Effect of exchange rates on cash and cash equivalents | |||||
| Increase (decrease) in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash at beginning of period | |||||
| Cash, cash equivalents and restricted cash at end of period | |||||
| Supplemental Disclosure of Cash Flow Information: | |||||
| Cash paid for income taxes | |||||
| Supplemental Disclosure of Non-Cash Investing and Financing Activities: | |||||
| Debt issuance costs in accrued expenses | |||||
| Leased assets obtained in exchange for operating lease liabilities | |||||
| Unpaid amounts related to purchase of property, plant and equipment | |||||
| Issuance of common stock | |||||
| Rights Offering | |||||
| Akeso License Agreement | |||||
| Deferred transaction costs included in other non-current assets | |||||
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