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FY2025
12 months to Dec 31, 2025
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FY2024
12 months to Dec 31, 2024
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FY2023
12 months to Dec 31, 2023
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FY2022
12 months to Dec 31, 2022
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FY2021
12 months to Dec 31, 2021
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|---|---|---|---|---|---|
| Operating activities | |||||
| Net loss | |||||
| Adjustments to reconcile net loss to net cash (used in) provided by operating activities: | |||||
| Depreciation and amortization | |||||
| Accretion of discount on marketable securities | |||||
| Stock-based compensation | |||||
| Non-cash lease expenses | |||||
| Impairment charges | |||||
| Realized gain on sale of equity securities | |||||
| Unrealized gain on equity securities | |||||
| Non-cash interest expense on deferred royalty obligation | |||||
| Other | |||||
| Changes in operating assets and liabilities: | |||||
| Accounts receivable | |||||
| Prepaid expenses and other assets | |||||
| Accounts payable | |||||
| Accrued compensation | |||||
| Accrued expenses and other liabilities | |||||
| Deferred revenue | |||||
| Change in operating lease liability | |||||
| Net cash used in operating activities | |||||
| Investing activities | |||||
| Purchases of marketable securities | |||||
| Maturities of marketable securities | |||||
| Sales of marketable securities | |||||
| Proceeds from sale of equity securities, net | |||||
| Purchases of equipment and leasehold improvements | |||||
| Proceeds from exercise of options for Vaxcyte shares | |||||
| Net cash provided by (used in) investing activities | |||||
| Financing activities | |||||
| Proceeds from sales of common stock, net of issuance costs | |||||
| Proceeds from sales of common stock to Ipsen Biopharmaceuticals, Inc. (USA) | |||||
| Payments of debt | |||||
| Proceeds from the sale of future royalties, net of issuance costs | |||||
| Proceeds from exercise of common stock options | |||||
| Taxes paid related to net share settlement of restricted stock units | |||||
| Proceeds from employee stock purchase plan | |||||
| Net cash provided by financing activities | |||||
| Net increase in cash, cash equivalents and restricted cash | |||||
| Cash, cash equivalents and restricted cash at beginning of year | |||||
| Cash, cash equivalents and restricted cash at end of year | |||||
| Supplemental disclosure of cash flow information | |||||
| Cash paid for interest | |||||
| Income tax paid | |||||
| Supplemental Disclosures of Non-cash Investing and Financing Information | |||||
| Purchase of property and equipment included in accounts payable | |||||
| Value of 167,780 shares of Vaxcyte common stock received under the Vaxcyte Agreement | |||||
| Financing Component Associated with Program Fees | |||||
| Premium on common stock issued to Ipsen Biopharma, Inc. (USA) | |||||
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