| Insider Name | Current Shares | Net Change (1yr) | Buy/Sell Ratio |
|---|---|---|---|
| NICOLE VITULLO | 1,743,854 | 0 | - |
| BioVentures IV LLC MPM | 1,138,210 | 0 | - |
| JAMES C BLAIR | 761,062 | 0 | - |
| IVOR ROYSTON | 625,545 | 0 | - |
| PARTNERS L P/IL BVF | 498,025 | 0 | - |
| Michael A Metzger | 491,690 | +40,895 | 1.22 |
| Dennis Podlesak | 239,763 | +48,000 | 1.83 |
| Steve M Sabus | 220,000 | 0 | - |
| Keith A. Goldan | 140,429 | +15,933 | 3.53 |
| Keith Katkin | 124,000 | +24,000 | ∞ |
| Jennifer Jarrett | 114,000 | +24,000 | ∞ |
| Pierre Legault | 114,000 | +24,000 | ∞ |
| Catherine Madigan | 110,000 | 0 | - |
| Martin H. Jr. Huber | 103,000 | +24,000 | ∞ |
| Daphne Karydas | 95,000 | 0 | - |
| William Meury | 90,000 | 0 | - |
| Neil Gallagher | 85,095 | 0 | - |
| Nicholas A.J. Botwood | 59,165 | +24,000 | ∞ |
| Aleksandra Rizo | 49,000 | +24,000 | ∞ |
| Richard P Shea | 43,200 | 0 | - |
| Briggs Morrison | 34,836 | 0 | - |
| Fabrice Egros | 32,000 | 0 | - |
| Michael L. Meyers | 17,350 | 0 | - |
| Alexander Nolte | 17,000 | 0 | - |
| LUKE EVNIN | 14,000 | 0 | - |
| Henry Chen | 14,000 | 0 | - |
| Kim P. Kamdar | 8,000 | 0 | - |
| Peter Ordentlich | 7,572 | 0 | - |
| Brian K Halak | 5,641 | 0 | - |
| George W. Jr. Sledge | 5,000 | 0 | - |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Michael A Metzger | Feb 10 |
Open Market Sale (S)
Market Sale
|
491,690 | -17,159 | $21.03 | -$360,819 |
| Keith A. Goldan | Feb 10 |
Open Market Sale (S)
Market Sale
|
140,429 | -3,410 | $21.03 | -$71,705 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Michael A Metzger | Feb 06 |
Open Market Sale (S)
Market Sale
|
508,849 | -7,412 | $20.62 | -$152,835 |
| Keith A. Goldan | Feb 06 |
Open Market Sale (S)
Market Sale
|
143,839 | -2,082 | $20.62 | -$42,930 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Michael A Metzger | Feb 06 |
Grant/Award Acquisition (A)
Compensation/Award
|
371,661 | +73,000 | $0.00 | +$0 |
| Keith A. Goldan | Feb 06 |
Grant/Award Acquisition (A)
Compensation/Award
|
115,171 | +21,500 | $0.00 | +$0 |
| Jennifer Jarrett | Feb 06 |
Grant/Award Acquisition (A)
Compensation/Award
|
114,000 | +24,000 | $0.00 | +$0 |
| Martin H. Jr. Huber | Feb 06 |
Grant/Award Acquisition (A)
Compensation/Award
|
103,000 | +24,000 | $0.00 | +$0 |
| Nicholas A.J. Botwood | Feb 06 |
Grant/Award Acquisition (A)
Compensation/Award
|
59,165 | +24,000 | $0.00 | +$0 |
| Aleksandra Rizo | Feb 06 |
Grant/Award Acquisition (A)
Compensation/Award
|
49,000 | +24,000 | $0.00 | +$0 |
| Pierre Legault | Feb 06 |
Grant/Award Acquisition (A)
Compensation/Award
|
114,000 | +24,000 | $0.00 | +$0 |
| Keith Katkin | Feb 06 |
Grant/Award Acquisition (A)
Compensation/Award
|
124,000 | +24,000 | $0.00 | +$0 |
| Dennis Podlesak | Feb 06 |
Grant/Award Acquisition (A)
Compensation/Award
|
239,763 | +48,000 | $0.00 | +$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Keith A. Goldan | Feb 06 |
Other Transaction (J)
Other
|
93,671 | +1,219 | $8.48 | +$10,337 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Keith A. Goldan | Dec 01 |
Gift (G)
Non-Market Transfer
|
92,452 | -1,224 | $0.00 | -$0 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Michael A Metzger | Sep 08 |
Open Market Sale (S)
Market Sale
|
298,661 | -157,307 | $16.41 | -$2,582,021 |
| Michael A Metzger | Sep 08 |
Option Exercise/Conversion (M)
Compensation/Award
|
455,968 | +157,307 | $10.90 | +$1,714,646 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Dennis Podlesak | Aug 18 |
Open Market Sale (S)
Market Sale
|
191,763 | -19,200 | $15.84 | -$304,170 |
| Dennis Podlesak | Aug 18 |
Option Exercise/Conversion (M)
Compensation/Award
|
210,963 | +19,200 | $7.20 | +$138,240 |
| Insider | Filing Date | Transaction | Shares | Change | Price | Value |
|---|---|---|---|---|---|---|
| Dennis Podlesak | Aug 18 |
Open Market Sale (S)
Market Sale
|
191,763 | -19,200 | $15.54 | -$298,408 |
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